Related ArticlesVitamin D3 attenuates lipopolysaccharide-induced cognitive impairment in rats by inhibiting inflammation and oxidative stress. Life Sci. 2020 Apr 22;:117703 Authors: Mokhtari-Zaer A, Hosseini M, Salmani H, Arab Z, Zareian P Abstract AIMS: Vitamin D is a well-known endocrine regulator of calcium/phosphate homeostasis and has been reported as having a wide range of activities that are potentially beneficial for human health. This study...
Sun Apr 26, 2020 15:03
Related ArticlesRole of Cannabis and Its Derivatives in Gastrointestinal and Hepatic Disease. Gastroenterology. 2020 Apr 22;: Authors: Gotfried J, Naftali T, Schey R Abstract Medical and recreational cannabis use has increased dramatically over the last decade, resulting from mainstream cultural acceptance and legalization in several countries worldwide. Cannabis and its derivatives affect many gastrointestinal processes, via the endocannabinoid system...
Sun Apr 26, 2020 15:03
Related ArticlesTreatment with 2-methoxyestradiol increases endothelial nitric oxide synthase activity via scavenger receptor class BI in human umbilical vein endothelial cells. Mol Hum Reprod. 2020 Apr 25;: Authors: Dong T, Sato S, Lyu J, Imachi H, Kobayashi T, Fukunaga K, Saheki T, Iwama H, Zhang G, Murao K Abstract Concentrations of 2-methoxyestradiol (2ME2), a principal metabolite of estradiol, are significantly lower in women with severe preeclampsia....
Sun Apr 26, 2020 15:03
Related ArticlesMethylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells. Nat Commun. 2020 Apr 24;11(1):2018 Authors: Rodrigues DC, Harvey EM, Suraj R, Erickson SL, Mohammad L, Ren M, Liu H, He G, Kaplan DR, Ellis J, Yang G Abstract Gene regulation and metabolism are two fundamental processes that coordinate the self-renewal and differentiation of neural precursor cells (NPCs) in the developing mammalian...
Sun Apr 26, 2020 13:04
Related ArticlesInnate lymphoid cells in treatment-induced gastrointestinal pathogenesis. Curr Opin Support Palliat Care. 2020 Apr 22;: Authors: Omar SZ, Blom B, Hazenberg MD Abstract PURPOSE OF REVIEW: Tissue injury often occurs as collateral damage after chemotherapy and radiotherapy and is associated with significant comorbidity and mortality. The arsenal of options to prevent tissue injury other than dose reduction is limited, and treatment is mostly...
Sun Apr 26, 2020 13:04
Related ArticlesCentral α-Klotho Suppresses NPY/AgRP Neuron Activity and Regulates Metabolism in Mice. Diabetes. 2020 Apr 24;: Authors: Landry T, Laing BT, Li P, Bunner W, Rao Z, Prete A, Sylvestri J, Huang H Abstract α-Klotho is a circulating factor with well-documented anti-aging properties; however, the central role of α-klotho in metabolism remains largely unexplored. The current study investigated the potential role of central α-klotho to modulate...
Sun Apr 26, 2020 13:04
Related ArticlesS-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid. J Biol Chem. 2020 Apr 24;: Authors: Yang J, Zhang H, Gong W, Liu Z, Wu H, Hu W, Chen X, Wang L, Wu S, Chen C, Perrett S Abstract Heat shock protein 70 (Hsp70) proteins are a family of ancient and conserved chaperones. Cysteine modifications have been widely detected among different Hsp70 family members in vivo, but their...
Sun Apr 26, 2020 13:04
Related ArticlesCocoa diet modulates gut microbiota composition and improves intestinal health in Zucker diabetic rats. Food Res Int. 2020 Jun;132:109058 Authors: Álvarez-Cilleros D, Ramos S, López-Oliva ME, Escrivá F, Álvarez C, Fernández-Millán E, Martín MÁ Abstract Cocoa supplementation improves glucose metabolism in Zucker diabetic fatty (ZDF) rats via multiple mechanisms. Furthermore, cocoa rich-diets modify the intestinal microbiota composition...
Sun Apr 26, 2020 13:04
Related ArticlesA Diagnostic Dilemma of a Subcutaneous Hibernoma: Case Report. Am J Case Rep. 2020 Apr 25;21:e921447 Authors: AlQattan AS, Al Abdrabalnabi AA, Al Duhileb MA, Ewies T, Mashhour M, Abbas A Abstract BACKGROUND Subcutaneous lipomatous lesions are commonly encountered in clinical practice. Hibernoma is a rare subtype of the benign lipomatous tumor, representing 1% of all types. It poses a challenge due to the difficulty of differentiating...
Sun Apr 26, 2020 13:01
Related ArticlesReal-time estimation and prediction of mortality caused by COVID-19 with patient information based algorithm. Sci Total Environ. 2020 Apr 08;727:138394 Authors: Wang L, Li J, Guo S, Xie N, Yao L, Cao Y, Day SW, Howard SC, Graff JC, Gu T, Ji J, Gu W, Sun D Abstract The global COVID-19 outbreak is worrisome both for its high rate of spread, and the high case fatality rate reported by early studies and now in Italy. We report a new methodology,...
Sun Apr 26, 2020 14:49
Related ArticlesAre dendritic cells the most appropriate therapeutic vaccine for patients with ovarian cancer? Curr Opin Biotechnol. 2020 Apr 22;65:190-196 Authors: Martin-Lluesma S, Graciotti M, Grimm AJ, Boudousquié C, Chiang CL, Kandalaft LE Abstract New treatments are urgently needed in patients with ovarian cancer (OC), as diagnosis is delayed in many instances, resulting in 85% recurrence of the disease following surgery and standard chemotherapy....
Sun Apr 26, 2020 14:49
Related ArticlesCullin-RING Ligase 5: Functional characterization and its role in human cancers. Semin Cancer Biol. 2020 Apr 22;: Authors: Zhao Y, Xiong X, Sun Y Abstract Cullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins Elongin B/C, and a substrate receptor protein SOCS. Through targeting a variety of substrates for proteasomal degradation...
Sun Apr 26, 2020 14:49
Related ArticlesDemographics and outcomes of meningioma patients treated at a tertiary care center in the Middle East. Clin Neurol Neurosurg. 2020 Apr 20;195:105846 Authors: Assi HI, Hilal L, Abu-Gheida I, Berro J, Sukhon F, Skaf G, Geara F, Boulos F, Charafeddine M, Tabbarah A, Khoury J, Najjar M Abstract OBJECTIVE: Meningioma is the most common intracranial primary brain tumor. Risk factors such as age and exposure to radiation as well as prognostic...
Sun Apr 26, 2020 14:49
Related ArticlesHarnessing the patient voice in prostate cancer research: Systematic review on the use of patient-reported outcomes in randomized controlled trials to support clinical decision-making. Cancer Med. 2020 Apr 25;: Authors: Van Hemelrijck M, Sparano F, Moris L, Beyer K, Cottone F, Sprangers M, Efficace F Abstract BACKGROUND: Given the growing importance of patient-reported outcomes (PROs) as part of "big data" in improving patient care, there...
Sun Apr 26, 2020 14:49
Related ArticlesCombination percutaneous and medical management of cardiac rhabdomyomas obstructing tricuspid valve inflow: Case report. J Neonatal Perinatal Med. 2020 Apr 23;: Authors: Knadler JJ, Lawrence E, Iacobas I, Justino H, Sheth S Abstract BACKGROUND: Cardiac rhabdomyomas can be prenatally diagnosed in patients with tuberous sclerosis complex. Many neonates require no intervention in early life other than close monitoring for regression of tumor...
Sun Apr 26, 2020 14:49
Related ArticlesCirculating tumor cells as Trojan Horse for understanding, preventing, and treating cancer: a critical appraisal. Cell Mol Life Sci. 2020 Apr 24;: Authors: Mentis AA, Grivas PD, Dardiotis E, Romas NA, Papavassiliou AG Abstract Circulating tumor cells (CTCs) are regarded as harbingers of metastases. Their ability to predict response to therapy, relapse, and resistance to treatment has proposed their value as putative diagnostic and prognostic...
Sun Apr 26, 2020 13:01
Related ArticlesPD-1 blockade-unresponsive human tumor-infiltrating CD8+ T cells are marked by loss of CD28 expression and rescued by IL-151. Cell Mol Immunol. 2020 Apr 24;: Authors: Kim KH, Kim HK, Kim HD, Kim CG, Lee H, Han JW, Choi SJ, Jeong S, Jeon M, Kim H, Koh J, Ku BM, Park SH, Ahn MJ, Shin EC Abstract Blockade of programmed death-1 (PD-1) reinvigorates exhausted CD8+ T cells, resulting in tumor regression in cancer patients. Recently, reinvigoration...
Sun Apr 26, 2020 13:01
Related ArticlesGlobal injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017. Inj Prev. 2020 Apr 24;: Authors: James SL, Castle CD, Dingels ZV, Fox JT, Hamilton EB, Liu Z, S Roberts NL, Sylte DO, Henry NJ, LeGrand KE, Abdelalim A, Abdoli A, Abdollahpour I, Abdulkader RS, Abedi A, Abosetugn AE, Abushouk AI, Adebayo OM, Agudelo-Botero M, Ahmad T, Ahmed R, Ahmed MB, Eddine Aichour MT, Alahdab F, Alamene GM, Alanezi FM, Alebel...
Sun Apr 26, 2020 13:01
Related ArticlesPulmonary resection is associated with long-term survival and should remain a therapeutic option in oligometastatic lung cancer. J Thorac Cardiovasc Surg. 2020 Mar 25;: Authors: Mitchell KG, Farooqi A, Ludmir EB, Corsini EM, Sepesi B, Gomez DR, Antonoff MB, MD Anderson Cancer Center Oligometastatic Lung Cancer Working Group Abstract OBJECTIVES: Comprehensive local consolidative therapy led to improved overall survival in oligometastatic...
Sun Apr 26, 2020 13:01
Related ArticlesCold Atmospheric Plasma: A Powerful Tool for Modern Medicine. Int J Mol Sci. 2020 Apr 22;21(8): Authors: Braný D, Dvorská D, Halašová E, Škovierová H Abstract Cold atmospheric plasma use in clinical studies is mainly limited to the treatment of chronic wounds, but its application in a wide range of medical fields is now the goal of many analyses. It is therefore likely that its application spectrum will be expanded in the future. Cold...
Sun Apr 26, 2020 13:01
Related ArticlesJapan's Practical Guidelines for Zinc Deficiency with a Particular Focus on Taste Disorders, Inflammatory Bowel Disease, and Liver Cirrhosis. Int J Mol Sci. 2020 Apr 22;21(8): Authors: Kodama H, Tanaka M, Naito Y, Katayama K, Moriyama M Abstract Zinc deficiency is common in Japan, yet awareness on this disorder is lacking. The Japanese Society of Clinical Nutrition recently issued the Japan's Practical Guideline for Zinc Deficiency...
Sun Apr 26, 2020 13:00
Background The surgical significance of the lingual process of the sphenoid bone (LPSB) has not been sufficiently addressed. The purpose of this study was to describe the anatomical details of the LPSB in relation to the quadrangular space. Moreover, the incidence of the LPSB and its correlation with the pneumatization of the sphenoid sinus and the development of the lateral recess of the sphenoid sinus (LRSS) were also evaluated. Methods A dissection and exposure of the LPSB and the...
Sat Apr 25, 2020 17:54
Objectives Intermittent hypoxemia is a risk factor for developing complications in obstructive sleep apnea (OSA) patients. The objective of this systematic review was to identify articles evaluating the accuracy of the oxygen desaturation index (ODI) as compared with the apnea–hypopnea index (AHI) and then provide possible values to use as a cutoff for diagnosing adult OSA. Study Design Systematic Review of Literature. Methods PubMed, the Cochrane Library, and SCOPUS databases...
Sat Apr 25, 2020 17:42
Abstract Purpose The precision of soft metal processing technologies is poorly documented. This study compared marginal and internal fit of presintered cobalt‐chromium (Co‐Cr) and zirconia three‐unit fixed dental prostheses to cast Co‐Cr. Material and Methods Three‐unit fixed dental prostheses (FDPs) were prepared on metal dies (N = 60) from typodont preparations of the maxillary right first premolar and molar. A standardized preparation of a metal‐ceramic restoration was done on...
Sat Apr 25, 2020 13:24
Efficient chemical protein synthesis using Fmoc‐masked N‐terminal cysteine in Cys‐peptide thioesters
We report here an operationally very simple method to greatly facilitate chemical protein synthesis by fully convergent and one‐pot native chemical ligations utilizing the Fluorenylmethyloxycarbonyl (Fmoc) moiety as an N‐masking group of the N‐terminal cysteine of the middle peptide thioester segment(s). The Fmoc group is stable to harsh oxidative conditions frequently used to generate peptide thioester from hydrazide or o‐aminoanilide. The ready availability of the Fmoc‐Cys(Trt)‐OH, routinely used...
Sat Apr 25, 2020 17:25
Cellular signaling is regulated by assembly of proteins into higher‐order complexes. Bottom‐up creation of synthetic protein assemblies, especially asymmetric complexes, is highly challenging. Here, we present the design and implementation of asymmetric assembly of a ternary protein complex facilitated by Rosetta modeling and thermodynamic analysis. We targeted the wildtype symmetric CT32‐CT32 interface of the 14‑3‑3/CT32 complex, ultimately favoring asymmetric assembly on the 14‑3‑3 scaffold. Biochemical...
Sat Apr 25, 2020 15:54
Layered covalent‐organic frameworks (2D‐COFs), composed of reversible imine‐linkages and accessible pores, offer a versatile platform for chemical modifications towards the development of catalytic materials. Notably, nitrogen‐enriched COF materials have been proved as good candidates for binding palladium species. Understanding the local structure of reacting palladium sites bonded to the COF pores is key to rationalize interactions between active sites and porous surfaces. By combining advanced...
Sat Apr 25, 2020 13:55
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