The field of ancient DNA is taxonomically dominated by studies focusing on mammals. This taxonomic bias limits our understanding of endogenous DNA preservation for vertebrate taxa with different bone physiology, such as teleost fish. In contrast to most mammalian bone, teleost bone is typically brittle, porous, lightweight and is characterized by a lack of bone remodeling during growth. Using high-throughput shotgun sequencing, we here investigate the preservation of DNA in a range of different bone...
Wed Apr 29, 2020 03:00
Genetic conflict is considered a key driver in the evolution of new reproductive and sex determining systems. In particular, reproductive strategies with non-Mendelian inheritance, where parents do not contribute equally to the genetic makeup of their offspring. One of the most extraordinary examples of non-Mendelian inheritance is paternal genome elimination (PGE), a form of haplodiploidy which has evolved repeatedly across arthropods. Under PGE, males are diploid but only transmit maternally-inherited...
Wed Apr 29, 2020 03:00
In the prebiotic evolution, molecular self-replicators are considered to develop into diverse, complex living organisms. The appearance of parasitic replicators is believed inevitable in this process. However, the role of parasitic replicators on prebiotic evolution remains elusive. Here, we demonstrated experimental coevolution of RNA self-replicators (host RNAs) and emerging parasitic replicators (parasitic RNAs) for the first time by using an RNA-protein replication system we had developed. During...
Wed Apr 29, 2020 03:00
Microbes are embedded in complex communities where they engage in a wide array of intra- and inter-specific interactions. The extent to which these interactions drive or impede microbiome diversity is not well understood. Two contrasting hypotheses have been put forward to explain how species interactions could influence diversity. 'Ecological Controls' (EC) predicts a negative relationship, where the evolution or migration of novel types is constrained as available niches become filled. In contrast,...
Tue Apr 28, 2020 03:00
Lactococcus lactis is a lactic acid bacterium widely used as starter culture for the manufacture of fermented milk products like quark, buttermilk and cheese. Bacteriophage infection of starter cultures is one of the biggest causes of fermentation failure and, therefore, lactococcal phages have received great attention from the scientific community in the past decades. In this work we present evidence for the establishment of a carrier state life cycle (CSLC) by a bacteriophage belonging to the c2...
Tue Apr 28, 2020 03:00
Thyroid, Ahead of Print.
Tue Apr 28, 2020 10:00
Thyroid, Ahead of Print.
Tue Apr 28, 2020 10:00
Thyroid, Ahead of Print.
Tue Apr 28, 2020 10:00
To the Editor: Data on Covid-19 in patients with immune-mediated inflammatory disease who have received anticytokine biologics, other immunomodulatory therapies, or both on a long-term basis are scarce. Trials to assess the efficacy of antirheumatic therapies such as hydroxychloroquine and…
Wed Apr 29, 2020 03:00
Journal of Neurotrauma, Ahead of Print.
Tue Apr 28, 2020 10:00
Circulating levels of fetuin-A are associated with moderate–severe hepatic steatosis in young adults
Abstract Purpose The hepatokine fetuin-A might have a role as molecular link between non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). The aim of this study was to evaluate the association between fetuin-A and the prevalence and severity of NAFLD in a population of young adults. Methods Ninety-seven adults (age 35.7 ± 12.4 years,...
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Therapeutic Hypothermia and Temperature Management, Ahead of Print.
Tue Apr 28, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Tue Apr 28, 2020 10:00
Abstract Introduction With shifting demographics and declining response rates, state and national health surveys are considering mixed mode approaches. Most states field the Pregnancy Risk Assessment Monitoring System (PRAMS) surveillance project, but few have studied the effect of encouraging online responses. Methods Like PRAMS, the 2016 Ohio Pregnancy...
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Abstract Background Infant nutrition can influence development, eating behaviors and obesity risk. Nearly half of infants in the U.S. are in non-parental care where they consume much of their daily nutrition. Because little is known about the quality of infant nutrition in childcare, the study objective was to characterize the foods and beverages provided to infants in childcare in California. ...
Wed Apr 29, 2020 03:00
Abstract Background Low birth weight (LBW) is associated with significant mortality and morbidity and remains a significant preventable problem. Risk factors include socioeconomic, demographics, and characteristics of the environment. Spatial analysis can uncover unusual frequencies of health problems in neighborhoods, eventually leading to insights for targeted interventions. ...
Wed Apr 29, 2020 03:00
Abstract Introduction Sleep quality and physical activity can affect the mental and physical health of pregnant women and their babies in utero. Methods We investigated the feasibility of objectively assessing sleep quality and physical activity among resource-constrained, pregnant women in urban Lima, Peru. Twenty pregnant women were asked to complete...
Wed Apr 29, 2020 03:00
Abstract Objective To analyze how engagement with a staffed family child network is associated with compliance on health and safety regulations among family day care (FDC) homes. Methods Publically available data on health and safety inspection violations on FDC homes were merged with engagement data from a staffed family child network. Descriptive...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1097: Deactivation of Glutaminolysis Sensitizes PIK3CA-Mutated Colorectal Cancer Cells to Aspirin-Induced Growth Inhibition Cancers doi: 10.3390/cancers12051097 Authors: Shogen Boku Motoki Watanabe Mamiko Sukeno Takeshi Yaoi Kiichi Hirota Mahiro Iizuka-Ohashi Kyoko Itoh Toshiyuki Sakai Aspirin is one of the most promising over-the-counter drugs to repurpose for cancer treatment. In particular, aspirin has been reported to be effective...
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Cancers, Vol. 12, Pages 1116: Chemoembolization Plus Radiotherapy Versus Chemoembolization Plus Sorafenib for the Treatment of Hepatocellular Carcinoma Invading the Portal Vein: A Propensity Score Matching Analysis Cancers doi: 10.3390/cancers12051116 Authors: Chu Kim Shim Yoon Kim Alrashidi A combination of transarterial chemoembolization (TACE) plus sorafenib or radiotherapy (RT) has demonstrated efficacy in patients with advanced hepatocellular carcinoma...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1117: Celecoxib Prevents Doxorubicin-Induced Multidrug Resistance in Canine and Mouse Lymphoma Cell Lines Cancers doi: 10.3390/cancers12051117 Authors: Edina Karai Kornélia Szebényi Tímea Windt Sára Fehér Eszter Szendi Valéria Dékay Péter Vajdovich Gergely Szakács András Füredi Background: Treatment of malignancies is still a major challenge in human and canine cancer, mostly due to the emergence of multidrug resistance (MDR)....
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1114: Improving the Diagnostic Accuracy of the PD-L1 Test with Image Analysis and Multiplex Hybridization Cancers doi: 10.3390/cancers12051114 Authors: Matthew P. Humphries Victoria Bingham Fatima Abdullahi Sidi Stephanie G. Craig Stephen McQuaid Jacqueline James Manuel Salto-Tellez Targeting of the programmed cell death protein (PD-1)/programmed death-ligand 1 (PD-L1) axis with checkpoint inhibitors has changed clinical practice in...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1115: Central Pathology Review in SENTIX, A Prospective Observational International Study on Sentinel Lymph Node Biopsy in Patients with Early-Stage Cervical Cancer (ENGOT-CX2) Cancers doi: 10.3390/cancers12051115 Authors: Nemejcova Kocian Kohler Jarkovsky Klat Berjon Pilka Sehnal Gil-Ibanez Lupo Petiz Sanchez Kascak Martinelli Buda Presl Barahona Lonkhuijzen Szatkowski ...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1113: Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer Cancers doi: 10.3390/cancers12051113 Authors: Elodie Lafont Throughout tumour progression, tumour cells are exposed to various intense cellular stress conditions owing to intrinsic and extrinsic cues, to which some cells are remarkably able to adapt. Death Receptor (DR) signalling and the Unfolded Protein Response (UPR) are two stress responses...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1110: The Prognostic and Predictive Value of SOX2+ Cell Densities in Patients Treated for Colorectal Cancer Cancers doi: 10.3390/cancers12051110 Authors: Tim J. Miller Melanie J. McCoy Tracey F. Lee-Pullen Chidozie C. Anyaegbu Christine Hemmings Max K. Bulsara Cameron F. Platell SOX2 (sex-determining region-Y homeobox-2) is a transcription factor essential for the maintenance of pluripotency and is also associated with stem-cell-like...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1112: Aberrant Expression of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) in Warthin Tumors Cancers doi: 10.3390/cancers12051112 Authors: Robert Mandic Abbas Agaimy Daniel Pinto-Quintero Katrin Roth Afshin Teymoortash Hans Schwarzbach Christine G. Stoehr Fiona R. Rodepeter Boris A. Stuck Michael Bette The Warthin tumor represents the second most frequent benign tumor of the parotid gland and is characterized by the...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1108: The Hippo Pathway Transducers YAP1/TEAD Induce Acquired Resistance to Trastuzumab in HER2-Positive Breast Cancer Cancers doi: 10.3390/cancers12051108 Authors: Paula González-Alonso Sandra Zazo Ester Martín-Aparicio Melani Luque Cristina Chamizo Marta Sanz-Álvarez Pablo Minguez Gonzalo Gómez-López Ion Cristóbal Cristina Caramés Jesús García-Foncillas Pilar Eroles Ana Lluch Oriol Arpí Ana Rovira Joan...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1111: Analysis of a Real-World Cohort of Metastatic Breast Cancer Patients Shows Circulating Tumor Cell Clusters (CTC-clusters) as Predictors of Patient Outcomes Cancers doi: 10.3390/cancers12051111 Authors: Clotilde Costa Laura Muinelo-Romay Victor Cebey-López Thais Pereira-Veiga Inés Martínez-Pena Manuel Abreu Alicia Abalo Ramón M. Lago-Lestón Carmen Abuín Patricia Palacios Juan Cueva Roberto Piñeiro Rafael López-López...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1109: Aberrant Expression of Androgen Receptor Associated with High Cancer Risk and Extrathyroidal Extension in Papillary Thyroid Carcinoma Cancers doi: 10.3390/cancers12051109 Authors: Chen-Kai Chou Shun-Yu Chi Fong-Fu Chou Shun-Chen Huang Jia-He Wang Chueh-Chen Chen Hong-Yo Kang Male gender is a risk factor for mortality in patients with papillary thyroid carcinoma (PTC). This study investigated the impact of androgen receptor (AR)...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1107: STAT3: Versatile Functions in Non-Small Cell Lung Cancer Cancers doi: 10.3390/cancers12051107 Authors: Julian Mohrherr Iris Z. Uras Herwig P. Moll Emilio Casanova Signal Transducer and Activator of Transcription 3 (STAT3) activation is frequently found in non-small cell lung cancer (NSCLC) patient samples/cell lines and STAT3 inhibition in NSCLC cell lines markedly impairs their survival. STAT3 also plays a pivotal role in driving tumor-promoting...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1105: TESC Promotes TGF-α/EGFR-FOXM1-Mediated Tumor Progression in Cholangiocarcinoma Cancers doi: 10.3390/cancers12051105 Authors: Cheng-Han Hsieh Cheng-Ying Chu Sey-En Lin Yu-Chen S.H. Yang Hung-Shu Chang Yun Yen Cholangiocarcinoma is a relatively uncommon but highly lethal malignancy. Improving outcomes in patients depends on earlier diagnosis and appropriate treatment; however, no satisfactory diagnostic biomarkers or targeted therapies...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1106: Molecular and Clinical Relevance of ZBTB38 Expression Levels in Prostate Cancer Cancers doi: 10.3390/cancers12051106 Authors: Maud de Dieuleveult Claire Marchal Anne Jouinot Anne Letessier Benoit Miotto Prostate cancer is one of the most commonly diagnosed cancers in men. A number of genomic and clinical studies have led to a better understanding of prostate cancer biology. Still, the care of patients as well as the prediction of disease...
Wed Apr 29, 2020 03:00
Otitis media with effusion (OME) may occur spontaneously because of poor Eustachian tube function or as an inflammatory response following AOM. Bacterial involvement in OME has been widely reported, with vario...
Wed Apr 29, 2020 03:00
A new way of looking at marine evolution over the past 540 million years has shown that levels of biodiversity in our oceans have remained fairly constant, rather than increasing continuously over the last 200 million years, as scientists previously thought.
Thu Apr 23, 2020 21:30
Cerebral Palsy (CP) is characterised by variable difficulties in muscular action, resulting in inability of the individual to perform functional movement. An option to provide functionality to the individual w...
Wed Apr 29, 2020 03:00
Compensations are commonly observed in patients with stroke when they engage in reaching without supervision; these behaviors may be detrimental to long-term functional improvement. Automatic detection and red...
Tue Apr 28, 2020 03:00
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