A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes. Proc Natl Acad Sci U S A. 2020 Apr 22;: Authors: Alic L, Papac-Milicevic N, Czamara D, Rudnick RB, Ozsvar-Kozma M, Hartmann A, Gurbisz M, Hoermann G, Haslinger-Hutter S, Zipfel PF, Skerka C, Binder EB, Binder CJ Abstract Genetic variants within complement factor H (CFH), a major alternative complement pathway regulator, are associated...
Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP in the vascular remodeling. Proc Natl Acad Sci U S A. 2020 Apr 22;: Authors: Yamashiro Y, Thang BQ, Ramirez K, Shin SJ, Kohata T, Ohata S, Nguyen TAV, Ohtsuki S, Nagayama K, Yanagisawa H Abstract The extracellular matrix (ECM) initiates mechanical cues that activate intracellular signaling through matrix-cell interactions. In blood vessels, additional mechanical cues derived from the...
Reduced perceptual narrowing in synesthesia. Proc Natl Acad Sci U S A. 2020 Apr 22;: Authors: Maurer D, Ghloum JK, Gibson LC, Watson MR, Chen LM, Akins K, Enns JT, Hensch TK, Werker JF Abstract Synesthesia is a neurologic trait in which specific inducers, such as sounds, automatically elicit additional idiosyncratic percepts, such as color (thus "colored hearing"). One explanation for this trait-and the one tested here-is that synesthesia results from...
MTV proteins unveil ER- and microtubule-associated compartments in the plant vacuolar trafficking pathway. Proc Natl Acad Sci U S A. 2020 Apr 22;: Authors: Delgadillo MO, Ruano G, Zouhar J, Sauer M, Shen J, Lazarova A, Sanmartín M, Lai LTF, Deng C, Wang P, Hussey PJ, Sánchez-Serrano JJ, Jiang L, Rojo E Abstract The factors and mechanisms involved in vacuolar transport in plants, and in particular those directing vesicles to their target endomembrane...
Single-cell O2 exchange imaging shows that cytoplasmic diffusion is a dominant barrier to efficient gas transport in red blood cells. Proc Natl Acad Sci U S A. 2020 Apr 22;: Authors: Richardson SL, Hulikova A, Proven M, Hipkiss R, Akanni M, Roy NBA, Swietach P Abstract Disorders of oxygen transport are commonly attributed to inadequate carrying capacity (anemia) but may also relate to inefficient gas exchange by red blood cells (RBCs), a process that...
Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody. Proc Natl Acad Sci U S A. 2020 Apr 22;: Authors: Esswein SR, Gristick HB, Jurado A, Peace A, Keeffe JR, Lee YE, Voll AV, Saeed M, Nussenzweig MC, Rice CM, Robbiani DF, MacDonald MR, Bjorkman PJ Abstract Recent epidemics demonstrate the global threat of Zika virus (ZIKV), a flavivirus transmitted by mosquitoes. Although infection is usually...
Landscape analysis of adjacent gene rearrangements reveals BCL2L14-ETV6 gene fusions in more aggressive triple-negative breast cancer. Proc Natl Acad Sci U S A. 2020 Apr 22;: Authors: Lee S, Hu Y, Loo SK, Tan Y, Bhargava R, Lewis MT, Wang XS Abstract Triple-negative breast cancer (TNBC) accounts for 10 to 20% of breast cancer, with chemotherapy as its mainstay of treatment due to lack of well-defined targets, and recent genomic sequencing studies have...
The microcircuits of striatum in silico. Proc Natl Acad Sci U S A. 2020 Apr 22;: Authors: Hjorth JJJ, Kozlov A, Carannante I, Frost Nylén J, Lindroos R, Johansson Y, Tokarska A, Dorst MC, Suryanarayana SM, Silberberg G, Hellgren Kotaleski J, Grillner S Abstract The basal ganglia play an important role in decision making and selection of action primarily based on input from cortex, thalamus, and the dopamine system. Their main input structure, striatum,...
Testing for dependence on tree structures. Proc Natl Acad Sci U S A. 2020 Apr 22;: Authors: Behr M, Ansari MA, Munk A, Holmes C Abstract Tree structures, showing hierarchical relationships and the latent structures between samples, are ubiquitous in genomic and biomedical sciences. A common question in many studies is whether there is an association between a response variable measured on each sample and the latent group structure represented by some...
Direct kinetic measurements and theoretical predictions of an isoprene-derived Criegee intermediate.
Direct kinetic measurements and theoretical predictions of an isoprene-derived Criegee intermediate. Proc Natl Acad Sci U S A. 2020 Apr 22;: Authors: Caravan RL, Vansco MF, Au K, Khan MAH, Li YL, Winiberg FAF, Zuraski K, Lin YH, Chao W, Trongsiriwat N, Walsh PJ, Osborn DL, Percival CJ, Lin JJ, Shallcross DE, Sheps L, Klippenstein SJ, Taatjes CA, Lester MI Abstract Isoprene has the highest emission into Earth's atmosphere of any nonmethane hydrocarbon....
News Feature: Venom back in vogue as a wellspring for drug candidates. Proc Natl Acad Sci U S A. 2020 Apr 22;: Authors: McDermott A PMID: 32321825 [PubMed - as supplied by publisher]
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