Abstract Fras1 is an extracellular protein of the basement membranes that surround embryonic epithelia, choroid plexuses and meninges in fetal mouse brain. Depletion of Fras1 in knockout mice results in sub‐epidermal blistering and, fusion of eye lids and digits as well as malformation of lungs and kidneys. Mutations in the human counterpart FRAS1 are responsible for the Fraser Syndrome with clinical manifestations similar to the murine phenotype. In addition, brain deformities or mental impairments...
Sat Apr 25, 2020 22:34
Abstract Objectives Isotopic analyses using human dental enamel provide information on the mobility and diet of individuals in forensic and archeological studies. Thus far, no study has systematically examined intraindividual coupled strontium (Sr), oxygen (O), and carbon (C) isotope variation in human enamel or the effect that caries have on the isotopic integrity of the enamel. The inadequate quantification of isotopic variation affects interpretations and may constrain sample selection...
Sat Apr 25, 2020 15:40
Abstract Natural killer group 2 member D (NKG2D) ligands (NKG2DLs) on tumor cells engage NKG2D and mediate the killing by NKG2D+ immune cells. However, tumor cells with high NKG2DLs are still malignant and proliferate rapidly. We investigated the reason for NKG2DL‐expressing cell progression. Tumor cells in mice were assessed for their NKG2DL expression, ability to attract immune cells, tumorigenicity, mTOR and signal transducer and activator of transcription 3 (STAT3) signaling activation. The...
Sat Apr 25, 2020 16:28
Abstract The ultimate success of any form of cancer therapy or cancer prevention depends on its ability to engage the power of the immune system to completely eliminate a growing tumor, lower the life‐time tumor risk and establish long‐term memory to prevent recurrence or future tumors. For that reason, all therapies but especially immunotherapies depend on the immune health (immunocompetence) of each treated individual. Cancer and chronic illnesses, combined with a usually more advanced age of...
Sat Apr 25, 2020 12:23
Abstract The immunosuppressive microenvironment in solid tumors is thought to form a barrier to the entry and efficacy of cell‐based therapies such as chimeric antigen receptor (CAR) T cells. Combining CAR T cell therapy with checkpoint inhibitors has been demonstrated to oppose immune escape mechanisms in solid tumors and augment antitumor efficacy. We evaluated PD‐1/PD‐L1 signaling capacity and the impact of an inhibitor of this checkpoint axis in an in vitro system for cancer cell challenge,...
Sat Apr 25, 2020 11:53
Abstract We report two cases of COVID‐19 showing negative respiratory swabs but positive salivary samples at the same time. These findings rise the concern about how to manage these patients before hospital discharging, thus avoiding contagion among their family members or a second coronavirus wave once the lockdown is over.
Sat Apr 25, 2020 11:53
Abstract More recently, researchers Top of FormBottom of Formhave reported about the chemosensory alterations observed in patients with COVID‐19 (Giacomelli et al., 2020). The findings on changes in olfactory and gustatory sensations are enlightening and probably one of the preliminary reports in this context and may have been overlooked earlier, since it is challenging to diagnose and also due to the gravity of the major symptoms, being dealt with.
Sat Apr 25, 2020 11:49
Abstract Patients often present in dental settings with orofacial lesions, which can be challenging to diagnose clinically due to their heterogenous characteristics. This can have serious implications for patient health, especially for head and neck tumours, which can undergo rapid metastatic spread (Kalele, Kulkarni, Patil, and Nayyar 2016). Histological examinations provide crucial diagnostic information and can indicate the likelihood of a malignant transformation, which impacts prognosis and...
Sat Apr 25, 2020 11:43
Abstract Oestrogen receptor β (ERβ) has been suggested to have anti‐proliferative and anti‐tumour effects in breast and prostate cancer cells, but other studies have indicated its tumour‐promoting effects. Understanding the complex effects of this receptor in different contexts requires further study. We reported that high ERβ expression is independently associated with improved prognosis in female colorectal cancer (CRC) patients. Herein, we investigated the possible anti‐tumour effect of ERβ...
Sat Apr 25, 2020 19:12
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Sat Apr 25, 2020 20:53
Sat Apr 25, 2020 19:29
Abstract Peripheral nerve injuries in which the nerve is not completely severed often result in neuromas‐in‐continuity. These can cause sensory and functional deficits and must be resected and reconstructed. In defects greater than 5 mm in length, nerve graft is indicated, and suture neurorrhaphy is typically used to secure the nerve ends. However, sutures may negatively impact nerve regeneration. Fibrin glue has recently been used to mitigate the inflammatory response associated with suture neurorrhaphy....
Sat Apr 25, 2020 18:00
Abstract Introduction In the selection of non‐small cell lung cancer (NSCLC) patients for immunotherapy, specimen processed as cell blocks (CBs) may be the only available material to assess PD‐L1 expression. Therefore, optimal CB preparation becomes paramount. In this context, here we assessed whether inadequate fixation time might be one of the pre‐analytical factors affecting PD‐L1 expression. Methods Ex vivo CBs from placental (n = 3) and NSCLC (n = 8) resection specimens were...
Sat Apr 25, 2020 17:31
Abstract Objective To examine the role of cervicovaginal cytology in diagnoses and surveillance of the patients with endometrial carcinoma (EC). Methods Patients who underwent EC surgery that included a follow‐up were reviewed retrospectively. The cohort was limited to the patients who had an available cervical cytology result within 12 months before the primary surgery took place. The glandular abnormalities were classified in the following subclassifications: “atypical glandular...
Sat Apr 25, 2020 17:29
Abstract Pleomorphic adenoma (PA) is the most common salivary gland tumor. The cytological features of PA are well recognized, and its diagnosis is straightforward in most cases. Some metaplastic changes in PA are well known; however, occurrence of oncocytic metaplasia in PA is very rare. In this report, we describe the first cytological case of prominent oncocytic metaplasia in PA identified based on immunocytochemical analysis. We report the case of a 62‐year‐old Japanese female who presented...
Sat Apr 25, 2020 17:29
New Findings What is the central question of this study? This study investigated intracranial cerebrovascular and ventilatory reactivity to 6% CO2 in children and adults and explored dynamic ventilatory and cerebrovascular onset responses. What is the main finding and its importance? We show cerebrovascular reactivity is similar in children and adults, but the intracranial blood velocity onset response was markedly attenuated in children. Sex differences were apparent, with greater...
Sat Apr 25, 2020 15:38
Abstract Background We sought to develop mapping functions that use EORTC responses to approximate health utility (HU) scores for patients with head and neck cancer (HNC). Methods In total, 209 outpatients with HNC completed the EORTC QLQ‐C30 & QLQ‐H&N35 (EORTC), EQ‐5D‐5L and the HUI‐3. Results of the EORTC were mapped onto both EQ‐5D‐5L and HUI‐3 scores using ordinary least squares regression and two‐part models. Results The OLS model mapping EORTC onto the EQ‐5D‐5L...
Sat Apr 25, 2020 19:40
Abstract Aim The COVID‐19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has put health care workers at risk when exposed to aerosolized viral particles during upper airway mucosal surgery. The objective of this review was to discuss topical preparations that could be utilized preoperatively to help to decrease viral load and potentially reduce the risks of viral transmission. Methods A PubMed/MEDLINE database review of articles was performed...
Sat Apr 25, 2020 12:14
Related Articles[Intra-nucleus accumbens shell injection of baclofen blocks the reconsolidation of conditioned place preference in morphine-addicted mice]. Sheng Li Xue Bao. 2020 Apr 25;72(2):255-261 Authors: Wang RC, Xiao LF, Zhang C, Sun T, Sun KS Abstract Preclinical studies suggest that the GABAB receptor is a potential target for treatment of substance use disorders. Baclofen (BLF), a prototypical GABAB receptor agonist, is the only specific GABAB...
Sun Apr 26, 2020 08:23
Related Articles[Protective effect of edaravone on balance of mitochondrial fusion and fission in MPP+-treated PC12 cells]. Sheng Li Xue Bao. 2020 Apr 25;72(2):249-254 Authors: Jiao Y, Zheng Y, Song CJ Abstract The aim of this study was to investigate the effect of edaravone (Eda) on the balance of mitochondrial fusion and fission in Parkinson's disease (PD) cell model. A cell model of PD was established by treating PC12 cells with 500 μmol/L 1-methyl-4-phenylpyridinium...
Sun Apr 26, 2020 08:23
Related Articles[Regulation of androgen on singing behavior and song control system of songbirds]. Sheng Li Xue Bao. 2020 Apr 25;72(2):243-248 Authors: Li DF, Wang SH, Meng W Abstract Androgen plays an important role in singing of songbirds. Recent studies have shown that androgen levels in vivo not only affect the external morphology of songbirds, but also affect their singing behavior. Androgens (including derivatives) affect singing behavior and singing...
Sun Apr 26, 2020 08:23
Related Articles[Role of adrenergic receptors in tumorigenesis and development of glioma]. Sheng Li Xue Bao. 2020 Apr 25;72(2):235-242 Authors: He Y, Zhu YG, Liu WZ, Zhang WH, Pan BX, Hu P Abstract Gliomas are malignant tumors with strong invasiveness. The current treatment strategy is surgical treatment assisted by a variety of radiotherapies, chemotherapies and immunotherapies. However, the curative efficacy is limited. Adrenergic receptor (AR) is...
Sun Apr 26, 2020 08:23
Related Articles[Research advances on adrenergic receptor signaling involved in disease microenvironment through regulation of macrophages]. Sheng Li Xue Bao. 2020 Apr 25;72(2):227-234 Authors: Wang JJ, Li DJ, DU MR Abstract Adrenergic receptor (AR), one of the key receptors for nervous system, plays an important role in the immune microenvironment and the progression of many diseases. In recent years, the regulation of ARs and its signal on macrophages...
Sun Apr 26, 2020 08:23
Related Articles[Progress on the role of synaptic cell adhesion molecules in stress]. Sheng Li Xue Bao. 2020 Apr 25;72(2):220-226 Authors: Wu ZZ, Wang XD Abstract Synaptic cell adhesion molecules (CAMs) are a type of membrane surface glycoproteins that mediate the structural and functional interactions between pre- and post-synaptic sites. Synaptic CAMs dynamically regulate synaptic activity and plasticity, and their expression and function are modulated...
Sun Apr 26, 2020 08:23
Related Articles[Research progress in regulation of exercise on mitochondrial respiratory chain spercomplex]. Sheng Li Xue Bao. 2020 Apr 25;72(2):205-219 Authors: Wang Y, Bo H, Zhang Y Abstract The mitochondrial respiratory chain supercomplex (mitoSC) is a complex super-assembly formed by free complexes on the mitochondrial inner membrane respiratory chain through the interaction between their subunits, mainly including mitoSCI1+III2+IV1-4, mitoSCI1+III2,...
Sun Apr 26, 2020 08:23
[New research advances in relationship of endoplasmic reticulum stress and cardiovascular diseases].
Related Articles[New research advances in relationship of endoplasmic reticulum stress and cardiovascular diseases]. Sheng Li Xue Bao. 2020 Apr 25;72(2):190-204 Authors: Ji DR, Qi YF Abstract Endoplasmic reticulum (ER) is an important organelle for protein folding, post-transcriptional modification and transport, which plays an important role in maintaining cell homeostasis. A variety of internal and external environmental stimuli can cause the accumulation...
Sun Apr 26, 2020 08:23
Related Articles[Long-term exposure to high altitude affects spatial working memory in migrants-evidence from time and frequency domain analysis]. Sheng Li Xue Bao. 2020 Apr 25;72(2):181-189 Authors: Ma HL, Mo T, Zeng TA, Wang Y Abstract Long-term exposure to high altitude affects spatial working memory. Previous studies have focused on the analysis of electroencephalogram (EEG) components in time domain rather than in frequency domain. To explore the...
Sun Apr 26, 2020 08:23
Related Articles[The molecular mechanism of fibroblast growth factor 21-inhibited leptin expression in adipocytes]. Sheng Li Xue Bao. 2020 Apr 25;72(2):175-180 Authors: Chen D, Zhao YY, Liang XY, Zhang LJ, Wei LL, Xie R, Zhang XC, Su XL, Zhao YF Abstract The present study was aimed to clarify the signaling molecular mechanism by which fibroblast growth factor 21 (FGF21) regulates leptin gene expression in adipocytes. Differentiated 3T3-F442A adipocytes...
Sun Apr 26, 2020 08:23
Related Articles[Different effects of long-term and short-term repeated restraints on the hematopoietic stem cells in mice]. Sheng Li Xue Bao. 2020 Apr 25;72(2):167-174 Authors: Ma CK, Wu X, Xu Z, Liu J, Zhang JY, Shi TX Abstract Humans with chronic psychological stress are prone to develop multiple disorders of body function including impairment of immune system. Chronic psychological stress has been reported to have negative effects on body immune...
Sun Apr 26, 2020 08:23
Related Articles[Regulatory mechanism of heat shock protein 90 on autophagy-related transcription factor EB in human hepatocellular carcinoma cells]. Sheng Li Xue Bao. 2020 Apr 25;72(2):157-166 Authors: Wang MN, Liu LX, Deng YT, Chen XM Abstract This study was aimed to investigate the regulatory mechanism of heat shock protein 90 (Hsp90) on transcription factor EB (TFEB) during autophagy in liver cancer cells. Human hepatocellular carcinoma cell line...
Sun Apr 26, 2020 08:23
Related Articles[Construction of transgenic mice with specific Cre recombinase expression in the zona fasciculata in adrenal cortex]. Sheng Li Xue Bao. 2020 Apr 25;72(2):148-156 Authors: Zhang NN, Wang CN, Ni X Abstract The adrenal gland is an important endocrine organ of human body. CYP11B1 gene was specifically expressed in the zona fasciculata in adrenal cortex. In order to better study the function of genes specifically expressed in the zona fasciculata...
Sun Apr 26, 2020 08:23
Related ArticlesChronic stress induces fur color change from dark to brown by decreasing follicle melanocytes and tyrosinase activity in female C57BL/6 mice. Sheng Li Xue Bao. 2020 Apr 25;72(2):139-147 Authors: Shen XL, Liu YZ, Gong H, Zhang Y, Wu TY, Xia M, Jiang CL Abstract Increasing evidence suggests that stress may induce changes in hair color, with the underlying mechanism incompletely understood. In this study, female C57BL/6 mice subjected to...
Sun Apr 26, 2020 08:23
Related ArticlesDivergent effects of lycopene on pancreatic alpha and beta cells. Sheng Li Xue Bao. 2020 Apr 25;72(2):133-138 Authors: Liu WH, Wang QN, Zhou Y, Wang YJ, Tong Z Abstract Lycopene is an antioxidant which has potential anti-diabetic activity, but the cellular mechanisms have not been clarified. In this study, different concentrations of lycopene were used to treat pancreatic alpha and beta cell lines, and the changes of cell growth, cell...
Sun Apr 26, 2020 08:23
Rajesh Benny, Satish V. KhadilkarAnnals of Indian Academy of Neurology 2020 23(7):40-42COVID-19 pandemic is ongoing and information on the neurological aspects of this viral infection is being gathered. Neuromuscular manifestations have been reported uncommonly in these early stages of the analysis. This manuscript studies the available information on the neuromuscular manifestations of COVID-19.
Fri Apr 24, 2020 00:00
Lakshmi Narasimhan Ranganathan, MM Arun Shivaraman, Guhan Ramamurthy, R ShrivarthanAnnals of Indian Academy of Neurology 2020 23(7):1-4
Fri Apr 24, 2020 00:00
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