Abstract The lungs are a common site of metastasis of head and neck (H&N) squamous cell carcinomas (SCC). This study attempts to define p16 immunoexpression and presence of HPV in primary SCC of the lung and determine their usefulness in discriminating between primary lung SCC and metastasis from HPV-associated oropharyngeal primary. Pathology archives were searched for patients with SCC of the lung without SCC elsewhere. Tissue microarray was constructed and immunohistochemistry...
Wed Apr 29, 2020 03:00
Abstract Epstein-Barr virus (EBV) is the main cause of infectious mononucleosis (IM), a self-limiting infection among immunocompetent patients. EBV is also implicated in the development of several malignancies. We describe a case of a previously healthy 34-year-old man who presented with non-tender, enlarging, right cervical lymphadenopathy for over a year that was associated with significant weight loss, fevers, and night sweats. Two fine needle core biopsies showed inconclusive...
Wed Apr 29, 2020 03:00
Abstract Oligometastatic disease is a hypothesized intermediate stage of disease between localized and widespread metastatic cancer. Localized treatment of oligometastatic lesions may offer survival advantages in addition to systemic treatment. In this case report, we describe a patient who presented with small cell neuroendocrine carcinoma “Merkel type” (SNECM) of the parotid gland which had metastasized to the brain and adrenal gland. He was treated with chemotherapy followed...
Wed Apr 29, 2020 03:00
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Sheng Zhang, Jingwen Yue, Zhuowang Ge, Yi Xie, Min Zhang, Li Jiang
Wed Apr 29, 2020 18:36
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Lipeng Du, Zhigang Mei, Yaguang Huang, Wei Tao, Kai Wang, Weifeng Huang, Huajun Zhou, Zhitao Feng
Wed Apr 29, 2020 18:36
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Susumu Ishiguro, Deepa Upreti, Nicole Robben, Riley Burghart, Mayme Loyd, Damilola Ogun, Tran Le, Jennifer Delzeit, Arashi Nakashima, Ravindra Thakkar, Ayaka Nakashima, Kengo Suzuki, Jeffrey Comer, Masaaki Tamura
Wed Apr 29, 2020 18:36
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Yuhao Zhang, Xiuchao Geng, Yanli Tan, Qiang Li, Can Xu, Jianglong Xu, Liangchao Hao, Zhaomu Zeng, Xianpu Luo, Fulin Liu, Hong Wang
Wed Apr 29, 2020 18:36
Publication date: Available online 28 April 2020Source: CortexAuthor(s): Pertzov Yoni, Krill Dana, Weiss Nilly, Lesinger keren, Avidan Galia
Wed Apr 29, 2020 18:35
Publication date: Available online 28 April 2020Source: Journal of Human EvolutionAuthor(s): Rob Dinnis, Alexander Bessudnov, Natasha Reynolds, Abi Pate, Mikhail Sablin, Andrei Sinitsyn
Wed Apr 29, 2020 18:23
H χρήση ηλεκτρονικού τσιγάρου βλάπτει τις αρτηρίες και τη λειτουργία των αιμοφόρων αγγείων όπως το παραδοσιακό κάπνισμα, σύμφωνα με μια νέα αμερικανική επιστημονική έρευνα. Οι ερευνητές, με επικεφαλής την επίκουρη καθηγήτρια Τζέσικα Φέτερμαν της Ιατρικής Σχολής του Πανεπιστημίου της Βοστόνης, που έκαναν τη σχετική δημοσίευση στο αμερικανικό καρδιολογικό περιοδικό «Journal of American Heart Association», μελέτησαν περισσότερους από 400 άνδρες και γυναίκες ηλικίας 21 έως 45 ετών, οι οποίοι δεν είχαν...
Wed Apr 29, 2020 15:30
Η ανοσοθεραπεία, η οποία ενισχύει τη δύναμη του ανοσοποιητικού συστήματος του ίδιου του σώματος να εντοπίζει και να καταστρέφει τα καρκινικά κύτταρα, έχει δώσει υποσχέσεις για τη θεραπεία διαφόρων τύπων καρκίνου. Αλλά, ο καρκίνος μπορεί και κρύβεται από το ανοσοποιητικό σύστημα, καθώς οι όγκοι που δεν είναι φλεγμονώδεις -οι λεγόμενοι κρύοι όγκοι- δεν ανταποκρίνονται στις ανοσοθεραπείες. Οι ερευνητές του Pritzker School of Molecular Engineering στο Πανεπιστήμιο του Σικάγο έχουν κάνει ένα βήμα προς...
Wed Apr 29, 2020 12:40
Τα τριγλυκερίδια είναι παράγοντας κινδύνου όταν υπερβαίνουν τα 200 mg. Για να τα ελέγξετε, οι αλλαγές στον τρόπο ζωής και οι υγιεινές συνήθειες είναι απαραίτητες. Ως γνωστόν υπάρχει η «κακή» LDL χοληστερόλη και η «καλή» HDL χοληστερόλη, με την πρώτη να κυκλοφορεί στο αίμα και να επιβαρύνει την υγεία της καρδιάς, οδηγώντας σε καρδιακές παθήσεις. Ας δούμε τι προτείνουν οι επιστήμονες του Πανεπιστημίου Harvard για τον έλεγχο των τριγλυκεριδίων και την συνολική ρύθμιση του μεταβολικού προφίλ. Αποφύγετε...
Wed Apr 29, 2020 12:34
Οι φακοί επαφής μπορεί μια μέρα να κάνουν περισσότερα από το να βελτιώνουν απλώς την όραση, υποστηρίζουν οι επιστήμονες σε με μια νέα, προκαταρκτική έρευνα που πραγματοποιήθηκε σε ζώα. Η εργασία δημοσιεύθηκε στο Science Advances και υποδεικνύει ότι ενδεχομένως οι φακοί επαφής να μπορούν να παρακολουθούν την πορεία του διαβήτη και να χορηγούν φαρμακευτική αγωγή. Οι νέοι αυτοί φακοί σχεδιάστηκαν για να ελέγχουν τα επίπεδα σακχάρου στο αίμα και να χορηγούν φάρμακα στο μάτι, πιθανότατα για την οφθαλμοπάθεια...
Wed Apr 29, 2020 09:32
Ο νέος κορωνοϊός καταστρέφεται γρήγορα από το φως του ήλιου, σύμφωνα με νέα έρευνα που ανακοίνωσε ανώτερος αξιωματούχος των ΗΠΑ την περασμένη Πέμπτη, αν και η μελέτη δεν έχει ακόμη δημοσιευτεί και αξιολογηθεί. Ο William Bryan, σύμβουλος επιστήμης και τεχνολογίας του υπουργού Εσωτερικής Ασφάλειας, δήλωσε σε δημοσιογράφους του Λευκού Οίκου ότι οι επιστήμονες διαπίστωσαν ότι οι υπεριώδεις ακτίνες επέφεραν ισχυρό πλήγμα στον ιό, προσφέροντας ελπίδα ότι η εξάπλωσή του θα μπορούσε να σταματήσει το καλοκαίρι....
Wed Apr 29, 2020 07:50
Publication date: Available online 29 April 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Zonne L.M. Hofman, Chantal C. Clark, C. Erik. Hack, Steven de Maat, Coen Maas
Wed Apr 29, 2020 18:16
Publication date: Available online 28 April 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Elena Goleva, Agustin Calatroni, Petra LeBeau, Evgeny Berdyshev, Patricia Taylor, Simion Kreimer, Robert N. Cole, Donald Y.M. Leung
Wed Apr 29, 2020 18:16
Publication date: Available online 28 April 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Maiko Emi-Sugie, Tetsuo Shoda, Kyoko Futamura, Tomohiro Takeda, Akira Ainai, Hideki Hasegawa, Hirohisa Saito, Kenji Matsumoto, Akio Matsuda
Wed Apr 29, 2020 18:16
Background This study aimed to compare the microbiota of pediatric patients with chronic rhinosinusitis (CRS) who are undergoing adenoidectomy to treat their disease with that of healthy control patients. Methods Patients undergoing adenoidectomy‐only for obstructive sleep apnea (n = 50) and CRS (n = 37) were recruited. Pre‐op Sino‐nasal Outcome Test (SN5 or SNOT22) was collected. Each patient had samples collected from their nasopharynx (adenoid bed) and nasal cavity (sinus) at the onset...
Wed Apr 29, 2020 17:18
ABSTRACT Severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2), which causes coronavirus disease 2019 (Covid‐19), is highly contagious with devastating impacts for healthcare systems worldwide. Medical staff are at high risk of viral contamination and it is imperative to know what personal protective equipment is appropriate for each situation. Furthermore, elective clinics and operations have been reduced in order to mobilize manpower to the acute specialties combatting the outbreak; appropriate...
Wed Apr 29, 2020 16:35
From the first reports, ageusia and anosmia appear to be frequent clinical features in coronavirus disease 19 (COVID‐19) patients. We have performed a survey of the literature, analyzing the possible causes of these chemosensory alterations, which may be useful as a starting point for specific further studies. This article is protected by copyright. All rights reserved
Mon Apr 27, 2020 18:23
Thu Apr 23, 2020 18:43
Publication date: Available online 28 April 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): R. Quatre, A. Baguant, H. Gil, S. Schmerber
Wed Apr 29, 2020 18:11
Publication date: Available online 29 April 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s):
Wed Apr 29, 2020 18:06
Publication date: Available online 28 April 2020Source: The Journal of Prosthetic DentistryAuthor(s): Lauren L. Lustig, Weslie Williams, David Gozalo-Diaz
Wed Apr 29, 2020 18:06
Publication date: Available online 28 April 2020Source: The Journal of Prosthetic DentistryAuthor(s): Marietta Taylor, Mohd Masood, George Mnatzaganian
Wed Apr 29, 2020 18:06
Background Nodular lymphocyte‐predominant Hodgkin lymphoma (NLPHL) represents a diagnostic challenge on surgical excisional or incisional biopsy. Classification is further challenging on fine needle aspiration (FNA) material accompanied by needle core and/or cell block biopsy (FNA+core/CB). Methods The authors studied all FNA+core/CB and surgical excisional or incisional biopsies to evaluate for lymphoma in patients who had a prior history of NLPHL or subsequent diagnosis of NLPHL over...
Tue Apr 28, 2020 16:49
Background The ThyroSeq panel tests for genetic alterations to risk‐stratify cytologically indeterminate nodules. The authors assessed the test performance of the tests, including the latest version (v3), at an academic center. Methods Results from ThyroSeq testing (v2 and v3) were reviewed over 2 years, and patient demographics, cytology diagnoses, results of ThyroSeq testing, and histopathologic diagnoses on resection (if available) were collected. Results One hundred eighty‐five...
Mon Apr 27, 2020 15:28
Abstract A low lymphocyte count puts immune‐compromised patients at risk of mortality. hIL‐7‐hyFc is a homodimeric interleukin‐7 (IL‐7), a potent T‐cell amplifier, fused to the hybridizing IgD/IgG4 immunoglobulin domain. We performed a randomized, double‐blind, placebo‐controlled, dose‐escalation, phase 1 study to assess the pharmacokinetic, pharmacodynamic, safety, tolerability and immunogenicity profiles of hIL‐7‐hyFc administered subcutaneously (SC) and intramuscularly (IM) to healthy volunteers....
Mon Apr 27, 2020 17:34
Abstract Purpose Motor mapping with direct cortical stimulation (DCS) is useful for motor function preservation. Nevertheless, many patients still experience postoperative motor dysfunction after motor mapping. This study aimed to provide a classification of gliomas involved in motor-related areas to help understand which types of gliomas are prone to induce postoperative motor impairments. ...
Wed Apr 29, 2020 03:00
Abstract Purpose Under-enrollment in clinical trials significantly limits valid analyses of clinical interventions and generalizability of findings. Often it results in premature study termination, with estimates of 22% to 50% of clinical trials terminated due to poor accrual. Currently, there are limited reports addressing the influence of race/ethnicity and socioeconomic status on clinical trial enrollment in adult glioma patients....
Wed Apr 29, 2020 03:00
Abstract Purpose PD-1 Immunotherapy is integral in treating multiple cancers, but has been associated with neurological adverse events (nAEs). Our study was aimed at identifying the clinical spectrum of nAEs associated with pembrolizumab and nivolumab. Methods We performed an IRB approved single-center retrospective cohort study on patients receiving...
Wed Apr 29, 2020 03:00
Publication date: May 2020Source: Journal of Oral and Maxillofacial Surgery, Volume 78, Issue 5Author(s):
Wed Apr 29, 2020 17:47
Publication date: May 2020Source: Journal of Oral and Maxillofacial Surgery, Volume 78, Issue 5Author(s): James R. Hupp
Wed Apr 29, 2020 17:47
Publication date: May 2020Source: Journal of Oral and Maxillofacial Surgery, Volume 78, Issue 5Author(s):
Wed Apr 29, 2020 17:47
Publication date: May 2020Source: Journal of Oral and Maxillofacial Surgery, Volume 78, Issue 5Author(s):
Wed Apr 29, 2020 17:47
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