Related ArticlesPalatopharyngoplasty and Palatal Anatomy and Phenotypes for Treatment of Sleep Apnea in the Twenty-first Century. Otolaryngol Clin North Am. 2020 Apr 22;: Authors: Puccia R, Woodson BT Abstract Successful palatopharyngoplasty is critical for successful sleep apnea surgery. Traditional uvulopalatopharyngoplasty was primarily excisional, whereas newer techniques, such as expansion sphincterpharyngoplasty, are more reconstructive. Studies...
Mon Apr 27, 2020 14:21
Related ArticlesSkeletal Surgery for Obstructive Sleep Apnea. Otolaryngol Clin North Am. 2020 Apr 22;: Authors: Awad M, Capasso R Abstract This article focuses on the role of skeletal surgery within the modified Stanford protocol with particular attention focused on the evolved role of MMA. First, surgery in patients presenting with congenital dentofacial deformity or characteristic drug-induced sleep endoscopy findings, then the growing role of maxillary...
Mon Apr 27, 2020 14:21
Related ArticlesObstructive sleep apnea and the risk of gout: a population-based case-control study. Arthritis Res Ther. 2020 Apr 25;22(1):92 Authors: van Durme C, Spaetgens B, Driessen J, Nielen J, Sastry M, Boonen A, de Vries F Abstract BACKGROUND: Patients with obstructive sleep apnea (OSA) might be at risk of gout because of pathophysiological mechanisms that can lead to hyperuricemia and eventually gout or because of shared risk factors between...
Mon Apr 27, 2020 14:21
Recognition memory is the capacity to recognize previously encountered objects, events or places. This ability is crucial for many fitness-related activities, and it appears very early in the development of several species. In the laboratory, recognition memory is most often investigated using the novel object recognition test (NORt), which exploits the tendency of most vertebrates to explore novel objects over familiar ones. Despite that the use of larval zebrafish is rapidly increasing in research...
Mon Apr 27, 2020 03:00
The Journal of Antibiotics, Published online: 27 April 2020; doi:10.1038/s41429-020-0306-5Emergence of a multidrug-resistant ST 27 Escherichia coli co-harboring blaNDM-1, mcr-1, and fosA3 from a patient in China
Mon Apr 27, 2020 03:00
Publication date: Available online 25 April 2020Source: TalantaAuthor(s): Liwei Qian, Wenqian Liu, Miaoxiu Yang, Valentin Nica, Jinfan Yang, Hanbin Liu, Lulu Ning, Sufeng Zhang, Qiuyu Zhang
Mon Apr 27, 2020 12:34
ABSTRACT Activating point mutations in two codons (R201 and Q227) in the alpha subunit of the stimulatory GTP binding protein (GNAS) gene ‐ coined gsp mutations ‐ were originally reported in growth hormone (GH) secreting pituitary adenomas. In these tumor types, gsp activating mutations were associated with uncontrolled intracellular cAMP accumulation leading to cellular proliferation and tumor formation. Since the original description of gsp mutations in pituitary and later thyroid neoplasia,...
Sun Apr 26, 2020 21:43
Abstract Objective This study aimed to delineate the causal relationship between Ménière’s disease and depression. Design Two longitudinal follow‐up studies Main Outcome Measures The 2002–2013 Korean National Health Insurance Service‐Health Screening Cohort was used. In study I, Ménière’s disease patients were 1:4 matched with the control I group for age group, sex, income group, and region of residence, and the occurrence of depression was observed. In study II, the depression patients...
Sun Apr 26, 2020 17:53
Abstract Objective To examine the construct validity, reliability and responsiveness of the Otology Questionnaire Amsterdam (OQUA). Design Multicentre, longitudinal study in 2 separate cohorts of patients visiting an ENT surgeon via an online survey program. Setting Tertiary ENT clinics. Participants Cohort 1 consisted of patients at their first visit at an ENT outpatient clinic with an ear complaint. Cohort 2 consisted of patients who underwent surgery, with a 3‐month follow‐up...
Sun Apr 26, 2020 11:24
Abstract Purpose To compare the implant replica position accuracy on a duplicated complete edentulous maxillary implant definitive cast made either using conventional procedures or material jetting additive manufacturing (AM) technology using a coordinate measuring machine (CMM). Material and Methods A complete edentulous maxillary cast with 6 implant replicas was prepared. The definitive cast was duplicated using two manufacturing procedures namely conventional (CNV group) and additive...
Sun Apr 26, 2020 20:44
Objective To foster trial‐readiness of COQ8A‐ataxia, we map the clinico‐genetic, molecular and neuroimaging spectrum of COQ8A‐ataxia in a large worldwide cohort, and provide first progression data, including treatment response to coenzyme Q10 (CoQ10). Methods Cross‐modal analysis of a multicenter cohort of 59 COQ8A patients, including genotype–phenotype correlations, 3D‐protein modelling, in vitro mutation analyses, MRI markers, disease progression and CoQ10 response data. Results...
Sun Apr 26, 2020 20:50
Background Farmland accounts for a relatively large fraction of the world’s vegetation cover, and the quantification of carbon fluxes over farmland is critical for understanding regional carbon budgets. The carbon cycle of farmland ecosystems has become a focus of global research in the field of carbon dynamics and cycling. The objectives of this study are to monitor the temporal variation in the net ecosystem exchange (NEE) and soil respiration in a spring maize (Zea mays L.) farmland...
Mon Apr 27, 2020 03:00
Urate oxidase (uricase, Uox) is a big obstacle for scientists to establish stable animal models for studying hyperuricemia and associated disorders. Due to the low survival rate of uricase-deficient mice, we generated a Uox-knockout model animal from Sprague Dawley (SD) rats using the CRISPR/Cas9 technique by deleting exons 2 to 4 of the Uox gene. The uricase-deficient rats were named “Kunming-DY rats”, and were apparently healthy with more than a 95% survival up to one year. The male rats’ serum...
Mon Apr 27, 2020 03:00
A new species of flat mite, Cenopalpus umbellatus sp. nov. (Acari: Trombidiformes: Tenuipalpidae) is described and illustrated based on females, males, deutonymphs, protonymphs and larvae. The morphological ontogeny in idiosomal and leg chaetotaxy is briefly described for all stages. Mite specimens were collected from the leaves of Rhaphiolepis indica var. umbellata Makino (Rosaceae), an evergreen shrub native to Japan. An identification key to the world species of Cenopalpus is also provided.
Mon Apr 27, 2020 03:00
Forest carbon sequestration offsets are methodologically uncertain, comprise a minor component of carbon markets and do not effectively slow deforestation. The objective of this study is to describe a commercial scale in situ measurement approach for determination of net forest carbon sequestration projects, the Direct Measurement Forest Carbon Protocol™, to address forest carbon market uncertainties. In contrast to protocols that rely on limited forest mensuration, growth simulation and exclusion...
Mon Apr 27, 2020 03:00
Radicalized: A thermally stable, T‐shaped, high‐spin iron(I) PNP complex displayed remarkable reactivity towards oxygen‐containing functional groups, allowing the isolation of a stable iron ketyl radical complex and a bridged, diferrous oxido complex. Abstract A thermally stable, T‐shaped, d7 high‐spin iron(I) complex was obtained by reduction of a PNP‐supported ferrous chloride. Paramagnetic NMR spectroscopy combined with DFT modeling was used to analyze the electronic structure of the coordinatively...
Mon Apr 27, 2020 11:23
The F 1 F O ‐ATP synthase is required for growth and viability of Mycobacterium tuberculosis . Bedaquiline validated this target clinically. We showed recently that a mycobacterium‐specific loop of the enzyme’s rotary γ subunit plays a role in coupling of ATP synthesis within the enzyme complex. Here, we report the discovery of a novel antimycobacterial, termed GaMF1, targeting this γ subunit loop. Biochemical and Nuclear Magnetic Resonance studies show that GaMF1 inhibits ATP synthase activity...
Sun Apr 26, 2020 20:28
The perovskite excited‐state lifetimes exhibit the conflicting experimental results exposure to humidity, which should correlate with defects because they inevitably present in perovskite films. Nonadiabatic (NA) molecular dynamics combined with time‐domain density functional theory calculations demonstrate that the formation energy of a lead vacancy decreases from 0.29 eV in pristine MAPbI 3 (MA= CH 3 NH 3 + ) to over ‐2 eV in the perovskite in the presence water regardless of its oxidation...
Sun Apr 26, 2020 18:29
Transition‐metal oxides as electrocatalysts for oxygen evolution reaction (OER) provide a promising route to face the energy and environmental crisis issues. Although palmeirite oxide A 2 Mo 3 O 8 as OER catalyst has been explored, the correlation between its active sites (tetrahedral or octahedral site) and OER performance is elusive so far. Here, we present a magnetic functioned Co 2 Mo 3 O 8 @NC‐800 composed of highly crystallized Co 2 Mo 3 O 8 nanosheets and ultrathin N‐rich...
Sun Apr 26, 2020 17:29
Chiral optical metamaterials with delicate structures are in high demand in various fields due to their strong light–matter interactions. Recently, a scalable strategy for the synthesis of chiral plasmonic nanoparticles using amino acids and peptides has been reported. In this work, three‐dimensional chiral gold nanoparticles using dipeptide γ‐Glu‐Cys and Cys‐Gly were synthesized and analyzed from a crystallographic perspective. The γ‐Glu‐Cys‐directed nanoparticles showed a cube‐like outline with...
Sun Apr 26, 2020 17:08
Predictability is a key requirement to encompass late‐stage C‐H functionalization in synthetic routes. However, prediction (and control) of reaction selectivity is usually challenging, especially for complex substrate structures and elusive transformations such as remote C( sp 3 )‐H oxidation, as it requires to distinguish a specific C‐H bond from many others with similar reactivity. Herein, we develop a strategy for predictable, remote C‐H oxidation that entails substrate binding to a supramolecular...
Sun Apr 26, 2020 17:07
Zero‐dimensional (0D) lead‐free perovskites have unique structures and optoelectronic properties. Here, we report undoped and Sb‐doped all inorganic, lead‐free, 0D perovskite single crystals A 2 InCl 5 (H 2 O) (A = Rb, Cs), which exhibit greatly enhanced yellow emission. To study the effect of coordination H 2 O, Sb‐doped A 3 InCl 6 (A = Rb, Cs) are also synthesized and further studied. The photoluminescence (PL) color changes from yellow to green emission. Interestingly, the photoluminescence...
Sun Apr 26, 2020 17:05
Electrochemical conversion of CO2 to ethane is seldom observed because of the generally higher selectivity towards methane, ethylene, and ethanol. Consequently, little experimental evidence for its reaction mechanism exists and thus remains largely unknown. Here, by combining electrochemistry with in‐situ X‐ray absorption fine structure and in‐situ Raman techniques, we study iodide‐derived copper (ID‐Cu) and oxide‐derived copper (OD‐Cu) systems to obtain a deeper understanding of the CO2 to ethane...
Sun Apr 26, 2020 17:04
Abstract Pathogenic variants in HNRNPH1 were first reported in 2018. The reported individual, a 13 year old boy with a c.616C > T (p.R206W) variant in the HNRNPH1 gene, was noted to have overlapping symptoms with those observed in HNRNPH2‐related X‐linked intellectual disability, Bain type (MRXSB), specifically intellectual disability and dysmorphic features. While HNRNPH1 variants were initially proposed to represent an autosomal cause of MRXSB, we report an additional seven cases which...
Sun Apr 26, 2020 14:33
Abstract Recent advances in Next‐Generation Sequencing (NGS) technologies have revolutionized the field of human genetics. Alongside a broad panel of bio‐informatics tools and databases, NGS technologies have unprecedentedly improved the molecular diagnosis rate and the identification of new genes associated with rare disorders. However, about 50% of patients remain without a final diagnosis. Here, we highlight the utility of NGS applications in developmental anomalies and intellectual...
Sun Apr 26, 2020 13:08
ABSTRACT Despite new strategies, such as evaluating deep intronic variants and new genes in whole‐genome‐sequencing studies, the diagnostic yield of genetic testing in hypertrophic cardiomyopathy (HCM) is still around 50%. FHOD3 has emerged as a novel disease‐causing gene for this phenotype, but the relevance and clinical implication of copy‐number‐variations (CNVs) have not been determined. In this study, CNVs were evaluated using a comparative depth‐of‐coverage strategy by NGS in 5493...
Sun Apr 26, 2020 12:54
ABSTRACT Objective The aim of systematic review was to describe the phenotypes and molecular profiles of syndromes with gingival fibromatosis (GF). Methods A comprehensive search of PubMed, LILACS, Livivo, Scopus and Web of Science was conducted using key terms relevant to the research questions, and supplemented by a grey literature search. The Methodological Quality and Synthesis of Case Series and Case Reports in association with the Case Series and Prevalence Studies from the...
Sun Apr 26, 2020 11:00
Abstract It is hypothesized that prenatal vitamin D deficiency may contribute to the development of childhood wheezing and asthma. Beyond its known functions in bone development and health, vitamin D is emerging as a pleiotropic hormone exerting several extraskeletal effects, some of which could reduce the risk of asthma. Experimental evidence shows that vitamin D is an important regulator of foetal and neonatal lung growth. It can also modulate innate and adaptive immune responses, enhancing antiviral...
Sun Apr 26, 2020 15:23
Abstract The primate ventral motor thalamus contains a large number of GABAergic interneurons of poorly understood function and anatomical connectivity. Glutamatergic inputs to these cells arise predominantly from corticothalamic (in both basal ganglia‐ and cerebellar‐receiving ventral motor thalamic territories; BGMT and CBMT, respectively) and cerebellothalamic terminals (in CBMT). In Parkinson’s Disease patients and animal models, neuronal activity is abnormal within both BGMT and CBMT. Historically,...
Sun Apr 26, 2020 17:53
Wild tufted capuchin (Sapajus libidinosus) Coco uses a compound grip to hold two palm nuts in Fazenda Boa Vista, Piaui, Brazil. Photo by Caroline Jones. Abstract An experimental study with captive individuals and study of video recordings of wild monkeys explored whether and how tufted capuchin monkeys use onehand to hold one or more objects with multiple grips (compound grips). A task designed to elicit compound grip was presented to five captive tufted capuchin monkeys (Sapajus spp). The monkeys...
Sun Apr 26, 2020 20:12
Abstract Disentangling the relationship between age and reproduction is central to understand life‐history evolution, and recent evidence shows that considering condition‐dependent mortality is a crucial piece of this puzzle. For example, non‐random mortality of “low‐condition” individuals can lead to an increase in average lifespan. However, selective disappearance of such low‐condition individuals may also affect reproductive senescence at the population level due to trade‐offs between physiological...
Sun Apr 26, 2020 16:15
Abstract The Mdm2 oncoprotein and its association with p53 were discovered 30 years ago, and a cornucopia of activities and regulatory pathways have been associated with it. In this review, we will raise questions about Mdm2 and its cousin Mdm4 that we consider worth pursuing in future research, reaching from molecular structures and intracellular activities all the way to development, evolution, and cancer therapy. We anticipate that such research will not only close a few gaps in our knowledge...
Sun Apr 26, 2020 19:14
Globularia alypum aqueous extract increases gastric emptying and gastrointestinal transit and protects colons against loperamide induced constipation with oxidative stress and inflammation modulation. Abstract Background Chronic constipation is a gastrointestinal functional disorder which affects patient quality of life. Therefore, many studies were oriented to search herbal laxative agents. In this study, we investigated the effect of Globularia alypum L. leaves aqueous extract (GAAE) against...
Sun Apr 26, 2020 18:49
Left: in the colon, the M1 receptor is located to myenteric ganglia (mg) and the mucosal epithelium. Right: a maximally effective dose of an M1PAM causes strong colorectal propulsion, whereas the 5‐HT4 receptor agonist, prucalopride, and the cholinesterase inhibitor, neostigmine cause contractions that are less efficient in causing colorectal propulsion. Abstract Background Muscarinic receptor 1 positive allosteric modulators (M1PAMs) enhance colonic propulsive contractions and defecation through...
Sun Apr 26, 2020 17:34
In patients with Amyotrophic Lateral Sclerosis, maximum tongue pressure is significantly associated with an impairment of swallowing efficacy and tongue endurance is significantly associated with an impairment of swallowing safety. Abstract Background Oropharyngeal dysphagia (OD) is common in amyotrophic lateral sclerosis (ALS), leading to a reduction of swallowing safety and efficacy. The tongue has an important role in swallowing function for oral processing and bolus propulsion through...
Sun Apr 26, 2020 15:24
A Q & A discussion of how the Mayo Clinic is using artificial intelligence to triage and manage dizzy patients.
Mon Apr 27, 2020 07:00
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Mon Apr 27, 2020 07:59
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