Objective: The element Iodine is an essential nutrient utilized by the thyroid glands, and deficiency of this element has been linked to reproductive failures. Iodide transporters are also present in reproductive tissues and cells of embryonic origin such as the endometrium and trophoblasts, respectively. The aim of this study is to understand if levels of iodide transporters are linked to pregnancy outcomes. Subjects and Methods: RNA derived from endometrial biopsies from controls or women with...
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Abstract This study aimed to explore whether the polymorphisms of CYP4F2 and CYP3A5 are correlated with the risk of lung cancer development. A case–control study was conducted among 510 patients with pathologically confirmed lung cancer as the case group and 504 healthy individuals as the control group. Four single-nucleotide polymorphisms of the CYP4F2 and CYP3A5 genes were genotyped, and their correlations with the risk of lung cancer were examined using Chi-square test and logistic...
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ObjectivesTo evaluate whether a newly developed care pathway, Treatment and Recovery In PsycHosis (TRIumPH), is feasible, acceptable and effective in meeting National Institute of Health and Care Excellence (NICE) quality standards in a timely manner. MethodsThis is a pragmatic, non-randomised, prospective, mixed methods study comparing an implementation (TRIumPH) and comparator site (not implementing TRIumPH) across three cohorts to assess feasibility, acceptability and effectiveness of the integrated...
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ObjectivesWe studied the characteristics of patient and visitor violence (PVV) and the workload of doctors and nurses, and identified the correlation between the incidence of PVV and healthcare worker (HCW) workload in China. DesignCross-sectional study. Setting288 public health institutions in a city in northern China. ParticipantsData on 87 998 HCWs were extracted from the 2015 database of the Medical Quality and Safety Notification System. MeasuresThe data included characteristics of the...
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ObjectivePeople living with diabetes need and deserve high-quality, individualised care. However, providing such care remains a challenge in many countries, including Canada. Patients’ expertise, if acknowledged and adequately translated, could help foster patient-centred care. This study aimed to describe Expert Patients’ knowledge, wisdom and advice to others with diabetes and to health professionals to improve diabetes self-management and care. Design and methodsWe recruited a convenience sample...
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Long-term hypervitaminosis D-induced hypercalcaemia treated with glucocorticoids and bisphosphonates
Hypercalcaemia is a common diagnosis with the majority of cases resulting from hyperparathyroidism or malignancy. We report a rare case of persistent symptomatic hypervitaminosis D-induced hypercalcaemia in an individual taking 50 000 IU of vitamin D supplement daily for several months following a diagnosis of vitamin D deficiency. His hypercalcaemia was initially treated with calcitonin and intravenous fluids, but due to recurrent symptomatic hypercalcaemia after discharge, additional treatment...
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An internal hernia is defined as a protrusion of an abdominal viscera through the defects of the gastrointestinal mesentery or peritoneum-lined fossa. Sigmoid mesocolic hernias are an uncommon type of internal hernias, accounting for only 6% of all internal hernias. Furthermore, intramesosigmoid hernia is one of the three subtypes of the sigmoid mesocolic hernias. Internal hernias are potentially fatal conditions with diagnostic challenges. Patients presenting with acute obstruction, no surgical...
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We describe a case of opportunistic coinfections with Coccidioides immitis and Pneumocystis jirovecii following treatment with idelalisib, a phosphoinositide 3-kinase inhibitor, for chronic lymphocytic leukaemia. This is the first case of pulmonary coccidioidomycosis reported in association with idelalisib. We review challenges related to diagnosis of opportunistic infections in this context. This report illustrates (1) the uncommon occurrence of two opportunistic infections concurrently or in rapid...
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Patients diagnosed with quadruple synchronous primary cancers are extremely rare and we present here, to the best of our knowledge, the first case report of this combination of primary cancers. A 70-year-old woman was diagnosed with cervical adenocarcinoma, melanoma on the right leg, invasive ductal cell carcinoma metastasis in the left axilla with no primary breast tumour detected and multiple basal cell carcinomas on the limbs, all within 2 months. The management was conducted in collaboration...
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Abstract Leishmaniasis comprises a group of neglected diseases caused by the protozoan parasite Leishmania spp. As is the case for other trypanosomatid parasites, Leishmania is auxotrophic for heme and must scavenge this essential compound from its human host. In mammals, the SLC transporter FLVCR2 mediates heme import across the plasma membrane. Herein we identify and characterize Leishmania major FLVCRb (LmFLVCRb), the first member of the FLVCR family studied in a non-metazoan...
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Abstract Premature intrapancreatic trypsinogen activation is widely regarded as an initiating event for acute pancreatitis. Previous studies have alternatively implicated secretory vesicles, endosomes, lysosomes, or autophagosomes/autophagolysosomes as the primary site of trypsinogen activation, from which a cell-damaging proteolytic cascade originates. To identify the subcellular compartment of initial trypsinogen activation we performed a time-resolution analysis of the first...
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Abstract CD4+Foxp3+ regulatory T (Treg) cells are key players in keeping excessive inflammation in check. Mounting evidence has shown that Treg cells exert much more diverse functions in both immunological and non-immunological processes. The development, maintenance and functional specification of Treg cells are regulated by multilayered factors, including antigens and TCR signaling, cytokines, epigenetic modifiers and transcription factors (TFs). In the review, we will focus...
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Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
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Abstract Capillary lymphatic venous malformations (CLVM) are complex vascular anomalies characterized by aberrant and enlarged lymphatic and blood vessels. CLVM appear during fetal development and enlarge after birth, causing life-long complications such as coagulopathy, pulmonary embolism, chronic pain, and disfigurement. Treatment includes surgical debulking, amputation, and recurrent sclerotherapy. Somatic, mosaic mutations in the 110-kD catalytic α-subunit of phosphoinositide-3-kinase...
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Systematic reviews adhere to the principle that science is cumulative and attempt to identify all empirical evidence in accordance with pre-determined eligibility criteria to answer a specific research questio...
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Challenges and opportunities towards the road of universal health coverage (UHC) in Nepal: a systematic review’ is a policy review paper and we published in BMC – Archives of Public Health. Policy research is ...
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Cancers, Vol. 12, Pages 1097: Deactivation of Glutaminolysis Sensitizes PIK3CA-Mutated Colorectal Cancer Cells to Aspirin-Induced Growth Inhibition Cancers doi: 10.3390/cancers12051097 Authors: Shogen Boku Motoki Watanabe Mamiko Sukeno Takeshi Yaoi Kiichi Hirota Mahiro Iizuka-Ohashi Kyoko Itoh Toshiyuki Sakai Aspirin is one of the most promising over-the-counter drugs to repurpose for cancer treatment. In particular, aspirin has been reported to be effective...
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Cancers, Vol. 12, Pages 1116: Chemoembolization Plus Radiotherapy Versus Chemoembolization Plus Sorafenib for the Treatment of Hepatocellular Carcinoma Invading the Portal Vein: A Propensity Score Matching Analysis Cancers doi: 10.3390/cancers12051116 Authors: Chu Kim Shim Yoon Kim Alrashidi A combination of transarterial chemoembolization (TACE) plus sorafenib or radiotherapy (RT) has demonstrated efficacy in patients with advanced hepatocellular carcinoma...
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Cancers, Vol. 12, Pages 1117: Celecoxib Prevents Doxorubicin-Induced Multidrug Resistance in Canine and Mouse Lymphoma Cell Lines Cancers doi: 10.3390/cancers12051117 Authors: Edina Karai Kornélia Szebényi Tímea Windt Sára Fehér Eszter Szendi Valéria Dékay Péter Vajdovich Gergely Szakács András Füredi Background: Treatment of malignancies is still a major challenge in human and canine cancer, mostly due to the emergence of multidrug resistance (MDR)....
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Cancers, Vol. 12, Pages 1114: Improving the Diagnostic Accuracy of the PD-L1 Test with Image Analysis and Multiplex Hybridization Cancers doi: 10.3390/cancers12051114 Authors: Matthew P. Humphries Victoria Bingham Fatima Abdullahi Sidi Stephanie G. Craig Stephen McQuaid Jacqueline James Manuel Salto-Tellez Targeting of the programmed cell death protein (PD-1)/programmed death-ligand 1 (PD-L1) axis with checkpoint inhibitors has changed clinical practice in...
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Cancers, Vol. 12, Pages 1115: Central Pathology Review in SENTIX, A Prospective Observational International Study on Sentinel Lymph Node Biopsy in Patients with Early-Stage Cervical Cancer (ENGOT-CX2) Cancers doi: 10.3390/cancers12051115 Authors: Nemejcova Kocian Kohler Jarkovsky Klat Berjon Pilka Sehnal Gil-Ibanez Lupo Petiz Sanchez Kascak Martinelli Buda Presl Barahona Lonkhuijzen Szatkowski ...
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Cancers, Vol. 12, Pages 1113: Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer Cancers doi: 10.3390/cancers12051113 Authors: Elodie Lafont Throughout tumour progression, tumour cells are exposed to various intense cellular stress conditions owing to intrinsic and extrinsic cues, to which some cells are remarkably able to adapt. Death Receptor (DR) signalling and the Unfolded Protein Response (UPR) are two stress responses...
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Cancers, Vol. 12, Pages 1110: The Prognostic and Predictive Value of SOX2+ Cell Densities in Patients Treated for Colorectal Cancer Cancers doi: 10.3390/cancers12051110 Authors: Tim J. Miller Melanie J. McCoy Tracey F. Lee-Pullen Chidozie C. Anyaegbu Christine Hemmings Max K. Bulsara Cameron F. Platell SOX2 (sex-determining region-Y homeobox-2) is a transcription factor essential for the maintenance of pluripotency and is also associated with stem-cell-like...
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Cancers, Vol. 12, Pages 1112: Aberrant Expression of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) in Warthin Tumors Cancers doi: 10.3390/cancers12051112 Authors: Robert Mandic Abbas Agaimy Daniel Pinto-Quintero Katrin Roth Afshin Teymoortash Hans Schwarzbach Christine G. Stoehr Fiona R. Rodepeter Boris A. Stuck Michael Bette The Warthin tumor represents the second most frequent benign tumor of the parotid gland and is characterized by the...
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Cancers, Vol. 12, Pages 1108: The Hippo Pathway Transducers YAP1/TEAD Induce Acquired Resistance to Trastuzumab in HER2-Positive Breast Cancer Cancers doi: 10.3390/cancers12051108 Authors: Paula González-Alonso Sandra Zazo Ester Martín-Aparicio Melani Luque Cristina Chamizo Marta Sanz-Álvarez Pablo Minguez Gonzalo Gómez-López Ion Cristóbal Cristina Caramés Jesús García-Foncillas Pilar Eroles Ana Lluch Oriol Arpí Ana Rovira Joan...
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Cancers, Vol. 12, Pages 1111: Analysis of a Real-World Cohort of Metastatic Breast Cancer Patients Shows Circulating Tumor Cell Clusters (CTC-clusters) as Predictors of Patient Outcomes Cancers doi: 10.3390/cancers12051111 Authors: Clotilde Costa Laura Muinelo-Romay Victor Cebey-López Thais Pereira-Veiga Inés Martínez-Pena Manuel Abreu Alicia Abalo Ramón M. Lago-Lestón Carmen Abuín Patricia Palacios Juan Cueva Roberto Piñeiro Rafael López-López...
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Cancers, Vol. 12, Pages 1109: Aberrant Expression of Androgen Receptor Associated with High Cancer Risk and Extrathyroidal Extension in Papillary Thyroid Carcinoma Cancers doi: 10.3390/cancers12051109 Authors: Chen-Kai Chou Shun-Yu Chi Fong-Fu Chou Shun-Chen Huang Jia-He Wang Chueh-Chen Chen Hong-Yo Kang Male gender is a risk factor for mortality in patients with papillary thyroid carcinoma (PTC). This study investigated the impact of androgen receptor (AR)...
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Cancers, Vol. 12, Pages 1107: STAT3: Versatile Functions in Non-Small Cell Lung Cancer Cancers doi: 10.3390/cancers12051107 Authors: Julian Mohrherr Iris Z. Uras Herwig P. Moll Emilio Casanova Signal Transducer and Activator of Transcription 3 (STAT3) activation is frequently found in non-small cell lung cancer (NSCLC) patient samples/cell lines and STAT3 inhibition in NSCLC cell lines markedly impairs their survival. STAT3 also plays a pivotal role in driving tumor-promoting...
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Cancers, Vol. 12, Pages 1105: TESC Promotes TGF-α/EGFR-FOXM1-Mediated Tumor Progression in Cholangiocarcinoma Cancers doi: 10.3390/cancers12051105 Authors: Cheng-Han Hsieh Cheng-Ying Chu Sey-En Lin Yu-Chen S.H. Yang Hung-Shu Chang Yun Yen Cholangiocarcinoma is a relatively uncommon but highly lethal malignancy. Improving outcomes in patients depends on earlier diagnosis and appropriate treatment; however, no satisfactory diagnostic biomarkers or targeted therapies...
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Cancers, Vol. 12, Pages 1106: Molecular and Clinical Relevance of ZBTB38 Expression Levels in Prostate Cancer Cancers doi: 10.3390/cancers12051106 Authors: Maud de Dieuleveult Claire Marchal Anne Jouinot Anne Letessier Benoit Miotto Prostate cancer is one of the most commonly diagnosed cancers in men. A number of genomic and clinical studies have led to a better understanding of prostate cancer biology. Still, the care of patients as well as the prediction of disease...
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The FDA approved niraparib for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to first-line platinum-based chemotherapy. (Source: CancerNetwork)
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Interim data from cohort B of KEYNOTE-555, a phase I trial evaluating a 400 mg every 6-week dosing regimen of pembrolizumab in patients with metastatic melanoma, demonstrated a consistent benefit-risk profile. (Source: CancerNetwork)
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The multi-center trial is comprised of 2 phases, with phase I determining the maximum tolerated dose of palbociclib and phase II determining the clinical benefit rate of treatment with anastrozole, palbociclib, trastuzumab, and pertuzumab. (Source: CancerNetwork)
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A recent clinical trial ’s results found that a targeted drug known as adavosertib caused tumors in nearly 30% of patients examined with uterine serous carcinoma, a hard-to-treat form of uterine cancer. (Source: CancerNetwork)
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Researchers analyzed pooled data from 159 patients enrolled in 3 larotrectinib trials to assess outcomes stratified by prior lines of therapy and ECOG performance status. (Source: CancerNetwork)
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