Antibiotics, Vol. 9, Pages 200: Investigating Bacteriophages Targeting the Opportunistic Pathogen Acinetobacter baumannii Antibiotics doi: 10.3390/antibiotics9040200 Authors: Kathryn M. Styles Rapee Thummeepak Udomluk Leungtongkam Sophie E. Smith Gabrielle S. Christie Andrew Millard John Moat Christopher G. Dowson Elizabeth M. H. Wellington Sutthirat Sitthisak Antonia P. Sagona The multi-drug resistance of the opportunistic pathogen Acinetobacter baumannii...
Wed Apr 22, 2020 03:00
Antibiotics, Vol. 9, Pages 199: Pharmacokinetics of Macrolide Antibiotics and Transport into the Interstitial Fluid: Comparison among Erythromycin, Clarithromycin, and Azithromycin Antibiotics doi: 10.3390/antibiotics9040199 Authors: Shinji Kobuchi Teruhiko Kabata Koki Maeda Yukako Ito Toshiyuki Sakaeda Recent research has found higher levels and longer total exposure of azithromycin, a macrolide antibiotic agent, in the interstitial fluid of the skin than in the plasma....
Wed Apr 22, 2020 03:00
Antioxidants, Vol. 9, Pages 342: Pure Trans-Resveratrol Nanoparticles Prepared by A Supercritical Antisolvent Process Using Alcohol and Dichloromethane Mixtures: Effect of Particle Size on Dissolution and Bioavailability in Rats Antioxidants doi: 10.3390/antiox9040342 Authors: Eun-Sol Ha Heejun Park Seon-Kwang Lee Woo-Yong Sim Ji-Su Jeong In-hwan Baek Min-Soo Kim The aim of this study was to prepare pure trans-resveratrol nanoparticles without additives (surfactants,...
Wed Apr 22, 2020 03:00
Antioxidants, Vol. 9, Pages 343: Phenolic Compounds and Bioaccessibility Thereof in Functional Pasta
Antioxidants, Vol. 9, Pages 343: Phenolic Compounds and Bioaccessibility Thereof in Functional Pasta Antioxidants doi: 10.3390/antiox9040343 Authors: Valentina Melini Francesca Melini Rita Acquistucci Consumption of food products rich in phenolic compounds has been associated to reduced risk of chronic disease onset. Daily consumed cereal-based products, such as bread and pasta, are not carriers of phenolic compounds, since they are produced with refined flour or semolina. Novel...
Wed Apr 22, 2020 03:00
Antioxidants, Vol. 9, Pages 341: Coenzyme Q10: Clinical Applications in Cardiovascular Diseases Antioxidants doi: 10.3390/antiox9040341 Authors: Alma Martelli Lara Testai Alessandro Colletti Arrigo F. G. Cicero Coenzyme Q10 (CoQ10) is a ubiquitous factor present in cell membranes and mitochondria, both in its reduced (ubiquinol) and oxidized (ubiquinone) forms. Its levels are high in organs with high metabolism such as the heart, kidneys, and liver because it acts as an energy...
Wed Apr 22, 2020 03:00
Atmosphere, Vol. 11, Pages 424: Projecting Changes in Temperature Extremes in the Han River Basin of China using Downscaled CMIP5 Multi-model Ensembles Atmosphere doi: 10.3390/atmos11040424 Authors: Xiao Wang Liu Feng Estimating the changes in the spatial–temporal characteristics of extreme temperature events under future climate scenarios is critical to provide reference information to help mitigate climate change. In this study, we analyzed 16 extreme temperature...
Wed Apr 22, 2020 03:00
Atmosphere, Vol. 11, Pages 425: A Budget-Based Turbulence Length Scale Diagnostic Atmosphere doi: 10.3390/atmos11040425 Authors: Ivan Bašták Ďurán Juerg Schmidli Ritthik Bhattacharya The most frequently used boundary-layer turbulence parameterization in numerical weather prediction (NWP) models are turbulence kinetic energy (TKE) based-based schemes. However, these parameterizations suffer from a potential weakness, namely the strong dependence on an ad-hoc quantity, the so-called...
Wed Apr 22, 2020 03:00
Atmosphere, Vol. 11, Pages 423: Estimating Tropical Cyclone Intensity in the South China Sea Using the XGBoost Model and FengYun Satellite Images Atmosphere doi: 10.3390/atmos11040423 Authors: Qingwen Jin Xiangtao Fan Jian Liu Zhuxin Xue Hongdeng Jian Conventional numerical methods have made significant advances in forecasting tropical cyclone (TC) tracks, using remote sensing data with high spatial and temporal resolutions. However, over the past two decades, no significant...
Wed Apr 22, 2020 03:00
Atmosphere, Vol. 11, Pages 422: Modelling Cyclists’ Multi-Exposure to Air and Noise Pollution with Low-Cost Sensors—The Case of Paris Atmosphere doi: 10.3390/atmos11040422 Authors: Jérémy Gelb Philippe Apparicio Cyclists are particularly exposed to air and noise pollution because of their higher ventilation rate and their proximity to traffic. However, few studies have investigated their multi-exposure and have taken into account its real complexity in building statistical models...
Wed Apr 22, 2020 03:00
Atmosphere, Vol. 11, Pages 420: Partitioning Waves and Eddies in Stably Stratified Turbulence Atmosphere doi: 10.3390/atmos11040420 Authors: Henri Lam Alexandre Delache Fabien S Godeferd We consider the separation of motion related to internal gravity waves and eddy dynamics in stably stratified flows obtained by direct numerical simulations. The waves’ dispersion relation links their angle of propagation to the vertical θ , to their frequency ω...
Wed Apr 22, 2020 03:00
Atmosphere, Vol. 11, Pages 421: Morphology of the Wavenumber 1 and Wavenumber 2 Stratospheric Kelvin Waves using the Long-Term Era-Interim Reanalysis Dataset Atmosphere doi: 10.3390/atmos11040421 Authors: Pan Yang Das Chen The atmospheric Kelvin wave has been widely studied due to its importance in atmospheric dynamics. Since a long-term climatological study is absent in the literature, we have employed the two-dimensional fast Fourier transform (2D-FFT) method for the 40-year...
Wed Apr 22, 2020 03:00
Biology, Vol. 9, Pages 84: The Impact of Insurance and Marital Status on Survival in Patients with Nasopharyngeal Carcinoma Biology doi: 10.3390/biology9040084 Authors: Chih-Chun Wang Ching-Chieh Yang Shyh-An Yeh Chung-I Huang Tzer-Zen Hwang Chuan-Chien Yang Yu-Chieh Su Objective: This study aimed to explore the influence of social support on the survival outcomes of patients with nasopharyngeal carcinoma (NPC). We examined whether the combined proxy influenced whether...
Wed Apr 22, 2020 03:00
Biology, Vol. 9, Pages 83: Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study Biology doi: 10.3390/biology9040083 Authors: Tatiana V. Kirichenko Igor A. Sobenin Yuliya V. Markina Elena V. Gerasimova Andrey V. Grechko Dmitry A. Kashirskikh Elena B. Romanenko Wei-Kai Wu Alexander N. Orekhov Chronic obstructive pulmonary...
Wed Apr 22, 2020 03:00
Biomedicines, Vol. 8, Pages 94: Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates Biomedicines doi: 10.3390/biomedicines8040094 Authors: Miriam Saiz-Rodríguez Susana Almenara Marcos Navares-Gómez Dolores Ochoa Manuel Román Pablo Zubiaur Dora Koller María Santos Gina Mejía Alberto M. Borobia Cristina Rodríguez-Antona Francisco Abad-Santos Several cytochrome P450 (CYP) CYP3A polymorphisms...
Wed Apr 22, 2020 03:00
Biomolecules, Vol. 10, Pages 649: Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists Biomolecules doi: 10.3390/biom10040649 Authors: Silvana Vasile Anders Hallberg Jessica Sallander Mathias Hallberg Johan Åqvist Hugo Gutiérrez-de-Terán Angiotensin II receptor type 1 and 2 (AT1R and AT2R) are two G-protein coupled receptors that mediate most biological functions of the octapeptide Angiotensin II (Ang II). AT2R...
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Biomolecules, Vol. 10, Pages 648: Src/NF-κB-Targeted Anti-Inflammatory Effects of Potentilla glabra var. Mandshurica (Maxim.) Hand.-Mazz. Ethanol Extract Biomolecules doi: 10.3390/biom10040648 Authors: Kim Shin Kim Jo Kim Lee Choung Li Lee Kim Yoo Cho Inflammation is a complex protective response of body tissues to harmful stimuli. Acute inflammation can progress to chronic inflammation, which can lead to severe disease. Therefore, this research...
Wed Apr 22, 2020 03:00
Biomolecules, Vol. 10, Pages 647: The Cytosolic Phospholipase A2α N-terminal C2 Domain Binds and Oligomerizes on Membranes with Positive Curvature Biomolecules doi: 10.3390/biom10040647 Authors: Ward Sengupta Ropa Amiar Stahelin Group IV phospholipase A2α (cPLA2α) regulates the production of prostaglandins and leukotrienes via the formation of arachidonic acid from membrane phospholipids. The targeting and membrane binding of cPLA2α to the...
Wed Apr 22, 2020 03:00
Biomolecules, Vol. 10, Pages 646: 3D Chitin Scaffolds from the Marine Demosponge Aplysina archeri as a Support for Laccase Immobilization and Its Use in the Removal of Pharmaceuticals Biomolecules doi: 10.3390/biom10040646 Authors: Jakub Zdarta Tomasz Machałowski Oliwia Degórska Karolina Bachosz Andriy Fursov Hermann Ehrlich Viatcheslav N. Ivanenko Teofil Jesionowski For the first time, 3D chitin scaffolds from the marine demosponge Aplysina archeri were used for...
Wed Apr 22, 2020 03:00
Biomolecules, Vol. 10, Pages 645: High-Density Lipoprotein Cholesterol in Age-Related Ocular Diseases Biomolecules doi: 10.3390/biom10040645 Authors: Bjorn Kaijun Betzler Tyler Hyungtaek Rim Charumathi Sabanayagam Chui Ming Gemmy Cheung Ching-Yu Cheng There is limited understanding of the specific role of high-density lipoprotein cholesterol (HDL-C) in the development of various age-related ocular diseases, despite it being a common measurable biomarker in lipid profiles....
Wed Apr 22, 2020 03:00
Brain Sciences, Vol. 10, Pages 249: Trajectories of Immediate and Delayed Verbal Memory in the Spanish General Population of Middle-aged and Older Adults Brain Sciences doi: 10.3390/brainsci10040249 Authors: Ivet Bayes-Marin Daniel Fernández Elvira Lara Natalia Martín-María Marta Miret Darío Moreno-Agostino José Luis Ayuso-Mateos Albert Sanchez-Niubo Josep Maria Haro Beatriz Olaya (1) Cognitive decline differs among individuals and cognition function domains....
Wed Apr 22, 2020 03:00
Brain Sciences, Vol. 10, Pages 248: Evaluating Social Interactions Using the Autism Screening Instrument for Education Planning-3rd Edition (ASIEP-3): Interaction Assessment in Children and Adults with Fragile X Syndrome Brain Sciences doi: 10.3390/brainsci10040248 Authors: Lisa Cordeiro Marcia Braden Elizabeth Coan Nanastasia Welnick Tanea Tanda Nicole Tartaglia An efficient and direct measure of social interactions and autism symptoms is needed for fragile X syndrome...
Wed Apr 22, 2020 03:00
Brain Sciences, Vol. 10, Pages 247: The Supplementary Motor Area Responsible for Word Retrieval Decline After Acute Thalamic Stroke Revealed by Coupled SPECT and Near-Infrared Spectroscopy Brain Sciences doi: 10.3390/brainsci10040247 Authors: Shigeru Obayashi Damage to the thalamus may affect cognition and language, but the underlying mechanism remains unknown. In particular, it remains a riddle why thalamic aphasia occasionally occurs and then mostly recovers to some degree. To explore...
Wed Apr 22, 2020 03:00
Cancers, Vol. 12, Pages 1029: A Novel Antibody-Drug Conjugate (ADC) Delivering a DNA Mono-Alkylating Payload to Chondroitin Sulfate Proteoglycan (CSPG4)-Expressing Melanoma Cancers doi: 10.3390/cancers12041029 Authors: Ricarda M. Hoffmann Silvia Crescioli Silvia Mele Eirini Sachouli Anthony Cheung Connie K. Chui Paolo Andriollo Paul J. M. Jackson Katie E. Lacy James F. Spicer David E. Thurston Sophia N. Karagiannis Despite emerging targeted and immunotherapy...
Wed Apr 22, 2020 03:00
Cancers, Vol. 12, Pages 1031: The Mitochondrial Protein VDAC1 at the Crossroads of Cancer Cell Metabolism: The Epigenetic Link Cancers doi: 10.3390/cancers12041031 Authors: Zohar Amsalem Tasleem Arif Anna Shteinfer-Kuzmine Vered Chalifa-Caspi Varda Shoshan-Barmatz Carcinogenesis is a complicated process that involves the deregulation of epigenetics, resulting in cellular transformational events, such as proliferation, differentiation, and metastasis. Most chromatin-modifying...
Wed Apr 22, 2020 03:00
Cancers, Vol. 12, Pages 1026: Single Radiotherapy Fraction with Local Anti-CD40 Therapy Generates Effective Abscopal Responses in Mouse Models of Cervical Cancer Cancers doi: 10.3390/cancers12041026 Authors: Jana Wood Sayeda Yasmin-Karim Romy Mueller Akila N. Viswanathan Wilfred Ngwa Current treatment options for advanced cervical cancer are limited, especially for patients in poor-resource settings, with a 17% 5-year overall survival rate. Here, we report results in animal...
Wed Apr 22, 2020 03:00
Cancers, Vol. 12, Pages 1032: The Effect of Higher Level Computerized Clinical Decision Support Systems on Oncology Care: A Systematic Review Cancers doi: 10.3390/cancers12041032 Authors: Klarenbeek Weekenstroo Sedelaar Fütterer Prokop Tummers Background: To deal with complexity in cancer care, computerized clinical decision support systems (CDSSs) are developed to support quality of care and improve decision-making. We performed a systematic review to explore the...
Wed Apr 22, 2020 03:00
Cancers, Vol. 12, Pages 1030: PET-FDG: Impetus Cancers doi: 10.3390/cancers12041030 Authors: Cristina Nanni The International Myeloma Working Group (IMWG)recommends FDG PET/CT (Fluoro-Deoxy-glucose Positron Emission Tomography/Computed Tomography) as the gold standard imaging modality for initial evaluation and response to therapy assessment in multiple myeloma. In fact, FDG PET/CT, provides multiple useful indexes to risk-stratify patients and has significant prognostic value. However,...
Wed Apr 22, 2020 03:00
Cancers, Vol. 12, Pages 1027: Primary Resistance to PD-1-Based Immunotherapy—A Study in 319 Patients with Stage IV Melanoma Cancers doi: 10.3390/cancers12041027 Authors: Teresa Amaral Olivia Seeber Edgar Mersi Stephanie Sanchez Ioannis Thomas Andreas Meiwes Andrea Forschner Ulrike Leiter Thomas Eigentler Ulrike Keim Claus Garbe Background: Primary resistance to immunotherapy can be observed in approximately 40–65% of the stage IV melanoma patients...
Wed Apr 22, 2020 03:00
Cancers, Vol. 12, Pages 1028: Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors Cancers doi: 10.3390/cancers12041028 Authors: Aurora Irene Idilli Francesca Pagani Emanuela Kerschbamer Francesco Berardinelli Manuel Bernabé María Luisa Cayuela Silvano Piazza Pietro Luigi Poliani Emilio Cusanelli Maria Caterina Mione Background: The up-regulation of a telomere maintenance mechanism (TMM) is a common feature of cancer...
Wed Apr 22, 2020 03:00
Cancers, Vol. 12, Pages 1025: Establishment and Characterization of Humanized Mouse NPC-PDX Model for Testing Immunotherapy Cancers doi: 10.3390/cancers12041025 Authors: Wai Nam Liu Shin Yie Fong Wilson Wei Sheng Tan Sue Yee Tan Min Liu Jia Ying Cheng Sherlly Lim Lisda Suteja Edwin Kunxiang Huang Jerry Kok Yen Chan Narayanan Gopalakrishna Iyer Joe Poh Sheng Yeong Darren Wan-Teck Lim Qingfeng Chen Immune checkpoint blockade (ICB) monotherapy shows...
Wed Apr 22, 2020 03:00
Cells, Vol. 9, Pages 1045: Association Analysis of Single-Cell RNA Sequencing and Proteomics Reveals a Vital Role of Ca2+ Signaling in the Determination of Skeletal Muscle Development Potential Cells doi: 10.3390/cells9041045 Authors: Kai Qiu Doudou Xu Liqi Wang Xin Zhang Ning Jiao Lu Gong Jingdong Yin This study is aimed at exploring the mechanism underlying the homeostasis between myogenesis and adipogenesis in skeletal muscle using a special porcine model with a...
Wed Apr 22, 2020 03:00
Cells, Vol. 9, Pages 1049: Mechanistic Paradigms of Natural Plant Metabolites as Remedial Candidates for Systemic Lupus Erythromatosus Cells doi: 10.3390/cells9041049 Authors: Balkrishna Thakur Singh Chandra Dev Varshney Systemic lupus erythematosus (SLE) is a complex autoimmune disorder involving a dysregulated immune response which ultimately leads to multiple organ failure. Several immunological and cellular checkpoints are available as drug targets. However, the...
Wed Apr 22, 2020 03:00
Cells, Vol. 9, Pages 1040: E-Cadherin in Pancreatic Ductal Adenocarcinoma: A Multifaceted Actor during EMT Cells doi: 10.3390/cells9041040 Authors: Michele Sommariva Nicoletta Gagliano Epithelial-to-mesenchymal transition (EMT) is a step-wise process observed in normal and tumor cells leading to a switch from epithelial to mesenchymal phenotype. In tumors, EMT provides cancer cells with a metastatic phenotype characterized by E-cadherin down-regulation, cytoskeleton reorganization,...
Wed Apr 22, 2020 03:00
Cells, Vol. 9, Pages 1042: Molecular Regulation of the RhoGAP GRAF3 and Its Capacity to Limit Blood Pressure In Vivo Cells doi: 10.3390/cells9041042 Authors: Rachel A. Dee Xue Bai Christopher P. Mack Joan M. Taylor Anti-hypertensive therapies are usually prescribed empirically and are often ineffective. Given the prevalence and deleterious outcomes of hypertension (HTN), improved strategies are needed. We reported that the Rho-GAP GRAF3 is selectively expressed in smooth muscle...
Wed Apr 22, 2020 03:00
Cells, Vol. 9, Pages 1047: The P2X7 Receptor and NLRP3 Axis in Non-Alcoholic Fatty Liver Disease: A Brief Review Cells doi: 10.3390/cells9041047 Authors: Rossato Di Vincenzo Pagano El Hadi Vettor Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, and its prevalence is reaching epidemic characteristics both in adults and in children. The increase of NAFLD prevalence parallels that of obesity, now representing the major cause of liver...
Wed Apr 22, 2020 03:00
Cells, Vol. 9, Pages 1041: The Emerging Role of MicroRNAs in NAFLD: Highlight of MicroRNA-29a in Modulating Oxidative Stress, Inflammation, and Beyond Cells doi: 10.3390/cells9041041 Authors: Hung-Yu Lin Ya-Ling Yang Pei-Wen Wang Feng-Sheng Wang Ying-Hsien Huang Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease and ranges from steatosis to steatohepatitis and to liver fibrosis. Lipotoxicity in hepatocytes, elevated oxidative stress and the...
Wed Apr 22, 2020 03:00
Cells, Vol. 9, Pages 1046: HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity Cells doi: 10.3390/cells9041046 Authors: Thomas L. Prince Benjamin J. Lang Martin E. Guerrero-Gimenez Juan Manuel Fernandez-Muñoz Andrew Ackerman Stuart K. Calderwood Heat shock factor 1 (HSF1) is the primary component for initiation of the powerful heat shock response (HSR) in eukaryotes. The HSR is an evolutionarily conserved mechanism for responding...
Wed Apr 22, 2020 03:00
Cells, Vol. 9, Pages 1044: Sorting Mechanisms for MicroRNAs into Extracellular Vesicles and Their Associated Diseases Cells doi: 10.3390/cells9041044 Authors: Michael Groot Heedoo Lee Extracellular vesicles (EV) are secretory membranous elements used by cells to transport proteins, lipids, mRNAs, and microRNAs (miRNAs). While their existence has been known for many years, only recently has research begun to identify their function in intercellular communication and gene regulation....
Wed Apr 22, 2020 03:00
Cells, Vol. 9, Pages 1033: Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death Cells doi: 10.3390/cells9041033 Authors: Joanna Kopecka Martina Godel Silvia Dei Roberta Giampietro Dimas Carolina Belisario Muhlis Akman Marialessandra Contino Elisabetta Teodori Chiara Riganti Doxorubicin is a strong inducer of immunogenic cell death (ICD), but it is ineffective in P-glycoprotein (Pgp)-expressing cells. Indeed, Pgp effluxes doxorubicin...
Wed Apr 22, 2020 03:00
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