Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoproliferation encompasses a broad range of clinicopathologic findings, including specific subtypes, for example, EBV+ mucocutaneous ulcer. Here we reassessed 36 cases of primary EBV+ diffuse large B-cell lymphomas (16 men and 20 women; median age, 69.5 y; range, 35 to 84 y), including 8 immunosuppressed patients (Lugano stage II-IV; median age, 74 y), 7 nonimmunosuppressed patients with stage I disease (median age, 69 y), and 21 nonimmunosuppressed...
Tue Apr 28, 2020 03:00
To the Editor: Data on Covid-19 in patients with immune-mediated inflammatory disease who have received anticytokine biologics, other immunomodulatory therapies, or both on a long-term basis are scarce. Trials to assess the efficacy of antirheumatic therapies such as hydroxychloroquine and…
Wed Apr 29, 2020 03:00
We report a case of IgE-mediated hypersensitivity to lemon seed. We demonstrate for the first time a pattern of cross-sensitisation between seeds of citrus hybrid species from similar ancestral species origins.
Wed Apr 29, 2020 03:00
To explore the possibility of a new diagnostic approach of endometriosis based on immunocytochemistry scoring of Aromatase P450 expressions in endometrial cells collected from menstrual sloughing. This is a ca...
Tue Apr 28, 2020 03:00
Horm Metab ResDOI: 10.1055/a-1129-6947The adrenal gland integrates catecholamine-producing neuroendocrine cells and steroid-producing cells with mesenchymal origin in a structured manner under one capsule and is a key regulator for vital bioactivity. In addition to adrenal-specific disease, dysregulation of adrenal hormones is associated with systemic effects, leading to undesirable metabolic and cardiovascular consequences. Mass spectrometry imaging (MSI) technique can simultaneously measure a broad...
Wed Apr 29, 2020 02:00
Positioning stent in head and neck radiotherapy seems to have benefit to prevent oral complications but it hasn’t been summarized by an evidence-based method.
Tue Apr 28, 2020 03:00
This study aimed to find the normative fundamental frequency values for adult native Urdu speakers from Pakistan. The age and gender differences were also examined.
Wed Apr 29, 2020 03:00
Groups of bacteria that stick together, known as a biofilm, have a strong working memory, according to new research. (CDC/)Tiny organisms do extraordinary things. Bacteria can both help bring life to soil and wreak havoc on a human digestive system during a bout with food poisoning. However, we don’t normally think of microbes like bacteria as being smart. Groundbreaking new research, though, suggests otherwise: When many bacteria live together as a unit, a conglomerate known as a biofilm, the biological...
01:00
These four Cheez-It crackers clock in at 6 grams. A scale can help you consume those snacks responsibly. (Stan Horaczek/)The coronavirus pandemic has made eating more complicated. Grocery availability is spotty, delivery apps are pushing hard to get people to order takeout, and few (legal) things provide the same kind of blissful instant gratification as a Hot Pocket. Those same factors, however, make this a great opportunity to start tracking what you eat. That’s because you’re almost certainly...
Wed Apr 29, 2020 23:20
Oil barrels were at negative prices (Erik Mclean/Unsplash/)In the past couple weeks, we’ve seen oil prices—already on the decline—plummet to historic lows. On April 20, the benchmark price for U.S. oil dipped to negative $40 a barrel. At the time of writing, the price per barrel for West Texas Intermediate crude, an industry benchmark, was just below $13, still well under the $50 or so needed to make a profit.But oil producers going bankrupt isn’t necessarily good news for the climate. In the past,...
Wed Apr 29, 2020 21:00
Without fire, this is just an egg on a bottle. The fun starts when you add matches. (John Kennedy/)Welcome to PopSci’s at-home science projects series. On weekdays at noon, we’ll be posting new projects that use ingredients you can buy at the grocery store. Show us how it went by tagging your project on social media using #popsciprojects.If you like fire and you like eggs, this is the project for you. Simply put, we’re going to toss a few lit matches into an empty glass bottle, plug the top with...
Wed Apr 29, 2020 19:00
Multi-cookers that'll change how you eat. (Amazon/)The evolution of the mythical one-pot dish is as old as cooking itself, beginning way back when our ancestors first threw some ingredients into a pot and lit a fire underneath it. This time-saving, convenient, and downright delicious style of cooking is the backbone of every stew and roast from here to eternity, and thanks to smart-home technology and the Internet of Things, one-pot cooking just got a whole lot easier, and more inspired. If you’re...
Wed Apr 29, 2020 22:02
Save money and Earth's resources by repairing things instead of replacing them. (Artur Tumasjan via Unsplash/)Anyone who has ever tried to tighten a screw on their eyeglasses with their fingernail knows that our instinct to fix things often overrides whether or not we have the right tools. Screws are everywhere from shelf brackets to furniture to watch casings, but unfortunately there isn’t one universal tool that works with all of them. These four handy screwdriver sets cover your bases, from jewelry...
Wed Apr 29, 2020 18:34
Weather radar stations, like this one in South Dakota, capture data on local storms and events. But planes and satellites can provide more regional projections by capturing atmospheric metrics. (Eric Kurth, NOAA/NWS/ER/WFO/Sacramento/)This story originally published on Flying.The drop in airline operations across the US and around the world has had an impact on weather reporting, particular with the input flight crews make to the World Meteorological Organization’s Global Observing System, part of...
Wed Apr 29, 2020 17:39
These tools will help you create an outdoor space that blossoms, blooms, and fruits. (Amazon/)There’s never been a better time to invest a little energy in cultivating your garden and discovering the creative potential of your backyard. Whether you’re a new gardener or have a seasoned green thumb, everyone can appreciate that good tools make a world of difference. Why spend time struggling when a good shovel can make something that could feel like a chore into a luxury. Here are three of our favorite...
Wed Apr 29, 2020 15:59
Ouch. (Unsplash/)What’s the weirdest thing you learned this week? Well, whatever it is, we promise you’ll have an even weirder answer if you listen to PopSci’s hit podcast. The Weirdest Thing I Learned This Week hits Apple, Anchor, and everywhere else you listen to podcasts every-other Wednesday morning. It’s your new favorite source for the strangest science-adjacent facts, figures, and Wikipedia spirals the editors of Popular Science can muster. If you like the stories in this post, we guarantee...
Wed Apr 29, 2020 15:00
Radiotherapy (RT) has been used for palliation for many years and constitutes up to 40% of the radiation oncologist’s practice[1]. It can be used independently or alongside systemic treatment in the interdisciplinary care of palliative patients to relieve an array of symptoms, such as pain, bleeding, obstruction and neurological issues, caused by the primary tumor or metastatic lesions. RT has proven itself to be a cost-effective, time-efficient and effective intervention with a relatively low toxicity...
Wed Apr 29, 2020 03:00
Severe asthma (SA) often requires subspecialist management and treatment with biologic therapies and/or maintenance systemic corticosteroids (mSCS). Objective: To describe contemporary, real-world biologic and mSCS use among U.S., subspecialist-treated patients with SA.
Wed Apr 29, 2020 03:00
Abstract Background Oral lichen planus is a chronic inflammatory disease which is considered as a potential precancerous condition. Numerous studies have confirmed that inflammation is a strong risk factor for cancer development. Smoking is associated with potentially malignant disorders of the oral and oropharyngeal mucosa. The adverse consequences of smoking in various pathologies are mediated by its effects on the immune-inflammatory...
Wed Apr 29, 2020 03:00
Abstract Background Recurrent aphthous stomatitis (RAS) is the most common form of oral ulcerative disease, whose cause is still unknown. Researchers have found the association of many factors with the occurrence of RAS, and proposed oral bacterial infection could be a cause for this disease. Methods To investigate whether the occurrence...
Wed Apr 29, 2020 03:00
Oncolytic virus therapy has been tested against cancer in preclinical models and clinical assays. Current evidence shows that viruses induce cytopathic effects associated with fusogenic protein-mediated syncytium formation and immunogenic cell death of eukaryotic cells. We have previously demonstrated that tumor cell bodies generated from cells expressing the fusogenic protein of the infectious salmon anemia virus (ISAV-F) enhance crosspriming and display prophylactic antitumor activity against melanoma...
Wed Apr 29, 2020 13:05
Publication date: Available online 29 April 2020Source: European Journal of CancerAuthor(s): D. Trapani, A. Marra, G. Curigliano
00:26
In October 2019, NHS England published “The Independent Review of Adult Screening Programmes in England”.1 This recognised the many achievements of current screening programmes, but also acknowledged that some still fall short of realising their full potential. It particularly highlighted the fact that access to current screening schemes must be improved if we are to increase uptake and keep pace with changes in the way we live our lives.
Wed Apr 29, 2020 03:00
Use of the coronoid process as a donor site for bone grafting was first described by Youmans and Russell1 to treat non-union of a fractured mandible. Since then, the coronoid process with or without the ramus has been used in the following ways: after the release of ankylosis of the temporomandibular joint;2 for grafting of the maxilla, orbital floor, and nose; and augmentation of the sinus3 and alveolar ridge.4 The advantages of using this intraoral donor site are the absence of an extraoral scar...
Wed Apr 29, 2020 03:00
As a facial plastic surgeon gains experience, further improvements can be gained with more aggressive surgery, but complications begin to occur when more aggressive measures are undertaken. Therefore, the ideal technique is one that maximizes rejuvenation while minimizing adverse effects. The senior author has found that the aggressive techniques in the region of the neck have improved dramatically the overall initial and long-term results for the neck portion of the rhytidectomy. More aggressive...
Wed Apr 29, 2020 03:00
Oral squamous cell carcinoma (OSCC) remains a challenge for head and neck surgeons, with low 5-year survival rates despite improvements in diagnostic techniques and therapies. This retrospective observational study was performed to evaluate the epidemiology and risk factors in a cohort of 666 patients with invasive OSCC over a 39-year period. Risk factors assessed were age, sex, toxic habits, premalignant lesions, tumour location and size, and neck involvement, and pathological factors such as surgical...
Wed Apr 29, 2020 03:00
This August marks the 75th anniversary of the conclusion of World War II. In history’s largest, most destructive war, an estimated 80 million people, or roughly 3% of the world population, died. Nearly 420,000 Americans were killed, and 670,000 were wounded. These grim numbers were mitigated,…
Wed Apr 29, 2020 03:00
How long will this pandemic last? When will we find a treatment or vaccine? Which drug should we give our patients? Will we run out of personal protective equipment (PPE)? When will everyone return to work? We find ourselves in a time of great economic, social, and medical uncertainty. Faced with a…
Tue Apr 28, 2020 03:00
Publication date: Available online 28 April 2020Source: Dental MaterialsAuthor(s): José Carlos Romanini-Junior, Ronaldo Hirata, Estevam A. Bonfante, Dimorvan Bordin, Rose Yakushijin Kumagai, Vinicius P. Fardin, Paulo G. Coelho, André F. Reis
Wed Apr 29, 2020 22:47
Publication date: Available online 28 April 2020Source: Dental MaterialsAuthor(s): Shenglong Tan, Shangsi Chen, Yifan Wang, Feige Wu, Yufei Shi, Jianglin Wang, Yinyin Du, Shengmin Zhang
Wed Apr 29, 2020 22:47
We evaluated the effectiveness of pressure-controlled ventilation-volume guaranteed (PCV-VG) mode combined with open-lung approach (OLA) in patients during one-lung ventilation (OLV). First, 176 patients undergoing thoracoscopic surgery were allocated randomly to four groups: PCV+OLA (45 cases, PCV-VG mode plus OLA involving application of individualized positive end-expiratory pressure (PEEP) after a recruitment maneuver), PCV (44 cases, PCV-VG mode plus standard lung-protective ventilation with...
Wed Apr 29, 2020 11:35
We aimed to perform a systematic review and meta-analysis on the safety of laparoscopic cholecystectomy performed in the day surgery unit versus those performed in the inpatient unit. Several databases including Ovid Embase, Medline Ovid, Cochrane Central, Web of Science, and Google Scholar were searched from inception through February 2019. Our results revealed that laparoscopic cholecystectomy can be conducted safely and effectively in day surgery units, helping bed shortage.
Wed Apr 29, 2020 11:05
Pancreatic cancer (PC) is one of the most malignant tumors. Despite considerable progress in the treatment of PC, the prognosis of patients with PC is poor. The aim of this study was to identify potential biomarkers for the diagnosis and prognosis of PC. First, the original data of three independent mRNA expression datasets were downloaded from the Gene Expression Omnibus and The Cancer Genome Atlas databases and screened for differentially expressed genes (DEGs) using the R software. Subsequently,...
Wed Apr 29, 2020 10:20
Publication date: June 2020Source: Clinical Neurophysiology, Volume 131, Issue 6Author(s):
Wed Apr 29, 2020 22:30
Publication date: Available online 28 April 2020Source: Clinical NeurophysiologyAuthor(s): Brice Passera, Sylvain Harquel, Laurent Vercueil, Michel Dojat, Arnaud Attye, Olivier David, Alan Chauvin
Wed Apr 29, 2020 22:30
Background The role of imaging in the management of Rosai-Dorfman disease (RDD), a rare non-Langerhans cell histiocytosis, is not clearly defined. We present an analysis of FDG PET/CT findings obtained for initial disease characterization, follow-up evaluation, and treatment planning for this disease. Methods From an institutional pathology database (2001–2018), we identified RDD patients who underwent FDG PET/CT scans either as part of clinical care or when done as part of clinical trials....
Tue Apr 28, 2020 03:00
A 56-year-old man underwent 18F-FDG PET/CT to evaluate possible pancreatic cancer, which was revealed by CT. The images showed a solid lesion with peripherally increased FDG activity in the tail of the pancreas, as well as hypermetabolic lesions in the lumbar spine and rib. Pathological examination following lumbar biopsy demonstrated multiple myeloma. Five months after chemotherapy, follow-up FDG PET/CT showed cystic change in the pancreatic lesion without elevated metabolism. Received for publication...
Tue Apr 28, 2020 03:00
Low back pain with radiation to lower limbs is due to nerve root impingement or involvement in most cases. 18F-FDG PET/CT has shown sacral nerve root involvement in several peripheral nerve pathologies, including neurolymphomatosis, peripheral nerve sheath tumor, and plexopathies. We present 2 cases of a low back pain with ulcerative colitis and metastatic neuroendocrine tumor who underwent 18F-FDG PET/CT and 68Ga-DOTANOC PET/CT, respectively. PET/CT can be used as an adjunct tool to evaluate sacral...
Tue Apr 28, 2020 03:00
A 74-year-old woman with hyperthyroidism was referred for radioiodine therapy. The patient was accidentally given 60 mCi of 177Lu-PSMA orally instead of 131I. Upon discovery of this medical event, we immediately started radiation protective actions including hydration, antiemetics, and laxatives. The patients did not have any symptoms. Static acquisition was performed from the abdominal-pelvic and head and neck regions at 20 and 90 hours after ingestion, which showed prominent intestinal activity...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου