Abstract De Garengeot’s hernia is a rare condition defined by the herniation of the vermiform appendix within a femoral hernia sac. We report a case of an 80-year-old woman admitted to our emergency department complaining of pain in the right groin. This symptomatology, present for 2 days, increased in the following 12 h. Ultrasonography (US) and contrast-enhanced computed tomography (CECT) were performed, which showed the herniation of the vermiform appendix in the femoral hernia...
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Background: Psoriasis is an immune-mediated inflammatory skin disease in conjunction with the systemic inflammatory process. It appears to be related to increased risks of cardiovascular disease events, especially in severe cases. The hemostatic balance is disrupted due to the prothrombotic bias in psoriasis, which might be mainly preserved by platelet hyperactivity. Platelets are also immune cells that initiate and regulate immune and inflammatory processes, except as the principal mediator of hemostasis...
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Introduction: In a rapidly aging society, the number of people suffering from osteoporosis keeps increasing. However, effective prevention strategies for osteoporosis are not yet currently available. Objective: In this study, we examined the ameliorative effects of tranexamic acid on osteoporosis in 24-month-old mice. Methods: During the study period, mice were orally administered tranexamic acid 3 times per week. Results: Bone mineral density, which is a parameter of osteoporosis, was improved following...
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Publication date: Available online 28 April 2020Source: Journal of Controlled ReleaseAuthor(s): Tatsuya Fukuta, Yasufumi Oshima, Kohki Michiue, Daichi Tanaka, Kentaro Kogure
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Abstract Relapsed high‐risk neuroblastoma has few effective therapies currently available or in development. Cabozantinib is an Food and Drug Administration approved multitargeted tyrosine kinase inhibitor for select adult malignancies with preclinical data suggesting efficacy against neuroblastoma. A safe and tolerable dose has been identified for children, but its efficacy remains unknown. We describe four children with relapsed metastatic neuroblastoma treated with cabozantinib. All four patients...
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Diverse populations and enrollment in pediatric cancer clinical trials: Challenges and opportunities
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Abstract Covered stents have a continually expanding spectrum of applications for patients with congenital heart disease. Here we report use of covered stents to successfully perform a first‐in‐human percutaneous biventricular conversion of a 1.5 ventricle Glenn palliation in an adult born with pulmonary atresia. This case demonstrates that in patients considered borderline for biventricular repair, surgery can potentially be modified to promote growth of underdeveloped structures and setup for...
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Abstract Objectives To evaluate outcome assessment of percutaneous balloon aortic valvuloplasty (BAV) in different flow and gradient patterns of severe aortic stenosis (AS). Background The mean pressure gradient reduction after BAV is an often‐used surrogate parameter to evaluate procedural success. The definition of a successful BAV has not been evaluated in different subgroups of severe AS, which were introduced in the latest guidelines on the management of patients with valvular...
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Abstract Objectives To evaluate short‐ and middle‐term outcomes after transcatheter patent ductus arteriosus (TC‐PDA) closure in small infants, specifically device‐related left pulmonary artery (LPA) stenosis and aortic coarctation, risk factors, and changes over time. Background Recent studies have demonstrated successful transcatheter PDA (TC‐PDA) closure in small infants. LPA stenosis and aortic coarctation have been seen after TC‐PDA, but it is not clear whether device‐related...
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Publication date: Available online 29 April 2020Source: Cancer CellAuthor(s): Samuel Rubinstein, John A. Steinharter, Jeremy Warner, Brian I. Rini, Solange Peters, Toni K. Choueiri
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Background: Target therapy can cause various cardiovascular complications. The aim of this study was to evaluate the burden of cardiovascular complications related to treatment with anti-BCR-ABL tyrosine kinase inhibitors (TKIs) and to determine if there are differences between the latest- and first-generation TKIs. Methods: A retrospective observational study was carried out on 55 patients (39 men, 16 women; mean age ± SD: 58 ± 11 years) treated with TKIs targeting Bcr-Abl for a median period of...
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Publication date: Available online 28 April 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Diana Pradhan, Jasmin Pradhan, Abtar Mishra, Kapudeep Karmakar, Rohan Dhiman, Dipshikha Chakravortty, Vidya Devi Negi
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Publication date: Available online 28 April 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Liberato Marzullo, Maria Caterina Turco, Margot De Marco
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Related ArticlesPrecision medicine in rare tumors and the need for multicenter trials and international collaboratives: Sinonasal cancer as paradigm. Oral Oncol. 2020 Apr 25;:104737 Authors: Bossi P, Hermsen M, Lechner M, Franchi A PMID: 32340860 [PubMed - as supplied by publisher]
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