Cancers, Vol. 12, Pages 1113: Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer Cancers doi: 10.3390/cancers12051113 Authors: Elodie Lafont Throughout tumour progression, tumour cells are exposed to various intense cellular stress conditions owing to intrinsic and extrinsic cues, to which some cells are remarkably able to adapt. Death Receptor (DR) signalling and the Unfolded Protein Response (UPR) are two stress responses that...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1108: The Hippo Pathway Transducers YAP1/TEAD Induce Acquired Resistance to Trastuzumab in HER2-Positive Breast Cancer Cancers doi: 10.3390/cancers12051108 Authors: Paula González-Alonso Sandra Zazo Ester Martín-Aparicio Melani Luque Cristina Chamizo Marta Sanz-Álvarez Pablo Minguez Gonzalo Gómez-López Ion Cristóbal Cristina Caramés Jesús García-Foncillas Pilar Eroles Ana Lluch Oriol Arpí Ana Rovira Joan Albanell Sander...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1111: Analysis of a Real-World Cohort of Metastatic Breast Cancer Patients Shows Circulating Tumor Cell Clusters (CTC-clusters) as Predictors of Patient Outcomes Cancers doi: 10.3390/cancers12051111 Authors: Clotilde Costa Laura Muinelo-Romay Victor Cebey-López Thais Pereira-Veiga Inés Martínez-Pena Manuel Abreu Alicia Abalo Ramón M. Lago-Lestón Carmen Abuín Patricia Palacios Juan Cueva Roberto Piñeiro Rafael López-López Circulating...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1109: Aberrant Expression of Androgen Receptor Associated with High Cancer Risk and Extrathyroidal Extension in Papillary Thyroid Carcinoma Cancers doi: 10.3390/cancers12051109 Authors: Chen-Kai Chou Shun-Yu Chi Fong-Fu Chou Shun-Chen Huang Jia-He Wang Chueh-Chen Chen Hong-Yo Kang Male gender is a risk factor for mortality in patients with papillary thyroid carcinoma (PTC). This study investigated the impact of androgen receptor (AR) gene expression...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1106: Molecular and Clinical Relevance of ZBTB38 Expression Levels in Prostate Cancer Cancers doi: 10.3390/cancers12051106 Authors: Maud de Dieuleveult Claire Marchal Anne Jouinot Anne Letessier Benoit Miotto Prostate cancer is one of the most commonly diagnosed cancers in men. A number of genomic and clinical studies have led to a better understanding of prostate cancer biology. Still, the care of patients as well as the prediction of disease aggressiveness,...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1105: TESC Promotes TGF-α/EGFR-FOXM1-Mediated Tumor Progression in Cholangiocarcinoma Cancers doi: 10.3390/cancers12051105 Authors: Cheng-Han Hsieh Cheng-Ying Chu Sey-En Lin Yu-Chen S.H. Yang Hung-Shu Chang Yun Yen Cholangiocarcinoma is a relatively uncommon but highly lethal malignancy. Improving outcomes in patients depends on earlier diagnosis and appropriate treatment; however, no satisfactory diagnostic biomarkers or targeted therapies are...
Wed Apr 29, 2020 03:00
Cancers, Vol. 12, Pages 1107: STAT3: Versatile Functions in Non-Small Cell Lung Cancer Cancers doi: 10.3390/cancers12051107 Authors: Julian Mohrherr Iris Z. Uras Herwig P. Moll Emilio Casanova Signal Transducer and Activator of Transcription 3 (STAT3) activation is frequently found in non-small cell lung cancer (NSCLC) patient samples/cell lines and STAT3 inhibition in NSCLC cell lines markedly impairs their survival. STAT3 also plays a pivotal role in driving tumor-promoting...
Wed Apr 29, 2020 03:00
Cells, Vol. 9, Pages 1109: The Histone Variant MacroH2A1 Regulates Key Genes for Myogenic Cell Fusion in a Splice-Isoform Dependent Manner Cells doi: 10.3390/cells9051109 Authors: Sarah Hurtado-Bagès Melanija Posavec Marjanovic Vanesa Valero Roberto Malinverni David Corujo Philippe Bouvet Anne-Claire Lavigne Kerstin Bystricky Marcus Buschbeck MacroH2A histone variants have functions in differentiation, somatic cell reprogramming and cancer. However, at present,...
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Cells, Vol. 9, Pages 1107: Ginsenoside Rg1 Acts as a Selective Glucocorticoid Receptor Agonist with Anti-Inflammatory Action without Affecting Tissue Regeneration in Zebrafish Larvae Cells doi: 10.3390/cells9051107 Authors: Min He Mahmoud Halima Yufei Xie Marcel J. M. Schaaf Annemarie H. Meijer Mei Wang Glucocorticoids are effective anti-inflammatory drugs, but their clinical use is complicated due to the wide range of side effects they induce. Patients requiring glucocorticoid...
Wed Apr 29, 2020 03:00
Cells, Vol. 9, Pages 1106: L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men Cells doi: 10.3390/cells9051106 Authors: Drescher Schippers Rosenhain Gremse Bongiovanni Bruin Eswaran Gallage Pfister Szydlowska Heikenwalder Weiskirchen Wagner Trautwein Weiskirchen Kroy CD62L (L-Selectin) dependent lymphocyte infiltration is known to induce inflammatory bowel disease (IBD), while its function in the...
Wed Apr 29, 2020 03:00
Cells, Vol. 9, Pages 1108: Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS Cells doi: 10.3390/cells9051108 Authors: Illes Rubini Ulrich Zhao Tang Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a process-bearing, ramified/surveying phenotype under resting conditions. Upon activation by cell-damaging factors, they get transformed into an amoeboid phenotype releasing various cell products...
Wed Apr 29, 2020 03:00
Cells, Vol. 9, Pages 1105: Special Issue on “Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis” Cells doi: 10.3390/cells9051105 Authors: Ralf Weiskirchen This Special issue contains 48 contributions highlighting novel findings and current concepts in basic and clinical liver fibrosis research. These articles emphasize issues on pathogenesis, cellular mediators, modulators, molecular pathways, disease-specific therapies, scoring systems, as well as novel...
Wed Apr 29, 2020 03:00
Cells, Vol. 9, Pages 1103: Mouse Gonad Development in the Absence of the Pro-Ovary Factor WNT4 and the Pro-Testis Factor SOX9 Cells doi: 10.3390/cells9051103 Authors: Furong Tang Nainoa Richardson Audrey Albina Marie-Christine Chaboissier Aitana Perea-Gomez The transcription factors SRY and SOX9 and RSPO1/WNT4/β-Catenin signaling act as antagonistic pathways to drive testis and ovary development respectively, from a common gonadal primordium in mouse embryos. In...
Wed Apr 29, 2020 03:00
Cells, Vol. 9, Pages 1102: Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD Cells doi: 10.3390/cells9051102 Authors: Sonali Nashine M. Cristina Kenney Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial‑Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases,...
Wed Apr 29, 2020 03:00
Cells, Vol. 9, Pages 1101: EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats Cells doi: 10.3390/cells9051101 Authors: Amit Kundu Prasanta Dey Jae Hyeon Park In Su Kim Seung Jun Kwack Hyung Sik Kim Sirtuin (SIRT) is known to prevent nonalcoholic fatty liver disease (NAFLD); however, the role of SIRT4 in the progression of hepatic fibrosis remains unknown. We hypothesize that EX-527, a selective SIRT1...
Wed Apr 29, 2020 03:00
Cells, Vol. 9, Pages 1104: Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development Cells doi: 10.3390/cells9051104 Authors: Dolores Ortiz-Masiá Laura Gisbert-Ferrándiz Cristina Bauset Sandra Coll Céline Mamie Michael Scharl Juan V. Esplugues Rafael Alós Francisco Navarro Jesús Cosín-Roger María D. Barrachina Sara Calatayud The pathogenesis of Crohn’s disease-associated fibrostenosis and...
Wed Apr 29, 2020 03:00
Cells, Vol. 9, Pages 1099: A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish Cells doi: 10.3390/cells9051099 Authors: Ashish K. Solanki Altaf A. Kondkar Joseph Fogerty Yanhui Su Seok-Hyung Kim Joshua H. Lipschutz Deepak Nihalani Brian D. Perkins Glenn P. Lobo Dietary vitamin A/all-trans retinol/ROL plays a critical role in human vision. ROL circulates...
Wed Apr 29, 2020 03:00
Cells, Vol. 9, Pages 1098: Targeting the IGF-Axis for Cancer Therapy: Development and Validation of an IGF-Trap as a Potential Drug Cells doi: 10.3390/cells9051098 Authors: Yinhsuan Michely Chen Shu Qi Stephanie Perrino Masakazu Hashimoto Pnina Brodt The insulin-like growth factor (IGF)-axis was implicated in cancer progression and identified as a clinically important therapeutic target. Several IGF-I receptor (IGF-IR) targeting drugs including humanized monoclonal antibodies...
Wed Apr 29, 2020 03:00
Cells, Vol. 9, Pages 1100: P0-Related Protein Accelerates Human Mesenchymal Stromal Cell Migration by Modulating VLA-5 Interactions with Fibronectin Cells doi: 10.3390/cells9051100 Authors: Maria G. Roubelakis Grigorios Tsaknakis Feng-Juan Lyu Ourania Trohatou Andrew C.W. Zannettino Suzanne M. Watt P0-related protein (PZR), a Noonan and Leopard syndrome target, is a member of the transmembrane Immunoglobulin superfamily. Its cytoplasmic tail contains two immune-receptor...
Wed Apr 29, 2020 03:00
Cells, Vol. 9, Pages 1097: Towards a Comprehensive Understanding of UA-ADRCs (Uncultured, Autologous, Fresh, Unmodified, Adipose Derived Regenerative Cells, Isolated at Point of Care) in Regenerative Medicine Cells doi: 10.3390/cells9051097 Authors: Eckhard U. Alt Glenn Winnier Alexander Haenel Ralf Rothoerl Oender Solakoglu Christopher Alt Christoph Schmitz It has become practically impossible to survey the literature on cells derived from adipose tissue for regenerative...
Wed Apr 29, 2020 03:00
Cells, Vol. 9, Pages 1096: Vascular Lipidomic Profiling of Potential Endogenous Fatty Acid PPAR Ligands Reveals the Coronary Artery as Major Producer of CYP450-Derived Epoxy Fatty Acids Cells doi: 10.3390/cells9051096 Authors: Matthew L. Edin Fred B. Lih Bruce D. Hammock Scott Thomson Darryl C. Zeldin David Bishop-Bailey A number of oxylipins have been described as endogenous PPAR ligands. The very short biological half-lives of oxylipins suggest roles as autocrine or...
Wed Apr 29, 2020 03:00
Challenges, Vol. 11, Pages 6: Novel Coronavirus: How Atmospheric Particulate Affects Our Environment and Health Challenges doi: 10.3390/challe11010006 Authors: Luigi Sanità di Toppi Lorenzo Sanità di Toppi Erika Bellini It is well-known that atmospheric pollution, first and foremost the particulate matter (PM), causes serious diseases in humans. China’s metropolises and Italy’s Po Valley have in fact achieved a concerning degree of notoriety thanks to runaway...
Wed Apr 29, 2020 03:00
Climate, Vol. 8, Pages 60: Editorial for the Special Issue “Sustainable Agriculture for Climate Change Adaptation” Climate doi: 10.3390/cli8050060 Authors: Lewis Warner As we lie firmly entrenched within what many have termed the Anthropocene, the time of humans, human influence on the functioning of the planet has never been greater or in greater need of mitigation. Climate change, the accelerated warming of the planet’s surface attributed to human activities, is now...
Wed Apr 29, 2020 03:00
Cosmetics, Vol. 7, Pages 30: Age-Deterring and Skin Care Function of a Polyphenol Rich Sugarcane Concentrate Cosmetics doi: 10.3390/cosmetics7020030 Authors: Jin Ji Xin Yang Matthew Flavel Zenaida P. Shields Julian Neoh Mae-Ling Bowen Barry Kitchen Increasing evidence suggests that environmental stress, such as UV radiation, generates reactive oxygen and nitrogen species in skin cells, leading to histochemical changes including skin disorders and aging, hyper pigmentation,...
Wed Apr 29, 2020 03:00
Cosmetics, Vol. 7, Pages 29: Controlled Release of Retinol in Cationic Co-Polymeric Nanoparticles for Topical Application Cosmetics doi: 10.3390/cosmetics7020029 Authors: Fabien Goudon Yohann Clément Lionel Ripoll Retinol is a compound used in many skin care formulations to act against skin conditions like acne, wrinkles, psoriasis, and ichthyosis. While retinol is used as an active ingredient, its efficacy is limited by an extreme sensitivity to light and temperature. Retinol...
Wed Apr 29, 2020 03:00
Dentistry Journal, Vol. 8, Pages 38: Effect of Hand and Rotary Instruments on the Fracture Resistance of Teeth: An In Vitro Study Dentistry Journal doi: 10.3390/dj8020038 Authors: Nisha Acharya Md Riasat Hasan Dashrath Kafle Anil Chakradhar Takashi Saito Objective: Endodontic treatment should be both conservative and effective. Endodontic instruments with a greater taper are used for coronal flaring, for proper debridement with efficient irrigation. However, increased taper...
Wed Apr 29, 2020 03:00
Diagnostics, Vol. 10, Pages 268: Role of Peroral Cholangioscopy in the Diagnosis of Primary Sclerosing Cholangitis Diagnostics doi: 10.3390/diagnostics10050268 Authors: Toshio Fujisawa Mako Ushio Sho Takahashi Wataru Yamagata Yusuke Takasaki Akinori Suzuki Yoshihiro Okawa Kazushige Ochiai Ko Tomishima Shigeto Ishii Hiroaki Saito Hiroyuki Isayama Primary sclerosing cholangitis (PSC) is characterized by idiopathic biliary stricture followed by progressive...
Wed Apr 29, 2020 03:00
Diagnostics, Vol. 10, Pages 267: Consistency of Trans-Abdominal and Water-Immersion Ultrasound Images of Diseased Intestinal Segments in Crohn’s Disease Diagnostics doi: 10.3390/diagnostics10050267 Authors: Feiqian Wang Kazushi Numata Hiromi Yonezawa Kana Sato Yoshito Ishii Katsuki Yaguchi Nao Kume Yu Hashimoto Masafumi Nishio Yoshinori Nakamori Aya Ikeda Akira Madarame Atsuhiro Hirayama Tsuyoshi Ogashiwa Tomohiko Sasaki Misato Jin Akiho Hanzawa...
Wed Apr 29, 2020 03:00
Diagnostics, Vol. 10, Pages 264: Pathophysiology of Hip Disorders in Patients with Mucopolysaccharidosis IVA Diagnostics doi: 10.3390/diagnostics10050264 Authors: Zhigang Wang Yunlan Xu Enze Jiang Jianmin Wang Shunji Tomatsu Kaiying Shen Patients with mucopolysaccharidoses IVA (MPS IVA) have a progressive accumulation of the specific glycosaminoglycans (GAGs): chondroitin-6-sulfate (C6S) and keratan sulfate (KS), leading to the degeneration of the cartilage matrix and...
Wed Apr 29, 2020 03:00
Diagnostics, Vol. 10, Pages 265: miR-196B-5P and miR-200B-3P Are Differentially Expressed in Medulloblastomas of Adults and Children Diagnostics doi: 10.3390/diagnostics10050265 Authors: Michela Visani Gianluca Marucci Dario de Biase Felice Giangaspero Francesca Romana Buttarelli Alba Ariela Brandes Enrico Franceschi Giorgia Acquaviva Alessia Ciarrocchi Kerry Jane Rhoden Giovanni Tallini Annalisa Pession Medulloblastoma is a highly aggressive brain tumor...
Wed Apr 29, 2020 03:00
Diagnostics, Vol. 10, Pages 263: The Influence of Methylating Mutations on Acute Myeloid Leukemia: Preliminary Analysis on 56 Patients Diagnostics doi: 10.3390/diagnostics10050263 Authors: Sergiu Pasca Cristina Turcas Ancuta Jurj Patric Teodorescu Sabina Iluta Ionut Hotea Anca Bojan Cristina Selicean Bogdan Fetica Bobe Petrushev Vlad Moisoiu Alina-Andreea Zimta Valentina Sas Catalin Constantinescu Mihnea Zdrenghea Delia Dima Ciprian Tomuleasa...
Wed Apr 29, 2020 03:00
Diagnostics, Vol. 10, Pages 266: Association of Carbonic Anhydrase 9 Polymorphism and the Epithelial Growth Factor Receptor Mutations in Lung Adenocarcinoma Patients Diagnostics doi: 10.3390/diagnostics10050266 Authors: Ya-Yen Yu Hui-Ling Chiou Shih-Ming Tsao Chen-Cheng Huang Chih-Yun Lin Chia-Yi Lee Thomas Chang-Yao Tsao Shun-Fa Yang Yi-Wen Huang Carbonic anhydrase 9 (CA9) plays a vital role in lung cancer progression. The current study explored the effect of...
Wed Apr 29, 2020 03:00
Diagnostics, Vol. 10, Pages 262: Cryptogenic Organizing Pneumonia: Evolution of Morphological Patterns Assessed by HRCT Diagnostics doi: 10.3390/diagnostics10050262 Authors: Francesco Tiralongo Monica Palermo Giulio Distefano Ada Vancheri Gianluca Sambataro Sebastiano Emanuele Torrisi Federica Galioto Agata Ferlito Giulia Fazio Pietro Valerio Foti Letizia Antonella Mauro Carlo Vancheri Stefano Palmucci Antonio Basile To evaluate the radiological...
Wed Apr 29, 2020 03:00
Environments, Vol. 7, Pages 34: Long-Term Environmental Monitoring in an Arctic Lake Polluted by Metals under Climate Change Environments doi: 10.3390/environments7050034 Authors: Zubova Kashulin Dauvalter Denisov Valkova Vandysh Slukovskii Terentyev Cherepanov Lake Kuetsjarvi (in the lower reaches of the Pasvik River, Murmansk Region, Russia) in the border area between Russia and Norway, is one of the most polluted water reservoirs in the European Arctic....
Wed Apr 29, 2020 03:00
Fermentation, Vol. 6, Pages 48: Impact of Genotype, Environment, and Malting Conditions on the Antioxidant Activity and Phenolic Content in US Malting Barley Fermentation doi: 10.3390/fermentation6020048 Authors: Bing Zhou Zhao Jin Paul Schwarz Yin Li The phenolic content and antioxidant potential of malting barley are important in brewing. The objective of our study was to investigate the effects of barley genotype, growing environment, and malting conditions on the total phenolic...
Wed Apr 29, 2020 03:00
Foods, Vol. 9, Pages 541: Brewing Quality of Hop Varieties Cultivated in Central Italy Based on Multivolatile Fingerprinting and Bitter Acid Content Foods doi: 10.3390/foods9050541 Authors: Massimo Mozzon Roberta Foligni Cinzia Mannozzi The brewing value of hops is mainly affected by the content and composition of humulones (α-acids) and essential oil. Interest in hop plantations is increasing more and more in Italy, in parallel with the rising number of microbreweries...
Wed Apr 29, 2020 03:00
Healthcare, Vol. 8, Pages 117: Comparison of the Measurement of Long-Term Care Costs between China and Other Countries: A Systematic Review of the Last Decade Healthcare doi: 10.3390/healthcare8020117 Authors: Qingjun Zeng Qingqing Wang Lu Zhang Xiaocang Xu Background: The rapid aging of populations in some countries has led to a growing number of the disabled elderly, creating a huge need for Long-Term Care (LTC) and meeting its costs, which is a heavy economic burden on the...
Wed Apr 29, 2020 03:00
IJERPH, Vol. 17, Pages 3115: Burnout in Gastroenterology Unit Nurses International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17093115 Authors: Andreea Iulia Socaciu Razvan Ionut Maria Barsan Andreea Petra Ungur Armand Gabriel Rajnoveanu (1) Background: Burnout syndrome is a significant problem in nursing professionals but may be dependent on the type of care that they provide. The objectives of our study are to identify and explore risk factors...
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IJERPH, Vol. 17, Pages 3111: Reply to "Comment on: Effects of Nigella Sativa on Type-2 Diabetes Mellitus: A Systematic Review" International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17093111 Authors: Hamdan Idrus Mokhtar Thank you for your interest and the comments [1] on our review article “Effects of Nigella Sativa on Type-2 Diabetes Mellitus: A Systematic Review” [2]; we believe research into natural products needs to be supported,...
Wed Apr 29, 2020 03:00
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