The analysis of network robustness tackles the problem of studying how a complex network behaves under adverse scenarios, such as failures or attacks. In particular, the analysis of interdependent networks’ robustness focuses on the specific case of the robustness of interacting networks and their emerging behaviors. This survey systematically reviews literature of frameworks that analyze the robustness of interdependent networks published between 2005 and 2017. This review shows that there exists...
13h
The trajectory tracking task of a magnetic levitation system connected to a beam mechanism is solved by means of a nested saturation control with a feedforward term. The flatness property of the system allows to use the nested saturation control technique and the feedforward control to stabilize the output tracking error around the equilibrium. The closed-loop error dynamics is proven to be locally exponentially stable. Numerical simulations prove the effectiveness of the proposal.
13h
Humor refers to the quality of being amusing. With the development of artificial intelligence, humor recognition is attracting a lot of research attention. Although phonetics and ambiguity have been introduced by previous studies, existing recognition methods still lack suitable feature design for neural networks. In this paper, we illustrate that phonetics structure and ambiguity associated with confusing words need to be learned for their own representations via the neural network. Then, we propose...
13h
We aimed to perform a systematic review and meta-analysis on the safety of laparoscopic cholecystectomy performed in the day surgery unit versus those performed in the inpatient unit. Several databases including Ovid Embase, Medline Ovid, Cochrane Central, Web of Science, and Google Scholar were searched from inception through February 2019. Our results revealed that laparoscopic cholecystectomy can be conducted safely and effectively in day surgery units, helping bed shortage.
13h
The rock-breaking characteristics and the influence factors of laser perforation are investigated in this study. A series of fiber laser perforation experiments on basalt, sandstone, and granite were conducted. Experimental measurements of rock failure morphologies and composition tests showed that the main surface features are thermal cracks and glazed layer formed by the melting and condensing of rock in laser perforation. It is also found that higher quartz content could help reduce the glazed...
13h
Background/Aims. The process of occupational therapy services starts with assessing the occupational performance problems, setting goals, and implementing various intervention strategies to achieve the goals. The aim of this study was to assess the extent of achieving occupational therapy goals for people with stroke and categorize the goals according to the aspects of the domain of occupational therapy. Methods. A cross-sectional retrospective study design was used. People with stroke receiving...
13h
Reciprocating compressors are important equipment in oil and gas industries which closely relate with the healthy development of the enterprise. It is essential to detect the valve fault because valve failures account for 60% in total failures. For this field, an artificial neural network (ANN) is widely used, but a complex network is not suitable for its low accuracy and easy overfitting. This paper proposes a fault diagnosis model of a reciprocating compressor valve based on a one-dimensional convolutional...
13h
Technical characteristics are an important influencing factor in fuzzy front-end of product innovation design and also an important output of the house of quality. The analysis and decision-making of technical characteristics are conducive to the rational allocation of resources according to their own advantages and the design of products in line with market demand. In view of the multiple objective constraints and internal fuzziness of technical property selection in the house of quality, the traditional...
13h
Background. Acne is a common condition of pilosebaceous follicle especially among young. Clinically, the most used medication in the treatment of moderate to severe acne is oral isotretinoin. However, interindividual variability in therapeutic response to isotretinoin and many side effects such as musculoskeletal pain, headache, and alteration in lipid profile can be seen with this treatment. Aim. In this study, the effect of genetic polymorphisms, rs2241766 and rs1501299, of the adiponectin gene...
13h
Pancreatic cancer (PC) is one of the most malignant tumors. Despite considerable progress in the treatment of PC, the prognosis of patients with PC is poor. The aim of this study was to identify potential biomarkers for the diagnosis and prognosis of PC. First, the original data of three independent mRNA expression datasets were downloaded from the Gene Expression Omnibus and The Cancer Genome Atlas databases and screened for differentially expressed genes (DEGs) using the R software. Subsequently,...
13h
Reaction term in the transport equation which described the migration of metal ions in the porous medium is frequently represented by conventional kinetic models such as pseudo-first order, pseudo-second order, and others. Unfortunately, these models are applicable for the constant value of solution pH, and they cannot simulate the real situation in the field scale where this pH may be changed with time. Accordingly, the present study is a good attempt to derive the kinetic model that can simulate...
13h
Geospatial mapping and antibacterial biomarkers were investigated in Nigerian honey used for therapeutic purposes in several communities affected with prevalent antibiotic-resistant enteric bacilli. Randomly collected enteric bacilli from faecal samples were biotyped and phenotypically assayed for antibiotic resistance and profiled for R plasmids. R plasmid molecular weight and multiantibiotic resistance index (MARI) relatedness were evaluated for resistance among phylogroups. Honey cidal activity,...
13h
Background. Rheumatoid arthritis (RA) is an autoimmune disease characterized by multijoint swelling, pain, and destruction of the synovial joints. Treatments are available but new therapies are still required. One source of new therapies is natural products, including herbs used in traditional medicines. In China and neighbouring countries, natural products have been used throughout recorded history and are still in use for RA and its symptoms. This study used text-mining of a database of classical...
13h
Aim. The aim of this systematic review was to analyze and synthesize available evidence for the effects of somatic acupoint stimulation (SAS) on cancer-related sleep disturbance in adults with cancer. Methods. Nine databases and four clinical trial registries were searched from their inception to July 2019 to identify potential articles and registered trials. Two authors independently extracted data and appraised the methodological quality of the included studies. The included studies could not be...
13h
Introduction. Gene signature has been used to predict prognosis in melanoma patients. Meanwhile, the efficacy of immunotherapy was correlated with particular genes expression or mutation. In this study, we systematically explored the gene expression pattern in the melanoma-immune microenvironment and its relationship with prognosis. Methods. A cohort of 122 melanoma cases with whole-genome microarray expression data were enrolled from the Gene Expression Omnibus (GEO) database. The findings were...
13h
One-pot efficient synthesis of novel chromone derivatives 4a–h and that of 5a–h were described in a simple method via four-component reaction between furochromone carbaldehyde, amine, isocyanate derivatives, and benzoic acid derivatives or nicotinic acid, respectively. Also, oxazocine derivatives 7a, b were prepared via reaction of visnagine carbaldehyde, ethyl acetoacetate and isocyanate derivatives 2a, b. The obtained derivatives of novel furochromone and oxazocine derivatives were evaluated as...
13h
The expansion of renewable generation has raised some red flags in terms of power system stability, control, and management. For instance, unlike traditional synchronous energy sources, the doubly-fed induction generator- (DFIG-) based wind turbines (WTs) do not instinctively act against frequency deviations. In fact, the power electronics interfacing the generator, merely controlled to warrant maximum wind power conversion, make its output power and mechanical speed immune to the characteristics...
13h
The multipulse homoclinic orbits and chaotic dynamics of a reinforced composite plate with the carbon nanotubes (CNTs) under combined in-plane and transverse excitations are studied in the case of 1 : 1 internal resonance. The method of multiple scales is adopted to derive the averaged equations. From the averaged equations, the normal form theory is applied to reduce the equations to a simpler normal form associated with a double zero and a pair of pure imaginary eigenvalues. The energy-phase method...
13h
In the electric power steering (EPS) system, low-frequency disturbances such as road resistance, irregular mechanical friction, and changing motor parameters can cause steering wheel torque fluctuation and discontinuity. In order to improve the steering wheel torque smoothness, an improved torque control method of an EPS motor is proposed in the paper. A target torque algorithm is established, which is related to steering process parameters such as steering wheel angle and angular speed. Then, a...
13h
Based on Schwarz–Christoffel mapping, this paper presents a fast analytical method to analyze the electromagnetic force of eccentric axial flux permanent magnet machines, considering static, dynamic, and mixed eccentricities. A quasi-3D model of an axial flux permanent magnet machine is established, and the magnetic field is obtained by Schwarz–Christoffel mapping. The electromagnetic force density is obtained by the Maxwell stress tensor method, and the electromagnetic force density is used to characterize...
13h
Abstract Baroreflex regulates short-term cardiovascular variability via the autonomic neural system. The contributions of the central autonomic system to the baroreflex regulations of arterial blood pressure (BP) and heart rate have been reported in young healthy adults, but not in older adults. Therefore, we investigated the association between the high-level central autonomic network (CAN) connectivity and baroreflex sensitivity (BRS) under a resting condition in a healthy older...
1h
Abstract Motivation can be generated intrinsically or extrinsically, and both kinds of motivation show similar facilitatory effects on memory. However, effects of extrinsic and intrinsic motivation on memory formation have not been studied in combination and thus, it is unknown whether they interact and how such interplay is neurally implemented. In the present study, both extrinsic monetary reward and intrinsic curiosity enhanced memory performance, without evidence for an interaction....
23h
Mutations in the myotubularin 1 (MTM1) gene can cause the fatal disease X-linked centronuclear myopathy (XLCNM), but the underlying mechanism is incompletely understood. In this report, using an Mtm1-/y disease model, we found that expression of the intragenic microRNA miR-199a-1 is up-regulated along with that of its host gene, dynamin 2 (Dnm2), in XLCNM skeletal muscle. To assess the role of miR-199a-1 in XLCNM, we crossed miR-199a-1-/- with Mtm1-/y mice, and found that the resultant miR-199a-1-Mtm1...
1h
Alpha synuclein (αsyn) is the primary component of proteinaceous aggregates termed Lewy Bodies that pathologically define synucleinopathies including Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB). αSyn is hypothesized to spread through the brain in a prion-like fashion by misfolded protein forming a template for aggregation of endogenous αsyn. The cell-to-cell release and uptake of αsyn are considered important processes for its prion-like spread. Rab27b is one of several GTPases essential...
3h
Core fucose is an N-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus and critically regulates the functions of various glycoproteins. However, how FUT8 activity is regulated in cells remains largely unclear. At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 domain (SH3 domain), which is usually found in cytosolic signal transduction molecules and generally mediates protein–protein interactions in the cytosol. However,...
3h
Many bacteria possess enzymes that modify the essential cell-wall polymer peptidoglycan by O-acetylation. This modification occurs in numerous Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus a common cause of human infections. O-Acetylation of peptidoglycan protects bacteria from the lytic activity of lysozyme, a mammalian innate immune enzyme, and as such is important for bacterial virulence. The O-acetylating enzyme in Gram-positive bacteria, O-acetyltransferase A...
3h
Epithelial cell–transforming sequence 2 (ECT2) is a guanine nucleotide exchange factor (GEF) for Rho GTPases that is overexpressed in many cancers and involved in signal transduction pathways that promote cancer cell proliferation, invasion, and tumorigenesis. Recently, we demonstrated that a significant pool of ECT2 localizes to the nucleolus of non-small cell lung cancer (NSCLC) cells where it binds the transcription factor upstream binding factor 1 (UBF1) on the promoter regions of ribosomal DNA...
3h
Z-DNA-binding protein 1 (ZBP1) is an innate immune sensor of nucleic acids that regulates both host defense responses and development. ZBP1 activation triggers inflammation and pyroptosis, necroptosis, and apoptosis (PANoptosis) by activating receptor-interacting Ser/Thr kinase 3 (RIPK3), caspase-8, and the NLRP3 inflammasome. ZBP1 is unique among innate immune sensors because of its N-terminal Zα1 and Zα2 domains, which bind to nucleic acids in the Z-conformation. However, the specific role of these...
3h
The Ser/Thr protein kinase MELK (maternal embryonic leucine zipper kinase) has been considered an attractive therapeutic target for managing cancer since 2005. Studies using expression analysis have indicated that MELK expression is higher in numerous cancer cells and tissues than in their normal, non-neoplastic counterparts. Further, RNAi-mediated MELK depletion impairs proliferation of multiple cancers, including triple-negative breast cancer (TNBC), and these growth defects can be rescued with...
3h
Protein kinase B (AKT1) is a central node in a signaling pathway that regulates cell survival. The diverse pathways regulated by AKT1 are communicated in the cell via the phosphorylation of perhaps more than 100 cellular substrates. AKT1 is itself activated by phosphorylation at Thr-308 and Ser-473. Despite the fact that these phosphorylation sites are biomarkers for cancers and tumor biology, their individual roles in shaping AKT1 substrate selectivity are unknown. We recently developed a method...
3h
Translesion DNA synthesis (TLS) mediated by low-fidelity DNA polymerases is an essential cellular mechanism for bypassing DNA lesions that obstruct DNA replication progression. However, the access of TLS polymerases to the replication machinery must be kept tightly in check in order to avoid excessive mutagenesis. Recruitment of DNA polymerase η (Pol η) and other Y-family TLS polymerases to damaged DNA relies on proliferating cell nuclear antigen (PCNA) monoubiquitylation and is regulated at several...
3h
USP1-associated factor 1 (UAF1) is an integral component of the RAD51-associated protein 1 (RAD51AP1)–UAF1–ubiquitin-specific peptidase 1 (USP1) trimeric deubiquitinase complex. This complex acts on DNA bound, monoubiquitinated FA complementation group D2 (FANCD2) protein in the Fanconi anemia pathway of the DNA damage response. Moreover, RAD51AP1 and UAF1 cooperate to enhance homologous DNA pairing mediated by the recombinase RAD51 in DNA repair via the homologous recombination (HR) pathway. However,...
3h
A human molecular chaperone protein, DnaJ heat shock protein family (Hsp40) member B6 (DNAJB6), efficiently inhibits amyloid aggregation. This inhibition is dependent on a unique motif with conserved serine and threonine (S/T) residues that have a high capacity for hydrogen bonding. Global analysis of kinetics data has previously shown that DNAJB6 especially inhibits the primary amyloid nucleation rate. These observations indicated that DNAJB6 achieves this remarkably effective and sub-stoichiometric...
3h
Growth differentiation factor-9 (GDF9) and bone morphogenetic protein-15 (BMP15) are co-expressed exclusively in oocytes throughout most of folliculogenesis and play central roles in controlling ovarian physiology. Although both growth factors exist as homodimers, recent evidence indicates that GDF9 and BMP15 can also heterodimerize to form the potent growth factor cumulin. Within the cumulin complex, BMP15 “activates” latent GDF9, enabling potent signaling in granulosa cells via type I receptors...
3h
The detection of the Epstein–Barr capsid antigen (VCA) immunoglobulin A (IgA) is widely used in the diagnosis of nasopharyngeal carcinoma (NPC), but a reference standard for evaluating the presence of VCA-IgA ...
1h
Abstract Purpose of Review Patients on antifungal therapy who develop breakthrough mold infections pose significant treatment challenges for clinicians. Treatment of these infections demands a multimodal approach, including a thorough patient assessment, immune restoration, and evaluation for nonadherence and drug–drug interactions. However, limited clinical trial data are available to guide therapeutic decision-making. ...
2h
Abstract Objective Mesenchymal stem cells (MSCs), one of the most important stromal cells in the tumor microenvironment, play a major role in the immunomodulation and development of tumors. In contrast to immunomodulatory effects of bone marrow-derived MSCs, resident MSCs were not well studied in tumor. The aim of this study was to compare the immunomodulatory properties and protein secretion profiles of MSCs isolated from breast tumor...
2h
Abstract Radiotherapy can elicit abscopal effects in non-irradiated metastases, particularly under immune checkpoint blockade (ICB). We report on two elderly patients with oligometastatic melanoma treated with anti-PD-1 and stereotactic body radiation therapy (SBRT). Before treatment, patient 1 showed strong tumor infiltration with exhausted CD8+ T cells and high expression of T cell-attracting chemokines. This patient rapidly mounted a complete response, now ongoing for more...
23h
Rejuvenation Research, Ahead of Print.
2h
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