Related ArticlesComplex Lobectomy in a Patient With Lung Cancer and Pulmonary Artery Sling. Ann Thorac Surg. 2020 01;109(1):e55-e57 Authors: Mammana M, Zuin A, Serra E, Bellini A, Rea F Abstract Pulmonary artery sling is a rare congenital anomaly of the origin and course of the left pulmonary artery. Patients with this condition typically present with respiratory failure in young infancy, and asymptomatic cases are uncommon. We describe the case of...
Fri Apr 24, 2020 13:00
Related ArticlesRare pathology of the ileocaecal valve: mature cystic teratoma. ANZ J Surg. 2019 03;89(3):268-269 Authors: Kandelaki T, Pal A, Tapper R PMID: 30827054 [PubMed - indexed for MEDLINE]
Fri Apr 24, 2020 13:00
Related ArticlesRemission of light chain proximal tubulopathy in IgG λ-type multiple myeloma by lenalidomide and dexamethasone therapy. CEN Case Rep. 2019 08;8(3):159-165 Authors: Kawamoto S, Hidaka Y, Kaneko Y, Misawa H, Nagahori K, Yoshino A, Okamura T, Ban S, Ueda Y, Takeda T Abstract Light chain proximal tubulopathy is a rare manifestation of monoclonal gammopathy. A 73-year-old Japanese woman was noted to have urinary protein and hypertension...
Fri Apr 24, 2020 13:00
Related ArticlesBeyond the message: advantages of snapshot proteomics with single-cell mass cytometry in solid tumors. FEBS J. 2019 04;286(8):1523-1539 Authors: Mistry AM, Greenplate AR, Ihrie RA, Irish JM Abstract Single-cell technologies that can quantify features of individual cells within a tumor are critical for treatment strategies aiming to target cancer cells while sparing or activating beneficial cells. Given that key players in protein networks...
Fri Apr 24, 2020 13:00
Background : Rapid spread of the SARS‐CoV‐2 virus has left many health systems around the world overwhelmed, forcing triaging of scarce medical resources. Identifying indicators of hospital admission for Covid‐19 patients early in the disease course could aid the efficient allocation of medical interventions. Self‐reported olfactory impairment has recently been recognized as a hallmark of Covid‐19 and may be an important predictor of clinical outcome. Methods : A retrospective review...
Fri Apr 24, 2020 11:18
Background Allergic rhinitis (AR) is a major public health problem and is increasing worldwide. Allergic rhinitis affects children's learning efficiency, sleep quality and other major aspects of life. Sublingual immunotherapy (SLIT) is effective and safe for children with seasonal allergic rhinitis, but for children with perennial allergic rhinitis (PAR) caused by house dust mites (HDM), its effectiveness and safety is less convincing. Methods Medical literature databases up to 2019 were...
Thu Apr 23, 2020 20:35
Objective/Hypothesis To assess the long‐term decannulation outcomes of bioresorbable microplates as an external stent for pediatric tracheostomy patients with suprastomal collapse. Study Design Retrospective cohort study. Methods Hospital records of all patients who underwent a bioresorbable microplate for suprastomal collapse from 2016 to 2019 were reviewed at a single institution. The primary outcome measure was tracheostomy decannulation. Results A total of nine...
Fri Apr 24, 2020 19:19
Objectives/Hypothesis Microlaryngeal surgery (ML) is a short procedure that requires a deep neuromuscular blockade to provide optimum surgical conditions. Succinylcholine is a relaxant widely used but involves numerous complications. One valid alternative is rocuronium, with a specific antagonist, sugammadex. The primary objective was to assess the surgical conditions in ML according to the relaxant. The secondary objectives were to assess intubation conditions and intraoperative and immediate...
Thu Apr 23, 2020 18:30
Objectives/Hypothesis A number of autoimmune disorders (ADs) are associated with a spectrum of sinonasal manifestations comparable to chronic rhinosinusitis (CRS). Our objective was to study the subjective and objective measurements of sinonasal manifestations of ADs. Study Design Retrospective cohort study. Methods All patients with ADs referred to our tertiary care rhinology clinic from 2008 to 2019 with sinonasal symptoms were compared to randomly selected cohorts of noneosinophilic...
Thu Apr 23, 2020 18:19
Objectives To review our experience with secondary surgery for persistent nasal obstruction following successful septal perforation repair and describe the potential contribution of the nasal swell body (NSB) to obstruction. Study Design Retrospective chart review. Methods IRB‐approved retrospective chart review of perforation repairs utilizing bilateral mucosal flaps performed by the senior author from October 2008 through April 2019 was performed. Patients who underwent secondary...
Thu Apr 23, 2020 18:10
Thu Apr 23, 2020 18:03
Abstract Background Human populations native to high altitude exhibit numerous genetic adaptations to hypobaric hypoxia. Among Tibetan plateau peoples, these include increased vasodilation and uncoupling of erythropoiesis from hypoxia. Objective/Methods We tested the hypothesis that these high‐altitude adaptations reduce risk for hypertension and diabetes‐associated anemia among the Mosuo, a Tibetan‐descended population in the mountains of Southwest China that is experiencing rapid...
Thu Apr 23, 2020 22:00
Abstract A majority of infant and pediatric leukemias are caused by the mixed‐lineage leukemia gene (MLL) fused with a variety of candidates. Several underlying mechanisms have been proposed. One currently popular view is that truncated MLL1 fusion and its associated complex constitutively hijacks super elongation complex, including positive transcription elongation factor b, CDK9, and cyclin T1 complex and DOT1L, to enhance the expression of transcription factors that maintain or restore stemness...
Fri Apr 24, 2020 18:00
Key points During exercise, blood flow to working skeletal muscle increases in parallel with contractile activity such that oxygen delivery is sufficient to meet metabolic demand. K+ released from active skeletal muscle fibres could facilitate vasodilatation in proportion to the degree of muscle fibre recruitment. Once released, K+ stimulates inwardly‐rectifying K+ (KIR) channels on the vasculature to elicit an increase in blood flow. In the present study, we demonstrate that KIR channels...
Fri Apr 24, 2020 17:00
Fri Apr 24, 2020 16:59
Key points Ketamine is a common anesthetic agent used in research and more recently as medication in treatment of depression. It has known effects on inhibition of interneurons and cortical stimulus‐locked responses, the underlying functional network mechanisms are still elusive. Analyzing population activity across all layers within the auditory cortex, we found that with anesthetic doses it induces a stronger activation and stimulus‐ locked response to pure‐tone stimuli. This cortical...
Fri Apr 24, 2020 16:59
Fri Apr 24, 2020 16:54
Abstract Fine‐needle aspiration biopsy (FNAB) is a useful technique in the evaluation of central lung tumors which is commonly encountered in clinical cytology practice. Some of these tumors may show endobronchial, polypoid growth which is readily apparent to the endoscopist. Pulmonary salivary gland‐type tumors and carcinoid tumors are overall uncommon in the lung, but these tumors tend to occur centrally and show endobronchial involvement. The prognosis of these tumors is generally better than...
Fri Apr 24, 2020 16:37
Abstract Multidisciplinary conferences (MDC) are an important component of head and neck oncologic care including diagnosis, treatment, and survivorship. Virtual MDC allows for improved collaboration between providers at distant sites and proper allocation of healthcare resources in a time of crisis. When approached systematically, a virtual MDC is feasible to design and implement in a large academic medical center with multiple satellite hospitals. This article is protected by copyright. All...
Fri Apr 24, 2020 16:55
Abstract Background The coronavirus infection is rapidly spreading putting a strain on healthcare services across the globe. Oral cancer patients are susceptible often immunosuppressed due to the disease and/or the treatment received. Methods We performed a simulationof the currently available data using a multi state and hazards model to provide an objective model for counseling and decision making for healthcare workers. Results Stage IV oral cancer patients that did...
Fri Apr 24, 2020 16:55
Abstract Background In the context of COVID‐19, cancer survivors represent a particularly vulnerable population that may be “doubly hit” both by costs of cancer treatment and financial strain imposed by the pandemic. Methods We performed a review of the literature pertaining to cancer, financial toxicity, and economic challenges. Results Multiple societies have put forth recommendations to modify delivery of cancer care in order to minimize patient exposure to the virus....
Fri Apr 24, 2020 16:51
Abstract Background The COVID‐19 pandemic has resulted in the implementation of rapidly changing protocols and guidelines related to the indications and perioperative precautions and protocols for tracheotomy. The purpose of this study was to evaluate current guidelines for tracheostomy during the COVID‐19 pandemic to provide a framework for health systems to prepare as the science evolves over the upcoming months and years. Methods Literature review was performed. Articles reporting...
Fri Apr 24, 2020 16:51
Abstract Background The SARS‐CoV‐2 (COVID‐19) pandemic has caused rapid changes in head and neck cancer (HNC) care. “Real‐time” methods to monitor practice patterns can optimize provider safety and patient care. Methods Head and neck surgeons from 14 institutions in the United States regularly contributed their practice patterns to a shared spreadsheet. Data from March 27th, 2020 to April fifth, 2020 was analyzed. Results All institutions had significantly restricted HNC...
Fri Apr 24, 2020 16:49
Abstract The COVID‐19 pandemic has upended head and neck cancer care delivery in ways unforeseen and unprecedented. The impact of these changes parallels other fields in oncology, but is disproportionate due to protective measures and limitations on potentially aerosolizing procedures and related interventions specific to the upper aerodigestive tract. The moral and professional dimensions of providing ethically appropriate and consistent care for our patients in the COVID‐19 crisis are considered...
Fri Apr 24, 2020 16:48
Abstract Background During the SARS‐CoV‐2 pandemic, tracheostomy may be required for COVID‐19 patients requiring long term ventilation in addition to other conditions such as airway compromise from head and neck cancer. As an aerosol generating procedure, tracheostomy increases healthcare worker exposure to COVID‐19 infection. Performing surgical tracheostomy and tracheostomy care requires a strategy that mitigates these risks and maintains the quality of patient care. Methods A...
Fri Apr 24, 2020 16:48
Abstract Background Combining photon or proton radiotherapy with targeted therapy shows promise for head and neck cancer (HNSCC). The poly (adenosine diphosphate [ADP]‐ribose) polymerase‐1/2 inhibitor niraparib targets DNA damage repair (DDR). We evaluated the effects of niraparib in combination with photons or protons, and its effects on the relative biological effectiveness (RBE) of protons, in human HNSCC cell lines. Methods Radiosensitivity was assessed and RBE was calculated...
Thu Apr 23, 2020 13:34
The clinical efficacy of rupatadine in terms of responders has not been previously explored in perennial allergic rhinitis (PAR).
Thu Apr 23, 2020 03:00
Publication date: Available online 24 April 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Fabienne CARRÉ, Marion Blanchard, Sophie ACHARD, Marine PARODI, Françoise DENOYELLE, Natalie LOUNDON
Fri Apr 24, 2020 17:13
Publication date: Available online 23 April 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Travis Haller, Angela Shoup, Albert Park
Fri Apr 24, 2020 17:13
Publication date: July 2020Source: Brain and Language, Volume 206Author(s): Fredrik Heinat, Eva Klingvall
Fri Apr 24, 2020 20:26
Publication date: Available online 23 April 2020Source: International Journal of PsychophysiologyAuthor(s): Juliana Yordanova, Michael Falkenstein, Vasil Kolev
Fri Apr 24, 2020 18:31
Publication date: Available online 23 April 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Justin C. Jagodinsky, Paul M. Harari, Zachary S. Morris
Fri Apr 24, 2020 17:43
Publication date: Available online 23 April 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Alexander F.C. Hulsbergen, Marco Mammi, Steven H.J. Nagtegaal, Asad M. Lak, Vasileios Kavouridis, Timothy R. Smith, Julian B. Iorgulescu, Rania A. Mekary, Joost J.C. Verhoeff, Marike L.D. Broekman, John G. Phillips
Fri Apr 24, 2020 17:43
Publication date: Available online 23 April 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Baho U. Sidiqi, Erin F. Gillespie, Kaitlyn Lapen, C. Jillian Tsai, Melissa Dawson, Abraham J. Wu
Fri Apr 24, 2020 17:43
Publication date: Available online 24 April 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Chang Shu, Qingguo Li
Fri Apr 24, 2020 16:13
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