Catalytic asymmetric iodoesterification of simple alkenes was achieved using a dinuclear zinc‐3,3’‐( R , S , S )‐bis(aminoimino)binaphthoxide ( di‐Zn ) complex. For iodoesterification using p ‐methoxybenzoic acid, the N ‐iodonaphthalenimide (NIN)‐I 2 system was effective for producing iodoesters in a highly enantioselective manner. The synthetic utility of the optically active iodo‐ p ‐methoxybenzoate products was also demonstrated. The quartet of metal ionic bond, hydrogen bond,...
Mon Apr 27, 2020 17:04
Using a one‐step synthetic route for block copolymers avoids the repeated addition of monomers to the polymerization mixture, which can easily lead to contamination and, therefore, to the unwanted termination of chain growth. For this purpose, monomers (M1 ‐ M5) with different steric hindrances and different propagation rates are explored. Copolymerization of M1 (propagating rapidly) with M2 (propagating slowly), M1 with M3 (propagating extremely slowly) and M4 (propagating rapidly) with M5 (propagating...
Mon Apr 27, 2020 16:59
Complexes of trivalent lanthanides are well known to possess strong magnetic anisotropy which enables them to be efficient single‐molecule magnets. We report here high‐level ab initio calculations for [LnO], Ln=Tb, Dy, Ho, which show that divalent lanthanides can exhibit equally strong magnetic anisotropy and magnetization blocking barriers. In particular, detailed calculations predict for a [DyO] complex deposited on the h‐BN surface a multilevel magnetization blocking barrier exceeding 3000 K,...
Mon Apr 27, 2020 14:07
Post‐synthetic modification (PSM) enables desired functional groups to be introduced while maintaining the structures of metal‐organic framework (MOF). We report the dual PSM of a MOF involving the microscopic transformations of C‐H bonds into C‐C bonds and the mesoscopic introduction of hierarchical porosity. MOF crystals underwent single‐crystal‐to‐single‐crystal transformation during the electrophilic aromatic substitution of Co 2 ( m ‐DOBDC) ( m ‐DOBDC 4− = 4,6‐dioxo‐1,3‐benzenedicarboxylate)...
Mon Apr 27, 2020 11:12
Microcrystallites are promising minute mirrorless laser sources. A variety of luminescent organic compounds have been exploited along this line, but dendrimers have been inapplicable due to their fragility and extremely poor crystallinity. Here we show a novel dendrimer family that overcomes these difficulties. First‐, second‐, and third‐generation carbazole (Cz) dendrimers with a carbon‐bridged oligo(phenylenevinylene) (COPV2) core ( G n COPV2 , n = 1–3) assemble to form microcrystals. The...
Mon Apr 27, 2020 11:11
In the emerging field of on‐surface synthesis, dehalogenative aryl‐aryl coupling is unarguably the most prominent tool for the fabrication of covalently bonded carbon‐based nanomaterials. Despite its importance, the reaction kinetics are still poorly understood. Here we present a comprehensive temperature‐programmed x‐ray photoelectron spectroscopy investigation of reaction kinetics and energetics in the prototypical on‐surface dehalogenative polymerization of 4,4’’‐dibromo‐p‐terphenyl into poly(para‐phenylene)...
Mon Apr 27, 2020 11:08
Cellular signaling is regulated by assembly of proteins into higher‐order complexes. Bottom‐up creation of synthetic protein assemblies, especially asymmetric complexes, is highly challenging. Here, we present the design and implementation of asymmetric assembly of a ternary protein complex facilitated by Rosetta modeling and thermodynamic analysis. We targeted the wildtype symmetric CT32‐CT32 interface of the 14‑3‑3/CT32 complex, ultimately favoring asymmetric assembly on the 14‑3‑3 scaffold. Biochemical...
Sat Apr 25, 2020 22:00
Abstract Overweight and obesity may damage the cerebrovascular architecture, resulting in a significant reduction in cerebral blood flow. To date, there have been few randomized clinical trials (RCT) examining whether obesity‐related reductions in cerebral blood flow could be modified by weight loss. Further, it is unknown whether the behavioral intervention strategy for weight loss (i.e., diet alone or diet combined with exercise) differentially influences cerebral blood flow in adults with overweight...
Tue Apr 28, 2020 17:34
To rapidly communicate information on the global clinical effort against Covid-19, the Journal has initiated a series of case reports that offer important teaching points or novel findings. The case reports should be viewed as observations rather than as recommendations for evaluation or treatment.…
Tue Apr 28, 2020 03:00
Publication date: Available online 28 April 2020Source: International Journal of PsychophysiologyAuthor(s): Afaf Abou-Ghazaleh, Asaid Khateb, Judith F. Kroll
Wed Apr 29, 2020 12:24
Abstract Non-surgical locally ablative treatments for primary liver cancer and liver metastases represent an effective therapeutic choice when surgery cannot be performed or is not indicated. Thermal ablative employing electric currents or electromagnetic fields have historically played an important role in this setting. Radiotherapy, in the last decades, due to a series of important technological development, has become an attractive option for the treatment of liver tumours,...
Wed Apr 29, 2020 03:00
New England Journal of Medicine, Ahead of Print.
Tue Apr 28, 2020 12:00
New England Journal of Medicine, Ahead of Print.
Tue Apr 28, 2020 07:08
New England Journal of Medicine, Ahead of Print.
Tue Apr 28, 2020 07:07
New England Journal of Medicine, Ahead of Print.
Tue Apr 28, 2020 07:01
New England Journal of Medicine, Ahead of Print.
Tue Apr 28, 2020 07:00
New England Journal of Medicine, Ahead of Print.
Tue Apr 28, 2020 07:00
New England Journal of Medicine, Ahead of Print.
Tue Apr 28, 2020 06:59
Mon Apr 27, 2020 22:33
The aim of this study was to examine the potential utility of resuscitative endovascular balloon occlusion of aorta among trauma victims who die within 24 h of arrival due to haemorrhage. Abstract Background Most of the trauma patients who die in the first 24 h from arrival to the hospital do so as a result of haemorrhagic shock. Resuscitative endovascular balloon occlusion of the aorta (REBOA) facilitates expedient proximal aortic control, potentially bridging a needed gap for partial or...
Mon Apr 27, 2020 19:22
Abstract A continual increase in the prevalence of osteoarthritis drives growing demand for total joint arthroplasty. So far, a decrease in length of stay has been the target for health professionals globally. However, a consensus pathway of achieving this has not yet been reached. This article reviews recent advances in pre‐operative and perioperative factors impacting length of stay.
Mon Apr 27, 2020 19:22
Mon Apr 27, 2020 19:22
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