Protective effect of dapsone against renal ischemia-reperfusion injury in rat. Immunopharmacol Immunotoxicol. 2020 Apr 23;:1-8 Authors: Nezamoleslami S, Sheibani M, Jahanshahi F, Mumtaz F, Abbasi A, Dehpour AR Abstract Background: Ischemia/reperfusion can cause injury to tissues and compromise functionality of organs due to inflammatory processes. Significantly, development of these effects in kidney tissue has been a challenging issue that leads to...
Fri Apr 24, 2020 14:14
Related ArticlesRecent advances in the management of chemotherapy-induced neutropenia: biosimilar granulocyte colony-stimulating factor use in Italy. Future Oncol. 2020 Apr 24;: Authors: Danova M, Pronzato P, Ingrasciotta Y, Antonuzzo A, Trama U, Tondini C, Bernardi FF Abstract During the National Congress of the Italian Association of Medical Oncology, which was held in Rome, Italy, October 2019, experts met to discuss advantages of febrile neutropenia...
Sat Apr 25, 2020 15:14
Related ArticlesReal-world treatment patterns in patients with advanced (stage III-IV) ovarian cancer in the USA and Europe. Future Oncol. 2020 Apr 24;: Authors: Hall JP, Chang J, Moon R, Higson O, Byrne K, Doherty JP, Cappelleri JC Abstract Aim: To analyze real-world data relating to treatment decision-making in stage III-IV ovarian cancer (OC). Materials & methods: Real world data were collected from a survey of physicians and their patients (n = 2413)...
Sat Apr 25, 2020 15:14
The impact of the coronavirus pandemic on the management of cancer patients in Lebanon: a single institutional experience. Future Oncol. 2020 Apr 23;: Authors: Kattan C, Badreddine H, Rassy E, Kourie HR, Kattan J PMID: 32323581 [PubMed - as supplied by publisher]
Fri Apr 24, 2020 14:39
What the oncologist needs to know about COVID-19 infection in cancer patients. Future Oncol. 2020 Apr 23;: Authors: Rassy E, Khoury-Abboud RM, Ibrahim N, Kattan C, Assi T, Kattan J PMID: 32323577 [PubMed - as supplied by publisher]
Fri Apr 24, 2020 14:39
Related ArticlesPhase I trial of the MET inhibitor tepotinib in Japanese patients with solid tumors. Jpn J Clin Oncol. 2020 Apr 24;: Authors: Shitara K, Yamazaki K, Tsushima T, Naito T, Matsubara N, Watanabe M, Sarholz B, Johne A, Doi T Abstract OBJECTIVES: Tepotinib (MSC2156119J) is an oral, potent and highly selective small molecule mesenchymal-epithelial transition factor (MET) inhibitor for which the recommended Phase II dose of 500 mg once daily...
Sat Apr 25, 2020 15:02
Related ArticlesImpact of gender and employment type on job loss among cancer survivors. Jpn J Clin Oncol. 2020 Apr 24;: Authors: Tsuchiya M, Horio Y, Funazaki H, Aogi K, Miyauchi K, Arai Y, Takahashi M Abstract OBJECTIVE: To identify factors associated with cancer-related job loss following cancer diagnosis. METHODS: A multicentre cross-sectional survey was conducted among adult cancer survivors employed at the time of cancer diagnosis. Hierarchical...
Sat Apr 25, 2020 15:02
Second transurethral resection for high-risk non-muscle invasive bladder cancer patients: a propensity score matched analysis. Jpn J Clin Oncol. 2020 Apr 23;: Authors: Matsushita Y, Watanabe K, Watanabe H, Tamura K, Motoyama D, Ito T, Sugiyama T, Otsuka A, Miyake H Abstract OBJECTIVES: Second transurethral resection is recommended for patients diagnosed with high-risk non-muscle invasive bladder cancer; however, there have been several studies showing...
Fri Apr 24, 2020 13:11
Four versus six chemotherapy cycles in endometrial carcinoma with a high risk of recurrence: a retrospective study. Jpn J Clin Oncol. 2020 Apr 23;: Authors: Mayama M, Asano H, Nomura E, Ihira K, Nozaki A, Kato T, Konno Y, Mitamura T, Kobayashi N, Takeda M, Kudo M, Watari H Abstract OBJECTIVE: This study compared the survival outcomes and the incidence of chemotherapy-related adverse events in endometrial cancer patients who received four and six cycles...
Fri Apr 24, 2020 13:11
ABSTRACT Metoclopramide is commonly used for gastroesphageal reflux. The aims of the present study were to develop a pediatric population pharmacokinetic (PopPK) model, which was applied to simulate the metoclopramide exposure following dosing used in clinical practice. Opportunistic pharmacokinetic (PK) data were collected from pediatric patients receiving enteral or parenteral metoclopramide per standard of care and these data were simultaneously fitted using NONMEM®. Allometric scaling with...
Thu Apr 23, 2020 15:56
Abstract Clearance (CL) is the major pharmacokinetic parameter for evaluating systemic exposure of drugs in the body and thus for developing new drugs. To predict in vivo CL, the Vmax/KM ratio estimated from in vitro metabolism study has been widely used. This canonical approach is based on the Michaelis‐Menten equation, which is valid only when the KM value of a drug is much higher than the hepatic concentration of the enzymes, especially cytochrome P450, involved in its metabolism. Here we find...
Thu Apr 23, 2020 15:54
Abstract Introduction Stereotactic radiation therapy is a highly specialised technique which requires careful and structured implementation. As part of a national stereotactic programme implementation, protocols were developed and a national stereotactic chart round was formed, which strongly recommended attendance and presentation of all cases before treatment. Herein, we describe our experiences launching a national chart round and its importance in a stereotactic programme. Method...
Thu Apr 23, 2020 18:59
Abstract Introduction The recent DAWN trial created a paradigm shift in acute stroke treatment from ‘time‐based’ criteria (within 6 hours) to ‘tissue‐based’ criteria dependent on advanced neuroimaging such as CT perfusion (CTP). This has expanded the thrombectomy window from 6 to 24 hours and has major implications for healthcare providers involved in acute stroke management. Our aim is to characterise changes in the utilisation, diagnostic yield and accuracy of CTP in the diagnosis of acute...
Thu Apr 23, 2020 18:59
Fri Apr 24, 2020 12:01
Abstract Basel‐Vanagaite‐Smirin‐Yosef syndrome is a recently described autosomal recessive intellectual disability syndrome caused by variants in the MED25 gene. While it was originally identified in Brazil, it was further described in Israel by authors who are now the namesake of the condition. A 2018 publication further contributed to its delineation, but the patient's phenotype was complicated by a dual diagnosis. More recently, an article describing a set of affected siblings was published....
Thu Apr 23, 2020 15:58
Abstract In the midst of the COVID‐19 pandemic, it is appropriate that our focus is on patient care and preparation. However, the genetics community is well poised to fill in the educational gap created by medical students transitioning to limiting patient contact, creation of telemedicine patient care, and online learning modules. Our history of agility in learning and teaching is now only inhibited by the time constraints of current clinical demands on the genetics community. This publication...
Thu Apr 23, 2020 13:25
Abstract To ensure adequate reliability (i.e., internal consistency), it is common in studies using event‐related brain potentials (ERPs) to exclude participants for having too few trials. This practice is particularly relevant for error‐related ERPs, such as error‐related negativity (ERN), where the number of recorded ERN trials is not entirely under the researcher's control. Furthermore, there is a widespread practice of inferring reliability based on published psychometric research, which assumes...
Thu Apr 23, 2020 16:15
Abstract Although economists have suggested that humans generally prioritize maximizing their own self‐interest rather than others’ when distributing rewards, recent psychological studies have shown that people are hyperaltruistic when allocating physical harm to themselves and others during moral decision‐making. However, little is known about how the neurocognitive mechanisms underlying self‐relevance modulate this behavioral tendency under different degrees of physical harm. This study adopted...
Thu Apr 23, 2020 15:37
Fri Apr 24, 2020 15:54
Background Stage III renal cell carcinoma (RCC) encompasses both lymph node–positive (pT1‐3N1M0) and lymph node–negative (pT3N0M0) disease. However, prior institutional studies have indicated that among patients with stage III disease, those with lymph node disease have worse oncologic outcomes and experience survival that is similar to that of patients with American Joint Committee on Cancer (AJCC) stage IV disease. The objective of the current study was to validate these findings using a large,...
Fri Apr 24, 2020 15:53
Thu Apr 23, 2020 16:04
Abstract Nowadays, medical doctors are fighting with new coronavirus, COVID‐19 problem in all countries. Corona means a circular crown, from the Latin word for “crown or garland”. We summarized corona associated some skin problems and also skin involvement like‐crown in dermatology. This article is protected by copyright. All rights reserved.
Thu Apr 23, 2020 19:24
Abstract Objective To assess whether digital workflow gives better results than the conventional one in the single implant crowns, when analyzing the impression time, patient preference, time‐efficiency, and adjustment time. Material and methods MEDLINE, Embase, and Cochrane were searched and supplemented via hand search up to June 19, 2019. Only clinical trials assessing conventional vs. digital workflows for single implant crowns were included. Impression time was evaluated using...
Thu Apr 23, 2020 20:21
The first reported case of coronavirus disease 2019 (Covid-19) in the United States was diagnosed in a resident of Snohomish County, Washington, on January 20, 2020. In late February, an outbreak was identified in a skilled nursing facility in neighboring King County; morbidity and mortality among…
Fri Apr 24, 2020 03:00
Abstract Patients perceive the impact of oral disorder in four major areas, the dimensions of oral health‐related quality life (OHRQoL) Oral Function, Orofacial Pain, Orofacial Appearance, and Psychosocial Impact. The functional aspect is essential given the need of chewing, biting, speech, and swallowing. The objective of this study was to identify OHRQoL information for dental subjects with functional oral health problems. In a systematic review, distinct and clinically relevant groups of dental...
Fri Apr 24, 2020 16:00
Abstract Background Electromyography (EMG) biofeedback (BF) training is potentially an effective cognitive‐behavioral approach to regulate bruxism. Objective This study examined sleep bruxism regulation by daytime clenching control using a single‐channel auditory EMG BF device. Methods Seventeen male subjects (mean age, 24.4 ± 3.1 years; mean ± SD) with self‐reported awake/sleep bruxism were recruited and divided into a BF (n = 10) and a control (CO) group (n = 7). All...
Thu Apr 23, 2020 20:58
Abstract Background Dental patient‐reported outcomes (dPROs) and their measures, dPROMs, are fundamental for evidence‐based dentistry. However when selecting, applying, and evaluating an instrument with a focus on OHRQoL assessment for adults, several methodological considerations are essential to derive valid and meaningful results. Methods In this review article, criteria for selecting the appropriate OHRQoL instrument, aspects of administering the instrument, and how to evaluate...
Thu Apr 23, 2020 12:10
New England Journal of Medicine, Ahead of Print.
Fri Apr 24, 2020 07:02
New England Journal of Medicine, Ahead of Print.
Fri Apr 24, 2020 07:01
New England Journal of Medicine, Ahead of Print.
Fri Apr 24, 2020 07:00
New England Journal of Medicine, Ahead of Print.
Fri Apr 24, 2020 07:00
Background and Objectives Non‐specific low back pain (LBP) is responsible for triggering increased biomarkers levels. In this way, photobiomodulation therapy (PBMT) may be an interesting alternative to treat these patients. One of the possible biological mechanisms of PBMT involved to decrease pain intensity in patients with musculoskeletal disorders is modulation of the inflammatory mediators’ levels. The aim of this study was to evaluate the effects of PBMT compared with placebo on inflammatory...
Fri Apr 24, 2020 19:24
Background and Objectives More studies are needed to assess the long‐term safety profile and clinical outcomes of lasers and energy‐based devices to treat the symptoms associated with vulvovaginal atrophy. This study evaluated a series of three fractional CO2 laser treatments to the vulva and vagina with a 1‐year follow‐up in a postmenopausal population. Study Design/Materials and Methods In this prospective, self‐controlled, open‐label clinical study, 18 postmenopausal females with atrophic...
Thu Apr 23, 2020 19:13
Abstract Background Rheumatoid arthritis (RA) is the most common systemic autoimmune disease characterized by chronic systemic inflammation. Half of the deaths of patients with RA are due to cardiovascular diseases (CVD), considered to be 1.5‐2.0 fold that in the general population. Patients with RA also experience poor sleep, which by itself is associated with endothelial dysfunction, CVD events and sudden death. Our aim was to study the mechanistic pathways and the correlations...
Fri Apr 24, 2020 11:49
Abstract Our objectives were to assess the prevalence of REM sleep behaviour disorder in patients with Essential Tremor, using video‐polysomnography and to compare REM sleep behaviour disorder features in essential tremor with those of patients with alpha‐synucleinopathies. Forty‐nine patients with essential tremor were screened with the REM Sleep Behaviour Disorder Screening Questionnaire. Patients scoring positive and those with spontaneous complaints of REM sleep behaviour disorder (n = 6) underwent...
Thu Apr 23, 2020 12:58
ABSTRACT There is increasing interest regarding potential protective effects of low‐dose aspirin against various gastrointestinal cancers. We aimed to quantify the association between use of low‐dose aspirin and risk of gastric/oesophageal cancer using a population‐based primary care database in the UK. Between January 2005 and December 2015, we identified a cohort of 223 640 new users of low‐dose aspirin (75‐300 mg/day) and a matched cohort of non‐users at the start of follow‐up from The Health...
Fri Apr 24, 2020 22:20
Journal of Clinical Sleep Medicine, Ahead of Print.
Fri Apr 24, 2020 10:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου