Protein phosphatase 1 nuclear-targeting subunit (PNUTS) is ubiquitously expressed and associates with PTEN and protein phosphatase 1 (PP1) to control its activity. The role of PNUTS overexpression has hardly been studied in cancer. In this study, we used immunohistochemistry to quantitate PNUTS expression on a tissue microarray containing 17,747 clinical prostate cancer specimens. As compared to normal prostate epithelium, PNUTS expression was often higher in cancer. Among 12,235 interpretable tumors,...
Sat Apr 25, 2020 15:35
Background. Patients undergoing hemodialysis experience a greater risk of cognitive impairment than the general population, but limited data elucidates the biomarkers on this. We evaluated the association of bone turnover markers on cognitive function among 251 prevalent hemodialysis enrollees in a cross-sectional study. Methods. 251 hemodialysis patients (, 55% men) and 37 control subjects (, 56% men) without a prior stroke or dementia diagnosis were enrolled. Serum concentrations of 8 bone markers...
Fri Apr 24, 2020 18:35
To evaluate the correlation between the changes in serum concentrations of cluster of differentiation-147 (scCD147) and chemotherapy outcome in patients with NSCLC and evaluate the combination of scCD147 with serum matrix metalloproteinase-9 (scMMP-9) levels in the prediction of chemotherapy response, eighty-two patients with advanced LC were enrolled. Newly diagnosed cases were treated with platinum-based chemotherapy. We measured scCD147 protein levels in LC cases by ELISA and used receiver operating...
Fri Apr 24, 2020 13:50
Publication date: Available online 27 April 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): A.R. Naylor, D.J.H. McCabe
Mon Apr 27, 2020 17:52
Publication date: Available online 25 April 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Niek Zonnebeld, Jan H.M. Tordoir, Magda M. van Loon, André A.E.A. de Smet, Laurens C. Huisman, Philippe W.M. Cuypers, Felix J.V. Schlösser, Susan Lemson, Stefan G.H. Heinen, Lee H. Bouwman, Raechel J. Toorop, Wouter Huberts, Tammo Delhaas, the Shunt Simulation Study Group
Sat Apr 25, 2020 13:52
Publication date: Available online 25 April 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Lars Husmann, Martin W. Huellner, Bruno Ledergerber, Nadia Eberhard, Marisa B. Kaelin, Alexia Anagnostopoulos, Ken Kudura, Irene A. Burger, Carlos-A. Mestres, Zoran Rancic, Barbara Hasse, A. Anagnostopoulos, B. Hasse (PI), N. Eberhard, M. Hoffmann, L. Husmann, R. Kopp, B. Ledergerber, Z. Rancic, C.A. Mestres
Sat Apr 25, 2020 13:52
Publication date: Available online 24 April 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Giovanni Mosti, Hugo Partsch
Sat Apr 25, 2020 13:52
Publication date: Available online 24 April 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Lara Jesani, Brenig Gwilym, Stephanie Germain, Hannah Jesani, Amy Stimpson, Alison Lennon, Ian Massey, Christopher P. Twine, David C. Bosanquet
Fri Apr 24, 2020 17:36
Publication date: Available online 23 April 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Jeanette Köppe, Eva Freisinger, Joachim Gerß, Holger Reinecke, Dennis Görlich
Fri Apr 24, 2020 17:36
Publication date: Available online 23 April 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Jonathan Golledge, Anthony S. Leicht, Lisan Yip, Sophie E. Rowbotham, Jenna Pinchbeck, Jason S. Jenkins, Roslyn Clapperton, Matthew Dally-Watkins, Maria A. Fiatarone Singh, Yorgi Mavros, Yian Noble, Marjan M. Haghighi, Matthew Hollings, Belinda J. Parmenter, Nicola W. Burton
Fri Apr 24, 2020 17:36
Abstract Purpose To evaluate the effect of a PP mesh on duct deferens morphology, testicular size and testosterone levels. Methods Forty adult male rats were distributed into groups: 1) no surgery; 2) inguinotomy; 3) mesh placed on the duct deferens; and 4) mesh placed on the spermatic funiculus. After 90 postoperative days, the inguinal region was resected, and blood samples were collected for the measurement of serum testosterone (pg/dl). The ducts deferens were sectioned in three axial sections...
Mon Apr 27, 2020 17:45
Abstract Purpose To evaluate the effect of remote ischemic conditioning associated to N-acetylcysteine (NAC) on testicular ischemia∕reperfusion (I∕R) injury in rats. Methods Twenty-five adult male Wistar rats were randomly distributed into five experimental groups (n=5), as follows: Sham, I∕R, Perconditioning (PER), NAC and PER+NAC. Two-hour ischemia was induced by rotating the left testis 720° to clockwise direction, followed by 4 hours of reperfusion. Perconditioning was performed by three...
Mon Apr 27, 2020 17:45
Abstract Purpose To present new endoscopic robotic devices in the context of minimally invasive procedures with high precision and automation. Methods Review of the literature by December 2018 on robotic endoscopy. Results We present the studies and investments for robotic implementation and flexible endoscopy evolution. We divided them into forceps manipulation platforms, active endoscopy and endoscopic capsule. They try to improve forceps handling and stability and to promote active movement....
Mon Apr 27, 2020 17:45
Conditions: Colorectal Neoplasms; Head and Neck NeoplasmsInterventions: Biological: SYN125; Biological: SYN004Sponsor: Synermore Biologics Co., Ltd.Recruiting
Mon Apr 27, 2020 17:41
Condition: Atopic DermatitisInterventions: Drug: Crisaborole Ointment; Drug: Crisaborole Placebo VehicleSponsor: PfizerNot yet recruiting
Fri Apr 24, 2020 14:39
Conditions: Head and Neck Cancer; Dysphagia; Oropharyngeal Dysphagia; Oropharynx Cancer; Oropharynx Squamous Cell CarcinomaInterventions: Radiation: Radiation Therapy; Drug: Cetuximab; Drug: Chemotherapy; Drug: ImmunotherapySponsor: Loren Mell, MDNot yet recruiting
Fri Apr 24, 2020 14:39
Condition: Small Cell Lung CarcinomaInterventions: Drug: Lurbinectedin; Drug: PembrolizumabSponsors: Antonio Calles Blanco; MedSIR; PharmaMar; Merck Sharp & Dohme Corp.Not yet recruiting
Fri Apr 24, 2020 14:39
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Yang Wang, Chang-Lai Hao, Zhi-Hua Zhang, Li-Hong Wang, Li-Na Yan, Rong-Juan Zhang, Li Lin, Yue Yang
Mon Apr 27, 2020 17:33
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Abeer Mohamed El Sayed, Essam AbdElSattar, Mohammed Nabil Khalil
Sat Apr 25, 2020 15:37
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Yan Xiao, Wanying Chen, Zehao Zhong, Liang Ding, Hua Bai, Hao Chen, Hongru Zhang, Yihuang Gu, Shengfeng Lu
Sat Apr 25, 2020 15:37
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Sarunya Kitdumrongthum, Somrudee Reabroi, Kanoknetr Suksen, Patoomratana Tuchinda, Bamroong Munyoo, Panupong Mahalapbutr, Thanyada Rungrotmongkol, Puey Ounjai, Arthit Chairoungdua
Sat Apr 25, 2020 15:37
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Soudeh Ghafouri-Fard, Sepideh Dashti, Mohammad Taheri
Fri Apr 24, 2020 21:31
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Qiong Wang, Jing Shang, Yun Zhang, Yan Zhou, Lihua Tang
Fri Apr 24, 2020 21:31
Abstract Targeted immunotherapy has improved the outcome of patients with high-risk neuroblastoma (NB). However, immune escape of tumor cells still occurs and about 40% of NB patients relapse and die from their disease. We previously showed that natural killer (NK) cell stimulation by Toll-like receptor (TLR)-activated plasmacytoid dendritic cells (pDC) increases the efficacy of dinutuximab-based immunotherapy against NB cell lines via the TRAIL death-receptor pathway. With the...
Mon Apr 27, 2020 03:00
Abstract Primary central nervous system lymphoma (PCNSL) is a rare type of non-Hodgkin lymphoma with an aggressive clinical course. To investigate the potential of immune-checkpoint therapy, we retrospectively studied the tumor microenvironment (TME) using high-plex immunohistochemistry in 22 PCNSL and compared to 7 secondary CNS lymphomas (SCNSL) and 7 “other” CNSL lymphomas with the presence of the Epstein–Barr virus and/or compromised immunity. The TME in PCNSL was predominantly...
Sat Apr 25, 2020 03:00
Abstract Combination immunotherapy targeting the PD-1 and CTLA-4 checkpoint inhibitor pathways provides substantial clinical benefit in patients with advanced-stage cancer but at the risk of dose-limiting inflammatory and autoimmune toxicity. The delicate balance that exists between unleashing tumor killing and promoting systemic autoimmune toxicity represents a major clinical challenge. We hypothesized that targeting anti-CTLA-4 so that it perfuses tumor-draining lymph nodes...
Fri Apr 24, 2020 03:00
Abstract Background The presence of liver metastasis correlates with poor therapeutic response of PD-1 blockade therapy in melanoma. A novel treatment protocol by combining cryoablation with transarterial infusion of pembrolizumab (CATAP) was proposed, and its feasibility and safety was assessed among this group of patients. Methods This registered...
Fri Apr 24, 2020 03:00
Abstract NK cells, which are composed of phenotypically and functionally heterogeneous subpopulations, play critical roles in immunity against cancer. The mechanism of generation of distinct subsets such as the effector and regulatory subtypes is unclear. Here, we show that this process comprises several steps, including generation of proliferating, highly cytotoxic cells activated by IL-15/IL-18 and differentiation into distinct cell populations induced with IL-12. Freshly prepared...
Fri Apr 24, 2020 03:00
Publication date: Available online 27 April 2020Source: Revue des Maladies RespiratoiresAuthor(s): M Lahfaoui, M Azizi, M Elbakkaoui, R El Amrani, I kamaoui, H Benhaddou
Mon Apr 27, 2020 17:26
42 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Asian Pac J Cancer Prev"[jour] These pubmed results were generated on 2020/04/27PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Apr 27, 2020 17:25
42 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Asian Pac J Cancer Prev"[jour] These pubmed results were generated on 2020/04/27PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Apr 27, 2020 13:27
Publication date: Available online 25 April 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s):
Mon Apr 27, 2020 17:12
Publication date: Available online 25 April 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Ezgi Ergezen, Sıdıka Sinem Akdeniz
Sat Apr 25, 2020 21:50
Publication date: Available online 25 April 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Yiwen Lin, Yang Wang, Hongwei Zhang, Meredith August, Xuerong Xiang, Fugui Zhang
Sat Apr 25, 2020 21:50
Publication date: Available online 24 April 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Hikaru Takasu, Makoto Hirota, Yosuke Yamashita, Toshinori Iwai, Koichi Fujita, Kenji Mitsudo
Fri Apr 24, 2020 18:13
Publication date: Available online 23 April 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Eric J. Granquist, Gary Bouloux, David Dattilo, Oscar Gonzalez, Patrick J. Louis, Joseph McCain, Douglass Sinn, Victor Szymela, Michael Warner, Peter D. Quinn
Fri Apr 24, 2020 18:13
Publication date: Available online 23 April 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Muammer Melih Şahin, Metin Yılmaz, Recep Karamert., Süleyman Cebeci, Eray Uzunoğlu, Mehmet Düzlü, Alper Ceylan
Fri Apr 24, 2020 18:13
Publication date: Available online 23 April 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Mohamed Elkahwagi, Ahmed Eldegwi
Fri Apr 24, 2020 18:13
Publication date: July 2020Source: International Immunopharmacology, Volume 84Author(s): Congcong Lu, Guoxia Fan, Dianyun Wang
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