Mon Apr 27, 2020 19:22
Mon Apr 27, 2020 19:22
Mon Apr 27, 2020 19:22
Total laparoscopic sigmoid vaginoplasty is a minimally invasive procedure with quick recovery and acceptable cosmetic effects. It is an ideal treatment for the congenital absence of the vagina. Abstract Background This study aimed to evaluate the technical feasibility and outcomes of total laparoscopic sigmoid vaginoplasty (TLSV) in women with congenital absence of the vagina. Methods We investigated 10 women with congenital absence of the vagina, who underwent TLSV at Guangdong Provincial...
Mon Apr 27, 2020 14:10
In recent years, there has been a concerted drive for an increase in public reporting of hospital‐level outcomes as a means of identifying strategies to improve patient safety. Surgical care, as a high‐risk area of medical practice, has come under sharp scrutiny. This is the first study to assess the Victorian rate of preventable surgical mortalities using data from the Victorian Audit of Surgical Mortality in conjunction with data from the Victorian Admitted Episode Dataset. Abstract Background...
Mon Apr 27, 2020 13:57
Gallstone pancreatitis has evidence‐based guidelines which recommend index admission cholecystectomy in patients with mild disease. A retrospective chart audit within the Sunshine Coast Health District found a 69.5% compliance rate to the guidelines. There was a 17% readmission rate in patients not receiving index cholecystectomy reinforcing the importance of guideline adherence. Abstract Background Gallstone pancreatitis (GSP) has evidence‐based guidelines regarding management. Both the...
Mon Apr 27, 2020 13:56
In the midst of an international opioid crisis, much of the focus has been aimed towards reducing the supply of opioids from hospital settings. Not all patients, however, are oversupplied with opioids and therefore communication to general practitioners is important as they are often tasked with ongoing management. This study evaluates how opioids are communicated to general practitioners. Abstract Background To address the opioid crisis, much work has focused on minimizing opioid supply...
Mon Apr 27, 2020 13:55
This study reviews the management of a rare skin tumour (pleomorphic dermal sarcoma) at a tertiary cancer centre. Abstract Background Pleomorphic dermal sarcoma (PDS) is a rare, poorly defined skin neoplasm with features similar to atypical fibroxanthoma, but with adverse histopathological characteristics indicating metastatic potential such as tumour necrosis, invasion beyond superficial subcutis or vascular and/or perineural infiltration. Optimal treatment for PDS is uncertain and reported...
Mon Apr 27, 2020 13:55
The aim of this study was to evaluate the safety and efficacy of low‐molecular weight heparin in the prevention of portal vein system thrombosis after splenectomy. Abstract Background The aim of this study was to evaluate the safety and efficacy of low‐molecular weight heparin (LMWH) in the prevention of portal vein system thrombosis (PVST) after splenectomy. Methods A systematic search was performed using PubMed, EMBASE, Springer and Cochrane Library databases to screen out studies...
Mon Apr 27, 2020 12:39
Tue Apr 28, 2020 14:44
Abstract Kinesin family member 11 (KIF11) is a plus end‐directed kinesin indispensable for the formation of the bipolar spindle in metaphase, where it objects to the action of minus end‐directed molecular motors. Here, we hypothesize that KIF11 might be a therapeutic target of breast cancer and regulated by miR‐30a. Cell Counting Kit 8 assays were used to investigate cell proliferation. Invasion assays were used to survey the motility of cells. Kaplan‐Meier and Cox proportional analyses were employed...
Wed Apr 29, 2020 12:07
Abstract Gastrointestinal stromal tumor (GIST) is a common mesenchymal tumor in the gastrointestinal tract. Prostate cancer associated transcript 6 (PCAT6) is a long noncoding RNA (lncRNA) and plays a pivotal role in tumor formation. Present study was designed to explore the function of PCAT6 in GIST. Ki67 staining, colony formation and trypan blue staining assays revealed that PCAT6 boosted GIST cell proliferation but inhibited cell apoptosis. Also, sphere formation assay and Western blot uncovered...
Mon Apr 27, 2020 18:17
Abstract Emerging evidence has shown that aberrant alternative splicing (AS) events are involved in the carcinogenesis. The association between genetic variants in AS and bladder cancer susceptibility remains to be fully elucidated. We searched for single nucleotide polymorphisms (SNPs) which are located in splicing quantitative trait loci (sQTLs) in bladder cancer through CancerSplicingQTL database and the 1000 Genomes Project. A case‐control study including 580 cases and 1,101 controls was conducted...
Mon Apr 27, 2020 17:33
Analyst, 2020, Advance ArticleDOI: 10.1039/C9AN02553G, PaperKristine Y. Tan, Amy E. HerrFerguson analysis of protein electromigration from single-cell lysate in an open microfluidic device to inform optimal assay design.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Apr 29, 2020 02:00
Abstract Ca2+/calmodulin‐dependent protein kinase II (CaMKII) is known to be a crucial regulator in the post‐synapse during long‐term potentiation. This important protein has been the subject of many studies centered on understanding memory at the molecular, cellular, and organismic level. CaMKII is encoded by four genes in humans, all of which undergo alternative splicing at the RNA level, leading to an enormous diversity of expressed proteins. Advances in sequencing technologies have facilitated...
Tue Apr 28, 2020 14:48
Abstract Voxelwise modeling is a powerful framework to predict single‐voxel functional selectivity for the stimulus features that exist in complex natural stimuli. Yet, because VM disregards potential correlations across stimulus features or neighboring voxels, it may yield suboptimal sensitivity in measuring functional selectivity in the presence of high levels of measurement noise. Here, we introduce a novel voxelwise modeling approach that simultaneously utilizes stimulus correlations in model...
Tue Apr 28, 2020 14:25
Abstract TDP‐43 is an RNA/DNA‐binding protein associated with amyotrophic lateral sclerosis (ALS). Under pathological conditions, TDP‐43 exported from the nucleus accumulates in the cytoplasm, forming inclusion bodies. However, the molecular mechanisms that contribute to such aggregation are unclear. The pathogenic processes that lead to aggregation in ALS were investigated by analyzing the effects of wildtype human TDP‐43 or with mutations in the nuclear‐localization sequence (NLS) or those associated...
Tue Apr 28, 2020 11:40
Niemann‐Pick disease type C (NPC) is a neurovisceral lipid‐storage disease. Although NPC patients show lipid storage in anterior horn cells of the spinal cord, little information is available regarding the electron microscopic analyses of the morphologies of intra‐endosomal lipid like‐materials in the anterior horn cells of NPC patients. In this study, we elucidated the intra‐endosomal ultrastructures in spinal anterior horn cells in an NPC patient, as well as in mutant BALB/c NPC1−/− mice with a...
Mon Apr 27, 2020 22:00
The solid variant of aneurysmal bone cyst (SVABC) is very uncommon and frequently misdiagnosed. We reevaluated and summarized the clinicopathologic features of 17 SVABCs and further discussed the use of this nomenclature to differ SVABCs from extragnathic giant cell reparative granuloma (GCRG) in the setting of the USP6 rearrangement era. The immunohistochemical markers included α‐SMA, SATB2, AE1/AE3, Ki67, S100, CD68 and P63. USP‐6 status was detected by fluorescence in situ hybridization using...
Mon Apr 27, 2020 19:13
Mon Apr 27, 2020 19:11
Mon Apr 27, 2020 19:10
Mon Apr 27, 2020 21:30
Abstract The European Academy of Allergy and Clinical Immunology (EAACI) is the leading organisation in the field of Allergy, Asthma and Clinical Immunology with nearly 12,000 members from 124 countries and works with over 70National Allergy Societies. It is the primary source of expertise in Europe and worldwide for all aspects of allergic diseases and asthma. Recent efforts by EAACI resulted in a successful Strategic Forum on Allergic Diseases (1), with key opinion leaders acknowledging the impact...
Mon Apr 27, 2020 20:49
Mon Apr 27, 2020 20:33
Mon Apr 27, 2020 20:29
Background The objective of this study was to evaluate treatment outcomes for patients with desmoid tumors (DTs) receiving local therapy with surgery alone, radiation therapy (RT) alone, or combined modality therapy (RT and surgery). Methods This was a cross‐sectional cohort study of 412 patients with nonmesenteric DTs who received local therapy at the authors' institution between 1965 and 2018. Results The median follow‐up time was 95 months (range, 1‐509 months). Local recurrence...
Tue Apr 28, 2020 22:43
Background The objective of this study was to determine the effect of Medicaid expansion under the Patient Protection and Affordable Care Act (January 1, 2014) on the epidemiology of high‐risk prostate‐specific antigen (PSA) levels (≥20 ng/mL) at the time of prostate cancer (PCa) diagnosis. The authors hypothesized that better access to care would result in a reduction of high‐risk features at diagnosis. Methods A retrospective cohort study was performed of 122,324 men aged <65 years...
Tue Apr 28, 2020 16:49
Tue Apr 28, 2020 16:32
Background Previous studies examining the time to initiate chemoradiation (CRT) after surgical resection of glioblastoma have been conflicting. To better define the effect that the timing of adjuvant treatment may have on outcomes, the authors examined patients within the National Cancer Database (NCDB) stratified by a validated prognostic classification system. Methods Patients with glioblastoma in the NCDB who underwent surgery and CRT from 2004 through 2013 were analyzed. Radiation...
Tue Apr 28, 2020 14:58
Background Partner and localizer BRCA2 (PALB2) is a breast cancer predisposition gene, but the clinical relevance of PALB2 germline mutations in Chinese patients with breast cancer remains unknown. This study attempted to investigate the full prevalence and spectrum of PALB2 germline mutations in China and the associations between PALB2 germline mutations and breast cancer risk. Methods A total of 21,216 unselected patients with breast cancer were enrolled from 10 provinces in China,...
Mon Apr 27, 2020 15:28
ABSTRACT Introduction This study applied mathematical modeling to examine the anatomy of the distal radius; to define the radiographic parameters in a 3D imaging modality; and to report their normal ranges in the uninjured radius. Materials and Methods A series of 50 cone‐beam computed tomography (CBCT) scans of uninjured radii were analyzed using computer‐aided image processing. The radius shape model was used to determine the optimal location for measuring the longitudinal axis....
Tue Apr 28, 2020 20:24
Background and Objectives The finite element method was used, and experiments were performed to analyze the effect of different electrode spacings and power combinations on the electrical and thermal aspects of biological tissues during bipolar radiofrequency (RF) fat dissolution. Through these efforts, this study also attempted to develop a reasonable electrode spacing and power combination that can achieve fat dissolution effects, the RF energy of which will not thermally damage the tissue. ...
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