Related ArticlesRhinology Future Debates 2018, a EUFOREA Report. Rhinology. 2020 Apr 25;: Authors: Prokopakis E, Vardouniotis A, Bachert C, Bousquet J, Carrie S, Castelnuevo P, Constantinidis J, Fokkens W, Hopkins C, Leunig A, Molteni G, Mullol J, Scadding G, Marien G, Doulaptsi M, Hellings P Abstract The third Rhinology Future Debates was organized by the European Forum for Research and Education in Allergy and Airways diseases (EUFOREA) in 2018 in...
Sun Apr 26, 2020 15:25
Related ArticlesFADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling. Cell Death Dis. 2020 Apr 24;11(4):272 Authors: Zhao R, Tian L, Zhao B, Sun Y, Cao J, Chen K, Li F, Li M, Shang D, Liu M Abstract Metabolic abnormality is the major feature of laryngeal squamous cell carcinoma (LSCC), however, the underlying mechanism remain largely elusive. Fatty acid desaturase 1 (FADS1), as the key rate-limiting...
Sun Apr 26, 2020 13:29
Related ArticlesNon-respiratory complaints are main reasons for disturbed sleep post lung transplant. Sleep Med. 2019 Nov 27;70:106-110 Authors: Sawhney V, Seethamraju H, Bourguet C, Hirshkowitz M, Bandi V, Sharafkhaneh A Abstract BACKGROUND: Poor sleep is prevalent in lung transplant recipients and affects quality of life negatively. To improve quality of sleep, it's important to identify the causes of poor sleep. We conducted a survey to identify the...
Sun Apr 26, 2020 14:41
Related ArticlesThe Value of Oxygen Desaturation Index for Diagnosing Obstructive Sleep Apnea: A Systematic Review. Laryngoscope. 2020 Apr 25;: Authors: Rashid NH, Zaghi S, Scapuccin M, Camacho M, Certal V, Capasso R Abstract OBJECTIVES: Intermittent hypoxemia is a risk factor for developing complications in obstructive sleep apnea (OSA) patients. The objective of this systematic review was to identify articles evaluating the accuracy of the oxygen desaturation...
Sun Apr 26, 2020 14:41
Related ArticlesEfficacy of continuous positive airway pressure on subcutaneous adipose tissue in patients with obstructive sleep apnea: a meta-analysis of randomized controlled trials. Sleep Breath. 2020 Apr 24;: Authors: Liu Y, Li C, Wu C, Li P, Su Y, Chen Q Abstract PURPOSE: It remains inconclusive whether continuous positive airway pressure (CPAP) therapy can significantly reduce subcutaneous adipose tissue (SAT) in patients with obstructive sleep...
Sun Apr 26, 2020 13:26
Related ArticlesDoes Obstructive Sleep Apnea Affect Perioperative Complications? A Retrospective Study Using a Modified NSQIP Database. World J Surg. 2020 Apr 24;: Authors: Abdulhai M, Sedeeq A, Neponmayshy D Abstract BACKGROUND: Obstructive sleep apnea (OSA) has been linked to increased perioperative complications. The National Surgical Quality Improvement Project (NSQIP), which is the leading outcomes-based patient database, does not report OSA as...
Sun Apr 26, 2020 13:26
Related ArticlesEffects of Photobiomodulation in Children with Down Syndrome and Possible Sleep Bruxism: Protocol For A Randomized, Controlled, Blind, Clinical Trial: Study protocol clinical trial (SPIRIT compliant). Medicine (Baltimore). 2020 Apr;99(17):e19904 Authors: Salgueiro MDCC, Silva T, Motta LJ, Horliana ACRT, Gonçalves MLL, Gomes AO, Pinto MM, Bortoletto CC, Altavista OM, Deana AM, Silva DFTD, Santos EM, Castelo PM, Fernandes KPS, Mesquita-Ferrari RA, Bussadori...
Sun Apr 26, 2020 13:26
Related ArticlesCharacterisation of ICU sleep by a commercially available activity tracker and its agreement with patient-perceived sleep quality. BMJ Open Respir Res. 2020 Apr;7(1): Authors: Louzon P, Andrews J, Torres X, Pyles E, Ali M, Du Y, Devlin J Abstract BACKGROUND: A low-cost, quantitative method to evaluate sleep in the intensive care unit (ICU) that is both feasible for routine clinical practice and reliable does not yet exist. We characterised...
Sun Apr 26, 2020 13:26
Related ArticlesSide effects of acetazolamide: a systematic review and meta-analysis assessing overall risk and dose dependence. BMJ Open Respir Res. 2020 Apr;7(1): Authors: Schmickl CN, Owens RL, Orr JE, Edwards BA, Malhotra A Abstract INTRODUCTION: Acetazolamide (AZM) is used for various conditions (eg, altitude sickness, sleep apnoea, glaucoma), but therapy is often limited by its side effect profile. Our objective was to estimate the risk of commonly...
Sun Apr 26, 2020 13:26
Related ArticlesSleep disturbance and insomnia in individuals seeking bariatric surgery. Surg Obes Relat Dis. 2020 Mar 18;: Authors: Salwen-Deremer JK, Schreyer C, Hymowitz GF, Montanari A, Smith MT, Coughlin JW Abstract BACKGROUND: Sleep disturbance is well established in individuals with obesity, and the relationship between poor sleep and obesity is supported by population, longitudinal, experimental, and intervention studies. However, the prevalence...
Sun Apr 26, 2020 13:26
Related ArticlesObstructive sleep apnea treatment disparities among older adults with neurological disorders. Sleep Health. 2020 Apr 21;: Authors: Dunietz GL, Chervin RD, Burke JF, Braley TJ Abstract OBJECTIVE: The objective of the study was to characterize obstructive sleep apnea treatment patterns among older Americans with neurological conditions. SETTING AND PARTICIPANTS: Claims data from a 5% fee-for-service sample of Medicare beneficiaries...
Sun Apr 26, 2020 13:26
Related ArticlesAuthors' Reply: Characteristics of Intestinal Volvulus and Risk of Mortality in Malawi. World J Surg. 2020 Apr 24;: Authors: Purcell LN, Reiss R, Mabedi C, Gallaher J, Maine R, Charles A PMID: 32333163 [PubMed - as supplied by publisher]
Sun Apr 26, 2020 13:19
Related ArticlesLetter to the Editor: Global Initiative for Children's Surgery: 2020 Implementation and the Way Forward. World J Surg. 2020 Apr 24;: Authors: Lakhoo K PMID: 32333161 [PubMed - as supplied by publisher]
Sun Apr 26, 2020 13:19
Related ArticlesOutcome Measurement at a Ugandan Referral Hospital: Validation of the Mbarara Surgical Services Quality Assurance Database. World J Surg. 2020 Apr 24;: Authors: Drevin G, Albutt K, Baluku M, Tuhumwiire C, Deng H, Musinguzi N, Modest V, Ngonzi J, Ttendo S, Firth P Abstract BACKGROUND: Five billion people lack access to surgery. Accurate and complete data have been identified as essential to the global scale-up of perioperative care. This...
Sun Apr 26, 2020 13:19
Related ArticlesThe Effects of Preferred Music on Laparoscopic Surgical Performance: A Randomized Crossover Study. World J Surg. 2020 Apr 24;: Authors: Oomens P, Fu VX, Kleinrensink VEE, Kleinrensink GJ, Jeekel J Abstract INTRODUCTION: Music can have a positive effect on stress and general task performance. This randomized crossover study assessed the effects of preferred music on laparoscopic surgical performance in a simulated setting. METHODS:...
Sun Apr 26, 2020 13:19
Related ArticlesComplexation with β-cyclodextrin enhances apoptosis-mediated cytotoxic effect of harman in chemoresistant BRAF-mutated melanoma cells. Eur J Pharm Sci. 2020 Apr 22;:105353 Authors: Ferraz CAA, Júnior RGO, de Oliveira AP, Groult H, Beaugeard L, Picot L, Filho EBA, Almeida JRGDS, Nunes XP Abstract Harman, a natural β-carboline alkaloid, has recently gained considerable interest due to its anticancer properties. However, its physicochemical...
Sun Apr 26, 2020 14:12
Related ArticlesMyrtle (Myrtus communis) leaf extract suppresses hepatotoxicity induced by monosodium glutamate and acrylamide through obstructing apoptosis, DNA fragmentation, and cell cycle arrest. Environ Sci Pollut Res Int. 2020 Apr 25;: Authors: Hassan HA, El-Kholy WM, El-Sawi MRF, Galal NA, Ramadan MF Abstract A large number of plant extracts have demonstrated to provide health benefits and mitigate several disease conditions. However, at the...
Sun Apr 26, 2020 13:17
Related ArticlesEffect of Bicalutamide on the proliferation and invasion of human triple negative breast cancer MDA-MB-231 cells. Medicine (Baltimore). 2020 Apr;99(17):e19822 Authors: Kong Y, Qu F, Yuan X, Yan X, Yu W Abstract Previous studies have shown androgen receptor (AR) is associated with the occurrence, development, recurrence, metastasis, and prognosis of triple negative breast cancer (TNBC). More and more experts have noticed that AR signaling...
Sun Apr 26, 2020 13:17
Related ArticlesNovel biomarkers of acute kidney injury in children: an update on recent findings. Curr Opin Pediatr. 2020 Apr 22;: Authors: Sandokji I, Greenberg JH Abstract PURPOSE OF REVIEW: The clinical diagnosis of acute kidney injury (AKI) relies largely on changes in serum creatinine; a delayed biomarker. Research in children has been focused on developing novel AKI biomarkers, which can improve the prediction, early detection and diagnosis...
Sun Apr 26, 2020 13:17
Related ArticlesSynthesis of novel spirobibenzopyrans as potent anticancer leads inducing apoptosis in HeLa cells. Bioorg Med Chem Lett. 2020 Apr 18;:127199 Authors: Kar S, Ramamoorthy G, Mitra K, Shivalingegowda N, Mahesha, Mavileti SK, Neratur Krishnappagowda L, Doble M, Golakoti NR Abstract Spirobibenzopyrans are an unexplored class of therapeutics. We report the anticancer activity of novel spirobibenzopyrans, synthesized by a one-pot reaction...
Sun Apr 26, 2020 13:17
Related ArticlesLow-Frequency Magnetic Fields (LF-MFs) Inhibit Proliferation by Triggering Apoptosis and Altering Cell Cycle Distribution in Breast Cancer Cells. Int J Mol Sci. 2020 Apr 22;21(8): Authors: Xu A, Wang Q, Lin T Abstract Breast cancer is a common malignancy threatening women's health around the world. Despite improved treatments for different subtypes of breast tumors that have been put forward, there still exists a poor therapeutic...
Sun Apr 26, 2020 13:17
Related ArticlesThe Distinct Roles of Transcriptional Factor KLF11 in Normal Cell Growth Regulation and Cancer as a Mediator of TGF-β Signaling Pathway. Int J Mol Sci. 2020 Apr 22;21(8): Authors: Lin L, Mahner S, Jeschke U, Hester A Abstract KLF11 (Krüppel-like factor 11) belongs to the family of Sp1/Krüppel-like zinc finger transcription factors that play important roles in a variety of cell types and tissues. KLF11 was initially described as a...
Sun Apr 26, 2020 13:17
Related ArticlesThe fibular notch: an anatomical study. Surg Radiol Anat. 2020 Apr 25;: Authors: Fojtík P, Kostlivý K, Bartoníček J, Naňka O Abstract INTRODUCTION: Reduction of the distal fibula into the fibular notch (FN) poses a problem that has not been fully resolved, yet. A number of methods have been developed for the assessment of the position of the fibula in the FN, but none of them is ideal. A majority of authors assess the FN 1 cm above...
Sun Apr 26, 2020 13:16
Related ArticlesThe superficial anatomical landmarks are not reliable for predicting the recurrent branch of the median nerve. Surg Radiol Anat. 2020 Apr 24;: Authors: Kunc V, Štulpa M, Feigl G, Neblett C, Kunc V, Kachlík D Abstract PURPOSE: The variability of the recurrent branch (RB) of the median nerve lends itself to an increased risk of injury when performing the minimally invasive approach for carpal tunnel release without its direct visualization....
Sun Apr 26, 2020 13:16
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Sun Apr 26, 2020 13:15
Related ArticlesMolecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain. Proc Natl Acad Sci U S A. 2020 Apr 24;: Authors: Vien TN, Wang J, Ng LCT, Cao E, DeCaen PG Abstract Genetic variants in PKD2 which encodes for the polycystin-2 ion channel are responsible for many clinical cases of autosomal dominant polycystic kidney disease (ADPKD). Despite our strong understanding of the genetic basis of ADPKD, we do not...
Sun Apr 26, 2020 13:15
Related ArticlesSample multiplexing for targeted pathway proteomics in aging mice. Proc Natl Acad Sci U S A. 2020 Apr 24;: Authors: Yu Q, Xiao H, Jedrychowski MP, Schweppe DK, Navarrete-Perea J, Knott J, Rogers J, Chouchani ET, Gygi SP Abstract Pathway proteomics strategies measure protein expression changes in specific cellular processes that carry out related functions. Using targeted tandem mass tags-based sample multiplexing, hundreds of proteins...
Sun Apr 26, 2020 13:15
Related ArticlesInduction of recurrent break cluster genes in neural progenitor cells differentiated from embryonic stem cells in culture. Proc Natl Acad Sci U S A. 2020 Apr 24;: Authors: Tena A, Zhang Y, Kyritsis N, Devorak A, Zurita J, Wei PC, Alt FW Abstract Mild replication stress enhances appearance of dozens of robust recurrent genomic break clusters, termed RDCs, in cultured primary mouse neural stem and progenitor cells (NSPCs). Robust RDCs occur...
Sun Apr 26, 2020 13:15
Related ArticlesThe structure of helical lipoprotein lipase reveals an unexpected twist in lipase storage. Proc Natl Acad Sci U S A. 2020 Apr 24;: Authors: Gunn KH, Roberts BS, Wang F, Strauss JD, Borgnia MJ, Egelman EH, Neher SB Abstract Lipases are enzymes necessary for the proper distribution and utilization of lipids in the human body. Lipoprotein lipase (LPL) is active in capillaries, where it plays a crucial role in preventing dyslipidemia by hydrolyzing...
Sun Apr 26, 2020 13:15
Related ArticlesMachine learning predicts the functional composition of the protein corona and the cellular recognition of nanoparticles. Proc Natl Acad Sci U S A. 2020 Apr 24;: Authors: Ban Z, Yuan P, Yu F, Peng T, Zhou Q, Hu X Abstract Protein corona formation is critical for the design of ideal and safe nanoparticles (NPs) for nanomedicine, biosensing, organ targeting, and other applications, but methods to quantitatively predict the formation of...
Sun Apr 26, 2020 13:15
Related ArticlesWidespread targeting of nascent transcripts by RsmA in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2020 Apr 24;: Authors: Gebhardt MJ, Kambara TK, Ramsey KM, Dove SL Abstract In the opportunistic pathogen Pseudomonas aeruginosa, RsmA is an RNA-binding protein that plays critical roles in the control of virulence, interbacterial interactions, and biofilm formation. Although RsmA is thought to exert its regulatory effects by binding...
Sun Apr 26, 2020 13:15
Related ArticlesPalmitoylation of the KATP channel Kir6.2 subunit promotes channel opening by regulating PIP2 sensitivity. Proc Natl Acad Sci U S A. 2020 Apr 24;: Authors: Yang HQ, Martinez-Ortiz W, Hwang J, Fan X, Cardozo TJ, Coetzee WA Abstract A physiological role for long-chain acyl-CoA esters to activate ATP-sensitive K+ (KATP) channels is well established. Circulating palmitate is transported into cells and converted to palmitoyl-CoA, which is...
Sun Apr 26, 2020 13:15
Related ArticlesPan-cancer analysis identifies mutations in SUGP1 that recapitulate mutant SF3B1 splicing dysregulation. Proc Natl Acad Sci U S A. 2020 Apr 24;: Authors: Liu Z, Zhang J, Sun Y, Perea-Chamblee TE, Manley JL, Rabadan R Abstract The gene encoding the core spliceosomal protein SF3B1 is the most frequently mutated gene encoding a splicing factor in a variety of hematologic malignancies and solid tumors. SF3B1 mutations induce use of cryptic...
Sun Apr 26, 2020 13:15
Related ArticlesNORs on human acrocentric chromosome p-arms are active by default and can associate with nucleoli independently of rDNA. Proc Natl Acad Sci U S A. 2020 Apr 24;: Authors: van Sluis M, van Vuuren C, Mangan H, McStay B Abstract Nucleoli, the sites of ribosome biogenesis and the largest structures in human nuclei, form around nucleolar organizer regions (NORs) comprising ribosomal DNA (rDNA) arrays. NORs are located on the p-arms of the five...
Sun Apr 26, 2020 13:15
Related ArticlesK6-linked SUMOylation of BAF regulates nuclear integrity and DNA replication in mammalian cells. Proc Natl Acad Sci U S A. 2020 Apr 24;: Authors: Lin Q, Yu B, Wang X, Zhu S, Zhao G, Jia M, Huang F, Xu N, Ren H, Jiang Q, Zhang C Abstract Barrier-to-autointegration factor (BAF) is a highly conserved protein in metazoans that has multiple functions during the cell cycle. We found that BAF is SUMOylated at K6, and that this modification is...
Sun Apr 26, 2020 13:15
Related ArticlesBenign overfitting in linear regression. Proc Natl Acad Sci U S A. 2020 Apr 24;: Authors: Bartlett PL, Long PM, Lugosi G, Tsigler A Abstract The phenomenon of benign overfitting is one of the key mysteries uncovered by deep learning methodology: deep neural networks seem to predict well, even with a perfect fit to noisy training data. Motivated by this phenomenon, we consider when a perfect fit to training data in linear regression is...
Sun Apr 26, 2020 13:15
Related ArticlesMultiple agents managing a harmful species population should either work together to control it or split their duties to eradicate it. Proc Natl Acad Sci U S A. 2020 Apr 24;: Authors: Lampert A Abstract The management of harmful species, including invasive species, pests, parasites, and diseases, is a major global challenge. Harmful species cause severe damage to ecosystems, biodiversity, agriculture, and human health. In particular,...
Sun Apr 26, 2020 13:15
Related ArticlesQuality and readability of English-language internet information for vestibular disorders. J Vestib Res. 2020 Apr 22;: Authors: Felipe L, Beukes EW, Fox BA, Manchaiah V Abstract BACKGROUND: The Internet has become a powerful, accessible resource for many patients to use for their own medical management and knowledge. Vestibular disorders affect all genders and ages with the odds increasing significantly with the years. As the Internet...
Sun Apr 26, 2020 14:14
Related ArticlesUtriculo-ocular pathway dysfunction is more frequent in vestibular migraine than probable vestibular migraine. J Neurol. 2020 Apr 24;: Authors: Fujimoto C, Kamogashira T, Takenouchi S, Kinoshita M, Sugasawa K, Kawahara T, Yamasoba T, Iwasaki S Abstract BACKGROUND: Abnormal vestibular function has been reported in patients with vestibular migraine (VM). However, it is unclear whether the proportion of patients with vestibular dysfunction...
Sun Apr 26, 2020 13:11
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