An evaluation of hepatocellular carcinoma practice guidelines from a radiation oncology perspective.
Related ArticlesAn evaluation of hepatocellular carcinoma practice guidelines from a radiation oncology perspective. Radiother Oncol. 2020 Apr 02;148:73-81 Authors: Rim CH, Cheng J, Huang WY, Kimura T, Lee V, Zeng ZC, Seong J Abstract INTRODUCTION: External beam radiotherapy (EBRT) is actively used for hepatocellular carcinoma (HCC) treatment in clinical practice but has not got attention in several guidelines owing to the lack of high-level evidences....
Mon Apr 27, 2020 14:10
Related ArticlesBRAF mutation and age in differentiated thyroid cancer risk stratification: Two sides of the same coin. Oral Oncol. 2020 Apr 23;106:104732 Authors: Subash A, Sinha P, Singh A Abstract BRAF V600E mutation is seen in about 45% of patients with Papillary Thyroid Carcinoma (PTC). Thyroid cancers are among the unique cancers where the age influences the prognosis. Current evidence suggests BRAF mutation in the presence of other risk factors...
Mon Apr 27, 2020 14:10
Related ArticlesThe Effectiveness of Dignity Therapy as Applied to End-of-Life Cancer Patients in Taiwan: A Quasi-experimental Study. Asian Nurs Res (Korean Soc Nurs Sci). 2020 Apr 23;: Authors: Li YC, Feng YH, Chiang HY, Ma SC, Wang HH Abstract PURPOSE: The study aimed to determine the effectiveness of dignity therapy for end-of-life cancer patients. MEATHODS: This was a quasi-experimental study design with a non-randomized controlled trial....
Mon Apr 27, 2020 14:10
Related ArticlesAttitudes and Beliefs Towards Advance Care Planning among Underserved Chinese-American Immigrants. J Pain Symptom Manage. 2020 Apr 23;: Authors: Dhingra L, Cheung W, Breuer B, Huang P, Lam K, Chen J, Zhou X, Chang V, Chui T, Hicks S, Portenoy R Abstract CONTEXT: Many in the rapidly-growing Chinese-American population are non-English-speaking and medically-underserved, and few engage in advance care planning (ACP). Evaluating culturally-determined...
Mon Apr 27, 2020 14:10
Related ArticlesEpidermal Growth Factor Receptor Inhibitors and Other Tyrosine Kinase Inhibitors for Solid Tumors. Infect Dis Clin North Am. 2020 Apr 22;: Authors: Ruiz-Camps I, Aguilar-Company J Abstract This article analyzes the risk of infection associated with small molecule kinase inhibitors used to treat solid organ malignancies and establishes specific recommendations. Most of these drugs are orally administered and have the ability to inhibit...
Mon Apr 27, 2020 14:10
Related ArticlesThe Otology Questionnaire Amsterdam: a generic patient reported outcome measure about the severity and impact of ear complaints. Validation, Reliability and Responsiveness. Clin Otolaryngol. 2020 Apr 26;: Authors: Kraak JT, van Dam TF, van Leeuwen LM, Kramer SE, Merkus P Abstract OBJECTIVE: To examine the construct validity, reliability and responsiveness of the Otology Questionnaire Amsterdam (OQUA). DESIGN: Multicentre,...
Mon Apr 27, 2020 14:12
Related ArticlesManagement and outcomes of vascular reconstruction in carotid body tumor resection: retrospective analysis of 60 cases. Eur Arch Otorhinolaryngol. 2020 Apr 25;: Authors: Sevil FC Abstract PURPOSE: Carotid body tumors (CBTs) are rare tumors of the head and neck area. We evaluated outcomes after carotid body tumor resection (CBR) requiring vascular reconstruction. METHODS: We retrospectively reviewed the patients, who underwent...
Mon Apr 27, 2020 14:12
Related ArticlesThe predictive and prognostic value of low skeletal muscle mass for dose-limiting toxicity and survival in head and neck cancer patients receiving concomitant cetuximab and radiotherapy. Eur Arch Otorhinolaryngol. 2020 Apr 25;: Authors: Huiskamp LFJ, Chargi N, Devriese LA, de Jong PA, de Bree R Abstract PURPOSE: This study aims to investigate the predictive value of low skeletal muscle mass (SMM) for cetuximab dose-limiting toxicity...
Mon Apr 27, 2020 14:12
Related ArticlesLetter: COVID-19 Pandemic: Safety Precautions for Stereotactic Radiosurgery. Neurosurgery. 2020 Apr 26;: Authors: Liaw J, Patel VA, Bann DV, Saadi RA, Mau C, Brettler S, Tuanquin L, Zacharia BE, Isildak H PMID: 32335668 [PubMed - as supplied by publisher]
Mon Apr 27, 2020 14:12
Related ArticlesRNA-seq analysis of potential lncRNAs for age-related hearing loss in a mouse model. Aging (Albany NY). 2020 Apr 26;12: Authors: Zhao T, Liu X, Sun Z, Zhang J, Zhang X, Wang C, Geng R, Zheng T, Li B, Zheng QY Abstract Age-related hearing loss (AHL) is an important health problem in the elderly population. Its molecular mechanisms have not been fully elucidated. In this study, we analyzed the differential expression of lncRNAs and...
Mon Apr 27, 2020 14:12
Related ArticlesUltrasound Elastic Parameters Predict Central Lymph Node Metastasis of Papillary Thyroid Carcinoma. J Surg Res. 2020 Apr 23;253:69-78 Authors: Guo JN, Song LH, Yu PY, Yu SY, Deng SH, Mao XH, Xiu C, Sun J Abstract BACKGROUND: This study aimed to explore the new factors that can predict central lymph node metastasis (CLNM) of papillary thyroid carcinoma (PTC) independently from ultrasound characteristics, elastic parameters, and endocrine...
Mon Apr 27, 2020 14:12
Related ArticlesDAHANCA 28: A phase I/II feasibility study of hyperfractionated, accelerated radiotherapy with concomitant cisplatin and nimorazole (HART-CN) for patients with locally advanced, HPV/p16-negative squamous cell carcinoma of the oropharynx, hypopharynx, larynx and oral cavity. Radiother Oncol. 2020 Mar 28;148:65-72 Authors: Saksø M, Jensen K, Andersen M, Hansen CR, Eriksen JG, Overgaard J Abstract BACKGROUND: A phase I-II study to evaluate...
Mon Apr 27, 2020 14:12
Related ArticlesConcordance of tumor infiltrating lymphocytes, PD-L1 and p16 expression in small biopsies, resection and lymph node metastases of oropharyngeal squamous cell carcinoma. Oral Oncol. 2020 Apr 23;106:104719 Authors: Brcic I, Gallob M, Schwantzer G, Zrnc T, Weiland T, Thurnher D, Wolf A, Brcic L Abstract OBJECTIVE: The incidence of oropharyngeal squamous cell carcinoma (OPSCC), especially human papillomavirus (HPV)-associated, is increasing...
Mon Apr 27, 2020 14:12
Related ArticlesConsensus on resectability in N3 head and neck squamous cell carcinomas: GETTEC recommendations. Oral Oncol. 2020 Apr 23;106:104733 Authors: Carsuzaa F, Gorphe P, Vergez S, Malard O, Fakhry N, Righini C, Philouze P, Lasne-Cardon A, Gallet P, Tonnerre D, Bozec A, de Mones E, Baujat B, Laccourreye L, Babin E, Dufour X, Thariat J Abstract BACKGROUND: Among patients with T0-2 N3 head and neck squamous cell carcinomas (HNSCC), those undergoing...
Mon Apr 27, 2020 14:12
Related ArticlesCarotid web of missed diagnosis: a case report. World Neurosurg. 2020 Apr 23;: Authors: Ren T, Sun S, Qu X, Gao Y Abstract BACKGROUND: The carotid web (CW), an atypical fibromuscular dysplasia, is a rare disease and may cause ischemic stroke. It is challenging to recognize CW promptly and treat it accordingly. Here we report an initially misdiagnosed case of CW. CASE DESCRIPTION: A 48-year-old male with recurrent cerebral...
Mon Apr 27, 2020 14:12
Related ArticlesGolden-Angle Radial Sparse Parallel (GRASP) MRI differentiates head & neck paragangliomas from schwannomas. Magn Reson Imaging. 2020 Apr 23;: Authors: Demerath T, Blackham K, Anastasopoulos C, Block KT, Stieltjes B, Schubert T Abstract PURPOSE: The aim of this study was to demonstrate the value of DCE MRI with high spatiotemporal resolution (GRASP) for differentiating paragangliomas and schwannomas in the head and neck. ...
Mon Apr 27, 2020 14:12
Related ArticlesRisk factors associated with microbial colonisation and infection of tracheostomy tubes. Am J Otolaryngol. 2020 Apr 18;:102495 Authors: Kumarasinghe D, Wong E, Duvnjak M, Sritharan N, Smith MC, Palme C, Riffat F Abstract BACKGROUND: A long-term tracheostomy tube has the potential to cause significant morbidity and mortality in both hospitalised patients and those in the community. This study aims to assess the rates of microbial colonisation...
Mon Apr 27, 2020 14:12
Ran promotes the proliferation and migration ability of head and neck squamous cell carcinoma cells.
Related ArticlesRan promotes the proliferation and migration ability of head and neck squamous cell carcinoma cells. Pathol Res Pract. 2020 Apr 11;:152951 Authors: Zhang C, Zhao X, Du W, Shen J, Li S, Li Z, Wang Z, Liu F Abstract HNSCC is an aggressive tumor that often recurrence and metastasis. Although the treatment of HNSCC has improved over the past few decades, it is easy to recurrence even after comprehensive treatment. Ran is a small Ras-related...
Mon Apr 27, 2020 14:12
Related ArticlesGenome and base editing for genetic hearing loss. Hear Res. 2020 Apr 05;:107958 Authors: Niggemann P, György B, Chen ZY Abstract Genome editing opens up a new frontier in developing personalized therapeutic solutions. With the unprecedented advance in the discovery and engineering of gene editing nucleases, it has now become potentially feasible to therapeutically influence up to 90% of all human genetic mutations. Hearing loss is...
Mon Apr 27, 2020 14:12
Related ArticlesPhenotypes of Obstructive Sleep Apnea. Otolaryngol Clin North Am. 2020 Apr 22;: Authors: Coughlin K, Davies GM, Gillespie MB Abstract Obstructive sleep apnea (OSA) is a multisystem breathing disorder associated with increased morbidity and mortality. Clinical and operative assessment tools improve surgical approaches to treat airway obstruction. The primary sites of anatomic obstruction are at the levels of the nasal, palatal, and...
Mon Apr 27, 2020 14:12
Related ArticlesCurrent Validated Medical Treatments: Pharmacologic Interventions. Otolaryngol Clin North Am. 2020 Apr 22;: Authors: Bauer CA Abstract The search for an effective medication that will eliminate tinnitus has a long history. Currently, no drugs exist that universally cure tinnitus. Pharmacologic interventions that have been investigated can be divided into those that attempt to eliminate the perception of tinnitus, and those that are...
Mon Apr 27, 2020 14:12
Related ArticlesBase of Tongue Surgery for Obstructive Sleep Apnea in the Era of Neurostimulation. Otolaryngol Clin North Am. 2020 Apr 22;: Authors: Shah RR, Thaler ER Abstract Retroglossal collapse is commonly seen in patients with obstructive sleep apnea. The role of upper airway stimulation surgery for these patients continues to evolve. However, base of tongue reduction surgery continues to have usefulness for appropriately selected patients...
Mon Apr 27, 2020 14:12
Related ArticlesCurrent Device-based Clinical Treatments for Tinnitus. Otolaryngol Clin North Am. 2020 Apr 22;: Authors: Sherlock LP, Eisenman DJ Abstract Device-based clinical treatments for tinnitus are predominantly sound based and include ear-level sound generators, hearing aids, cochlear implants, and tinnitus treatment devices. They are intended for patients with bothersome tinnitus. Bothersome tinnitus is characterized by problems with sleep,...
Mon Apr 27, 2020 14:12
Related ArticlesNoise exposure alters MMP9 and brevican expression in the rat primary auditory cortex. BMC Neurosci. 2020 Apr 25;21(1):16 Authors: Park SS, Lee DH, Lee SM, Lee CH, Kim SY Abstract BACKGROUND: This study aimed to investigate the changes in molecules related to perineuronal nets (PNNs) and synaptic transporters in the primary auditory cortices of rats with noise-induced hearing loss. Female Sprague-Dawley rats at postnatal day 7 were...
Mon Apr 27, 2020 14:12
Publication date: Available online 25 April 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Beverley Kramer, Carol Hartmann, Francesca du Toit, Erin Hutchinson, Nalini Pather
Mon Apr 27, 2020 13:11
Related ArticlesThe effectiveness of virtual reality-based technology on anatomy teaching: a meta-analysis of randomized controlled studies. BMC Med Educ. 2020 Apr 25;20(1):127 Authors: Zhao J, Xu X, Jiang H, Ding Y Abstract BACKGROUND: Virtual reality (VR) is an innovation that permits the individual to discover and operate within three-dimensional (3D) environment to gain practical understanding. This research aimed to examine the general efficiency...
Mon Apr 27, 2020 18:59
Related ArticlesQuality improvement education for medical students: a near-peer pilot study. BMC Med Educ. 2020 Apr 25;20(1):128 Authors: McGeorge E, Coughlan C, Fawcett M, Klaber RE Abstract BACKGROUND: Quality improvement (QI) is an essential component of modern clinical practice. Front-line professionals offer valuable perspectives on areas for improvement and are motivated to deliver change. In the UK, all junior doctors are expected to participate...
Mon Apr 27, 2020 18:59
Related ArticlesTime Course of Changes in Sorafenib-Treated Hepatocellular Carcinoma (HCC) Cells Suggests Involvement of Phospho-Regulated Signaling in Ferroptosis Induction. Proteomics. 2020 Apr 26;:e2000006 Authors: Werth EG, Rajbhandari P, Stockwell BR, Brown LM Abstract Ferroptosis is a form of regulated, non-apoptotic cell death characterized by excessive lipid peroxidation that can be triggered by inhibition of the cystine-glutamate antiporter,...
Mon Apr 27, 2020 15:07
Related ArticlesSPCA1 governs the stability of TMEM165 in Hailey-Hailey disease. Biochimie. 2020 Apr 23;: Authors: Roy AS, Miskinyte S, Garat A, Hovnanian A, Krzewinski-Recchi MA, Foulquier F Abstract TMEM165 is a Golgi protein whose deficiency causes a Congenital Disorder of Glycosylation (CDG). We have demonstrated that Mn2+ supplementation could suppress the glycosylation defects observed in TMEM165-deficient cells and that TMEM165 was a Mn2+-sensitive...
Mon Apr 27, 2020 15:07
Related ArticlesRedox signaling in the pathogenesis of human disease and the regulatory role of autophagy. Int Rev Cell Mol Biol. 2020;352:189-214 Authors: Pervaiz S, Bellot GL, Lemoine A, Brenner C Abstract Aberrant cell death signaling and oxidative stress are implicated in myriad of human pathological states such as neurodegenerative, cardiovascular, metabolic and liver diseases, as well as drug-induced toxicities. While regulated cell death and mild...
Mon Apr 27, 2020 15:07
Related ArticlesSleep apnea syndrome comorbid with and without restless legs syndrome: differences in insomnia specific symptoms. Sleep Breath. 2020 Apr 25;: Authors: Pistorius F, Geisler P, Wetter TC, Crönlein T Abstract OBJECTIVE: Sleep Apnea Syndrome (SAS) is frequently comorbid with Restless Legs Syndrome (RLS). Both disorders are associated with disturbed sleep. However, data about insomnia specific symptoms in patients suffering from both sleep...
Mon Apr 27, 2020 14:21
Related ArticlesPrevalence of Atrial Fibrillation in Obstructive Sleep Apnea Patients in a Tertiary Care Center. JNMA J Nepal Med Assoc. 2020 Feb;58(222):80-83 Authors: Dhakal SS, Neupane A, Bhattarai M, Karki DB Abstract INTRODUCTION: Atrial fibrillation is the most common sustained arrhythmias.Recently there has been evidence of higher prevalence of atrial fibrillation in obstructive sleep apnea patients compared to the general population. The aim...
Mon Apr 27, 2020 14:21
Related ArticlesComment on: Prevalence of obstructive sleep apnea in an Asian bariatric population. An undiagnosed dilemma. Surg Obes Relat Dis. 2020 Mar 29;: Authors: Albaugh VL PMID: 32334973 [PubMed - as supplied by publisher]
Mon Apr 27, 2020 14:21
Related ArticlesThe Goals of Treating Obstructive Sleep Apnea. Otolaryngol Clin North Am. 2020 Apr 22;: Authors: Evans EC, Sulyman O, Froymovich O Abstract Obstructive sleep apnea (OSA) syndrome is a destructive and insidious entity mostly underdiagnosed and undertreated. It affects not only individuals but the society as a whole. The costs to the populations can be measured not only in morbidity and mortality but also in the financial wellbeing of a...
Mon Apr 27, 2020 14:21
Related ArticlesImplantable Neurostimulation for Treatment of Sleep Apnea: Present and Future. Otolaryngol Clin North Am. 2020 Apr 22;: Authors: Whelan R, Soose RJ Abstract Hypoglossal nerve stimulation (HNS) therapy represents a novel approach and a paradigm shift in the evolution of obstructive sleep apnea (OSA) treatment as a hybrid surgically implanted, medically titratable device. Unlike traditional sleep apnea surgical procedures, HNS augments...
Mon Apr 27, 2020 14:21
Related ArticlesSleep Studies Interpretation and Application. Otolaryngol Clin North Am. 2020 Apr 22;: Authors: Hiensch R, Rapoport DM Abstract Obstructive sleep apnea is a common, but under-recognized, condition. Polysomnography remains the gold standard for diagnosing obstructive sleep apnea and determining whether treatment is appropriate. The development of home sleep apnea testing has allowed for a faster and more convenient method of diagnosis....
Mon Apr 27, 2020 14:21
Related ArticlesSurgical and Nonsurgical Weight Loss for Patients with Obstructive Sleep Apnea. Otolaryngol Clin North Am. 2020 Apr 22;: Authors: Saunders KH, Igel LI, Tchang BG Abstract A strong association exists between excess weight and obstructive sleep apnea (OSA), and most patients with OSA have elevated body mass index. Weight loss is an essential part of treatment for patients with OSA and overweight or obesity. Lifestyle interventions are cornerstones...
Mon Apr 27, 2020 14:21
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