JPM, Vol. 10, Pages 30: Returning Results in the Genomic Era: Initial Experiences of the eMERGE Network Journal of Personalized Medicine doi: 10.3390/jpm10020030 Authors: Georgia L. Wiesner Alanna Kulchak Rahm Paul Appelbaum Sharon Aufox Sarah T. Bland Carrie L. Blout Kurt D. Christensen Wendy K. Chung Ellen Wright Clayton Robert C. Green Margaret H. Harr Nora Henrikson Christin Hoell Ingrid A. Holm Gail P. Jarvik Iftikhar J. Kullo Philip E....
Mon Apr 27, 2020 03:00
Life, Vol. 10, Pages 52: Factoring Origin of Life Hypotheses into the Search for Life in the Solar System and Beyond Life doi: 10.3390/life10050052 Authors: Alex Longo Bruce Damer Two widely-cited alternative hypotheses propose geological localities and biochemical mechanisms for life’s origins. The first states that chemical energy available in submarine hydrothermal vents supported the formation of organic compounds and initiated primitive metabolic pathways which became...
Mon Apr 27, 2020 03:00
Life, Vol. 10, Pages 51: Early-Life Stress Induced Epigenetic Changes of Corticotropin-Releasing Factor Gene in Anorexic Low Body Weight–Selected Chicks Life doi: 10.3390/life10050051 Authors: Yang Xiao Jinxin Wang Paul B. Siegel Mark A. Cline Elizabeth R. Gilbert The expression of neuropeptide Y (NPY) in the arcuate nucleus (ARC) and corticotropin-releasing factor (CRF) in the paraventricular nucleus (PVN) were increased when low body weight–selected (LWS) line...
Mon Apr 27, 2020 03:00
Medicina, Vol. 56, Pages 213: Clinical Predictors of Preeclampsia in Pregnant Women with Chronic Kidney Disease Medicina doi: 10.3390/medicina56050213 Authors: Sorohan Andronesi Ismail Jurubita Obrisca Baston Harza Background and Objectives: Pregnant women with chronic kidney disease (CKD) are at high risk of adverse maternal and fetal outcomes. Preeclampsia (PE) superimposed on CKD is estimated to occur in 21%–79% of pregnancies. Both conditions share...
Mon Apr 27, 2020 03:00
Medicina, Vol. 56, Pages 212: BRCA1 and BRCA2 Gene Mutations and Lung Cancer Sisk: A Meta-Analysis Medicina doi: 10.3390/medicina56050212 Authors: Lee Lee Li Lee Chen Background and objective: BRCA1 and BRCA2 are associated with many cancer types in addition to hereditary breast and ovarian cancers. However, their relation to lung cancer remains to be explored. Materials and Methods: Observation studies were systematically reviewed to explore the association of BRCA1...
Mon Apr 27, 2020 03:00
Medicina, Vol. 56, Pages 211: Assessment of the Relationship between Selected Factors and Stress-Coping Strategies in Handcyclists—A Preliminary Study Medicina doi: 10.3390/medicina56050211 Authors: Agnieszka Turoń-Skrzypińska Wioletta Pawlukowska Aleksandra Szylińska Natalia Tomska Anna Mikołajczyk-Kocięcka Magdalena Ptak Grażyna Dutkiewicz Iwona Rotter Background and Objectives: Playing competitive sports is associated with stress, especially during the starting...
Mon Apr 27, 2020 03:00
Membranes, Vol. 10, Pages 81: Precipitation of Inorganic Salts in Mitochondrial Matrix Membranes doi: 10.3390/membranes10050081 Authors: Jasielec Filipek Dołowy Lewenstam In the mitochondrial matrix there are insoluble, osmotically inactive complexes that maintain constant pH and calcium concentration. In the present paper we examine the properties of insoluble calcium and magnesium salts, namely phosphates, carbonates and polyphosphates which might play this role. We find...
Mon Apr 27, 2020 03:00
Metabolites, Vol. 10, Pages 174: Volatilomics Reveals Potential Biomarkers for Identification of Renal Cell Carcinoma: An In Vitro Approach Metabolites doi: 10.3390/metabo10050174 Authors: Amaro Pinto Rocha Araújo Miranda-Gonçalves Jerónimo Henrique de Lourdes Bastos Carvalho de Pinho The identification of noninvasive biomarkers able to detect renal cell carcinoma (RCC) at an early stage remains an unmet clinical need. The recognition that altered...
Mon Apr 27, 2020 03:00
Metabolites, Vol. 10, Pages 173: Evaluation of MDA-MB-468 Cell Culture Media Analysis in Predicting Triple-Negative Breast Cancer Patient Sera Metabolic Profiles Metabolites doi: 10.3390/metabo10050173 Authors: Wojtowicz Wróbel Pyziak Tarkowski Balcerzak Bębenek Młynarz Triple-negative breast cancer (TNBC) is characterized by limited survival, poor prognosis, and high recurrence. Understanding the metabolic adaptations of TNBC could help reveal improved treatment...
Mon Apr 27, 2020 03:00
MPs, Vol. 3, Pages 33: Analysis of GPI-Anchored Receptor Distribution and Dynamics in Live Cells by Tag-mediated Enzymatic Labeling and FRET Methods and Protocols doi: 10.3390/mps3020033 Authors: Balatskaya Baglay Rubtsov V. Sharonov The analysis of glycosylphosphatidylinositol (GPI)-anchored receptor distribution and dynamics in live cells is challenging, because their clusters exhibit subdiffraction-limited sizes and are highly dynamic. However, the cellular response depends...
Mon Apr 27, 2020 03:00
MPs, Vol. 3, Pages 32: Monitoring Epithelial–Mesenchymal Transition of Pancreatic Cancer Cells via Investigation of Mitochondrial Dysfunction Methods and Protocols doi: 10.3390/mps3020032 Authors: Jae Jun Sim Keun-Yeong Jeong In this protocol, we introduced a method of measuring mitochondrial dysfunction to confirm the epithelial–mesenchymal transition (EMT) in pancreatic cancer cells under a hypoxic environment. There are many expertized and complicated methods to verify...
Mon Apr 27, 2020 03:00
MPs, Vol. 3, Pages 31: The Making of Transgenic Drosophila guttifera Methods and Protocols doi: 10.3390/mps3020031 Authors: Shittu Steenwinkel Koshikawa Werner The complex color patterns on the wings and body of Drosophila guttifera (D. guttifera) are emerging as model systems for studying evolutionary and developmental processes. Studies regarding these processes depend on overexpression and downregulation of developmental genes, which ultimately rely upon an effective...
Mon Apr 27, 2020 03:00
Microorganisms, Vol. 8, Pages 633: Characterization of a Sequential UV Photolysis-Biodegradation Process for Treatment of Decabrominated Diphenyl Ethers in Sorbent/Water Systems Microorganisms doi: 10.3390/microorganisms8050633 Authors: Chang Chao Chen Li Boyd Decabrominated diphenyl ether (BDE-209) is a primary component of the brominated flame retardants used in a variety of industrial and domestic applications. BDE-209 bioaccumulates in aquatic organisms and has been...
Mon Apr 27, 2020 03:00
Microorganisms, Vol. 8, Pages 639: Bacteriocins, Antimicrobial Peptides from Bacterial Origin: Overview of their Biology and their Impact Against Multidrug-Resistant Bacteria Microorganisms doi: 10.3390/microorganisms8050639 Authors: Simons Alhanout Duval Currently, the emergence and ongoing dissemination of antimicrobial resistance among bacteria are critical health and economic issue, leading to increased rates of morbidity and mortality related to bacterial infections. Research...
Mon Apr 27, 2020 03:00
Microorganisms, Vol. 8, Pages 630: A Plasmid-Encoded FetMP-Fls Iron Uptake System Confers Selective Advantages to Salmonella enterica Serovar Typhimurium in Growth under Iron-Restricted Conditions and for Infection of Mammalian Host Cells Microorganisms doi: 10.3390/microorganisms8050630 Authors: Vanesa García Ana Herrero-Fresno Rosaura Rodicio Alfonso Felipe-López Ignacio Montero John E. Olsen Michael Hensel María Rosario Rodicio The resistance plasmid pUO-StVR2,...
Mon Apr 27, 2020 03:00
Microorganisms, Vol. 8, Pages 638: Intestinal Microbiota of Fattening Pigs Offered Non-Fermented and Fermented Liquid Feed with and without the Supplementation of Non-Fermented Coarse Cereals Microorganisms doi: 10.3390/microorganisms8050638 Authors: Bunte Grone Keller Keller Galvez Strowig Kamphues Hankel Introducing high numbers of lactic acid bacteria into the gastrointestinal tract of pigs via fermented liquid feed (FLF) could have an impact on intestinal...
Mon Apr 27, 2020 03:00
Microorganisms, Vol. 8, Pages 636: Thymol Protects Channel Catfish from Aeromonas hydrophila Infection by Inhibiting Aerolysin Expression and Biofilm Formation Microorganisms doi: 10.3390/microorganisms8050636 Authors: Dong Zhang Liu Xu Zhou Yang Yang Ai Aeromonas hydrophila is an opportunistic pathogen responsible for a number of diseases in freshwater farming. Moreover, the bacterium has been identified as a zoonotic pathogen that threatens human health....
Mon Apr 27, 2020 03:00
Microorganisms, Vol. 8, Pages 634: Description of Three Novel Members in the Family Geobacteraceae, Oryzomonas japonicum gen. nov., sp. nov., Oryzomonas sagensis sp. nov., and Oryzomonas ruber sp. nov. Microorganisms doi: 10.3390/microorganisms8050634 Authors: Xu Masuda Hayakawa Ushijima Kawano Shiratori Senoo Itoh Bacteria of the family Geobacteraceae are particularly common and deeply involved in many biogeochemical processes in terrestrial and freshwater...
Mon Apr 27, 2020 03:00
Microorganisms, Vol. 8, Pages 632: Revealing Fungal Communities in Alpine Wetlands Through Species Diversity, Functional Diversity and Ecological Network Diversity Microorganisms doi: 10.3390/microorganisms8050632 Authors: Xie Ma Zhou Liang Yin Ma Zhuang Zhuang The biodiversity of fungi, which are extremely important in maintaining the ecosystem balance in alpine lakeside wetlands, has not been fully studied. In this study, we investigated the fungal communities...
Mon Apr 27, 2020 03:00
Microorganisms, Vol. 8, Pages 637: Growth, Cell Division, and Gene Expression of Escherichia coli at Elevated Concentrations of Magnesium Sulfate: Implications for Habitability of Europa and Mars Microorganisms doi: 10.3390/microorganisms8050637 Authors: Sudip Nepal Pradeep Kumar We perform quantitative studies of the growth, death, and gene expression of Escherichia coli in a wide range of magnesium sulfate (MgSO 4 ) concentrations (0–2.5 M). Elevated concentration...
Mon Apr 27, 2020 03:00
Microorganisms, Vol. 8, Pages 635: Siccibacter turicensis from Kangaroo Scats: Possible Implication in Cellulose Digestion Microorganisms doi: 10.3390/microorganisms8050635 Authors: Dhakal Boath Van Moore Macreadie Microbiota in the kangaroo gut degrade cellulose, contributing to the kangaroo’s energy and survival. In this preliminary study, to discover more about the gut microbes that contribute to the survival of kangaroos, cellulose-degrading bacteria were...
Mon Apr 27, 2020 03:00
Microorganisms, Vol. 8, Pages 631: Bacterial Synthesis of Ternary CdSAg Quantum Dots through Cation Exchange: Tuning the Composition and Properties of Biological Nanoparticles for Bioimaging and Photovoltaic Applications Microorganisms doi: 10.3390/microorganisms8050631 Authors: Nicolás Órdenes-Aenishanslins Giovanna Anziani-Ostuni Juan Pablo Monrás Alejandra Tello Denisse Bravo Daniela Toro-Ascuy Ricardo Soto-Rifo Paras N. Prasad José Manuel Pérez-Donoso In this...
Mon Apr 27, 2020 03:00
Microorganisms, Vol. 8, Pages 629: Exploring Coagulase-Negative Staphylococci Diversity from Artisanal Llama Sausages: Assessment of Technological and Safety Traits Microorganisms doi: 10.3390/microorganisms8050629 Authors: Annalisa Rebecchi Francesco Miragoli Constanza Lopez Daniela Bassi Cecilia Fontana Llama sausage is still produced following artisanal procedures, with the autochthonous microbiota being mainly responsible for the fermentation process. In this work, the...
Mon Apr 27, 2020 03:00
Molbank, Vol. 2020, Article M1128: Synthesis of (R) and (S)-3-Chloro-5-(3-methylmorpholino)-4H-1,2,6-thiadiazin-4-ones Molbank doi: 10.3390/M1128 Authors: Andreas S. Kalogirou Christopher R. M. Asquith Panayiotis A. Koutentis Reaction of 3,5-dichloro-4H-1,2,6-thiadiazin-4-one with (R) and (S)-3-methylmorpholines (2 equiv), in THF, at ca. 20 °C gave (R) and (S)-3-chloro-5-(3-methylmorpholino)-4H-1,2,6-thiadiazin-4-ones in 95 and 97% yields, respectively. The new compounds were fully...
Mon Apr 27, 2020 03:00
Molecules, Vol. 25, Pages 2043: Quantitative Determination and Validation of Four Ketones in Salvia miltiorrhiza Bunge Using Quantitative Proton Nuclear Magnetic Resonance Spectroscopy Molecules doi: 10.3390/molecules25092043 Authors: Yuanyuan Li Zhuoni Hou Feng Su Jipeng Chen Xiaodan Zhang Ling Xu Dongfeng Yang Zongsuo Liang Salvia mltiorrhiza Bunge (SMB) is native to China, whose dried root has been used as medicine. A few chromatographic- or spectrometric-based...
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Molecules, Vol. 25, Pages 2042: Genistin: A Novel Potent Anti-Adipogenic and Anti-Lipogenic Agent Molecules doi: 10.3390/molecules25092042 Authors: Yae Rim Choi Jaewon Shim Min Jung Kim Soy isoflavones are popular ingredients with anti-adipogenic and anti-lipogenic properties. The anti-adipogenic and anti-lipogenic properties of genistein are well-known, but those of genistin and glycitein remain unknown, and those of daidzein are characterized by contrasting data. Therefore, the...
Mon Apr 27, 2020 03:00
Molecules, Vol. 25, Pages 2040: Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties Molecules doi: 10.3390/molecules25092040 Authors: Mohammad Bagher Majnooni Sajad Fakhri Yalda Shokoohinia Mahdi Mojarrab Sara Kazemi-Afrakoti Mohammad Hosein Farzaei Isofraxidin (7-hydroxy-6, 8-dimethoxy coumarin) (IF) is a hydroxy coumarin with several biological and pharmacological activities. The plant kingdom is of the most prominent sources...
Mon Apr 27, 2020 03:00
Molecules, Vol. 25, Pages 2041: Iron Absorption in Celiac Disease and Nutraceutical Effect of 7-Hydroxymatairesinol Mini-Review Molecules doi: 10.3390/molecules25092041 Authors: Zanella Paiardi Di Lorenzo Biasiotto Anemia is the main extra-gastrointestinal symptom in inflammatory bowel diseases (IBDs). Interleukin-6 (IL-6) and other cytokines are secreted and act in the microenvironment of the small intestine mucous membrane of IBD patients. Iron is essential for multiple...
Mon Apr 27, 2020 03:00
Molecules, Vol. 25, Pages 2033: Anti-osteoarthritic Effects of an Herbal Composition LI73014F2 on Interleukin-1β-induced Primary Human Articular Chondrocytes Molecules doi: 10.3390/molecules25092033 Authors: Hae Lim Kim Hae Jin Lee Dong-Ryung Lee Bong-Keun Choi Seung Hwan Yang Osteoarthritis (OA) is one of the most well-characterized joint diseases and is associated with chondrocyte inflammation, metalloproteinase upregulation and apoptosis. LI73014F2 is a novel composition...
Mon Apr 27, 2020 03:00
Molecules, Vol. 25, Pages 2038: Enhanced Lycopene Extraction from Tomato Peels by Optimized Mixed-Polarity Solvent Mixtures Molecules doi: 10.3390/molecules25092038 Authors: Antonio Zuorro Mounting evidence from clinical and epidemiological studies suggests that lycopene, the most abundant carotenoid in tomatoes, may be beneficial in the prevention or treatment of some important diseases. Ripe tomato peels are the richest source of lycopene, but the use of conventional solvent extraction...
Mon Apr 27, 2020 03:00
Molecules, Vol. 25, Pages 2037: Realization of Rapid Large-Size 3D Printing Based on Full-Color Powder-Based 3DP Technique Molecules doi: 10.3390/molecules25092037 Authors: Chen Wang Chen Chen The powder-based 3DP (3D printing) technique has developed rapidly in creative and customized industries on account of it’s uniqueness, such as low energy consumption, cheap consumables, and non-existent exhaust emissions. Moreover, it could actualize full-color 3D printing....
Mon Apr 27, 2020 03:00
Molecules, Vol. 25, Pages 2034: Special Issue: Biogenic Nanomaterials: Versatility and Applications Molecules doi: 10.3390/molecules25092034 Authors: Clayton Jeffryes Si Amar Dahoumane Greener processes have emerged as serious and competitive routes to produce various nanomaterials [...]
Mon Apr 27, 2020 03:00
Molecules, Vol. 25, Pages 2036: Rapid Classification and Quantification of Camellia (Camellia oleifera Abel.) Oil Blended with Rapeseed Oil Using FTIR-ATR Spectroscopy Molecules doi: 10.3390/molecules25092036 Authors: Jianxun Han Ruixue Sun Xiuying Zeng Jiukai Zhang Ranran Xing Chongde Sun Ying Chen Currently, the authentication of camellia oil (CAO) has become very important due to the possible adulteration of CAO with cheaper vegetable oils such as rapeseed oil (RSO)....
Mon Apr 27, 2020 03:00
Molecules, Vol. 25, Pages 2035: Syntheses, Reactivities, Characterization, and Crystal Structures of Dipalladium Complexes Containing the 1,3-pyrimidinyl Ligand: Structures of [Pd(PPh3)(Br)]2(μ,η2-C4H3N2)2, [Pd(Br)]2(μ,η2-Hdppa)2, and [{Pd(PPh3)(CH3CN)}2(μ,η2-C4H3N2)2][BF4]2 Molecules doi: 10.3390/molecules25092035 Authors: Hsiao-Fen Wang Kuang-Hway Yih Gene-Hsiang Lee In a refluxing chloroform solution, the η1-pyrimidinyl {pyrimidinyl = C4H3N2} palladium complex [Pd(PPh3)2(η1-C4H3N2)(Br)],...
Mon Apr 27, 2020 03:00
Molecules, Vol. 25, Pages 2039: Development of UHPLC-MS/MS Method for Indirubin-3′-Oxime Derivative as a Novel FLT3 Inhibitor and Pharmacokinetic Study in Rats Molecules doi: 10.3390/molecules25092039 Authors: Na Yoon Kim Yong-Chul Kim Yoon Gyoon Kim This study aimed to develop and validate a sensitive liquid chromatography-coupled tandem mass spectrometry method for the quantification of LDD-2614, an indirubin derivative and novel FLT3 inhibitor, in rat plasma. In addition, the...
Mon Apr 27, 2020 03:00
Molecules, Vol. 25, Pages 2032: Phenolic Profile of Croton urucurana Baill. Leaves, Stems and Bark: Pairwise Influence of Drying Temperature and Extraction Solvent Molecules doi: 10.3390/molecules25092032 Authors: Jáliston Júlio Lopes Alves Maria Inês Dias João C. M. Barreira Lillian Barros Osvaldo Resende Ana Carolina Ribeiro Aguiar Isabel C. F. R. Ferreira Cerrado biome represents an area with great biodiversity. Some of its plants have significant ethnopharmacological...
Mon Apr 27, 2020 03:00
Molecules, Vol. 25, Pages 2030: A New Tetradentate Mixed Aza-Thioether Macrocycle and Its Complexation Behavior towards Fe(II), Ni(II) and Cu(II) Ions Molecules doi: 10.3390/molecules25092030 Authors: Sze-Wing Ng Siu-Chung Chan Chi-Fung Yeung Shek-Man Yiu Chun-Yuen Wong A new tetradentate mixed aza-thioether macrocyclic ligand 2,6-dithia[7](2,9)-1,10-phenanthrolinophane ([13]ane(phenN2)S2) was successfully synthesized. Reacting metal precursors [Fe(CH3CN)2(OTf)2], Ni(ClO4)2·6H2O,...
Mon Apr 27, 2020 03:00
Molecules, Vol. 25, Pages 2031: Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors Molecules doi: 10.3390/molecules25092031 Authors: Tarfah Al-Warhi Ahmed M. El Kerdawy Nada Aljaeed Omnia E. Ismael Rezk R. Ayyad Wagdy M. Eldehna Hatem A. Abdel-Aziz Ghada H. Al-Ansary On account of their overexpression in a wide range of human malignancies, cyclin-dependent kinases (CDKs) are among the most validated...
Mon Apr 27, 2020 03:00
Molecules, Vol. 25, Pages 2028: Effect of Angelica gigas Nakai Ethanol Extract and Decursin on Human Pancreatic Cancer Cells Molecules doi: 10.3390/molecules25092028 Authors: Bitna Kweon Yo-Han Han Ji-Ye Kee Jeong-Geon Mun Hee Dong Jeon Dae Hwan Yoon Byung-Min Choi Seung-Heon Hong Pancreatic cancer (PC) is one of the most severe cancers, and its incidence and mortality rates have steadily increased in the past decade. In this study, we demonstrate the effect of Angelica...
Mon Apr 27, 2020 03:00
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