Abstract The placebo (Latin “I will please”) effect commonly occurs in clinical trials. The psychological and physiological factors associated with patients’ expectations about a treatment’s positive and negative effects have yet to be well characterized, although a functional prefrontal cortex and intense bidirectional communication between the central nervous system and the immune system appear to be prerequisites for a placebo effect. The use of placebo raises certain ethical issues, especially...
Thu Apr 23, 2020 21:12
ABSTRACT Food protein‐induced enterocolitis syndrome (FPIES) is a non‐IgE‐mediated food allergy (1). Acute FPIES is typical and characterized by repetitive and often incoercible emesis starting 1–4 h after ingestion of the culprit food (1). Severe forms may result in dehydration or hypovolemic shock (1). In the absence of biomarkers, the diagnosis of FPIES is based on clinical presentation (1). Symptoms improve after exclusion of the culprit foods and acute FPIES occurs at re‐exposure. FPIES generally...
Thu Apr 23, 2020 20:48
Abstract Background Conventional type 1 dendritic cells (cDC1s) control antiviral and antitumor immunity by inducing antigen‐specific cytotoxic CD8+ T‐cell responses. Controversy exists whether cDC1s also control CD4+ T helper 2 (Th2) cell responses, since suppressive and activating roles have been reported. DC activation status, controlled by the transcription factor NF‐κB, might determine the precise outcome of Th‐cell differentiation upon encounter with cDC1s. To investigate the role of...
Thu Apr 23, 2020 19:09
Thu Apr 23, 2020 15:23
Squirrel monkeys in Eastern Amazonia are seasonal breeders, with the weaning period, rather than the birth peak/early lactation, matching the peak of fruit availability in the environment. This species of squirrel monkey are income‐I breeders, where seasonal breeding maximizes weanling survival. Abstract Many mammals coincide their reproductive activities with factors such as ambient temperature, rainfall, and food availability. In primates that invest immediate food intake into reproduction,...
Fri Apr 24, 2020 22:00
Scratch contagion is stronger between weakly bonded individuals (nonkin/friends) during tense situations. Abstract Primates show various forms of behavioral contagion that are stronger between kin and friends. As a result, behavioral contagion is thought to promote group coordination, social cohesion, and possibly state matching. Aside from contagious yawning, little is known about the contagious effect of other behaviors. Scratching is commonly observed during arousal and as such may play a...
Fri Apr 24, 2020 22:00
Abstract The mechanisms that underlie the diversification of Neotropical primates remain contested. One mechanism that has found support is the riverine barrier hypothesis (RBH), which postulates that large rivers impede gene flow between populations on opposite riverbanks and promote allopatric speciation. Ayres and Clutton‐Brock (1992) demonstrated that larger Amazonian rivers acted as barriers, delineating the distribution limits of primate species. However, profound changes in taxonomy and...
Thu Apr 23, 2020 11:40
Abstract Treatment‐free remission (TFR), wherein patients discontinue pharmacotherapy and remain in molecular remission, is an emerging treatment goal for patients with chronic myeloid leukemia (CML). Attainment of TFR requires an increased frequency of molecular monitoring, to ensure that patients maintain a deep molecular response. The objective of this analysis was to assess the economic impact of stopping nilotinib among Japanese TFR‐eligible patients. A Markov model evaluated the economic...
Thu Apr 23, 2020 16:14
Abstract Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in Southeast Asia, hence, identifying easily detectable biomarkers for NPC screening is essential for better diagnosis and prognosis. Using genome‐wide and targeted analyses based on next‐generation sequencing approaches, we previously showed that gene promoters are hypermethylated in NPC tissues. To confirm whether DNA methylation rates of genes could be used as biomarkers for NPC screening, Seventy‐nine histologically diagnosed...
Thu Apr 23, 2020 16:14
Abstract Invariant natural killer T (iNKT) cells are innate‐like CD1d‐restricted T cells that express the invariant T cell receptor (TCR) composed of Va24 and Vb11 in humans. iNKT cells specifically recognize glycolipid antigens such as a‐galactosylceramide (aGalCer) presented by CD1d. iNKT cells show direct cytotoxicity toward CD1d‐positive tumor cells, especially when CD1d presents glycolipid antigens. However, iNKT cell recognition of CD1d‐negative tumor cells is unknown, and direct cytotoxicity...
Thu Apr 23, 2020 16:09
Gelsolin inhibits malignant phenotype of glioblastoma and is regulated by miR‐654‐5p and miR‐450b‐5p
Abstract We have previously shown that gelsolin (GSN) levels are significantly lower in the blood of patients with glioblastoma (GBM) than in healthy controls. Here, we analyzed the function of GSN in GBM and examined its clinical significance. Furthermore, microRNAs (miRNAs) involved in GSN expression were also identified. The expression of GSN was determined using western blot analysis and found to be significantly lower in GBM samples than normal ones. GSN was mainly localized in normal astrocytes,...
Thu Apr 23, 2020 16:08
After a careful clinical evaluation and inspection of the oropharynx via direct laryngoscopy, evaluation and treatment trials can proceed in a stepwise fashion. The order of the tests and trials may be modified by clinical suspicion. Functional globus should be diagnosed after the appropriate ROME IV exclusion criteria have been applied. Abstract Globus is a non‐painful sensation of a tightness or a lump/foreign body in the throat that is not associated with dysphagia and may actually improve during...
Thu Apr 23, 2020 18:59
This study utilized HRM to investigate the effects of sildenafil on esophageal motility in healthy adults. Sildenafil inhibits both LES function and esophageal primary peristalsis without impacting UES function. Besides inhibitory impact on esophageal motor activity, sildenafil also affects excitatory peristaltic response after provocative testing using MRS. Abstract Background/aim Sildenafil induces smooth muscle relaxation of the esophagus by blocking type 5 phosphodiesterase that degrades...
Thu Apr 23, 2020 17:58
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Fri Apr 24, 2020 11:32
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Fri Apr 24, 2020 11:27
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Fri Apr 24, 2020 11:19
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Fri Apr 24, 2020 11:17
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Fri Apr 24, 2020 08:30
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Fri Apr 24, 2020 08:28
Abstract Surgery is still the first choice to treat oral cancer, where it is important to detect surgical margins in order to reduce cancer recurrence and maintain oral-maxillofacial function simultaneously. As a non-invasive and in situ imaging technique, optical coherence tomography (OCT) can obtain images close to the resolution of histopathology, which makes it have great potential in intraoperative diagnosis. However, it is not enough to find surgical margins accurately just...
Sat Apr 25, 2020 03:00
Abstract The aim of this study was to compare the clinical performance of clinical-visual examination using the International Caries Detection and Assessment System (ICDAS) II, digital bitewing radiography, near-infrared light transillumination (NIR-LT), and laser fluorescence (LF) for the detection of non-cavitated proximal enamel and dentin caries. The study included 335 patients, aged 12–18 years, with no cavities in the posterior teeth. Clinical-visual inspections of 335 non-cavitated...
Fri Apr 24, 2020 03:00
Abstract Cutaneous leishmaniasis (CL) is a major health problem in developing countries with high economic and health impact. Despite suggested treatment for CL, there is still no definite therapy for this infection, and many of these treatments are associated with serious local and systemic side effects. In the current paper, use of different laser types including continuous and fractional CO2, argon, PDL, erbium glass, and Nd:YAG have been reviewed. Based on our review, given...
Fri Apr 24, 2020 03:00
Abstract Photobiomodulation (PBM) has been used in different populations as a strategy to attenuate muscle fatigue and improve exercise performance. Recent findings demonstrated that a single session with specific PBM doses during hemodialysis (HD) increased the upper limb muscle strength of chronic kidney failure (CKF) patients. Now, the primary objective of this study was to evaluate the chronic effect of PBM on the functional capacity of this population. Secondarily, we aimed...
Fri Apr 24, 2020 03:00
Abstract Post-traumatic stress disorder (PTSD) is a mental disorder that is linked with the onset of multiple anxiety-like behaviors. This study was designed to assess how these behaviors and anterior cingulate cortex (ACC) c-Fos expression were impacted by 10.6-μm laser stimulation at acupoint ST36 a rat model of PTSD. A rat model of PTSD was prepared via prolonged exposure of animals to a stressor, followed by a 7-day period during which animals were allowed to rest undisturbed...
Fri Apr 24, 2020 03:00
The fundamental frequency and harmonic organization of voice can be quantified using cepstral measure. The two commonly studied cepstral measures are Cepstral Peak Prominence (CPP) and smoothened Cepstral peak prominence (sCPP). CPP is determined by measuring the amplitude difference from the highest peak of the cepstrum to the corresponding regression line, drawn directly below the cepstral peaks and when a smoothening factor is applied, sCPP is obtained. Cepstral analysis has been reported to be...
Fri Apr 24, 2020 03:00
Vocal fold leukoplakia is clinically defined by the presence of white mucosal lesions. Benign and malignant lesions of vocal fold leukoplakia can be distinguished clinically based on pathological biopsy. This study compared the acoustic and aerodynamic parameters of vocal cord carcinoma and dysplasia (mild to severe).
Fri Apr 24, 2020 03:00
Fri Apr 24, 2020 04:14
Related ArticlesThe long-term outcome of an isolated vascular ring - A single-center experience. Pediatr Pulmonol. 2019 12;54(12):2028-2034 Authors: Depypere A, Proesmans M, Cools B, Vermeulen F, Daenen W, Meyns B, Rega F, Boon M Abstract BACKGROUND AND OBJECTIVES: The aim of this study is to document the long-term outcome of patients with a vascular ring. METHODS: A single-center retrospective review of clinical symptoms was conducted in all...
Fri Apr 24, 2020 15:27
Laparoscopic paraduodenal hernia repair with bioabsorbable mesh: A case of a novel technique for a rare cause of bowel obstruction. Int J Surg Case Rep. 2020 Apr 04;70:1-4 Authors: Kwan B, Theodore JE, Wong J Abstract INTRODUCTION: Paraduodenal hernias are the most common type of internal hernia but a rare cause of bowel obstruction. Given the high risk of incarceration, obstruction and associated mortality, surgical repair is recommended. PRESENTATION...
Fri Apr 24, 2020 13:26
An impact of microscopic positive margin on incomplete response after I-131 treatment in differentiated thyroid cancer. Ann Nucl Med. 2020 Apr 22;: Authors: Raruenrom Y, Sawangsri K, Somboonporn C, Theerakulpisut D, Wongsurawat N, Ratanaanekchai T Abstract OBJECTIVE: To find an impact of microscopic positive margin on incomplete response after initial I-131 therapy in differentiated thyroid cancer. METHODS: We retrospectively recruited...
Fri Apr 24, 2020 13:23
Related ArticlesHuman Keratinocyte UVB-Protective Effects of a Low Molecular Weight Fucoidan from Sargassum horneri Purified by Step Gradient Ethanol Precipitation. Antioxidants (Basel). 2020 Apr 21;9(4): Authors: Fernando IPS, Dias MKHM, Madusanka DMD, Han EJ, Kim MJ, Jeon YJ, Lee K, Cheong SH, Han YS, Park SR, Ahn G Abstract Ultraviolet B (UVB) radiation-induced oxidative skin cell damage is a major cause of photoaging. In the present study, a low...
Sat Apr 25, 2020 16:33
The effects of ultraviolet radiation and climate on oil toxicity to coral reef organisms - A review.
Related ArticlesThe effects of ultraviolet radiation and climate on oil toxicity to coral reef organisms - A review. Sci Total Environ. 2020 Jun 10;720:137486 Authors: Nordborg FM, Jones RJ, Oelgemöller M, Negri AP Abstract Oil pollution remains a significant local threat to shallow tropical coral reef environments, but the environmental conditions typical of coral reefs are rarely considered in oil toxicity testing and risk assessments. Here we review...
Sat Apr 25, 2020 16:33
Related ArticlesDietary Intake, Hydration Status, and Body Composition of Three Belgian Military Groups. Mil Med. 2020 Apr 24;: Authors: De Bry W, Mullie P, D'Hondt E, Clarys P Abstract INTRODUCTION: Malnutrition, suboptimal hydration, and inadequate body composition can have negative consequences on soldiers' performance and health. A recent consensus statement concerning "soldiers' physical performance" points to the scarcity of data in specific military...
Sat Apr 25, 2020 15:30
Related ArticlesMental Health Diagnostic Patterns in Behavioral Weight Loss Program Attendees. Mil Med. 2020 Apr 24;: Authors: Hayes JF, Hoggatt KJ, Breland JY Abstract INTRODUCTION: Individuals with obesity have higher rates of mental health disorders, both singly and in combination, than individuals of normal weight. Mental health disorders may negatively impact weight loss treatment outcomes; however, little is known about the mental health burden...
Sat Apr 25, 2020 15:30
CORRIGENDUM for "Treatment of Children With GH in the United States and Europe: Long-Term Follow-Up From NordiNet® IOS and ANSWER Program". J Clin Endocrinol Metab. 2020 Jun 01;105(6): Authors: PMID: 32324865 [PubMed - as supplied by publisher]
Fri Apr 24, 2020 14:39
Hypoparathyroidism. J Clin Endocrinol Metab. 2020 Jun 01;105(6): Authors: Bilezikian JP Abstract BACKGROUND: Hypoparathyroidism is a rare endocrine disorder characterized by hypocalcemia and low or undetectable levels of parathyroid hormone. METHODS: This review is an evidence-based summary of hypoparathyroidism in terms of relevant pathophysiological, clinical, and therapeutic concepts. RESULTS: Many clinical manifestations of hypoparathyroidism...
Fri Apr 24, 2020 14:39
Letter to Editor Response to Covid-19 Endocrinology & Diabetology. J Clin Endocrinol Metab. 2020 Apr 23;: Authors: Nadolsky KZ PMID: 32322893 [PubMed - as supplied by publisher]
Fri Apr 24, 2020 14:39
Related ArticlesTransposition and variant termination of azygos and hemiazygos veins: an extremely rare variation. Surg Radiol Anat. 2020 Apr 23;: Authors: Nayak SB, Soumya KV Abstract Azygos system of veins is the main source of venous drainage from the thoracic wall. Knowledge of azygos vein anomalies could be of importance to cardiothoracic surgeons and radiologists. We report a rare variation of azygos vein as seen in an adult male cadaver aged 65 years...
Sat Apr 25, 2020 15:33
Analysis of anatomical variation of the inclination of lamellas attached to the skull base and its correlation with the anterior ethmoidal artery floating in the ethmoid sinus for use in endoscopic sinus surgery. Surg Radiol Anat. 2020 Apr 22;: Authors: Takeda T, Kajiwara R, Omura K, Otori N, Wada K Abstract PURPOSE: Attention to the inclination of lamellas attached to the skull base, including the basal lamella of the middle turbinate, facilitates...
Fri Apr 24, 2020 13:35
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