Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Mon Apr 27, 2020 14:15
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Mon Apr 27, 2020 14:11
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Mon Apr 27, 2020 13:05
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Mon Apr 27, 2020 12:30
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Mon Apr 27, 2020 12:27
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Mon Apr 27, 2020 11:24
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Mon Apr 27, 2020 09:15
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Mon Apr 27, 2020 08:42
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Mon Apr 27, 2020 08:41
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Mon Apr 27, 2020 08:06
Journal of International Medical Research, Volume 48, Issue 4, April 2020.
Mon Apr 27, 2020 08:04
Background: US health care is increasingly defined by over expenditure and inefficiency. Optimizing patient follow-up is critical, especially in cancers treated with high control rates. To optimize patient care, this study assessed time to disease recurrence or toxicity in patients with anal carcinoma. Materials and Methods: In total, 140 patients with biopsy-proven, nonmetastatic anal carcinoma, treated with chemoradiation utilizing intensity-modulated radiation therapy, were identified...
Sat Apr 25, 2020 01:45
Objectives: To report long-term outcomes of nonmelanoma skin cancer (NMSC) in immunosuppressed cardiac and liver transplant recipients (CLTR). Materials and Methods: The authors reviewed CLTR at the Mayo Clinic in Arizona from 1986 to 2013. Patient and tumor characteristics were recorded. Survival rates were calculated using the Kaplan-Meier method. Patient-specific and lesion-specific analyses were performed. Univariate and multivariate cox regressions were performed for comparisons. Results:...
Sat Apr 25, 2020 01:45
Objective: The objective of this study was to compare posttransplant outcomes in patients undergoing bridging locoregional therapy (LRT) with Y-90 transarterial radioembolization (TARE) based protocol compared with transarterial chemoembolization based protocol for hepatocellular carcinoma (HCC) prior liver transplantation (LT). Materials and Methods: Patients listed for LT with HCC within the Milan criteria at our center who had bridging LRT were treated according to transarterial chemoembolization...
Sat Apr 25, 2020 01:45
Objectives: Gastrointestinal neuroendocrine carcinoma (NEC) is a lethal, uncommon, and understudied neoplasm. We present the efficacy and safety of first-line capecitabine (CP), oxaliplatin, irinotecan, and bevacizumab (CAPOXIRI-BEV) combination followed by pazopanib plus CP maintenance therapy in patients with advanced high-grade poorly differentiated gastrointestinal NEC. Methods: This was a two-stage phase II study conducted at multiple institutions. Patients were consecutively enrolled...
Sat Apr 25, 2020 01:45
Background: Preoperative chemotherapy is important in the management of women with breast cancer, with the ability to downstage the breast primary tumor and axillary lymph nodes. Long-term studies are needed to identify late toxicities, recurrence patterns, and equivalency with postoperative chemotherapy for recurrence-free survival (RFS) and overall survival (OS). Patients and Methods: We conducted a single-institution prospective randomized control trial comparing preoperative or postoperative...
Sat Apr 25, 2020 01:45
Objectives: Small cell lung cancer (SCLC) is an aggressive disease treated as soon as possible given its rapid doubling time. Evidence for the appropriate time to chemotherapy initiation (TCI) for SCLC is lacking. This study evaluated TCI in SCLC on a national level. Materials and Methods: The National Cancer Database identified 64,491 SCLC patients treated with chemotherapy from 2010 to 2014. Factors associated with TCI were identified with multiple linear regression analyses. TCI was categorized...
Sat Apr 25, 2020 01:45
Objective: The authors conducted a cost-effectiveness analysis incorporating recent phase III clinical trial (IMpassion130) data to evaluate the cost-effectiveness of atezolizumab in combination with nab-paclitaxel (AnP) against nab-paclitaxel alone as the first-line treatment for advanced triple-negative breast cancer in developed and developing countries. Materials and Methods: A decision-analytic Markov model was developed using IMpassion130 data to evaluate the cost-effectiveness of AnP...
Sat Apr 25, 2020 01:45
Multiple myeloma (MM) is an incurable malignancy of plasma cells. Recently multiple new therapeutic options have been introduced which was able to improve overall survival but ultimately patient become refractory specifically in patients with poor cytogenetics. Therefore, novel therapeutic options like immunotherapy are needed to improve outcomes. Chimeric antigen receptor (CAR) T-cell therapy is immunotherapy in which T cell are genetically engineered against a tumor-specific antigen and transfused...
Sat Apr 25, 2020 01:45
Objective: The objective of this study was to understand recent trends in direct health care expenditures among cancer survivors using novel cost-estimation methods and a nationally representative database. Materials and Methods: This study was a retrospective analysis of 193,003 adults, ≥18 years of age, using the Medical Expenditure Panel Survey during the years 2009-2016. Manning and Mullahy two-part model was used to calculate adjusted mean and incremental medical expenditures after adjusting...
Sat Apr 25, 2020 01:45
No abstract available
Sat Apr 25, 2020 01:45
Late recurrence of prostate cancer after remission with prior radical prostatectomy is uncommon. This is a unique case of biochemical recurrence after being in remission for 12 years. The patient presented with swelling of the right lower extremity with pelvic MRI demonstrating an arterially enhancing filling defect in the right common iliac. An 18F-fluciclovine PET/CT showed corresponding increased intravascular radiotracer activity. Targeted biopsy of the intravascular lesion showed poorly differentiated...
Tue Apr 21, 2020 03:00
We describe a case of a 5-year-old boy with a history of intermittent melena underwent 99mTcO4− scintigraphy. On dynamic images, no abnormal activity was noted. After voiding and also in the lateral view, the focus of activity was noted in the superior and anterior aspect of the urinary bladder, compatible with a Meckel's diverticulum, which was confirmed pathologically as well. Received for publication January 20, 2020; revision accepted February 10, 2020. Conflicts of interest and sources...
Tue Apr 21, 2020 03:00
68Ga-FAPI PET/CT was performed in a 56-year-old cirrhotic patient with multiple liver nodules, which were suspected of hepatocellular carcinoma by contrast-enhanced magnetic resonance but were not visualized by 18F-FDG PET/CT. Increased 68Ga-FAPI liver uptake was observed in this cirrhotic patient. However, the nodules had no pathological 68Ga-FAPI uptake and were clearly visualized due to the low activity compared with surrounding liver parenchyma. The 68Ga-FAPI PET/CT features, suggestive of benign...
Tue Apr 21, 2020 03:00
A 72-year-old man, who is known with a case of metastatic carcinoma of the breast, was referred for 18F-PMSA 1007 PET/CT with clinical suspicion of synchronous prostate cancer. 18F-PSMA 1007 PET/CT scan detected no abnormal tracer concentrating lesion in the prostate gland; however, abnormal tracer concentration was noted in soft tissue lesions in left breast, metastatic lymph nodes, and skeletal lesions. Compared with 18F-FDG PET/CT, more bone lesions were detected on 18F-PSMA 1007 imaging. The...
Tue Apr 21, 2020 03:00
DOTA-D-Phe1-Tyr3-octreotide labeled with 68Ga (68Ga-DOTATOC) is the commonly used PET tracer for imaging meningioma because of its high affinity to somatostatin receptor subtype 2 (SSTR2) and an established imaging modality for planning radiation and radionuclide therapy. However, SSTR2 is not an exclusive marker for meningioma, and not all meningiomas express high levels of SSTR2. The SSTR2 expression has been reported in other intracranial tumors, for example, glioma, pituitary adenoma, medullablastoma,...
Tue Apr 21, 2020 03:00
Hyperestrogenism on 18F-FDG PET/CT in a Patient With Estrogen-Producing Ovarian Clear Cell Carcinoma
A 78-year-old woman was referred to the gynecologic outpatient department because she was suspected of having ovarian cancer based on an imaging study performed during a general medical examination. Further examination using 18F-FDG PET/CT revealed a bulky mass lesion with low FDG avidity, as well as surprisingly strong bilateral breast radiotracer uptake despite the patient's age. Thus, an estrogen-producing tumor was suspected. Bilateral salpingo-oophorectomy was performed, and surgical pathology...
Tue Apr 21, 2020 03:00
Primary central nervous system lymphoma is an extranodal lymphoma originating in the brain, spinal cord, and leptomeninges, which rarely spreads outside the nervous system. Neurolymphomatosis is the term used to describe lymphomatous involvement of the cranial nerves (except optic nerve) and peripheral nerve roots or plexus. We report a case of a 23-year-old man presented with progressive weakness of all 4 limbs. 18F-FDG PET/CT revealed FDG-avid thickening along the multiple cranial nerve roots,...
Tue Apr 21, 2020 03:00
We describe the extrastriatal accumulation of dopamine transporter imaging agent 99mTc-TRODAT in the peri-infarct area in a 75-year-old man referred for dopamine transporter SPECT imaging with a suspicion of idiopathic Parkinson disease. Received for publication February 5, 2020; revision accepted February 7, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Madhavi Tripathi, MD, DNB, Department of Nuclear Medicine, RAK OPD, Block Ansari Nagar AIIMS,...
Tue Apr 21, 2020 03:00
In the present case, we report the first experience of a patient with high-grade glioma who underwent dual 18F-FAZA PET/CT imaging for intratumoral hypoxia assessment, before treatment, and for therapy monitoring in the suspicious of recurrence, as part of a clinical research protocol. In addition, despite the diagnosis of glioblastoma, the patient at 3 years from diagnosis was alive and underwent 11C-methionine simultaneous PET/MRI for disease monitoring after treatment, showing stability of disease....
Tue Apr 21, 2020 03:00
Using real-time SPECT/US fusion imaging, the localization of an uptake defect in DMSA scan could be identified unambiguously after being uncertain in ultrasound alone. Thereby, a localized functional loss, due to history of pyelonephritis, without scarring, but reduced cortical thickness could be verified. DMSA-SPECT/US primarily demonstrates its utility in depiction of renal pathologies and may be a descriptive tool in equivocal constellation of findings. Received for publication April 29, 2019;...
Tue Apr 21, 2020 03:00
Colon Adenocarcinoma Associated With Clostridium Septicum Endophthalmitis Detected on 18F-FDG PET/CT
Endogenous Clostridium septicum endophthalmitis is a rare and fulminant ocular infection, usually encountered in immunocompromised or diabetic patients. It is also highly associated with both gastrointestinal and hematologic malignancies. We describe herein the detection of an adenocarcinoma of the cecum on PET/CT with 18F-FDG in a patient with an active endogenous C. septicum endophthalmitis of the right eye. FDG PET/CT should be considered for all patients with endogenous endophthalmitis to exclude...
Tue Apr 21, 2020 03:00
A 34-year-old woman, after being treated for cervical cancer, presented with severe pain in the inguinal and the upper abdominal region with restriction in range of motion of the trunk 71 days after radiation therapy and 19 days after receiving adjuvant gemcitabine and cisplatin chemotherapy. The 18F-FDG PET/CT showed complete response to cancer treatment, but also revealed a localized inflammatory process that was delimited by radiation fields rather than anatomical structures, suggesting a radiation...
Tue Apr 21, 2020 03:00
Pancreatic disease can be associated with polyarthritis and panniculitis in a small number of patients, and this triad constitutes PPP syndrome. Early diagnosis is critical as it has high morbidity and mortality. Panniculitis can occur in fat present anywhere in the body. Involvement of fat in bone marrow is relatively uncommon, and radiologic imaging shows osteolytic lesions involving long bones. Here we present a case of acute pancreatitis, referred to our department for evaluation of severe joint...
Tue Apr 21, 2020 03:00
Only a few studies and images of 99mTc-besilesomab scintigraphy are documented in the literature. We present a 99mTc-besilesomab image consistent with soft tissue infection of the lower limbs in a febrile 67-year-old man. Received for publication October 3, 2019; revision accepted February 16, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Patrícia Gouveia, MS, Nuclear Medicine Department, Centro Hospitalar e Universitário do Porto, Largo do Prof....
Tue Apr 21, 2020 03:00
The majority of glomus tumors are localized to cutaneous sites and are benign. However, extracutaneous malignant glomus tumors have been reported and are aggressive. Here, we report a case of a 45-year-old man who presented severe dysphagia, diagnosed with malignant glomus tumor of the esophagus. 18F-FDG PET/CT played a decisive role in several phases of the patient management offering previously unknown accuracy. It was first performed in the initial staging of local tumor extent before surgery....
Tue Apr 21, 2020 03:00
Renal medullary carcinoma is a rare and highly aggressive tumor seen almost exclusively in young individuals of African descent with sickle cell disease. Here, we describe a case of a 29-year-old man, who did not have sickle cell disease, with pathologically confirmed renal medullary carcinoma using dual-time FDG PET/CT. Received for publication October 22, 2019; revision accepted February 15, 2020. G.H. and Y.J. contributed equally to this work. Conflicts of interest and sources of funding:...
Tue Apr 21, 2020 03:00
A 39-year-old man presented with progressive painful swelling on the left chest since 6 months. Examination revealed osseous consistency mass. CT of the thorax suggested mass arising from left fourth rib with intrathoracic and extrathoracic soft tissue components. It had extensive sunburst periosteal reaction consistent with primary malignant bone tumor. True cut biopsy revealed plasmacytoma. Routine hematological, biochemical, and bone marrow examinations were normal. Patient referred for whole-body...
Tue Apr 21, 2020 03:00
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