Abstract Purpose Inadequate sleep duration affects asthma and weight. The associations among sleep duration, asthma, and different weight statuses in the Chinese population need to be further determined. Methods The study included 32,776 Chinese adults from the China Health and Nutrition Survey during 2009–2015. Self-reported sleep duration was classified...
Sat Apr 25, 2020 03:00
Abstract Objective Sleep Apnea Syndrome (SAS) is frequently comorbid with Restless Legs Syndrome (RLS). Both disorders are associated with disturbed sleep. However, data about insomnia specific symptoms in patients suffering from both sleep disorders (SAS-RLS) are rare. Methods In a restrospective design, we investigated 202 patients suffering from...
Sat Apr 25, 2020 03:00
Abstract Purpose It remains inconclusive whether continuous positive airway pressure (CPAP) therapy can significantly reduce subcutaneous adipose tissue (SAT) in patients with obstructive sleep apnea (OSA). This meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the impact of CPAP treatment on SAT in patients with OSA. Methods We...
Fri Apr 24, 2020 03:00
Purpose: Although platinum compounds are the first-line treatment for ovarian cancer, the majority of patients relapse and develop resistance to treatment. However, the mechanism underlying resistance is unclear. The goal of our study is to decipher the mechanism by which a metabolic kinase, diacylglycerol kinase alpha (DGKA), confers platinum resistance in ovarian cancer. Experimental Design: Metabolic kinase RNAi synthetic lethal screening was used to identify a cisplatin resistance driver in...
Mon Apr 27, 2020 16:29
Purpose: Aggressive variant prostate cancer (AVPC) represents a clinical subset distinguished by therapy resistance and poor prognosis, linked to combined losses of the tumor suppressor genes (TSG) PTEN, RB1, and TP53. Circulating tumor cells (CTC) provide a minimally-invasive opportunity for identification and molecular characterization of AVPC. We aimed to evaluate the incidence and clinical significance of compound (2+)TSG losses and genomic instability in prostate cancer CTC, and to expand the...
Mon Apr 27, 2020 16:29
Purpose: A major challenge in ductal carcinoma in situ treatment is selection of the most appropriate therapeutic approach for individual patients. We conducted an external prospective-retrospective clinical validation of a DCIS biologic risk signature, DCISionRT, in a population-based observational cohort of women diagnosed with ductal carcinoma in situ and treated with breast-conserving surgery. Experimental design: Participants were 455 health plan members of Kaiser Permanente Northwest diagnosed...
Mon Apr 27, 2020 16:29
Purpose: The recent emergence of radioligand therapies for cancer treatment has increased enthusiasm for developing new theranostic strategies coupling both imaging and cytotoxicity in the same entity. We evaluated if CUB domain containing protein 1 (CDCP1), a transmembrane protein highly overexpressed in human cancers, is a target for cancer theranostics. Experimental Design: The ectodomain of CDCP1 was targeted using radiolabeled forms of 4A06, a potent and specific recombinant human antibody...
Mon Apr 27, 2020 16:29
Purpose: To identify a predictive biomarker of sorafenib for HCC personalized therapy. Experimental Design: The patients treated with or without sorafenib after HCC recurrence from multi-centers were matched with propensity score matching analysis. The expression levels of FLT3 in HCC specimens of the matched patients (n=276) were analyzed by immunohistochemistry. The optimal cutoff point of FLT3 levels for overall survival (OS) was defined via Cutoff Finder. Subgroup analysis of OS was employed...
Fri Apr 24, 2020 16:29
Purpose: Drug induced interstitial lung disease (DILD) is a rare, but potentially fatal toxicity. Clinical and radiological features of DILD in the early experimental setting are poorly described. Experimental Design: 2499 consecutive advanced cancer patients on phase I clinical trials were included. DILD was identified by a dedicated radiologist and investigators, categorized per internationally recognized radiological patterns and graded per CTCAE and the Royal Marsden Hospital DILD score. Clinical...
Fri Apr 24, 2020 16:29
Purpose: Clinical trials with immune checkpoint (IC) inhibition in sarcomas have demonstrated minimal response. Here, we interrogated the tumor microenvironment (TME) of two contrasting soft tissue sarcomas (STS) - Rhabdomyosarcomas (RMS) and Undifferentiated Pleomorphic Sarcomas (UPS) - with differing genetic underpinnings and responses to IC inhibition in order to understand the mechanisms that lead to response. Experimental Design: Utilizing fresh and Formalin Fixed Paraffin Embedded (FFPE) tissue...
Fri Apr 24, 2020 16:29
Purpose: Diffuse intrinsic pontine glioma (DIPG) bears a dismal prognosis. A genetically engineered brainstem glioma model harboring the recurrent DIPG mutation, ACVR1-G328V (mACVR1), was developed for testing an immune-stimulatory gene therapy. Experimental Design: We utilized the Sleeping Beauty transposase system to generate an endogenous mouse model of mACVR1 brainstem glioma. Histology was used to characterize and validate the model. We performed RNAseq analysis on neurospheres (NS) harboring...
Fri Apr 24, 2020 16:29
Purpose: DNA damage response and repair (DDR) gene alterations are associated with increased tumor infiltrating lymphocytes, higher genomic instability, and higher tumor mutational burden (TMB) in cancer. Whether DDR alterations are associated with clinical outcomes to PD-(L)1 blockade in non-small cell lung cancer (NSCLC) is unknown. Experimental Design: Tumors from patients treated with PD-(L)1 inhibitors were analyzed using targeted next-generation sequencing (NGS). Cancers were categorized based...
Fri Apr 24, 2020 16:29
Purpose: Endoglin is a coreceptor for Transforming Growth factor (TGF)-β ligands that is highly expressed on proliferating endothelial cells and other cells in the tumor microenvironment (TME). Clinical studies have noted increased programmed cell death (PD)1 expression on cytotoxic T-cells in the peripheral blood of cancer patients treated with TRC105, an endoglin targeting antibody. In the current study, we investigated the combination of endoglin antibodies (TRC105 and M1043) with an anti-PD1...
Fri Apr 24, 2020 16:29
The development of the most successful cancer immunotherapies in solid tumors, immune-checkpoint blockade, has focused on factors regulating T cell activation. Until recently, the field has maintained a predominately T-cell centric view of immunotherapy, leaving aside the impact of innate immunity and especially myeloid cells. Dendritic cells (DC) are dominant partners of T cells, necessary for initiation of adaptive immune responses. Emerging evidence supports a broader role for DCs in tumors including...
Fri Apr 24, 2020 16:29
In children and adolescents, anxiety disorders (ADs) are among the most prevalent mental disorders. While there is a solid empirical foundation to support CBT as an evidence-based treatment for childhood ADs, ...
Mon Apr 27, 2020 03:00
Recognising the influence of context and the context-sensitive nature of quality improvement (QI) interventions is crucial to implementing effective improvements and successfully replicating them in new settin...
Sun Apr 26, 2020 03:00
Acute hypoxemic respiratory failure is one of the leading causes of intensive care unit admission and is associated with high mortality. Noninvasive oxygenation strategies such as high-flow nasal cannula, stan...
Sun Apr 26, 2020 03:00
Epilepsy affects nearly 50 million people worldwide. Self-management is critical for individuals with epilepsy in order to maintain optimal physical, cognitive, and emotional health. Implementing and adopting ...
Sat Apr 25, 2020 03:00
Sub-Saharan Africa carries the greatest burden of HIV-infection with increasing drug resistance burden, which requires improved patient management and monitoring. Current WHO recommendations suggest transition...
Sat Apr 25, 2020 03:00
The importance of teaching the skills and practice of evidence-based medicine (EBM) for medical professionals has steadily grown in recent years. Alongside this growth is a need to evaluate the effectiveness o...
Fri Apr 24, 2020 03:00
Globally, miniscule improvements have been implemented regarding equality, inclusion, access, and protection of people with diverse gender identities whilst accessing health care facilities of which transgende...
Fri Apr 24, 2020 03:00
The necessity of antibiotic prophylaxis for postoperative urinary tract infections (UTIs) after transurethral resection of bladder tumours is controversial. This potentially leads to the overuse of antibiotic ...
Thu Apr 23, 2020 03:00
Abstract The potential for central nervous system (CNS) involvement in coronavirus disease 2019 (COVID-19) is a matter of grave concern and there is a relevant body of evidence in the basic sciences to support this possibility. A neuroradiologist should be aware of the potential mechanisms involved in the neuropathogenesis of this virus, as we begin to see cases with abnormal brain scans emerging from all parts of the world.
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Abstract Purpose Microcystic meningioma (MCM) appears similar to atypical meningioma(AM) as per conventional diagnostic imaging. However, considering their different recurrence rate and prognosis, accurate differential diagnosis is essential for determine the appropriate treatment strategy. The aim of the study was to differentiate MCM from AM by diffusion-weighted imaging (DWI), in order to provide the basis for accurate preoperative...
Mon Apr 27, 2020 12:18
Abstract Purpose Cough-associated headache (CAH) is the most distinctive symptom of patients with Chiari I malformation (CMI) and indicates clinically significant disease. We determined the clinical utility of simple 2D anatomic measurements performed on a PACS workstation by assessing their diagnostic accuracy in predicting CAH in CMI patients. Methods ...
Mon Apr 27, 2020 12:18
Abstract Purpose Vertebral artery fenestration (VAF) is a rare congenital vascular anomaly which has been associated with intracranial aneurysm. VAF can share some similar imaging features with vertebral artery dissection (VAD), which may confound diagnosis of the latter on CT and MR angiography. The purpose of this investigation is to assess the prevalence of VAF, evaluate its association with other vascular anomalies, and identify...
Mon Apr 27, 2020 12:18
Abstract Purpose Embolization of middle meningeal artery (MMA) has been proposed for postoperative recurrences and primary treatment of chronic subdural hematoma (CSDH). This endovascular intervention is safe only when MMA originates from the internal maxillary artery. The aim of this study was to report an unusual high frequency of MMA originating from the ophthalmic artery, which prohibits this treatment. ...
Mon Apr 27, 2020 12:18
Abstract Purpose The aim of this study is to provide normative data about the appearances and dimensions of the cavum septi pellucidi and vergae (CSPV) on in utero MR (iuMR) imaging in second and third trimester foetuses. Methods Two hundred normal foetuses (from a low-risk pregnancy, with normal ante-natal USS findings and no intracranial...
Mon Apr 27, 2020 12:18
Abstract Purpose Natural language processing (NLP) can be used for automatic flagging of radiology reports. We assessed deep learning models for classifying non-English head CT reports. Methods We retrospectively collected head CT reports (2011–2018). Reports were signed in Hebrew. Emergency department (ED) reports of adult patients from January to...
Sat Apr 25, 2020 03:00
The performance of tracheotomy is a common procedural request by critical care departments to the surgical services of general surgery, thoracic surgery and otolaryngology - head & neck surgery. A Canadian Soc...
Mon Apr 27, 2020 03:00
The incidence of human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC) is increasing. Patients with HPV-associated and HPV-unassociated OPSCC differ in many aspects, which may als...
Thu Apr 23, 2020 03:00
Distichodus is a clade of tropical freshwater fishes currently comprising 25 named species distributed continent-wide throughout the Nilo-Sudan and most Sub-Saharan drainages. This study investigates the phylogen...
Sun Apr 26, 2020 03:00
Maladaptive plasticity facilitates evolution of thermal tolerance during an experimental range shift
Many organisms are responding to climate change with dramatic range shifts, involving plastic and genetic changes to cope with novel climate regimes found at higher latitudes. Using experimental lineages of th...
Thu Apr 23, 2020 03:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01115
Mon Apr 27, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00738
Mon Apr 27, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00197
Mon Apr 27, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05169
Mon Apr 27, 2020 07:00
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