Abstract Background In recent randomized, placebo-controlled, phase III trials, highly purified cannabidiol demonstrated efficacy with an acceptable safety profile in patients with Lennox–Gastaut syndrome or Dravet syndrome. It is anticipated that antiepileptic drugs such as stiripentol and valproate will be administered concomitantly with cannabidiol. Objectives ...
18m
Covid-19All essential workers can now be testedAll key workers in England and members of their households with symptoms of covid-19 will be able to get tested for the virus through an online system,...
19m
An antibody blood test for covid-19, which the manufacturer Abbott claims is 99% accurate, has been certified for use by the European Union.The test—which has received its CE mark, meaning that it...
12h
The covid-19 pandemic is a global health and societal emergency123; doctors and healthcare workers will stand together on the front line making life and death decisions at personal risk. Together we...
12h
Doctors in the UK have been warned over a rising number of children presenting with a multisystem inflammatory state and needing intensive care.In an urgent alert shared by North Central London...
12h
Some NHS services that were temporarily stopped to release capacity for dealing with the covid-19 pandemic will restart from today, the health secretary has announced.Matt Hancock said that the...
12h
The world’s been turned upside down in the past six weeks, and many people’s familiar routines of work, school, family, and friends are gone. Although GPs are not immune, the disruption we face is...
12h
Measures being taken to control the spread of covid-19 are causing what has been dubbed a “secondary pandemic”1 of child neglect and abuse. As one senior paediatrician summed it up: “Children are...
12h
An antibody blood test for covid-19, which the manufacturer Abbott claims is 99% accurate, has been certified for use by the European Union.The test—which has received its CE mark, meaning that it...
13h
A new analysis estimates that at least 6270 additional deaths could occur in England over the next 12 months in patients with new cancer diagnoses—a 20% increase—as a result of the covid-19...
14h
Lawyers for an NHS doctor are threatening legal action over the government’s failure to release an unpublished report on Exercise Cygnus, a 2016 exercise to test the UK’s preparedness for a flu...
15h
The Scottish government has recommended that the public wear face coverings when in enclosed public spaces where social distancing is difficult, such as in food shops.First minister Nicola Sturgeon...
16h
New figures have shown 4343 deaths from covid-19 in care homes in England and Wales in a fortnight, prompting calls for fresh efforts to stop treating people in care homes as “second class...
16h
ABSTRACTHead and neck structures govern the vital functions of breathing and swallowing. Additionally, these structures facilitate our sense of self through vocal communication, hearing, facial...
16h
The anaesthetics department will probably be the largest medical specialty in any hospital.1 Anaesthetists are responsible for the intraoperative care of patients in all surgical specialties—both...
16h
bmj;369/apr29_3/m1660/FAF1faPeter John Watkins was one of the great clinical diabetologists: a man of great abilities and stature, a brilliant clinician, a respected teacher, and a valued mentor,...
16h
People with intellectual disability are vulnerable in society because of their dependence on support from services and other people.1 The prevalence of physical and mental disorders is higher among...
16h
The Scottish government has recommended that the public wear face coverings when in enclosed public spaces where social distancing is difficult, such as in food shops.First minister Nicola Sturgeon...
18h
New figures have shown 4343 deaths from covid-19 in care homes in England and Wales in a fortnight, prompting calls for fresh efforts to stop treating people in care homes as “second class...
19h
ABSTRACTHead and neck structures govern the vital functions of breathing and swallowing. Additionally, these structures facilitate our sense of self through vocal communication, hearing, facial...
20h
The anaesthetics department will probably be the largest medical specialty in any hospital.1 Anaesthetists are responsible for the intraoperative care of patients in all surgical specialties—both...
20h
bmj;369/apr29_3/m1660/FAF1faPeter John Watkins was one of the great clinical diabetologists: a man of great abilities and stature, a brilliant clinician, a respected teacher, and a valued mentor,...
20h
People with intellectual disability are vulnerable in society because of their dependence on support from services and other people.1 The prevalence of physical and mental disorders is higher among...
20h
The covid-19 pandemic is a global health and societal emergency123; doctors and healthcare workers will stand together on the front line making life and death decisions at personal risk. Together we...
21h
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British Journal of Cancer, Published online: 30 April 2020; doi:10.1038/s41416-020-0827-5Stearoyl-CoA-desaturase-1 regulates gastric cancer stem-like properties and promotes tumour metastasis via Hippo/YAP pathway
6h
British Journal of Cancer, Published online: 30 April 2020; doi:10.1038/s41416-020-0846-2Scheduling nab-paclitaxel combined with gemcitabine as first-line treatment for metastatic pancreatic adenocarcinoma
6h
Black pepper (Piper nigrum) is a vital spice crop with uses ranging from culinary to pharmacological applications. However, limited genetic information has constrained the understanding of the molecular regulation of flower and fruit development in black pepper. In this study, a comparison among three different black pepper varieties, Semengok Aman (SA), Kuching (KC), and Semengok 1 (S1), with varying fruit characteristics was used to provide insight on the genetic regulation of flower and fruit...
1h
Background and Objectives. The prevalence of the metabolic syndrome (MetS) and nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. MetS-affected individuals stand the risk of coronary heart disease, stroke, and increased cardiovascular mortality while NAFLD results in advanced liver diseases, such as liver fibrosis, cirrhosis, and hepatocellular carcinoma, if not diagnosed and treated on time. This study is aimed at determining the prevalence of MetS and NAFLD among premenopausal and...
1h
In this paper, the effect of Er addition (0.2, 0.5, 0.65, 0.8, 1.0, and 1.5 wt. %) on the microstructure evolution and tensile properties of as-cast hypereutectic Al-10Si-0.8Fe alloy was investigated. The phases and their morphologies in these alloys were identified by XRD and SEM equipped with EDX with the help of metallographic analysis techniques; the length of the secondary phase (LSP) and secondary dendrite arm spacing (SDAS) of α-Al grain were quantified. The results indicated that the second...
1h
Background. With the development of biological technology, biomarkers for the prevention and diagnosis of acute coronary syndrome (ACS) have become increasingly evident. However, the study of novel circular RNAs (circRNAs) in ACS is still in progress. This study aimed to investigate whether the regulation of circRNA-miRNA networks is involved in ACS pathogenesis. Methods. We used microarray analysis to detect significantly expressed circRNAs and miRNAs in the peripheral blood of patients in the control...
1h
The purpose of this paper is to introduce and analyze the shrinking projection algorithm with errors for a finite set of costerro bounded linear mappings in the setting of uniformly convex smooth Banach spaces. Here, under finite dimensional or compactness restriction or the error term being zero, the strong limit point of the sequence stated in the iterative scheme for these mappings in uniformly convex smooth Banach spaces was studied. This paper extends Ezearn and Prempeh’s result for nonexpansive...
1h
Dedicated to Prof. Len Miller (PhD advisor to J. O. Bonyo) and Prof. Vivien Miller of Mississippi State University on their retirement
1h
In this article, we present several new inequalities involving the κ-fractional integral for the integrable function which satisfies one of the following conditions: is preinvex for some ; is bounded; is a Lipschitz function. As applications, we establish new inequalities for the weighted arithmetic and generalized logarithmic means.
1h
Lassa fever is an animal-borne acute viral illness caused by the Lassa virus. This disease is endemic in parts of West Africa including Benin, Ghana, Guinea, Liberia, Mali, Sierra Leone, and Nigeria. We formulate a mathematical model for Lassa fever disease transmission under the assumption of a homogeneously mixed population. We highlighted the basic factors influencing the transmission of Lassa fever and also determined and analyzed the important mathematical features of the model. We extended...
1h
Let G be a simple undirected connected graph, then is called the α-distance matrix of G, where , is the distance matrix of G, and is the vertex transmission diagonal matrix of G. In this paper, we study some bounds on the α-distance energy and α-distance Estrada index of G. Furthermore, we establish the relation between α-distance Estrada index and α-distance energy.
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