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Δευτέρα 6 Απριλίου 2020


Developing a multivariable prediction model for functional outcome after reperfusion therapy for acute ischaemic stroke: study protocol for the Targeting Optimal Thrombolysis Outcomes (TOTO) multicentre cohort study
IntroductionIntravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) is the only approved pharmacological reperfusion therapy for acute ischaemic stroke. Despite population benefit, IVT is not equally effective in all patients, nor is it without significant risk. Uncertain treatment outcome prediction complicates patient treatment selection. This study will develop and validate predictive algorithms for IVT response, using clinical, radiological and blood-based biomarker...
BMJ Open Current Issue
4m
Systematic review of gender differences in the epidemiology and risk factors of exertional heat illness and heat tolerance in the armed forces
ObjectivesThis review aimed to describe the epidemiology of all heat-related illnesses in women compared with men in the armed forces and to identify gender-specific risk factors and differences in heat tolerance. DesignA systematic review of multiple databases (MEDLINE, Emcare, CINAHL, PsycINFO, Informit and Scopus) was conducted from the inception of the databases to 1 April 2019 using the preferred reporting items for systematic review and meta-analysis guidelines. Eligibility criteriaAll...
BMJ Open Current Issue
4m
Understanding behavioural changes through community-based participatory research to promote oral health in socially disadvantaged neighbourhoods in Southern Sweden
ObjectivesInequalities in oral health have been on the rise globally. In Sweden, these differences exist not between regions, but among subgroups living in vulnerable situations. This study aims at understanding behavioural change after taking part in participatory oral health promotional activity among families living in socially disadvantaged neighbourhoods in Southern Sweden. SettingThe current study involved citizens from a socially disadvantaged neighbourhood in Malmö, together with actors...
BMJ Open Current Issue
4m
Polish adaptation and validation of the Perceived Implicit Rationing of Nursing Care (PIRNCA) questionnaire: a cross-sectional validation study
ObjectivesTo develop a Polish adaptation of the Perceived Implicit Rationing of Nursing Care (PIRNCA)questionnaire. DesignCross-sectional validation study. SettingsNurses working in surgical and cancer wards in Poland. ParticipantsA sample of 513 professionally active nurses was enrolled in the study. InterventionTo complete a Polish translation of the full original PIRNCA questionnaire. Primary and secondary outcome measuresThe primary outcome was translation and adaptation of the full...
BMJ Open Current Issue
4m
Cohort profile: the Funen Diabetes Database--a population-based cohort of patients with diabetes in Denmark
PurposeDetailed population-based data are essential to understanding the epidemiology of diabetes and its clinical course. This article describes the Funen Diabetes Database (FDDB). The purpose of the FDDB was to serve as a shared electronic medical record system for healthcare professionals treating patients with diabetes. The cohort can also be used for research. ParticipantsThe FDDB covers a geographical area of almost 500 000 Danish inhabitants. It currently includes 3691 patients with type...
BMJ Open Current Issue
4m
Biomarker-guided implementation of the KDIGO guidelines to reduce the occurrence of acute kidney injury in patients after cardiac surgery (PrevAKI-multicentre): protocol for a multicentre, observational study followed by randomised controlled feasibility trial
IntroductionAcute kidney injury (AKI) is a frequent complication after cardiac surgery with adverse short-term and long-term outcomes. Although prevention of AKI (PrevAKI) is strongly recommended, the optimal strategy is uncertain. The Kidney Disease: Improving Global Outcomes (KDIGO) guideline recommended a bundle of supportive measures in high-risk patients. In a single-centre trial, we recently demonstrated that the strict implementation of the KDIGO bundle significantly reduced the occurrence...
BMJ Open Current Issue
4m
Organisational and individual characteristics associated with glycaemic control among patients with type 2 diabetes: cross-sectional study in China
ObjectiveThere is a high prevalence of poor glycaemic control among patients with type 2 diabetes (T2DM) in China. This study aimed to explore both organisational and individual characteristics associated with glycaemic control among patients with T2DM. DesignCross-sectional survey. SettingShandong Province, China. ParticipantsThe participants were 2166 patients with T2DM and 337 healthcare providers from 36 urban communities and 36 rural villages in Shandong Province. Primary and secondary...
BMJ Open Current Issue
4m
Trend analysis of tuberculosis case notifications with scale-up of antiretroviral therapy and roll-out of isoniazid preventive therapy in Zimbabwe, 2000-2018
ObjectivesAntiretroviral therapy (ART) and isoniazid preventive therapy (IPT) are known to have a tuberculosis (TB) protective effect at the individual level among people living with HIV (PLHIV). In Zimbabwe where TB is driven by HIV infection, we have assessed whether there is a population-level association between IPT and ART scale-up and annual TB case notification rates (CNRs) from 2000 to 2018. DesignEcological study using aggregate national data. SettingAnnual aggregate national data on...
BMJ Open Current Issue
4m
Comparative study on prevalence of metabolic syndrome based on three criteria among adults in Zhejiang province, China: an observational study
ObjectivesIn this study, we aimed to estimate the prevalence of metabolic syndrome (MetS) among Chinese adults, describe the disease components and compare utility of the existing international criteria and Chinese diagnostic criteria. Design, setting and participantsA retrospective database analysis was conducted for one hospital in Zhejiang province, China. We analysed data (collected in 2017) from a total of 64 902 participants (37 500 males and 27 402 females), aged between 18 and 97 years,...
BMJ Open Current Issue
4m
Core outcome set in paediatric sepsis in low- and middle-income countries: a study protocol
IntroductionSepsis is the leading cause of death in children worldwide and has recently been declared a major global health issue. New interventions and a concerted effort to enhance our understanding of sepsis are required to address the huge burden of disease, especially in low- and middle-income countries (LMIC) where it is highest. An opportunity therefore exists to ensure that ongoing research in this area is relevant to all stakeholders and is of consistently high quality. One method to address...
BMJ Open Current Issue
4m
Understanding physical activity and sedentary behaviour among preschool-aged children in Singapore: a mixed-methods approach
ObjectivesThis study investigated physical activity (PA) and sedentary behaviour (SB) among preschool-aged children in Singapore and potential correlates at multiple levels of the socioecological model from in-school and out-of-school settings. DesignA cross-sectional study using a mixed-methods approach. ParticipantsParent–child dyads from six preschools in Singapore. MethodsPA and SB of children (n=72) were quantified using wrist-worn accelerometers for seven consecutive days. Three focus...
BMJ Open Current Issue
4m
Investigating the critical elements and psychosocial outcomes of Youth Flexible Assertive Community Treatment: a study protocol for an observational prospective cohort study
IntroductionWhen adolescents experience complex psychiatric and social problems, numerous healthcare services usually become involved. In these cases, fragmentation of care services is a risk that often results in both ineffective care and in patients disengaging from care services. To address these issues, Youth Flexible Assertive Community Treatment (Youth Flexible ACT) was developed in the Netherlands. This client-centred service delivery model aims to tackle the fragmented care system by providing...
BMJ Open Current Issue
4m
Leadership development in complex health systems: a qualitative study
ObjectiveLeadership is associated with organisational performance in healthcare, including quality, safety and clinical outcomes for patients. Leadership development programmes have proliferated in recent years. Nevertheless, very few have examined participant experiences in depth in order to understand which programmatic aspects they regard as most valuable relative to leadership in increasingly complex systems, or whether and how learnings may sustain over time. Accordingly, we explored experiences...
BMJ Open Current Issue
4m
Persistence of patient and family experiences of critical illness
ObjectiveTo investigate: (1) patient and family experiences with healthcare and the intensive care unit (ICU); (2) experiences during their critical illness; (3) communication and decision making during critical illness; (4) feelings about the ICU experience; (5) impact of the critical illness on their lives; and (6) concerns about their future after the ICU. DesignFour semistructured focus group interviews with former ICU patients and family members. SettingsMulticultural community group and...
BMJ Open Current Issue
4m
Association between functional social support and cognitive function in middle-aged and older adults: a protocol for a systematic review
IntroductionMaintenance of cognitive function into old age is important for ageing populations. Researchers seek to identify modifiable risk and protective factors for cognitive function. One such modifiable factor is functional social support, that is, one’s perception of whether their social network can provide resources such as material help, companionship, information and emotional contact, if needed. While the literature generally reports positive associations between functional social support...
BMJ Open Current Issue
4m
Community engagement with immigrant communities involving health and wellness research: a systematic review protocol towards developing a taxonomy of community engagement definitions, frameworks, and methods
IntroductionThe importance of community engagement has been established globally in health and wellness research. A certain degree of ambiguity remains, however, regarding the meaning of community engagement, which term has been used for various purposes and implemented in various forms. In this study, we aimed to explore the different definitions of community engagement, discuss the various objectives that have been proposed and uncover the diverse ways this concept has been implemented among researchers...
BMJ Open Current Issue
4m
Low-risk myelodysplastic syndrome managed with an erythroid-stimulating agent for 10 years
A 57-year-old man with a history of diabetes and coronary artery disease was referred to haematology for the evaluation of anaemia in the setting of non-cardiac chest pain, fatigue, dyspnoea and dizziness. Previous investigations into these recurrent symptoms focused on a re-evaluation of his known ischaemic heart disease, which required multiple percutaneous interventions with stenting several years ago. In the year leading up to his referral, the patient required two transfusions during separate...
BMJ Case Reports Last 6 Issues
20m
Isolated cardiovascular involvement in light chain amyloidosis
A 50-year-old woman presented with complaints of palpitations and breathlessness of 6 months’ duration. She was being treated elsewhere as a case of dilated cardiomyopathy. On evaluation she had racoon eyes, poor progression of R wave on ECG and low-voltage complexes in the limb leads. Echocardiography revealed biventricular hypertrophy, diastolic dysfunction and moderate systolic dysfunction. Cardiac MRI showed features suggestive of amyloidosis. Bone marrow biopsy revealed raised plasma cell count,...
BMJ Case Reports Last 6 Issues
20m
Rapid development of severe acute respiratory distress syndrome after abatacept treatment in a patient with rheumatoid arthritis
Abatacept is a biological agent that modulates T-cell costimulation by blocking CD28 signalling. This cytotoxic T-lymphocyte-associated antigen-4-Ig fusion protein was approved for treatment of rheumatoid arthritis (RA). However, a few case reports have revealed respiratory failure after abatacept treatment. In this report, we present a patient with RA who developed severe acute respiratory distress syndrome (ARDS) and who passed away 2 months after starting abatacept. A comprehensive analysis including...
BMJ Case Reports Last 6 Issues
20m
Bony cystic lesion with associated submandibular lymphadenopathy on a background of breast carcinoma: an unexpected case of cervicofacial actinomycosis
Actinomycosis is an uncommon, chronic suppurative granulomatous infection and needs to be considered as a differential diagnosis. A 56-year-old woman with a background of type 2 diabetes mellitus and breast carcinoma was referred to the Oral and Maxillofacial Surgery 2-week wait clinic, regarding a tender sublingual mass and firm erythematous swelling in the right submandibular and submental region. This was slowly progressive and had not responded to oral co-amoxiclav. An orthopantomogram showed...
BMJ Case Reports Last 6 Issues
20m
Intense exercise may not be so benign: chest pain in a young athletic woman may be spontaneous coronary artery dissection (SCAD)
We present a 26-year-old woman who came to the emergency department with chest pain of 1 hour duration that started while she was exercising on the treadmill. At presentation, ECG showed sinus bradycardia. Initial troponin level was 0.05 ng/mL and her chest pain resolved within 3 hours of onset. Troponins were trended serially, which continued to rise and peaked at 28.77 ng/mL and so heparin drip was started. On the second day of admission, a coronary angiogram was performed along with intravascular...
BMJ Case Reports Last 6 Issues
20m
Aggressive presentation of plasmablastic myeloma
BMJ Case Reports Last 6 Issues
20m
Rare case of adult pancreatoblastoma
BMJ Case Reports Last 6 Issues
20m
Grade I meningioma with disseminated bone disease: a rare clinical phenomenon
Meningioma, the second most common primary tumour of the central nervous system, is classified into three different grades based on their characteristics. Each tumour grade includes different molecular subtype, growth potential, and thus, different prognosis. Grade I meningioma is the most common subtype with a benign course, in which systemic dissemination rarely occurs. We present the case of a 48-year-old male patient with a history of grade I meningioma who was referred 3 years after the initial...
BMJ Case Reports Last 6 Issues
20m
Unusual extradural chordoma in an adolescent presenting with lumbar radiculopathy
BMJ Case Reports Last 6 Issues
20m
Multiple ecchymotic signs in acute pancreatitis
BMJ Case Reports Last 6 Issues
20m
Syphilitic chorioretinitis presenting as a choroidal granuloma
A rare case of syphilitic uveitis presenting as a choroidal granuloma is described in this case report. The clinical picture resembled that of a tubercular choroidal granuloma. However, the patient was positive for treponemal (treponema pallidum hemagglutination assay) as well as non-treponemal tests (venereal disease research laboratory test) for syphilis. Therefore, the patient was treated for ocular syphilis and responded to antisyphilitic therapy. There was a complete resolution of the lesion...
BMJ Case Reports Last 6 Issues
20m
TACO and TRALI: visualising transfusion lung injury on plain film
BMJ Case Reports Last 6 Issues
16h
Purification and Characterization of D-psicose 3 Epimerase (DPEase) From Escherichia coli BL21 (DE3) pET21b dpe
Background and Objective: The DPEase enzyme from Agrobacterium tumefaciens is more efficient and has a high activity in D-fructose. The dpe gene has been successfully cloned to Escherichia coli BL21 (DE3) pET-21b dpe but the enzyme has not been purified and its character is unknown. The intent of this study was to purify and assign of DPEase enzyme by recombinant E. coli. Materials and Methods: The enzyme was clarified by affinity chromatography and then characterized by following pH, temperature,...
Pakistan Journal of Biological Sciences - Current Issue
48m
Naringenin Attenuates Toxicity and Oxidative Stress Induced by Lambda-cyhalothrin in Liver of Male Rats
Background and Objectives: Extensive use of Lambda-cyhalothrin (LTC), a synthetic pyrethroid insecticide, has been associated with serious health problems to the non-target organisms including mammals. The present study investigated the protective effect of naringenin (NGN), an antioxidant flavonoid, against the toxicity induced LTC in the liver of male rats. Materials and Methods: Five groups of rats were assigned as follows; control group, LTC group (6.12 mg kg1, 1/10 LD50), LTC-NGN group (6.12...
Pakistan Journal of Biological Sciences - Current Issue
48m
Effects of Antiretroviral Therapy on CD4+ Cell Count, HIV Viral Load and Death in a South African Cohort: A Modelling Study
Background and Objective: Combination antiretroviral therapy (cART) has improved the survival of HIV infected patients significantly. However, in some patients, survival is not guaranteed due to several factors that are either individual-based or cART based. This study presents an HIV, AIDS, Death (HAD) model to analyse the survival of patients on cART. Materials and Methods: Continuous-time Markov models are fitted based on the states occupied for an HIV, AIDS and Death (HAD) model. These states...
Pakistan Journal of Biological Sciences - Current Issue
48m
Hypermethylation in Gene Promoters Are Induced by Chronic Exposure to Benzene, Toluene, Ethylbenzene and Xylenes
Background and Objective: Gas station attendants are occupationally exposed to benzene, toluene, ethylbenzene and xylene (BTEX) compounds and thus more susceptible to the biological effects of this mixture present in gasoline, especially due to the carcinogenicity of benzene. Furthermore, the harmful effects of BTEX exposure may be potentiated by genetic and epigenetic inactivation of critical genes. The objective was to evaluate such gene-BTEX interactions accessing the promoter methylation status...
Pakistan Journal of Biological Sciences - Current Issue
48m
Vermicomposting of Organic Waste with Eisenia fetida Increases the Content of Exchangeable Nutrients in Soil
Background and Objective: Vermicomposting is a green technique used to produce organic compost from organic waste with the aid of specific earthworm species. The resulting compost is rich in nutrients that can improve plant health and fertility. This study was conducted to produce organic compost using a developed vermicomposting technique. And that is to enhance and increase the exchangeable nutritional content in the soil for utilization in sustainable agriculture. Materials and Methods: The...
Pakistan Journal of Biological Sciences - Current Issue
48m
Vitamin E Supplementation and Early Age Heat Conditioning to Alleviate the Negative Effects of Heat Stress in Quail Chicks
Background and Objective: Inclusion of vitamin E in poultry diets and manipulation of temperature at early age has been known to help birds cope with heat stress at later age of their life. This study was conducted to investigate the effects of early age heat conditioning (EHC) and vitamin E addition on the performance and blood parameters to alleviate deleterious impact of heat stress in quail chicks. Material and Methods: Three hundred one-day-old quail chicks were randomly divided into 4 groups...
Pakistan Journal of Biological Sciences - Current Issue
48m
Applications of Chromatographic Techniques for Fingerprinting of Toxic and Non-toxic Euphorbia Species
Background and Objective: Euphorbia species have historically been used as medicinal plants to treat different ailments. However, some species have been reported to exhibit various degrees of toxicity. It becomes critical to distinguish toxic species from those that are non-toxic, for a particular application. The aim of the study was to determine the method for fingerprinting the chemical constituents of the selected toxic and non-toxic Euphorbia species to identify markers of toxicity. Material...
Pakistan Journal of Biological Sciences - Current Issue
48m
Quality Characteristics of Processed Cheese Fortified with Spirulina Powder
Background and Objective: Spirulina is a rich source of nutrients viz., essential amino acids, essential fatty acids, carotenoids and vitamins. The study was carried out to evaluate of Spirulina maxima addition as source of nutrients, antioxidants and color on processed cheese properties. Materials and Methods: Processed cheese analogue treatments were supplemented with Spirulina maxima powder (1, 2 and 3%). The chemical, physical, color and sensorial properties of processed cheese analogue supplemented...
Pakistan Journal of Biological Sciences - Current Issue
48m
In silico Identification of Peptide as Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Cancer Treatment
Background and Objective: Epidermal growth factor receptor (EGFR) is the biomarker for lung cancer in which the protein has the most active mutated genes in lung cancer patients. Peptides have pharmacological potential as drugs because of their bioactivity and accessibility. The research objective was to obtain peptide compounds drug candidates with good interaction and pharmacological properties that can act as an inhibitor for EGFR for lung cancer treatment by using in silico method. Materials...
Pakistan Journal of Biological Sciences - Current Issue
48m
Appreciation of Genetic Parameters and Molecular Characterization in Some Promising Accessions of Soybean (Glycine max L.)
Background and Objective: Soybean crop occupies a high position among cereal crops because it is a highly nutritious plant. This investigation aimed to take advantage of the imported soybean lines in improving the local varieties. Materials and Methods: Three local varieties and 4 imported lines of soybean plant were planted during two seasons for estimating some genetic parameters including (Heritability in broad sense, PCV (%), GCV (%), DZ, expected genetic advance and genetic advance as percentage...
Pakistan Journal of Biological Sciences - Current Issue
18h
Nano-Zinc Oxide and Arbuscular mycorrhiza Effects on Physiological and Biochemical Aspects of Wheat Cultivars under Saline Conditions
Background and Objective: Saline soils are restrictive factors to agriculture in arid and semi-arid regions, plant growth and productivity. Thus, it was important to consider how, nano-zinc oxide or bulk zinc oxide alleviates the oxidative salt stress in the presence of Arbuscular mycorrhiza (AM) fungi by two wheat cultivars (Sids 13 and Sakha 94). Materials and Methods: A field experiment was carried out during two winter successive seasons to study the beneficial role of nano-zinc oxide or bulk...
Pakistan Journal of Biological Sciences - Current Issue
18h

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