Related ArticlesIntranasal Delivery of Nanoformulations: A Potential Way of Treatment for Neurological Disorders. Molecules. 2020 Apr 21;25(8): Authors: Islam SU, Shehzad A, Ahmed MB, Lee YS Abstract Although the global prevalence of neurological disorders such as Parkinson's disease, Alzheimer's disease, glioblastoma, epilepsy, and multiple sclerosis is steadily increasing, effective delivery of drug molecules in therapeutic quantities to the central...
Sat Apr 25, 2020 14:38
Related ArticlesEpilepsy and Physical Activity in US Adults. South Med J. 2020 02;113(2):81-86 Authors: Churilla JR, Boltz AJ, Johnson TM, Richardson MR Abstract OBJECTIVES: To examine the prevalence of self-reported aerobic leisure-time physical activity (LTPA) and muscle-strengthening activity (MSA) participation using a representative sample of US adults (18 years old and older) with a seizure disorder or epilepsy. METHODS: Data from the...
Sat Apr 25, 2020 14:38
Related ArticlesSudden unexpected death in epilepsy (SUDEP) in New Zealand; a retrospective review. N Z Med J. 2020 01 17;133(1508):65-71 Authors: Brennan M, Scott S, Bergin P Abstract AIM: Sudden unexpected death in epilepsy (SUDEP) is well recognised and widely reported but remains poorly understood. SUDEP in young adults is 27 times more common than sudden death in control populations. The incidence of SUDEP in New Zealand is not known but up to 40...
Sat Apr 25, 2020 14:38
Related ArticlesA Cross-Sectional Analysis of Migraine-Related Disability in CADASIL: A Mayo Clinic Cohort. Neurologist. 2019 Nov;24(6):161-164 Authors: Goldstein ED, Badi MK, Klaas JP, Glover P, Rozen TD, Huang JF, Lin MP, Meschia JF Abstract OBJECTIVES: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is inherited microangiopathy characterized by recurrent subcortical infarcts. A majority of those...
Sat Apr 25, 2020 14:38
Related ArticlesPrecision Medicine in Epilepsy-The Way Forward? ACS Chem Neurosci. 2019 04 17;10(4):2080-2081 Authors: Abbott CM PMID: 30991807 [PubMed - indexed for MEDLINE]
Sat Apr 25, 2020 14:38
Related ArticlesRole of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review. Neurochem Int. 2019 09;128:32-38 Authors: Lee-Hotta S, Uchiyama Y, Kametaka S Abstract In most mature neurons, low levels of intracellular Cl- concentrations ([Cl-]i) are maintained by channels and transporters, particularly the K+-Cl- cotransporter 2 (KCC2), which is the only Cl- extruder in most neurons. Recent studies have...
Sat Apr 25, 2020 14:38
Related ArticlesDistinct effects of resveratrol on seizures and hyperexcitability induced by NMDA and 4-aminopyridine. Nutr Neurosci. 2019 Dec;22(12):867-876 Authors: Wang YJ, Hsieh CP, Chan MH, Chan TY, Chen L, Chen HH Abstract Objectives: The antiepileptic activity of resveratrol has been revealed in various experimental models of epilepsy. The present study evaluated the effects of resveratrol on the seizures and hyperexcitable neuronal activity...
Sat Apr 25, 2020 14:38
Related ArticlesWhat are the optimal measures to identify anxiety and depression in people diagnosed with head and neck cancer (HNC): a systematic review. J Patient Rep Outcomes. 2020 Apr 23;4(1):26 Authors: Shunmugasundaram C, Rutherford C, Butow PN, Sundaresan P, Dhillon HM Abstract BACKGROUND: A cancer diagnosis is potentially life-threatening, likely causing distress and uncertainty, which may be psychologically debilitating. Depression and anxiety...
Sat Apr 25, 2020 14:31
Related ArticlesAn Anatomical Site and Genetic-Based Prognostic Model for Patients With Nuclear Protein in Testis (NUT) Midline Carcinoma: Analysis of 124 Patients. JNCI Cancer Spectr. 2020 Apr;4(2):pkz094 Authors: Chau NG, Ma C, Danga K, Al-Sayegh H, Nardi V, Barrette R, Lathan CS, DuBois SG, Haddad RI, Shapiro GI, Sallan SE, Dhar A, Nelson JJ, French CA Abstract Background: NUT midline carcinoma, renamed NUT carcinoma (NC), is an aggressive squamous...
Sat Apr 25, 2020 14:31
Related ArticlesDystrophic Calcification in the Oral Cavity Resulting in Mechanical Dysphagia: A Case Report and Review of Calcification in the Head and Neck Region. Cureus. 2020 Mar 30;12(3):e7469 Authors: Kumar G A, Deora SS Abstract Soft tissue calcifications in the oral cavity and maxillofacial region are most often detected as incidental findings on routine radiographic examination. But sometimes these soft tissue calcifications can be serious...
Sat Apr 25, 2020 14:31
Related ArticlesPredicting the risk of sarcopenia in elderly patients with patellar fracture: development and assessment of a new predictive nomogram. PeerJ. 2020;8:e8793 Authors: Chen YS, Cai YX, Kang XR, Zhou ZH, Qi X, Ying CT, Zhang YP, Tao J Abstract Purpose: To develop a risk prediction model for postoperative sarcopenia in elderly patients with patellar fractures in China. Patients and methods: We conducted a community survey of patients...
Sat Apr 25, 2020 14:31
Related ArticlesMiRNAs in Radiotherapy Resistance of Nasopharyngeal Carcinoma. J Cancer. 2020;11(13):3976-3985 Authors: Tian Y, Tang L, Yi P, Pan Q, Han Y, Shi Y, Rao S, Tan S, Xia L, Lin J, Oyang L, Tang Y, Liang J, Luo X, Liao Q, Wang H, Zhou Y Abstract Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors of the head and neck in Southeast Asia and southern China. Although the comprehensive treatment based on intensity-modulated...
Sat Apr 25, 2020 14:31
Related ArticlesmiR-93-5p enhances migration and invasion by targeting RGMB in squamous cell carcinoma of the head and neck. J Cancer. 2020;11(13):3871-3881 Authors: Zhang S, He Y, Liu C, Li G, Lu S, Jing Q, Chen X, Ma H, Zhang D, Wang Y, Huang D, Tan P, Chen J, Zhang X, Liu Y, Qiu Y Abstract Invasion and metastasis represent the primary causes of therapeutic failure in patients diagnosed with squamous cell carcinoma of the head and neck (SCCHN)....
Sat Apr 25, 2020 14:31
Related ArticlesSwallow Motor Pattern Is Modulated by Fixed or Stochastic Alterations in Afferent Feedback. Front Hum Neurosci. 2020;14:112 Authors: King SN, Shen TY, Musselwhite MN, Huff A, Reed MD, Poliacek I, Howland DR, Dixon W, Morris KF, Bolser DC, Iceman KE, Pitts T Abstract Afferent feedback can appreciably alter the pharyngeal phase of swallow. In order to measure the stability of the swallow motor pattern during several types of alterations...
Sat Apr 25, 2020 14:31
Related ArticlesManagement of HPV-Related Squamous Cell Carcinoma of the Head and Neck: Pitfalls and Caveat. Cancers (Basel). 2020 Apr 15;12(4): Authors: Perri F, Longo F, Caponigro F, Sandomenico F, Guida A, Della Vittoria Scarpati G, Ottaiano A, Muto P, Ionna F Abstract : Head and neck squamous cell carcinomas (HNSCCs) are a very heterogeneous group of malignancies arising from the upper aerodigestive tract. They show different clinical behaviors...
Sat Apr 25, 2020 14:31
Related ArticlesThe Impact of Locoregional Treatment on Response to Nivolumab in Advanced Platinum Refractory Head and Neck Cancer: The Need Trial. Vaccines (Basel). 2020 Apr 20;8(2): Authors: Botticelli A, Mezi S, Pomati G, Sciattella P, Cerbelli B, Roberto M, Mammone G, Cirillo A, Cassano A, Di Dio C, Cortellini A, Pizzuti L, Ronzino G, Salati M, Vici P, Polimeni A, Merlano MC, Nuti M, Marchetti P Abstract BACKGROUND: Previous locoregional treatment...
Sat Apr 25, 2020 14:31
Related ArticlesHuman Papillomaviruses and Epstein-Barr Virus Interactions in Colorectal Cancer: A Brief Review. Pathogens. 2020 Apr 20;9(4): Authors: Fernandes Q, Gupta I, Vranic S, Al Moustafa AE Abstract Human papillomaviruses (HPVs) and the Epstein-Barr virus (EBV) are the most common oncoviruses, contributing to approximately 10%-15% of all malignancies. Oncoproteins of high-risk HPVs (E5 and E6/E7), as well as EBV (LMP1, LMP2A and EBNA1), play...
Sat Apr 25, 2020 14:31
Related ArticlesAutochthonous Cases of Mucosal Leishmaniasis in Northeastern Italy: Clinical Management and Novel Treatment Approaches. Microorganisms. 2020 Apr 18;8(4): Authors: Gaspari V, Zaghi I, Macrì G, Patrizi A, Salfi N, Locatelli F, Carra E, Re MC, Varani S Abstract Mucosal leishmaniasis (ML) is a rare clinical variant of tegumentary leishmaniasis in Mediterranean Europe. Here we report on three autochthonous cases of head and neck ML in...
Sat Apr 25, 2020 14:31
Related ArticlesLncRNA OIP5-AS1 promotes cell proliferation and migration and induces angiogenesis via regulating miR-3163/VEGFA in hepatocellular carcinoma. Cancer Biol Ther. 2020 Apr 24;:1-11 Authors: Shi C, Yang Q, Pan S, Lin X, Xu G, Luo Y, Zheng B, Xie X, Yu M Abstract Long noncoding RNAs (lncRNAs) have been reported to play a significant role in the occurrence and progression of tumors. In different tumors, they can either act as an oncogene or...
Sat Apr 25, 2020 14:30
Related ArticlesMAPK-directed activation of the whitefly transcription factor CREB leads to P450-mediated imidacloprid resistance. Proc Natl Acad Sci U S A. 2020 Apr 23;: Authors: Yang X, Deng S, Wei X, Yang J, Zhao Q, Yin C, Du T, Guo Z, Xia J, Yang Z, Xie W, Wang S, Wu Q, Yang F, Zhou X, Nauen R, Bass C, Zhang Y Abstract The evolution of insect resistance to pesticides poses a continuing threat to agriculture and human health. While much is known about...
Sat Apr 25, 2020 14:24
Related ArticlesIntertwined signatures of desiccation and drought tolerance in grasses. Proc Natl Acad Sci U S A. 2020 Apr 23;: Authors: Pardo J, Wai CM, Chay H, Madden CF, Hilhorst HWM, Farrant JM, VanBuren R Abstract Grasses are among the most resilient plants, and some can survive prolonged desiccation in semiarid regions with seasonal rainfall. However, the genetic elements that distinguish grasses that are sensitive versus tolerant to extreme drying...
Sat Apr 25, 2020 14:24
Related ArticlesSpread and dynamics of the COVID-19 epidemic in Italy: Effects of emergency containment measures. Proc Natl Acad Sci U S A. 2020 Apr 23;: Authors: Gatto M, Bertuzzo E, Mari L, Miccoli S, Carraro L, Casagrandi R, Rinaldo A Abstract The spread of coronavirus disease 2019 (COVID-19) in Italy prompted drastic measures for transmission containment. We examine the effects of these interventions, based on modeling of the unfolding epidemic....
Sat Apr 25, 2020 14:24
Related ArticlesQuasi-Fermi level splitting in nanoscale junctions from ab initio. Proc Natl Acad Sci U S A. 2020 Apr 23;: Authors: Lee J, Yeo H, Kim YH Abstract The splitting of quasi-Fermi levels (QFLs) represents a key concept utilized to describe finite-bias operations of semiconductor devices, but its atomic-scale characterization remains a significant challenge. Herein, the nonequilibrium QFL or electrochemical potential profiles within single-molecule...
Sat Apr 25, 2020 14:24
Related ArticlesHigh-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry. Proc Natl Acad Sci U S A. 2020 Apr 23;: Authors: Sawyer WS, Srikumar N, Carver J, Chu PY, Shen A, Xu A, Williams AJ, Spiess C, Wu C, Liu Y, Tran JC Abstract Toward the goal of increasing the throughput of high-resolution mass characterization of intact antibodies, we developed a RapidFire-mass spectrometry (MS) assay using electrospray...
Sat Apr 25, 2020 14:24
Related ArticlesSocial tipping intervention strategies for rapid decarbonization need to consider how change happens. Proc Natl Acad Sci U S A. 2020 Apr 23;: Authors: Smith SR, Christie I, Willis R PMID: 32327605 [PubMed - as supplied by publisher]
Sat Apr 25, 2020 14:24
Related ArticlesReply to Smith et al.: Social tipping dynamics in a world constrained by conflicting interests. Proc Natl Acad Sci U S A. 2020 Apr 23;: Authors: Otto IM, Donges JF, Lucht W, Schellnhuber HJ PMID: 32327604 [PubMed - as supplied by publisher]
Sat Apr 25, 2020 14:24
Related ArticlesEpileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis. Proc Natl Acad Sci U S A. 2020 Apr 23;: Authors: Shao C, Yuan J, Liu Y, Qin Y, Wang X, Gu J, Chen G, Zhang B, Liu HK, Zhao J, Zhu HL, Qian Y Abstract Myeloperoxidase (MPO)-mediated oxidative stress has been suggested to play an important role in the pathological dysfunction of epileptic brains. However,...
Sat Apr 25, 2020 14:24
Related ArticlesGenistein and 17β-Estradiol Protect Hepatocytes from Fatty Degeneration by Mechanisms Involving Mitochondria, Inflammasome and Kinases Activation. Cell Physiol Biochem. 2020 Apr 25;54(3):401-416 Authors: Farruggio S, Cocomazzi G, Marotta P, Romito R, Surico D, Calamita G, Bellan M, Pirisi M, Grossini E Abstract BACKGROUND/AIMS: Oxidative stress and mitochondria dysfunction could be involved in the onset of non-alcoholic fatty liver disease...
Sat Apr 25, 2020 14:22
Related ArticlesMapping the digital food environment: a scoping review protocol. BMJ Open. 2020 Apr 22;10(4):e036241 Authors: Granheim SI, Opheim E, Terragni L, Torheim LE, Thurston M Abstract INTRODUCTION: Food environments are the interface through which people interact with the broader food system. They are a key determinant of healthy and sustainable diets. The widespread use of digital technology in late modernity and the shift towards a digital...
Sat Apr 25, 2020 14:17
Related ArticlesClinician-recalled quoted speech in electronic health records and risk of suicide attempt: a case-crossover study. BMJ Open. 2020 Apr 22;10(4):e036186 Authors: Jayasinghe L, Bittar A, Dutta R, Stewart R Abstract OBJECTIVE: Clinician narrative style in electronic health records (EHR) has rarely been investigated. Clinicians sometimes record brief quotations from patients, possibly more frequently when higher risk is perceived. We investigated...
Sat Apr 25, 2020 14:17
Related ArticlesEffectiveness and feasibility of internet-based and mobile-based interventions for individuals experiencing bereavement: a systematic review protocol. BMJ Open. 2020 Apr 22;10(4):e036034 Authors: Luppa M, Löbner M, Pabst A, Schlapke C, Stein J, Riedel-Heller SG Abstract INTRODUCTION: Internet-based and mobile-based interventions (IMIs) provide an innovative and efficient self-management tool for mental health problems. This systematic...
Sat Apr 25, 2020 14:17
Related Articles[18F]DCFPyL PET-MRI/CT for unveiling a molecularly defined oligorecurrent prostate cancer state amenable for curative-intent ablative therapy: study protocol for a phase II trial. BMJ Open. 2020 Apr 22;10(4):e035959 Authors: Glicksman RM, Metser U, Valliant J, Chung PW, Fleshner NE, Bristow RG, Green D, Finelli A, Hamilton R, Stanescu T, Hussey D, Catton C, Gospodarowicz M, Warde P, Bayley A, Breen S, Vines D, Jaffray DA, Berlin A Abstract ...
Sat Apr 25, 2020 14:17
Related ArticlesTrends in attention-deficit and hyperactivity disorder (ADHD) medications among children and young adults in Ireland: a repeated cross-sectional study from 2005 to 2015. BMJ Open. 2020 Apr 22;10(4):e035716 Authors: Mac Avin M, Teeling M, Bennett KE Abstract OBJECTIVE: This study examined the prescribing patterns of attention-deficit hyperactivity disorder (ADHD) medications in Ireland between 2005 and 2015 in children, adolescents and...
Sat Apr 25, 2020 14:17
Related ArticlesKorean frailty and aging cohort study (KFACS): cohort profile. BMJ Open. 2020 Apr 22;10(4):e035573 Authors: Won CW, Lee S, Kim J, Chon D, Kim S, Kim CO, Kim MK, Cho B, Choi KM, Roh E, Jang HC, Son SJ, Lee JH, Park YS, Lee SG, Kim BJ, Kim HJ, Choi J, Ga H, Lee KJ, Lee Y, Kim M Abstract PURPOSE: The purpose of the Korean Frailty and Aging Cohort Study (KFACS) is to initiate a nationwide, population-based prospective cohort study of older...
Sat Apr 25, 2020 14:17
Related ArticlesEffect of time interval from diagnosis to treatment for non-small cell lung cancer on survival: a national cohort study in Taiwan. BMJ Open. 2020 Apr 22;10(4):e034351 Authors: Tsai CH, Kung PT, Kuo WY, Tsai WC Abstract OBJECTIVES: This study aimed to determine if treatment delay after non-small cell lung cancer (NSCLC) diagnosis impacts patient survival rate. STUDY DESIGN: This study is a natural experiment in Taiwan. A retrospective...
Sat Apr 25, 2020 14:17
Related ArticlesPrevalence and risk factors for wheeze, decreased forced expiratory volume in 1 s and bronchoconstriction in young children living in Havana, Cuba: a population-based cohort study. BMJ Open. 2020 Apr 22;10(4):e034192 Authors: Suárez-Medina R, Venero-Fernández S, Alvarez-Valdés V, Sardiñas-Baez N, Cristina C, Loinaz-Gonzalez M, Verdecia-Pérez Z, Corona-Tamayo B, Betancourt-López M, Britton J, Fogarty AW Abstract OBJECTIVES: Asthma has...
Sat Apr 25, 2020 14:17
Related ArticlesReducing medicine-induced deterioration and adverse reactions (ReMInDAR) trial: study protocol for a randomised controlled trial in residential aged-care facilities assessing frailty as the primary outcome. BMJ Open. 2020 Apr 22;10(4):e032851 Authors: Lim R, Bereznicki L, Corlis M, Kalisch Ellett LM, Kang AC, Merlin T, Parfitt G, Pratt NL, Rowett D, Torode S, Whitehouse J, Andrade AQ, Bilton R, Cousins J, Kelly L, Schubert C, Williams M, Roughead EE ...
Sat Apr 25, 2020 14:17
Related ArticlesTMS activation site estimation using multiscale realistic head models. J Neural Eng. 2020 Apr 24;: Authors: Gomez-Tames J, Laakso I, Murakami T, Ugawa Y, Hirata A Abstract OBJECTIVE: Transcranial magnetic stimulation (TMS) activates brain structures non-invasively. Computational models can be used to elucidate the activation site; however, the exact activation site is controversial. The aim is to present an imaging technique of the TMS...
Sat Apr 25, 2020 14:13
Related ArticlesNeurophysiological and medical considerations for better-performing microelectronic retinal prostheses. J Neural Eng. 2020 Apr 23;: Authors: Im M, Kim SW Abstract Objective. Microelectronic retinal prostheses are a promising solution for sight restoration in cases of blindness caused by outer retinal degenerative diseases. Despite immense technological advances, the best visual acuity restored by microelectronic prostheses remains limited,...
Sat Apr 25, 2020 14:13
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