Related ArticlesSuperior cancer preventive efficacy of low versus high dose of mTOR inhibitor in a mouse model of prostate cancer. Oncotarget. 2020 Apr 14;11(15):1373-1387 Authors: Antoch MP, Wrobel M, Gillard B, Kuropatwinski KK, Toshkov I, Gleiberman AS, Karasik E, Moser MT, Foster BA, Andrianova EL, Chernova OV, Gudkov AV Abstract The mechanistic target of rapamycin (mTOR) is a PI3K-related kinase that regulates cell growth, proliferation and...
Wed Apr 29, 2020 13:03
Related ArticlesGene expression dynamic analysis reveals co-activation of Sonic Hedgehog and epidermal growth factor followed by dynamic silencing. Oncotarget. 2020 Apr 14;11(15):1358-1372 Authors: Maroufy V, Shah P, Asghari A, Deng N, Le RNU, Ramirez JC, Yaseen A, Zheng WJ, Umetani M, Wu H Abstract Aberrant activation of the Sonic Hedgehog (SHH) gene is observed in various cancers. Previous studies have shown a "cross-talk" effect between the canonical...
Wed Apr 29, 2020 13:03
Related ArticlesMolecular imaging reveals biodistribution of P-cadherin LP-DART bispecific and trafficking of adoptively transferred T cells in mouse xenograft model. Oncotarget. 2020 Apr 14;11(15):1344-1357 Authors: Gupta VR, Root A, Fisher T, Norberg R, David J, Clark T, Cohen J, May C, Giddabasappa A Abstract P-cadherin-LP-DART is a bispecific antibody targeting P-cadherin expressed on the tumor cells and CD3 on the T-cells. Previously we demonstrated...
Wed Apr 29, 2020 13:03
Related ArticlesA phase II study of axalimogene filolisbac for patients with previously treated, unresectable, persistent/recurrent loco-regional or metastatic anal cancer. Oncotarget. 2020 Apr 14;11(15):1334-1343 Authors: Eng C, Fakih M, Amin M, Morris V, Hochster HS, Boland PM, Uronis H Abstract Squamous cell carcinoma of the anorectal canal (SCCA) is a rare HPV-related malignancy that is steadily increasing in incidence. A high unmet need exists...
Wed Apr 29, 2020 13:03
Related ArticlesAssociation of germline genetic variants with TMPRSS2-ERG fusion status in prostate cancer. Oncotarget. 2020 Apr 14;11(15):1321-1333 Authors: Kohaar I, Li Q, Chen Y, Ravindranath L, Young D, Ali A, Sesterhenn IA, Rosner IL, Cullen J, Srivastava S, Freedman M, Petrovics G Abstract INTRODUCTION: Oncogenic activation of ERG resulting from TMPRSS2-ERG gene fusion is a key molecular genetic alteration in prostate cancer (CaP). The frequency...
Wed Apr 29, 2020 13:03
Related ArticlesPirfenidone anti-fibrotic effects are partially mediated by the inhibition of MUC1 bioactivation. Oncotarget. 2020 Apr 14;11(15):1306-1320 Authors: Ballester B, Milara J, Cortijo J Abstract Pirfenidone is a pleiotropic molecule approved to treat idiopathic pulmonary fibrosis (IPF). Pirfenidone has demonstrated to downregulate transforming growth factor-β1 (TGF-β1) cellular effects. However, its anti-fibrotic mechanism remains unclear....
Wed Apr 29, 2020 13:03
Related ArticlesZebrafish B cell acute lymphoblastic leukemia: new findings in an old model. Oncotarget. 2020 Apr 14;11(15):1292-1305 Authors: Park G, Burroughs-Garcia J, Foster CA, Hasan A, Borga C, Frazer JK Abstract Acute lymphoblastic leukemia (ALL) is the most common pediatric, and ninth most common adult, cancer. ALL can develop in either B or T lymphocytes, but B-lineage ALL (B-ALL) exceeds T-ALL clinically. As for other cancers, animal models...
Wed Apr 29, 2020 13:03
Related ArticlesPrevalence of Intestinal Parasites among Patients with Chronic Urticaria in Northern Iran. Infect Disord Drug Targets. 2020 Apr 27;: Authors: Mahdi F, Javad G, Abbas D, Jamshid YC, Bahman G, Bahman RE Abstract BACKGROUND: Chronic urticaria (CU) has a range of clinical demonstrations and causes. Parasitic infections are mentioned as one of the main causes of the CU. OBJECTIVES: The aim of this study was to investigate the prevalence...
Wed Apr 29, 2020 15:57
Related ArticlesT9-T10 Osteomyelitis, Epidural Abscess and Cord Compression Secondary to Mycobacterium abscessus. A Case Report. Infect Disord Drug Targets. 2020 Apr 27;: Authors: Davis MA, Antony S Abstract CASE REPORT: We report a case of spinal abscess/osteomyelitis at the T9-T10 levels in a non-immunocompromised patient who presented with lower extremity weakness secondary to a Mycobacterium abscessus infection. This patient was successfully treated...
Wed Apr 29, 2020 15:57
Related ArticlesEmerging biomarkers in HCC patients: Current status. Int J Surg. 2020 Apr 25;: Authors: Marques HP, Gomes da Silva S, De Martin E, Agopian VG, Martins PN Abstract Hepatocellular carcinoma (HCC) is the liver's most common primary malignancy, with over half a million new cases diagnosed each year and being the fourth leading cause of cancer death, worldwide. The poor prognosis of HCC is largely related to late diagnosis. Historically,...
Wed Apr 29, 2020 14:59
The article “Effect of exosomes derived from mir-126-modified mesenchymal stem cells on the repair process of spinal cord injury in rats, by B. Yuan, S. Pan, Y.-Q. Dong, W.-W. Zhang, X.-D. He, published in Eur Rev Med Pharmacol Sci 2020; 24(2):483-490. DOI: 10.26355/eurrev_202001_20025. PMID: 32016949” has been withdrawn from the publisher for plagiarism. The Publisher apologizes for any inconvenience this may cause. L'articolo Effect of exosomes derived from mir-126-modified mesenchymal stem...
Wed Apr 29, 2020 12:35
Key points Receptor‐operated activation of TRPC4 cation channels requires Gi/o proteins and phospholipase‐Cδ1 (PLCδ1) activation by intracellular Ca2+ Concurrent stimulation of Gq/11 pathway accelerates Gi/o activation of TRPC4, which is not mimicked by increasing cytosolic Ca2+ The kinetic effect of Gq/11 was diminished by alkaline intracellular pH (pHi) and increased pHi buffer capacity Acidic pHi (6.75–6.25) together with the cytosolic Ca2+ rise accelerated Gi/o‐mediated TRPC4 activation...
Mon Apr 27, 2020 11:24
Key points Intrauterine growth restriction (IUGR) is associated with perinatal morbidity and increased risk of lifelong disease, including neurodevelopmental impairment. Fatty acids (FA) are critical for normal brain development, but their transport across the placenta in IUGR pregnancies is poorly understood. This study used a baboon model of IUGR (maternal nutrient restriction, MNR) to investigate placental expression of FA transport and binding proteins, and to determine gestational age‐related...
Mon Apr 27, 2020 11:24
Construction of porous organic polymers (POPs) with high surface areas, well‐defined nanopores and excellent stability remains extremely challenging due to unmanageable reaction process. Until now, only a few reported POPs have Brunauer–Emmett–Teller (BET) surface areas ( S BET ) exceeding 3000 m 2 g –1 . Herein, we demonstrate a molecular expansion strategy to integrate high surface areas, large nanopore sizes and outstanding stability into POPs. A series of hyper‐crosslinked conjugated polymers...
Wed Apr 29, 2020 11:05
Circularly polarized luminescence (CPL) is attractive in understanding the excited‐state chirality and developing advanced materials. Herein, we propose a chiral reticular self‐assembly strategy to unite achiral AIEgen, chirality donor and metal ion to fabricate optically pure AIEgen MOFs as efficient CPL materials. We have found that CPL activity of the single‐crystal AIEgen MOF was generated by the framework enabled strong emission from AIEgens and through‐space chirality transfer from chirality...
Tue Apr 28, 2020 22:04
Getting rid of O2 cylinders: Dry ambient air is utilized for a K‐air (dry) battery, which sheds light on the reversible potassium superoxide electrochemistry. This motivates the development of high‐efficiency superoxide battery technology and is an important step towards the direct use of air in metal–air batteries. Abstract Although using an air cathode is the goal for superoxide‐based potassium‐oxygen (K‐O2) batteries, prior studies were limited to pure oxygen. Now, the first K‐air (dry)...
Tue Apr 28, 2020 22:00
The key to bringing the electrocatalytic nitrogen fixation from conception to application lies in the development of high‐efficiency, cost‐effective electrocatalysts. Layered double hydroxides (LDHs), also known as hydrotalcites, are promising electrocatalysts for water splitting due to multiple metal centers and large surface areas. However, their activities in the electrocatalytic nitrogen fixation are unsatisfactory. Herein, we report a simple and effective way of phosphorus doping to regulate...
Tue Apr 28, 2020 21:35
Synthetic strategies that enable rapid construction of covalent organic nanotubes with an angstrom‐scale tubular pore remain scarcely reported. In this research article, we report a remarkably simple and mild one‐pot polymerization protocol, employing POCl 3 as the polymerization agent. This protocol efficiently generates polypyridine amide foldamer‐based covalent organic nanotubes of 2.8 nm long at yield of 50%. Trapping single file water chains in their 2.8 Å tubular cavity rich in H‐bond donors...
Tue Apr 28, 2020 21:35
<p class="Abstract" style="margin: 0in 0in 0.25in; text‐align: justify; line‐height: 11.25pt; font‐size: 8pt; font‐family: Arial, sans‐serif; color: rgb(0, 0, 0);">The extension of reticular chemistry concepts to electrically conductive three‐dimensional metal‐organic frameworks (MOFs) has been challenging, particularly for cases in which strong interactions between electroactive linkers create the charge transport pathways. Here, we report the successful replacement of tetrathiafulvalene (TTF)...
Tue Apr 28, 2020 21:33
Hierarchical FeCoS 2 ‐CoS 2 double‐shelled nanotubes have been rationally designed and constructed for efficient photocatalytic CO 2 reduction under visible light. The synthetic strategy, engaging the two‐step cation‐exchange reactions, precisely integrates two metal sulfides into a double‐shelled tubular heterostructure with both of the shells assembled from ultrathin two‐dimensional (2D) nanosheets. Benefiting from the distinctive structure and composition, the FeCoS 2 ‐CoS 2 hybrid can...
Tue Apr 28, 2020 20:31
The reaction of a Lewis acidic borane with an alkyne is a key step in a diverse range of main group transformations. Alkyne 1,1‐carboboration, the Wrackmeyer reaction, is an archetypal transformation of this kind. 1,1‐Carboboration has been proposed to proceed through a zwitterionic intermediate. We report the isolation and spectroscopic, structural and computational characterization of the zwitterionic intermediates generated by reaction of B(C6F5)3 with alkynes. The stepwise reactivity of the zwitterion...
Tue Apr 28, 2020 20:07
Cancer possesses normoxic and hypoxia microenvironments with different levels of oxygen, which needs different efficacies of photothermal and photodynamic therapies. Thus, it is important to precisely tune the photothermal and photodynamic effects of phototherapy nano‐agents for efficient cancer treatment. Herein, a series of copolymeric nanoparticles (PPy‐Te NPs) were facilely synthesized in situ through controlled oxidative copolymerization with different ratios of pyrrole to tellurophene by...
Tue Apr 28, 2020 20:05
Enynes are an important functionality in organic chemistry. The 1,3‐enyne moiety is commonly found in cyclohexanoid natural products produced by endophytic and plant pathogenic fungi. Asperpentyn ( 1 ) is a 1,3‐enyne‐containing cyclohexanoid terpenoid isolated from Aspergillus and Pestalotiopsis . The genetic basis and biochemical mechanism of 1,3‐enyne biosynthesis in 1, and other natural products containing this motif, has remained enigmatic despite their potential ecological roles. Here,...
Tue Apr 28, 2020 19:04
Biological ion channels and ion pumps with sub‐nanometer sizes modulate ion transport in response to external stimuli. Realizing such functions with sub‐nanometer solid‐state nanopores have been an important topic with wide practical applications. Herein, we demonstrate biomimetic photoresponsive ion channel and photodriven ion pump using porphyrin‐based metal‐organic framework membrane with pore sizes comparable to hydrated ions. We show that the molecular‐size pores enable precise and robust optoelectronic...
Tue Apr 28, 2020 17:34
Synthesis of All‐carbon Disubstituted Bicyclo[1.1.1]pentanes by Iron‐Catalyzed Kumada Cross‐Coupling
1,3‐Disubstituted bicyclo[1.1.1]pentanes (BCPs) are important motifs in drug design as surrogates for p‐substituted arenes and alkynes. Access to all‐carbon disubstituted BCPs via cross coupling has to date been limited to use of the BCP as the organometallic component, which restricts scope due to the harsh conditions typically required for the synthesis of metallated BCPs. Here we report a general method to access 1,3‐C‐disubstituted BCPs from 1‐iodo‐bicyclo[1.1.1]pentanes (iodo‐BCPs) by direct...
Tue Apr 28, 2020 17:10
Triazole‐based deubiquitylase (DUB)‐resistant ubiquitin (Ub) probes have recently emerged as effective tools for the discovery of Ub‐chain specific interactors in proteomic studies, but their structural diversity is limited. Herein, we report a new family of DUB‐resistant Ub probes based on isopeptide‐N‐ethylated dimeric or polymeric Ub chains, which can be efficiently prepared through a one‐pot, E1‐catalyzed condensation reaction of recombinant Ub percursors to give various homotypic and even branched...
Tue Apr 28, 2020 17:03
One‐dimensional (1D) nanochannels modified with responsive molecules have been fabricated to replicate gating functionalities of biological ion channels. But gating effects of the small‐molecular‐modified nanochannels are usually weak mainly because small molecular gates could not efficiently block the large channels at the close states. Herein we report three‐dimensional (3D) metal‐organic‐framework (MOF) sub‐nanochannels (SNCs) confined with azobenzene (AZO) molecules to achieve efficient light‐gating...
Tue Apr 28, 2020 17:03
Although acetalization is a fundamental transformation in organic synthesis, intermolecular asymmetric acetalization remains an unsolved problem. In this study, a thiourea–ammonium hybrid catalyst was revealed to promote the O‐alkylation of enols with a racemic γ‐chlorobutenolide via dynamic kinetic resolution to give chiral acetals with good enantioselectivity. The catalyst simultaneously activates both the nucleophile and electrophile in a multifunctional manner. This method was applied to the...
Tue Apr 28, 2020 16:12
A double cation–π driven strategy was proposed to prepare stable and long‐range ordered two‐dimensional supramolecular polymers, as described by W. Tian and co‐workers in their Research Article (DOI: https://doi.org/10.1002/anie.202000025510.1002/anie.2020000255). The illustration recalls the famous “mortise‐and‐tenon” structure in ancient Chinese architecture, efficiently connecting two pieces of complementary wood components to create a desired geometry.
Tue Apr 28, 2020 16:08
A broadly applicable electrophotocatalytic method for the direct decarboxylative C−H alkylation and carbamoylation of heteroarenes has been developed. This method combines the advantages of photocatalysis and electrochemistry to enable the functionalization of a broad range of substrates and to allow the decarboxylative C−H functionalization reactions to proceed by H2 evolution, obviating the need for oxidizing reagents and proton acceptors. Abstract Decarboxylative C−H functionalization reactions...
Tue Apr 28, 2020 16:07
Intrinsically disordered proteins (IDPs) within the cellular milieu can phase‐separate into membraneless organelles. The phase separation of IDPs in the intracellular environment has inspired the study of spatial distribution and dynamic coacervation of a thermoresponsive elastin‐like polypeptide (ELP) as a model of an artificial IDP inside a synthetic cell‐like chassis. Abstract Elastin‐like polypeptides (ELPs) have been proposed as a simple model of intrinsically disordered proteins (IDPs)...
Tue Apr 28, 2020 16:06
Noble metal aerogels were crafted by harmonizing freeze‐thaw and freeze‐casting methods, as described by R. Du, A. Eychmüller, et al. in their Research Article (DOI: https://doi.org/10.1002/anie.20191648410.1002/anie.201916484). Due to the intrinsic properties of nanostructured noble metals as well as the ice‐templating effect, the resulting metal aerogels show impressive electrocatalytic and photo‐electrocatalytic performance towards ethanol oxidation.
Tue Apr 28, 2020 16:05
Cryo‐electron micrography was used to precisely determine the three‐dimensional structure of nanocomposite microgels and to provide insights into the interactions between small hydrophobic molecules and the microgels. As explained by K. Murata, D. Suzuki, et al. in their Communication (DOI: https://doi.org/10.1002/anie.20200349310.1002/anie.202003493), styrene monomers recognize molecular‐scale differences in polarity within the microgels during emulsion polymerization. This discovery enabled the...
Tue Apr 28, 2020 16:04
A scalable route to α‐ and β‐amanitin: The bicyclic octapeptide is built up by solid‐phase assembly of a linear octamer followed by two consecutive cyclization steps in solution. The key non‐proteinogenic amino acids, 6‐hydroxytryptophan and (3R,4R)‐dihydroxyisoleucine, are accessible via multistep synthesis on a multigram scale. Amatoxins are important for the development of new payload linkers for antibody–drug conjugates. Abstract α‐Amanitin and related amatoxins have been studied for more...
Tue Apr 28, 2020 16:04
Three families of structurally diverse methylammonium ruthenium halide perovskites and related compounds have been synthesized for the first time: MA2RuX 6 (X=Cl or Br), MA2MRuX 6 (M=Na, K or Ag; X=Cl or Br) and MA3Ru2X 9 (X=Br). The effective magnetic moments of these compounds decrease in the order MA2RuX 6 > MA2MRuX 6 > MA3Ru2X 9. Abstract There has been a great deal of recent interest in extended compounds containing Ru3+ and Ru4+ in light of their range of unusual physical...
Tue Apr 28, 2020 16:04
Giant nanocapsules with dimensions of up to 4 nm and a molecular weight of 57 kDa were obtained from Dawson‐type polyoxometalates functionalized with aromatic boronic acids, as reported by Z. Zheng, C. Streb, X. Chen, et al. in their Communication (DOI: https://doi.org/10.1002/anie.20200355010.1002/anie.202003550). A “lock‐and‐key” organofunctionalization route was used for the regiospecific attachment of the boronic acids to pre‐functionalized sites within the Dawson anions. This results in the...
Tue Apr 28, 2020 16:04
Controlled coupling of phase separation and reactions provides a step towards mimicking the ability of cells to conduct a symphony of functions in space and time. In their Communication (DOI: https://doi.org/10.1002/anie.20200083510.1002/anie.202000835), P. Arosio and co‐workers leverage a class of bio‐inspired intrinsically disordered proteins to generate composite protein–inorganic compartments that couple reversible self‐assembly in response to multiple stimuli with the ability to locally confine...
Tue Apr 28, 2020 16:04
The electrode potential is generally utilized for tuning the chemoselectivity in organic electrosynthesis. In contrast to this concept, J. Chen et al. employ in their Research Article (DOI: https://doi.org/10.1002/anie.20200151010.1002/anie.202001510) a novel reaction parameter, current density, to enable versatile C−N bond forming reactions. Pyrido[1,2‐a]benzimidazole and tetraarylhydrazine frameworks were afforded in a sustainable manner with broad substrate scope.
Tue Apr 28, 2020 16:02
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