Abstract This quasi-experimental study examined a guided learning approach towards the use of mobile devices and investigated the performance of language learners who were guided in the usage. A total of 419 students from two faculties were invited to participate in this 8-week intervention, 155 participants in the control group and 264 in the experimental group. In the experimental group, the researchers incorporated guided activities Module Intervention Model (MIM) using mobile...
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Abstract This paper provides a comparative analysis of policies, strategies and programmes for Information and Communication Technology (ICT) integration in primary and post-primary education, that were active in the Kingdom of Saudi Arabia (KSA) and in the Republic of Ireland in 2016. The analysis showed that while KSA was a relative newcomer to the integration of ICT in education, it was responsive in seeking to enhance the quality of education and support transitions to the...
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Abstract The presented work is a student marks and grade prediction system using supervised machine learning techniques, the system is developed on the historic performance of students. The data used in this research is collected from Federal Board of Intermediate and Secondary Education Islamabad Pakistan, there are 7 regions in FBISE i.e. Punjab, Sindh, Khyber Pakhtunkhwa, Balochistan, Azad Jammu and Kashmir and overseas. The aims of this work is to analyze the education quality...
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Abstract Malingering, or intentional feigning of impairment for an external incentive, has been the topic of extensive psychological research in recent decades. The emphasis on symptom validity assessment in training, practice, and research in clinical psychology is not echoed across other health professions. While past surveys of clinical psychologists revealed positive beliefs and attitudes toward validity assessment, much less is known about physicians in this area, particularly...
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This study aimed to find the normative fundamental frequency values for adult native Urdu speakers from Pakistan. The age and gender differences were also examined.
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Cytokine storm occurred during SARS-CoV-2 infection and contributed to the disease progression. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19.
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Capsule summary: The oral kallikrein inhibitor ATN-249 is a candidate therapy for hereditary angioedema. We demonstrate the biological activity of this compound in plasma samples from a phase I study through investigation of ex vivo triggered contact activation.
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COVID patients in ICU present a high mortality rate and immunoprofiling reveals heterogeneous IFN-α2 production with about 20% of critically-ill patients unable to produce IFN-α2, highlighting the immune response heterogeneity and opening avenues for targeted therapies.
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The role of performance status in small-cell lung cancer in the era of immune checkpoint inhibitors.
Small-cell lung cancer (SCLC) represents about 15% of all new lung cancer diagnoses. It is strongly associated with smoking, develops at a median age of 65-70, and is diagnosed at an advanced stage in 70% of cases[1]. SCLC is characterized by aggressive tumour growth and early metastatic spread. SCLC also stands out due to an impressive initial response to chemotherapy, even in the advanced setting, though the response is consistently and predictably transient.
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Publication date: Available online 29 April 2020Source: European Journal of CancerAuthor(s): D. Trapani, A. Marra, G. Curigliano
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Abstract Sunlight is important to health, but higher exposure to radiation causes early aging of the skin and skin damage that can lead to skin cancers. This study aimed at producing a stable octyl p-methoxycinnamate (OMC)–loaded nanostructured lipid carrier (NLC) sunscreen, which can help in the photoprotective effect. NLC was produced by emulsification-sonication method and these systems were composed of myristyl myristate (MM), caprylic capric triglyceride (CCT), Tween® 80...
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by Wei Guo, Juan Song, Pengcheng Yang, Xiangyong Chen, Dafeng Chen, Dani Ren, Le Kang, Xianhui Wang Animals often exhibit dramatically behavioral plasticity depending on their internal physiological state, yet little is known about the underlying molecular mechanisms. The migratory locust, Locusta migratoria, provides an excellent model for addressing these questions because of their famous phase polyphenism involving remarkably behavioral plasticity between gregarious and solitarious phases....
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by Lorena González-Montes, Irene del Campo, M. Pilar Garcillán-Barcia, Fernando de la Cruz, Gabriel Moncalián Plasmids, when transferred by conjugation in natural environments, must overpass restriction-modification systems of the recipient cell. We demonstrate that protein ArdC, encoded by broad host range plasmid R388, was required for conjugation from Escherichia coli to Pseudomonas putida. Expression of ardC was required in the recipient cells, but not in the donor cells. Besides, ardC was...
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by Xia Zhang, Ya'nan Xu, Bing Chen, Le Kang Some long noncoding RNAs (lncRNAs) are specifically expressed in brain cells, implying their neural and behavioural functions. However, how lncRNAs contribute to neural regulatory networks governing the precise behaviour of animals is less explored. Here, we report the regulatory mechanism of the nuclear-enriched lncRNA PAHAL for dopamine biosynthesis and behavioural adjustment in migratory locusts (Locusta migratoria), a species with extreme behavioral...
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Mature B-cell neoplasms are the fifth most common neoplasm. Due to significant heterogeneity at the clinical and genetic levels, current therapies for these cancers fail to provide long-term cures. The clinical success of proteasome inhibition for the treatment of multiple myeloma and B-cell lymphomas has made the ubiquitin pathway an important emerging therapeutic target. In this study, we assessed the role of the E3 ligase FBXW7 in mature B-cell neoplasms. FBXW7 targeted the frequently inactivated...
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The protein-tyrosine phosphatase SHP2 binds to phosphorylated signaling motifs on regulatory immunoreceptors including PD-1, but its functional role in tumor immunity is unclear. Using preclinical models, we show that RMC-4550, an allosteric inhibitor of SHP2, induces anti-tumor immunity with effects equivalent to or greater than those resulting from checkpoint blockade. In the tumor microenvironment, inhibition of SHP2 modulated T cell infiltrates similar to checkpoint blockade. Additionally, RMC-4550...
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Abstract Purpose of Review The purpose was to discuss appropriate methods for advancing our understanding of health disparities or minority aging including life-course perspectives, biological measures, pain measurement, and generational approaches. Recent Findings Life course perspectives provide an orientation for studying older minorities that concomitantly...
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Abstract Purpose of the Review This article outlines considerations for individuals interested in developing and implementing breast cancer risk models and has relevance for individuals developing risk models with the goal of implementing them into health systems. Recent Findings There has been increased focus on developing risk models for clinical...
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Publication date: Available online 29 April 2020Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Amy L. Hughes, Jessica R. Kelley, Robert J. Klose
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The cyclic GMP-AMP synthase (cGAS) protein is a pattern-recognition receptor of the mammalian innate immune system that is recognized as a main cytosolic sensor of pathogenic or damaged DNA. cGAS DNA binding initiates catalytic production of the second messenger, cyclic GMP-AMP, which activates the STING-TBK1-IRF3 signaling axis to induce cytokine expression. Post-translational modification (PTM) has started to be recognized as a critical component of cGAS regulation, yet the extent of these modifications...
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Imaging software developer Median Technologies prolonged its streak of six...Read more on AuntMinnieEurope.comRelated Reading: Median receives 15M euros in loan funding Median Technologies posts solid revenue growth Median Technologies signs finance deal Median posts healthy 6-month revenues
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Many radiologists are working from home during the COVID-19 pandemic, but how...Read more on AuntMinnieEurope.comRelated Reading: Sectra secures 10-year contract from Swedish hospital group Sectra posts double-digit gains in Q3 Sectra secures digital pathology contract in Switzerland U.K. NHS consortium renews Sectra PACS contract Sectra expands Dutch contract to digital pathology
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Researchers from Turin, Italy, have found that lung ultrasound scans may be...Read more on AuntMinnieEurope.comRelated Reading: Will COVID-19 screens become new norm in ultrasound? COVID-19 patients can benefit from ob/gyn ultrasound tools Esaote delivers more than 100 ultrasound units to fight COVID-19 in Italy Can ultrasound be used effectively for COVID-19?
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Four professional organizations in the U.K. have collaborated on a joint statement...Read more on AuntMinnieEurope.comRelated Reading: Radiographers speak on PPE and COVID-19 infection control Online COVID-19 resource now available for radiographers MRI and teamworking boost outcome in endometriosis RCR, SCoR update hospital imaging accreditation plan U.K. issues progress report on safe radiology reporting
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Results from a national survey conducted by the French union of private radiologists...Read more on AuntMinnieEurope.comRelated Reading: Radiographers speak on PPE and COVID-19 infection control Mobile CT proves vital to China's efforts to combat COVID-19 French group VIDI makes pledge on PPE supplies Dutch airline makes pledge on radioisotope deliveries How to protect radiographers from COVID-19
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Abstract Background Wolfram syndrome (WFS) is a rare, monogenic neurodegenerative syndrome characterised by insulin requiring non-autoimmune diabetes mellitus (DM) and optic atrophy which are usually the earliest and commonest manifestations. However, there are other features which are under-recognized, adding to morbidity and premature mortality in these patients. Methods...
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by Anna Buchman, Stephanie Gamez, Ming Li, Igor Antoshechkin, Hsing-Han Li, Hsin-Wei Wang, Chun-Hong Chen, Melissa J. Klein, Jean-Bernard Duchemin, James E. Crowe Jr., Prasad N. Paradkar, Omar S. Akbari
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by Leah E. Latham, Daniel J. Wikenheiser, Jason S. Stumhofer The co-stimulatory molecule ICOS is associated with the induction and regulation of T helper cell responses, including the differentiation of follicular helper T (Tfh) cells and the formation and maintenance of memory T cells. However, the role of ICOS signaling in secondary immune responses is largely unexplored. Here we show that memory T cell formation and maintenance are influenced by persistent infection with P. chabaudi chabaudi...
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Abstract This study aimed to investigate the value of miR-222 in hypertrophic scars (HS). Specific mechanisms were used to measure the level of miR-222, while MTT assay, flow cytometry, western blot and qRT-PCR were employed to detect the relative proteins after fibroblasts were transfected with the miR-222 mimic/inhibitor. The direct target of miR-222 was determined by Dual-Luciferase Reporter assay. Furthermore, qRT-PCR and western blot were employed to...
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Publication date: Available online 29 April 2020Source: Experimental Cell ResearchAuthor(s): Kirill A. Danilov, Svetlana G. Vassilieva, Anna V. Polikarpova, Anna V. Starikova, Anna A. Shmidt, Ivan I. Galkin, Alexandra A. Tsitrina, Tatiana V. Egorova, Sergei N. Orlov, Yuri V. Kotelevtsev
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