This study describes demographic characteristics and hospital bed capacities of the 5 New York City boroughs, and evaluates whether differences in testing for coronavirus disease 2019 (COVID-19), hospitalizations, and deaths have emerged as a signal of racial, ethnic, and financial disparities.
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This Viewpoint discusses the prospect that face shields might be more effective than face masks at reducing community SARS-CoV-2 transmission and calls for rapid adoption of face shield-wearing by the public as an infection control strategy.
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MiR‐646 is downregulated in non‐small cell lung cancer (NSCLC) and could suppress the proliferation and EMT‐induced metastasis of NSCLC by suppressing FGF2 and CCND2. Thus, downregulation of miR‐646 can play a central role in tumor progression and may be a potential therapeutic target for NSCLC. Abstract MicroRNA‐646 (miR‐646) has been implicated in several other cancers; however, its functional mechanism in non‐small cell lung cancer (NSCLC) remains unclear. In this study, we observed the downregulation...
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Lorlatinib can increase the permeability of the blood‐brain barrier whereby we suggest it's underlying working mechanism is related to downregulating SPP1, inhibiting VEGF, TGF‐β and Claudin subsequently reducing the number of tight junctions between BBB cells. Lorlatinib plays a protective role on injured nerve cells and does not change the amount of P‐gp expression in brain tissue, which may be important for its ability to be efficacious across the BBB with a low incidence of resistance. Abstract...
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APG‐1252‐M1 is a new Bcl‐2/Bcl‐xl inhibitor. APG‐1252‐M1 both alone and in combination with chemotherapy exhibited antitumor effects though the intrinsic mitochondrial pathway of apoptosis in gastric cancer. Abstract Gastric carcinoma is the third major cause of cancer‐related death in China. Bcl‐2 and other BH3 family proteins are critically important in the process of apoptosis pathway, which may be a promising target. APG‐1252‐M1 specifically connects to Bcl‐2 and Bcl‐xl. The antitumor effect...
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FAM225A presents high expression in CRC tissues and cell lines. FAM225A expedites CRC cell proliferation, migration abilities, and impairs cell apoptosis capacity. FAM225A acts as a sponge of miR‐613 and is negatively correlated with miR‐613. Abstract Colorectal cancer (CRC) is a fatal disease ranking the third among the commonplace cancer types around the world. It is extremely significant to exploit effective treatments against CRC. FAM225A was proved to influence cell progression and forecast...
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Body surface area, height, and body fat percentage has higher sensitivity in assessing cancer risk than BMI. Body fat percentage shows the largest hazard ratios in all cardiovascular events. BSA, height, and BFP have considerable application value in routine healthcare practice. Abstract Background Limited studies have compared the association between various physical measurements and the risk of cancer or cardiovascular disease (CVD). We aim to explore the best‐individualized indicators of...
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Publication date: Available online 28 April 2020Source: GeneAuthor(s): Jingjing Yin, Lili Sun, Qihui Zhang, Chuanwang Cao
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Abstract Although accumulating evidence had revealed that NFAT1 has oncogenic characteristics, the role of this molecule in melanoma cells remains unclear. Previous studies proved that CD147 plays a crucial function in melanoma cell metastasis and invasion through matrix metalloproteinase 9 (MMP‐9) expression; however, the details of how CD147 regulates MMP‐9 expression remain elusive. In this study, we demonstrated that CD147 and NFAT1 are overexpressed in the tissues of patients with primary...
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Abstract In Dynamis. Ontologia dell’incommensurabile, Gaetano Chiurazzi offers an account of the philosophical sense and implications of the discovery of incommensurable magnitudes in ancient thought. In his study, Chiurazzi presents the scope of the idea of incommensurability in contrast to those theories that have interpreted perception as the primary access to reality. Chiurazzi claims that the discovery of incommensurable relations, such as that of “1/square root of 2,” which...
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Background This study aimed to compare the microbiota of pediatric patients with chronic rhinosinusitis (CRS) who are undergoing adenoidectomy to treat their disease with that of healthy control patients. Methods Patients undergoing adenoidectomy‐only for obstructive sleep apnea (n = 50) and CRS (n = 37) were recruited. Pre‐op Sino‐nasal Outcome Test (SN5 or SNOT22) was collected. Each patient had samples collected from their nasopharynx (adenoid bed) and nasal cavity (sinus) at the onset...
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ABSTRACT Severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2), which causes coronavirus disease 2019 (Covid‐19), is highly contagious with devastating impacts for healthcare systems worldwide. Medical staff are at high risk of viral contamination and it is imperative to know what personal protective equipment is appropriate for each situation. Furthermore, elective clinics and operations have been reduced in order to mobilize manpower to the acute specialties combatting the outbreak; appropriate...
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From the first reports, ageusia and anosmia appear to be frequent clinical features in coronavirus disease 19 (COVID‐19) patients. We have performed a survey of the literature, analyzing the possible causes of these chemosensory alterations, which may be useful as a starting point for specific further studies. This article is protected by copyright. All rights reserved
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Publication date: Available online 28 April 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): R. Quatre, A. Baguant, H. Gil, S. Schmerber
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With the growing number of corporate foundations and their increasing visibility as philanthropic actors, interests are raised regarding the way these corporate foundations function as well as about the nature of their relationship with the founding company. The foundation literature generally assumes that a foundation's ability to create social impact and innovation rests to a large part on their independence from external control. However, corporate foundations are dependent to varying degrees...
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The objective is to give an insight into what we know and what we don't know about the current situation of corporate foundations. While we are able to put the spotlight on several interesting developments in the field, this chapter cannot give a comprehensive overview of corporate foundations in all European foundation sectors. As corporate foundations are predominantly public-benefit foundations and part of the nonprofit sector, it is useful to start with a brief overview of the European foundation...
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Although trichuriasis affects millions of children worldwide, recommended drugs lack efficacy and new treatment options are urgently needed. Ivermectin has promising potential to complement the anthelminthic armamentarium.; A randomized placebo-controlled trial was conducted in rural Côte d'Ivoire to provide evidence on the efficacy and safety of ascending oral ivermectin dosages in preschool-aged children (PSAC) and school-aged children (SAC) infected with Trichuris trichiura. The primary outcome...
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1. A critical question in symbiosis research is where and how organisms obtain beneficial microbial symbionts in different ecological contexts. Microbiota of juveniles are often derived directly from their mother or from the immediate environment. The origin of beneficial symbionts, however, is less obvious in organisms with diapause and dispersal stages, such as plants with dormant seeds and animals in ephemeral or strongly seasonal habitats. In these cases, parents and offspring are separated in...
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Deregulation of centriole duplication has been implicated in cancer and primary microcephaly. Accordingly, it is important to understand how key centriole duplication factors are regulated. E3 ubiquitin ligases have been implicated in controlling the levels of several duplication factors, including PLK4, STIL and SAS-6, but the precise mechanisms ensuring centriole homeostasis remain to be fully understood. Here, we have combined proteomics approaches with the use of MLN4924, a generic inhibitor...
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Giant cell arteritis (GCA) is a large vessel vasculitis of unknown cause. Infections were long suspected as potential disease triggers, yet a disease causing pathogen has not been identified to date(1). Recently, several studies reported Varicella zoster virus (VZV) particles in artery biopsies(2). Alike other herpes viruses, VZV has a very high prevalence, remaining dormant in a latent stage controlled by the immune system. Loss of T cell-mediated viral control results in herpes zoster (or shingles)....
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Eukaryotic cyclic nucleotide-modulated channels perform their diverse physiological roles by opening and closing their pores to ions in response to cyclic nucleotide binding. We here present a structural model for the cyclic nucleotide-modulated potassium channel homolog from Mesorhizobium loti, MloK1, determined from 2D crystals in the presence of lipids. Even though crystals diffract electrons to only ∼10 Å, using cryoelectron microscopy (cryo-EM) and recently developed computational methods, we...
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The literature on multiple intracranial aneurysms (MIA) in patients with aneurysmal subarachnoid hemorrhage (aSAH) focuses largely on risk factor analysis and consists essentially of retrospective cohort studies of limited sample size, or studies in populations outside Europe and North America. The purpose of this cohort study was to identify predictors for aneurysm multiplicity and to investigate the anatomic distribution of MIA in a representative Western cohort of patients with aSAH.; The Swiss...
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This review compares and discusses conventional versus miniaturized specimen preparation methods for transmission electron microscopy (EM). The progress brought by direct electron detector cameras, software developments and automation have transformed transmission cryo-electron microscopy (cryo-EM) and made it an invaluable high-resolution structural analysis tool. In contrast, EM specimen preparation has seen very little progress in the last decades and is now one of the main bottlenecks in cryo-EM....
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The multidrug transporter ABCB1 (P-glycoprotein) is an ATP-binding cassette transporter that has a key role in protecting tissues from toxic insult and contributes to multidrug extrusion from cancer cells. Here, we report the near-atomic resolution cryo-EM structure of nucleotide-free ABCB1 trapped by an engineered disulfide cross-link between the nucleotide-binding domains (NBDs) and bound to the antigen-binding fragment of the human-specific inhibitory antibody UIC2 and to the third-generation...
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Entry of the facultative intracellular pathogen; Brucella; into host cells results in the formation of endosomal; Brucella; -containing vacuoles (eBCVs) that initially traffic along the endocytic pathway. eBCV acidification triggers the expression of a type IV secretion system that translocates bacterial effector proteins into host cells. This interferes with lysosomal fusion of eBCVs and supports their maturation to replicative; Brucella; -containing vacuoles (rBCVs). Bacteria replicate in rBCVs...
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C-di-GMP is an attractive target in the fight against bacterial infections as it is a near ubiquitous second messenger that regulates important cellular processes, including biofilm formation and virulence of pathogens. The screening of a combinatorial peptide library enabled the identification of the proline-rich tetrapeptide Gup-Gup-Nap-Arg that binds C-di-GMP in water with selectivity over other nucleotides. Computational and CD spectroscopic studies provided a binding mode of the complex and...
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The aim of this study was to examine how patient safety indicators and processes and structures of nursing care have changed since the 2012 introduction of Swiss Diagnosis-Related Groups.; Diagnosis-Related Groups have been implemented worldwide; yet, research findings regarding their impact on efficiency and quality of care remain inconsistent. The Matching Registered Nurse Services with Changing Care Demands study will assess how structures, processes and patient and nurse outcomes have changed...
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Although postoperative delirium (POD) is a common in-hospital complication associated with negative outcomes, evidence in liver transplantation (LT) is scarce.; We examined the incidence and duration of POD, its impact on outcomes and health-care utilization, and described predisposing and precipitating factors favoring POD development.; This prospective cohort study included adults undergoing transplantation in a tertiary hospital. Postoperative delirium was assessed 3 times daily until 24 days...
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