Chloride - The Underrated Ion in Nociceptors. Front Neurosci. 2020;14:287 Authors: Wilke BU, Kummer KK, Leitner MG, Kress M Abstract In contrast to pain processing neurons in the spinal cord, where the importance of chloride conductances is already well established, chloride homeostasis in primary afferent neurons has received less attention. Sensory neurons maintain high intracellular chloride concentrations through balanced activity of Na+-K+-2Cl-...
Fri Apr 24, 2020 13:57
Analyzing the Quality and Challenges of Uncertainty Estimations for Brain Tumor Segmentation. Front Neurosci. 2020;14:282 Authors: Jungo A, Balsiger F, Reyes M Abstract Automatic segmentation of brain tumors has the potential to enable volumetric measures and high-throughput analysis in the clinical setting. Reaching this potential seems almost achieved, considering the steady increase in segmentation accuracy. However, despite segmentation accuracy,...
Fri Apr 24, 2020 13:57
Microstructural Investigations of the Visual Pathways in Pediatric Epilepsy Neurosurgery: Insights From Multi-Shell Diffusion Magnetic Resonance Imaging. Front Neurosci. 2020;14:269 Authors: Lacerda LM, Clayden JD, Handley SE, Winston GP, Kaden E, Tisdall M, Cross JH, Liasis A, Clark CA Abstract Background: Surgery is a key approach for achieving seizure freedom in children with focal onset epilepsy. However, the resection can affect or be in the vicinity...
Fri Apr 24, 2020 13:57
Current radiotherapy techniques in NSCLC: challenges and potential solutions. Expert Rev Anticancer Ther. 2020 Apr 22;: Authors: Giaj-Levra N, Borghetti P, Bruni A, Ciammella P, Cuccia F, Fozza A, Franceschini D, Scotti V, Vagge S, Alongi F Abstract Introduction: Radiotherapy is an important therapeutic strategy in the management of non-small cell lung cancer (NSCLC). In recent decades, technological implementations and the introduction of image guided...
Fri Apr 24, 2020 14:33
Publication date: Available online 25 April 2020Source: Ultrasound in Medicine & BiologyAuthor(s): Michael A. Pinkert, Benjamin L Cox, Bing Dai, Timothy J. Hall, Kevin W. Eliceiri
Sat Apr 25, 2020 13:44
Related ArticlesMetabolic changes in human brain evolution. Evol Anthropol. 2020 Apr 24;: Authors: Bauernfeind AL, Babbitt CC Abstract Because the human brain is considerably larger than those of other primates, it is not surprising that its energy requirements would far exceed that of any of the species within the order. Recently, the development of stem cell technologies and single-cell transcriptomics provides novel ways to address the question of...
Sat Apr 25, 2020 17:42
Abstract Purpose of Review Low back and lower extremity pain have been treated since 1901 with local anesthetics alone and since 1952 in combination with steroids. Over the years, multiple randomized controlled trials, systematic reviews with or without meta-analysis have been reaching discordant conclusions regarding the effectiveness of sodium chloride solution, local anesthetics, and steroids in managing spinal pain. Further,...
Sat Apr 25, 2020 03:00
Related ArticlesChordoid Glioma of the Third Ventricle: A Case Report and a Treatment Strategy to This Rare Tumor. Front Oncol. 2020;10:502 Authors: Chen X, Zhang B, Pan S, Sun Q, Bian L Abstract Chordoid glioma (CG) of the third ventricle is a rare type of brain tumor. Here, we present a case, review of the literature and proposed a treatment strategy for this rare tumor. Here, A 33-years-old woman presented with the menstrual disorder and progressive...
Sat Apr 25, 2020 15:31
Related ArticlesAnti-cancer Activity of Centipeda minima Extract in Triple Negative Breast Cancer via Inhibition of AKT, NF-κB, and STAT3 Signaling Pathways. Front Oncol. 2020;10:491 Authors: Lee MM, Chan BD, Wong WY, Qu Z, Chan MS, Leung TW, Lin Y, Mok DK, Chen S, Tai WC Abstract Breast cancer is the most commonly diagnosed cancer in females worldwide. Estimates from the World Health Organization (WHO) International Agency for Research on Cancer, suggest...
Sat Apr 25, 2020 15:31
Related ArticlesSingle-Center Experience With Epigenetic Treatment for Juvenile Myelomonocytic Leukemia. Front Oncol. 2020;10:484 Authors: Marcu A, Colita A, Radu LE, Jercan CG, Bica AM, Asan M, Coriu D, Tanase AD, Diaconu CC, Mambet C, Botezatu A, Pasca S, Teodorescu P, Anton G, Gurban P, Colita A Abstract Background: Juvenile myelomonocytic leukemia (JMML) is a rare myelodysplastic/myeloproliferative neoplasm diagnosed in young children, characterized...
Sat Apr 25, 2020 15:31
Related ArticlesCorrigendum: Individualized Prediction of Survival Benefit From Locoregional Surgical Treatment for Patients With Metastatic Breast Cancer. Front Oncol. 2020;10:482 Authors: Zheng Y, Zhong G, Yu K, Lei K, Yang Q Abstract [This corrects the article DOI: 10.3389/fonc.2020.00148.].PMID: 32328463 [PubMed - in process]
Sat Apr 25, 2020 15:31
Related ArticlesAltered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology. Front Oncol. 2020;10:476 Authors: Brown RAM, Richardson KL, Kabir TD, Trinder D, Ganss R, Leedman PJ Abstract Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism must be tightly controlled within cells. Whilst fundamental to many cellular processes and required for cell survival, excess labile iron is toxic to cells....
Sat Apr 25, 2020 15:31
Related ArticlesPreoperative Prediction of Extramural Venous Invasion in Rectal Cancer: Comparison of the Diagnostic Efficacy of Radiomics Models and Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging. Front Oncol. 2020;10:459 Authors: Yu X, Song W, Guo D, Liu H, Zhang H, He X, Song J, Zhou J, Liu X Abstract Background: To compare the diagnostic performance of radiomics models with that of dynamic contrast-enhanced magnetic resonance imaging...
Sat Apr 25, 2020 15:31
Related ArticlesA Novel Multimodal Radiomics Model for Preoperative Prediction of Lymphovascular Invasion in Rectal Cancer. Front Oncol. 2020;10:457 Authors: Zhang Y, He K, Guo Y, Liu X, Yang Q, Zhang C, Xie Y, Mu S, Guo Y, Fu Y, Zhang H Abstract Objective: To explore a new predictive model of lymphatic vascular infiltration (LVI) in rectal cancer based on magnetic resonance (MR) and computed tomography (CT). Methods: A retrospective study was conducted...
Sat Apr 25, 2020 15:31
Factors Influencing the Incidental Dose Distribution in Internal Mammary Nodes: A Comparative Study.
Related ArticlesFactors Influencing the Incidental Dose Distribution in Internal Mammary Nodes: A Comparative Study. Front Oncol. 2020;10:456 Authors: Wang W, Wang J, Qiu P, Sun T, Zhang Y, Shao Q, Xu M, Liu X, Li J Abstract Objective: To investigate the effect of anatomic and technical parameters on the incidental internal mammary lymph node (IMN) irradiation (IIMNI) dose among postmastectomy patients. Methods: We retrospectively delineated the IMN...
Sat Apr 25, 2020 15:31
Related ArticlesChanging Technologies of RNA Sequencing and Their Applications in Clinical Oncology. Front Oncol. 2020;10:447 Authors: Wang Y, Mashock M, Tong Z, Mu X, Chen H, Zhou X, Zhang H, Zhao G, Liu B, Li X Abstract RNA sequencing (RNAseq) is one of the most commonly used techniques in life sciences, and has been widely used in cancer research, drug development, and cancer diagnosis and prognosis. Driven by various biological and technical questions,...
Sat Apr 25, 2020 15:31
Related ArticlesPhysiological Role of Glutamate Dehydrogenase in Cancer Cells. Front Oncol. 2020;10:429 Authors: Moreno-Sánchez R, Marín-Hernández Á, Gallardo-Pérez JC, Pacheco-Velázquez SC, Robledo-Cadena DX, Padilla-Flores JA, Saavedra E, Rodríguez-Enríquez S Abstract NH 4 + increased growth rates and final densities of several human metastatic cancer cells. To assess whether glutamate dehydrogenase (GDH) in cancer cells may catalyze the reverse...
Sat Apr 25, 2020 15:31
Related ArticlesPrognostic Significance of β-Catenin Expression in Osteosarcoma: A Meta-Analysis. Front Oncol. 2020;10:402 Authors: Xie X, Li Y, Zhu H, Kuang Z, Chen D, Fan T Abstract Background: β-catenin plays a crucial role in the progression of osteosarcoma. However, the clinical significance of β-catenin over-expression in osteosarcoma still remains unclear. Thus, we performed a meta-analysis of studies that evaluated the impact of β-catenin on...
Sat Apr 25, 2020 15:31
Related ArticlesThe Epidemiological Characteristics and Prognostic Factors of Low-Grade Brainstem Glioma: A Real-World Study of Pediatric and Adult Patients. Front Oncol. 2020;10:391 Authors: Liu Z, Feng S, Li J, Cao H, Huang J, Fan F, Cheng L, Liu Z, Cheng Q Abstract Purpose: Our current understanding of low-grade brainstem glioma (LGBSG) is still limited. This study aimed to conduct a large-scale population-based real-world study to understand the...
Sat Apr 25, 2020 15:31
Related ArticlesThe Effects of Hyperbaric Oxygen Therapy on Pelvic Radiation Induced Gastrointestinal Complications (Rectal Bleeding, Diarrhea, and Pain): A Meta-Analysis. Front Oncol. 2020;10:390 Authors: Yuan JH, Song LM, Liu Y, Li MW, Lin Q, Wang R, Zhang CS, Dong J Abstract Background: Radiotherapy is a routine treatment for pelvic cancer patients. While it had been proven effective, gastrointestinal side effects remain a concern, impairing the quality...
Sat Apr 25, 2020 15:31
Related ArticlesIdentification of Cerebrospinal Fluid MicroRNAs Associated With Leptomeningeal Metastasis From Lung Adenocarcinoma. Front Oncol. 2020;10:387 Authors: Pan Z, Yang G, He H, Gao P, Jiang T, Chen Y, Zhao G Abstract Background: Leptomeningeal metastasis (LM) has frequently been observed in patients with lung adenocarcinoma. So far, its diagnosis and disease course monitoring are still extremely difficult. Moreover, there is no effective treatment...
Sat Apr 25, 2020 15:31
Related ArticlesSignificance of PET-CT for Detecting Occult Lymph Node Metastasis and Affecting Prognosis in Early-Stage Tongue Squamous Cell Carcinoma. Front Oncol. 2020;10:386 Authors: Zhao G, Sun J, Ba K, Zhang Y Abstract Objective: We aimed to clarify the significance of PET-CT for detecting occult lymph node metastasis and for affecting prognosis in early-stage tongue squamous cell carcinoma (SCC). Methods: Patients with surgically treated primary...
Sat Apr 25, 2020 15:31
Quantitative SWATH-Based Proteomic Profiling for Identification of Mechanism-Driven Diagnostic Biomarkers Conferring in the Progression of Metastatic Prostate Cancer. Front Oncol. 2020;10:493 Authors: Singh AN, Sharma N Abstract Prostate cancer (PCa), the most frequently diagnosed malignancy in men is associated with significant mortality and morbidity. Therefore, demand exists for the identification of potential biomarkers for patient stratification...
Fri Apr 24, 2020 14:46
Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond. Front Oncol. 2020;10:486 Authors: Tam SY, Wu VWC, Law HKW Abstract Metastasis is the main cause of cancer-related mortality. Although the actual process of metastasis remains largely elusive, epithelial-mesenchymal transition (EMT) has been considered as a major event in metastasis. Besides, hypoxia is common in solid cancers and has been considered as an important factor...
Fri Apr 24, 2020 14:46
Dosimetric Predictors of Acute and Chronic Alopecia in Primary Brain Cancer Patients Treated With Volumetric Modulated Arc Therapy. Front Oncol. 2020;10:467 Authors: Scoccianti S, Simontacchi G, Greto D, Perna M, Terziani F, Talamonti C, Teriaca MA, Caramia G, Lo Russo M, Olmetto E, Delli Paoli C, Grassi R, Carfora V, Saieva C, Bonomo P, Detti B, Mangoni M, Desideri I, Francolini G, Di Cataldo V, Marrazzo L, Pallotta S, Livi L Abstract Purpose: To determine...
Fri Apr 24, 2020 14:46
How Do We Meet the Supportive Care and Information Needs of Those Living With and Beyond Bladder Cancer? Front Oncol. 2020;10:465 Authors: MacLennan SJ, MacLennan S Abstract This perspective paper presents the case for adopting a new approach to the design and delivery of supportive care for those with bladder cancer. It is our assertion that the design and delivery of supportive care for those diagnosed with bladder cancer needs to (1) build on existing...
Fri Apr 24, 2020 14:46
Related ArticlesNear Total Versus Gross Total Resection of Large Vestibular Schwannomas: Facial Nerve Outcome. Oper Neurosurg (Hagerstown). 2020 Apr 24;: Authors: Schneider JR, Chiluwal AK, Arapi O, Kwan K, Dehdashti AR Abstract BACKGROUND: Large vestibular schwannomas (VSs) with brainstem compression are generally reserved for surgical resection. Surgical aggressiveness must be balanced with morbidity from cranial nerve injury. The purpose of the present...
Sat Apr 25, 2020 15:25
Related ArticlesCerebrospinal fluid leak presented with the C1-C2 sign caused by spinal canal stenosis: a case report. BMC Neurol. 2020 Apr 23;20(1):151 Authors: Akiba C, Bandai H, Ito Y, Maeda T, Yamaguchi K, Nakajima M, Miyajima M Abstract BACKGROUND: Intracranial hypotension is a disorder characterized by low cerebrospinal fluid (CSF) pressure typically caused by loss of CSF. Although some mechanisms account for the CSF leakage have been elucidated,...
Sat Apr 25, 2020 15:25
Exploring Balloon Sinuplasty Adverse Events With the Innovative OpenFDA Database. Am J Rhinol Allergy. 2020 Apr 22;:1945892420920505 Authors: Wright AE, Davis ED, Khan M, Chaaban MR PMID: 32321287 [PubMed - as supplied by publisher]
Fri Apr 24, 2020 14:52
Related ArticlesLumbar drain trial outcomes of normal pressure hydrocephalus: a single-center experience of 254 patients. J Neurosurg. 2019 01 04;132(1):306-312 Authors: El Ahmadieh TY, Wu EM, Kafka B, Caruso JP, Neeley OJ, Plitt A, Aoun SG, Olson DM, Ruchinskas RA, Cullum CM, Barnett S, Welch BG, Batjer HH, White JA Abstract OBJECTIVE: A short-term lumbar drain (LD) trial is commonly used to assess the response of normal pressure hydrocephalus (NPH)...
Fri Apr 24, 2020 14:52
Related ArticlesIntussusceptive angiogenesis and its counterpart intussusceptive lymphangiogenesis. Histol Histopathol. 2020 Apr 24;:18222 Authors: Díaz-Flores L, Gutiérrez R, Gayoso S, García MP, González-Gómez M, Díaz-Flores L, Sánchez R, Carrasco JL, Madrid JF Abstract Intussusceptive angiogenesis (IA) is currently considered an important alternative and complementary form of sprouting angiogenesis (SA). Conversely, intussusceptive lymphangiogenesis...
Sat Apr 25, 2020 14:18
Evaluating Trastuzumab in the treatment of HER2 positive breast cancer. Histol Histopathol. 2020 Apr 23;:18221 Authors: Jaques R, Xu S, Matsakas A Abstract The transmembrane oncoprotein HER2 is encoded by ERBB2 gene and overexpressed in around 20% of invasive breast cancers. It can be specifically targeted by Trastuzumab (Herceptin®), a humanised IgG1 antibody. Trastuzumab has been regarded as one of the most effective therapeutic drugs targeted to HER2...
Fri Apr 24, 2020 13:11
Related ArticlesBipedicled Vocal Fold Mucosal Flap Use in Phonomicrosurgery: Case Series. J Voice. 2020 Apr 20;: Authors: Tsuji DH, Kinchoku VM, Imamura R, Hachiya A, Yamasaki R, Marinho GR, Sennes LU Abstract OBJECTIVES: The objective of this study was to present a novel surgical technique involving the use of a "bipedicled vocal fold mucosal flap" to repair a mucosal defect and to evaluate the outcomes of patients in whom it was used. MATERIAL...
Sat Apr 25, 2020 17:12
Related ArticlesShape of the Cochlear Basal Turn: An Indicator for an Optimal Electrode-to-Modiolus Proximity With Precurved Electrode Type. Ear Nose Throat J. 2020 Apr 24;:145561320920965 Authors: Khurayzi T, Dhanasingh A, Almuhawas F, Alsanosi A Abstract OBJECTIVE: The objective of this study was to determine the shape of cochlear basal turn through basic cochlear parameters measurement. The secondary aim was to overlay an image of the precurved electrode...
Sat Apr 25, 2020 15:10
Related ArticlesPotential of infrared microscopy to differentiate between dementia with Lewy bodies and Alzheimer's diseases using peripheral blood samples and machine learning algorithms. J Biomed Opt. 2020 Apr;25(4):1-15 Authors: Salman A, Lapidot I, Shufan E, Agbaria AH, Porat Katz BS, Mordechai S Abstract SIGNIFICANCE: Accurate and objective identification of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) is of major clinical importance...
Sat Apr 25, 2020 17:12
Related ArticlesScan-Time Corrections for 80-100-min Standardizetd Uptake Volume Ratios to Measure the 18F-AV-1451 Tracer for Tau Imaging. IEEE Trans Med Imaging. 2019 03;38(3):697-709 Authors: He M, Baker SL, Shah VD, Lockhart SN, Jagust WJ Abstract The 18F-AV-1451 PET tracer binds to tau, an Alzheimer's disease biomarker. The standardized uptake value ratio (SUVR) 80-100 min window is widely used to quantify tau binding, although 18F-AV-1451 continues...
Sat Apr 25, 2020 13:16
Related ArticlesIn Reply. Arch Pathol Lab Med. 2020 May;144(5):543-544 Authors: Lanjewar DN, Sheth NS, Lanjewar SD, Wagholikar UL PMID: 32330098 [PubMed - as supplied by publisher]
Sat Apr 25, 2020 15:13
Related ArticlesGharpure's Papers (1927-1951) on Autopsies at Grant Medical College and Sir J. J. Hospital, Mumbai. Arch Pathol Lab Med. 2020 May;144(5):543 Authors: Pandya SS, Pai SA, Pandya SK PMID: 32330097 [PubMed - as supplied by publisher]
Sat Apr 25, 2020 15:13
Related ArticlesThe expression of thioredoxin-1 and inflammatory cytokines in patients with sepsis. Immunopharmacol Immunotoxicol. 2020 Apr 23;:1-6 Authors: Shao R, Yang Y, Zhang Y, Zhao S, Zheng Z, Chen G Abstract Background: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Inflammatory response and oxidative stress play an important role in the pathophysiological process of sepsis. Thioredoxin-1 (Trx-1)...
Sat Apr 25, 2020 15:07
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