Horm Metab ResDOI: 10.1055/a-1155-0501COVID-19 is a rapidly spreading outbreak globally. Emerging evidence demonstrates that older individuals and people with underlying metabolic conditions of diabetes mellitus, hypertension, and hyperlipidemia are at higher risk of morbidity and mortality. The SARS-CoV-2 infects humans through the angiotensin converting enzyme (ACE-2) receptor. The ACE-2 receptor is a part of the...
Mon Apr 27, 2020 02:00
Horm Metab ResDOI: 10.1055/a-1141-3526Adrenal venous sampling is the standard of care for identifying patients with unilateral primary aldosteronism, which is often caused by an aldosterone producing adenoma and can be cured with surgery. The numerous limitations of adrenal venous sampling, including its high cost, scarce availability, technical challenges, and lack of standardized protocols, have driven efforts to...
Fri Apr 24, 2020 02:00
Prenatal intake of alcohol and tobacco have been associated with negative outcomes in children. Consumption of alcohol while breastfeeding has also been associated with dose-dependent decreases in abstract rea...
Sun Apr 26, 2020 03:00
The authorship list on the original article [1] was incorrect and should instead show as Aklilu Abera Ayele, Kemal Ahmed Seid and Oumer Sada Muhammed. The authors apologise for this error.
Fri Apr 24, 2020 03:00
We noticed that syphilis patients seem to be more susceptible to diabetes and the lesions often involve the kidneys, but the pathogenesis is not yet completely understood. In this study, microarray analysis wa...
Mon Apr 27, 2020 03:00
Hops is an almost unique source of the potent phytoestrogen 8-prenylnaringenin (8-PN). As hops contain only low levels of 8-PN, synthesis may be more attractive than extraction. A strain of the Gram-positive Euba...
Fri Apr 24, 2020 03:00
Doubts surrounding the potential adverse effects of antimicrobial preservatives have modified the demand of consumers, who increasingly insist on the production of low-level and even preservative-free cosmetic...
Fri Apr 24, 2020 03:00
Quorum sensing (QS) inhibition by metal-antibiotic complexes is a promising strategy for the management and control of multidrug resistant Pseudomonas aeruginosa infections. We investigated the anti-quorum sensin...
Fri Apr 24, 2020 03:00
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are neurodegenerative diseases (NDD) characterized by progressive degeneration of the central nervous system, and few medications are available to halt the...
Fri Apr 24, 2020 03:00
Abstract Coronavirus disease 2019 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2. It has taken a toll of lots of lives since its outbreak. Infection prevention at present is an appropriate control measure in addition to other measure like hand hygiene and personal protective equipment (PPE). In our country with a large population, supplying PPE to all the health care workers of all hospitals definitely is an economic burden. Hence we have come...
Mon Apr 27, 2020 03:00
Abstract Recurrent aphthous stomatitis (RAS) is a frequently seen oral ulcerative lesion, manifesting as multiple, recurrent, shallow, irregular ulcers encircled by an erythematous halo. The precise etiopathogenesis is obscure, although the recent understanding suggests an underlying immune-mediated etiology. However, there is no defined management protocol and the principal therapy aims to attain symptomatic respite. 150 clinically diagnosed RAS patients of both sexes in the...
Mon Apr 27, 2020 03:00
Abstract Cutaneous cancer is a rare entity accounting for less than 1% of all diagnosed cancers in India. In contrast to the West, squamous cell carcinoma is the commonest skin cancer in India, often affecting the scalp. However, due to their rarity, not much is known regarding their biological behavior and prognosis. The present study is a retrospective cohort study undertaken in a tertiary cancer centre on 19 consecutive cases of squamous cell carcinoma of the scalp over a period...
Fri Apr 24, 2020 03:00
Distichodus is a clade of tropical freshwater fishes currently comprising 25 named species distributed continent-wide throughout the Nilo-Sudan and most Sub-Saharan drainages. This study investigates the phylogen...
Sun Apr 26, 2020 03:00
Maladaptive plasticity facilitates evolution of thermal tolerance during an experimental range shift
Many organisms are responding to climate change with dramatic range shifts, involving plastic and genetic changes to cope with novel climate regimes found at higher latitudes. Using experimental lineages of th...
Thu Apr 23, 2020 03:00
Despite lower asthma prevalence in rural compared to urban children,1,2 studies suggest that rural children have higher asthma morbidity and uncontrolled asthma.2-4 Investigation into potential differences in management and healthcare utilization following asthma diagnosis would help provide a better understanding of these results. Potential barriers to healthcare access in rural areas may contribute to poor management of asthma and help explain uncontrolled disease in these areas.
Mon Apr 27, 2020 03:00
Hypersensitivity reactions (HSR) to antineoplastic agents may lead to discontinuation of first-line treatments. Rapid drug desensitization (RDD) allows for a safe reintroduction in allergic patients.
Mon Apr 27, 2020 03:00
Omenn syndrome (OS) is an autosomal recessive subtype of severe combined immunodeficiency (SCID) with increased mortality.1 Gilbert Omenn first reported this in 1965, describing reticuloendotheliosis with eosinophilia in several siblings from a consanguineous American family of Irish descent.2 The incidence of SCID is 1:58 000 to 1:100 000, while OS has a frequency of 1: 5000 000.2,3 OS is most frequently caused by mutations in the RAG genes, but also in mutations in ARTEMIS, ADA, ILRA2, ILRA7, CHD7,...
Mon Apr 27, 2020 03:00
Current laboratory methods to determine the presence of circulating allergen-specific IgE involve use of crude biological extracts or purified recombinant allergens.1 Extracts differ in composition due to difficulties in obtaining pure, raw materials and/or differences in processing,1,2 and recombinant allergens are difficult to obtain in biologically relevant, conformationally active forms.2 These limitations can lead to variable results in assays.1 In addition, challenges arise in patients undergoing...
Sat Apr 25, 2020 03:00
Measles was officially declared eradicated from the United States in 2000. Unfortunately, this status was temporary with measles outbreaks currently impacting multiple countries. In 2019, the World Health Organization listed vaccine hesitancy a top-ten global health threat.1 Ever since Edward Jenner developed the world’s first successful smallpox injection, vocal segments of the population have resisted vaccines. Two original themes of the 1800’s persist among today’s anti-vaccine advocates: misguided...
Fri Apr 24, 2020 03:00
The goal of asthma management is to achieve optimal asthma control, defined by absence of daytime symptoms, night time waking, reliever use, functional limitation and lung function stability, and to also reduce the future risks of asthma exacerbations, deterioration in lung function and medication's side effects. The most widely used maintenance therapy is inhaled corticosteroids (ICS). This review will consider the evidence that the combination of the ICS budesonide and the rapid onset long acting...
Fri Apr 24, 2020 03:00
For this month’s issue of Annals, which focuses on vaccines, I’ve selected 3 article summaries from recent Allergy Watch that reviewed studies on various aspects of vaccines. The first reports data from the pivotal study showing the improved efficacy of the new recombinant subunit herpes zoster vaccine. The next review describes a report of a unique vaccine for cats that induces IgG blocking antibodies for Fel d 1. The last review shows discrepant results of pneumococcal titers from different labs.
Fri Apr 24, 2020 03:00
01:07
A survey shows one in five New Yorkers tested positive for antibodies to SARS-CoV-2, which causes COVID-19. But we will still likely be social distancing in some form well into summer. (Pexels/)Follow all of PopSci’s COVID-19 coverage here, including tips on cleaning groceries, ways to tell if your symptoms are just allergies, and a tutorial on making your own mask.The COVID-19 pandemic is a fast-moving target. Each week, doctors identify novel aspects of the viral infection, researchers discover...
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Cooking with magnets makes every meal feel a bit like living in the future. (Amazon/)There’s a magic to cooking with gas—the ability to adjust the flame just right to control the heat, the click of starting the burner. But not every home can accommodate a gas stove and, despite that magic, it takes a lot of time to bring water to a boil, or do any other necessary task. Enter the induction cooktop. Popular with chefs, these magnet-powered burners both heat and cool quickly, and give you the precision...
Mon Apr 27, 2020 21:13
Brighten your day with an indoor garden. (Scott Webb via Unsplash/)Indoor gardening is often focused on growing herbs you can eat, or hanging large plants that gobble up the sun streaming through your window. Terrariums are more like a small-scale greenhouse. They can be enclosed or open to the air, and are essentially a tiny world of your own making. These essential terrarium supplies will get you started cultivating living flora in your living space, and provide a welcome bit of natural landscape...
Mon Apr 27, 2020 21:06
A pale blue blip in time. (Set Reset/)Humans have gotten a lot done in 300,000 years: We invented agriculture, developed writing systems, built cities, created the internet, and shrugged off gravity to land on the moon. These innovations make our past seem long—and stuffed with significance. But in the brief history of life, everything we’ve ever accomplished fits into a tiny sliver of time—just 0.008 percent of the entire continuum shown below. This is how the rise of the animal kingdom stretches...
Mon Apr 27, 2020 21:00
The storm happens fast, so be ready if you want to take a photo of it. (John Kennedy/)Welcome to PopSci’s at-home science projects series. On weekdays at noon, we’ll be posting new projects that use ingredients you can buy at the grocery store. Show us how it went by tagging your project on social media using #popsciprojects.The air we breathe every day is full of moisture—even in the desert. Under the right conditions, that moisture will form clouds, which may eventually let loose some rain. It’s...
Mon Apr 27, 2020 21:30
An easy-to-clean cooking surface. (Amazon/)Those of you who love a griddle know it’s often the secret to a perfectly cooked breakfast. We’re talking about the kind of breakfast where everything is served hot and buttery. We want the kind of breakfast where your pancakes are lovely caramel colored disks. If you happen to be a griddle enthusiast, you know that some griddles can be your best friend in the kitchen all day long, too. Even temperatures and large surface areas give you a perfect sear, and...
Mon Apr 27, 2020 18:31
Rooms will give you the tiled view that helped make Zoom so popular. (Facebook Rooms/)Since Facebook added video chat to Instagram back in 2018, Facebook has offered its users numerous ways to carry out real-time face-to-face interactions. By that point, almost every corner of the Facebook world—including Messenger and WhatsApp—offered some kind of video chat option. When social distancing began, however, users flocked to Zoom for their group chats—it turns out people wanted work-style conference...
Mon Apr 27, 2020 17:43
Rock your exercise routine. (Alessio Billeci via Unsplash/)A strong core helps you have good balance, and practicing your balance helps you have a strong core. So where to start? If you’re tired of your usual gym routine, try adding in a few of these tools for a fun and beneficial challenge. With these four simple pieces of equipment, it’s easy to wobble your way to better health.Hold your posture, not your breath. (Amazon/)If you’ve ever been through physical therapy, you may have used a balance...
Mon Apr 27, 2020 16:12
Sampling our stool could offer a faster and cheaper way to pinpoint where outbreaks of COVID-19 are brewing before scores of people become seriously ill. (ASU, Media Relations/)Your poop might soon be pressed into service in the fight against COVID-19.When we flush the toilet, our effluvia are whisked out of sight and mind and in most cases wind up at a wastewater treatment plant. All this waste represents a golden (so to speak) opportunity to track the spread of the coronavirus that causes COVID-19.Around...
Mon Apr 27, 2020 23:01
This so-called "impossible object" takes form when the brain attempts to turn a 2D image into a 3D object. (Stuart Patience/)Glance at the stairs above.Find the base...rather, spot the top. Upon closer examination, you’ll realize that there is no beginning or end. There’s no way that’s feasible, right?These familiar steps, called the Penrose stairs, are a type of “impossible object”—a construction that could not exist in reality even though its individual pieces look totally valid, says Erez Freud,...
Sun Apr 26, 2020 16:00
An American woodcock probes for worms and insects in the duff of the spring woods. (Deposit Photos/)This story originally featured on Field & Stream.My woodcock season opens right about now. The landscape is colorless, trees are still black skeletons, but these little birds are seemingly celebrating the coming of spring with a sky dance that few hunters ever witness. The performance may begin as early as February in some places, as late as May in others. Completing their night flights from the...
Sat Apr 25, 2020 18:00
Trust us—if you were reading "War and Peace," that hammock wouldn't be half as comfortable. (Perfecto Capucine / Unsplash/)E-book readers are one of the clearest signs the future is now—having an entire library in your pocket powered by a battery that almost never runs out is exactly what my seven-year-old self was dreaming of (sorry, iPhone).If you love reading but are still new to e-readers, you’re in for a serious treat. It’s never been easier to carry around what would be a large hardcover to...
Sat Apr 25, 2020 12:00
Hubble zooms in for an up-close look at star assembly in one of the galaxies orbiting the Milky Way. (NASA, ESA and STScI/)On April 24, 1990, the Space Shuttle Discovery blasted off from Florida with an instrument that would forever divide astronomy into two eras: the time before space telescopes, and the time after. From its perch above Earth’s fuzzy atmosphere, the Hubble Space Telescope has spent three decades peering into the darkness, indiscriminately collecting whatever stray light beams found...
Sat Apr 25, 2020 01:00
Campus shutdowns mean researchers must be classified as essential personnel to tend collections, like these fungus-colonized plants. (Cameron Stauder/)Matt Kasson is an assistant Professor of Plant Pathology and Mycology, West Virginia University. Brian Lovett is a Postdoctoral Researcher in Mycology, West Virginia University. Rita Rio is a Professor of Biology, West Virginia University. This story originally featured on The Conversation. Read PopSci’s coverage on disruptions in lab work here.During...
Fri Apr 24, 2020 23:00
For cleaning purposes only. (Unsplash/)Follow all of PopSci’s COVID-19 coverage here, including tips on cleaning groceries, ways to tell if your symptoms are just allergies, and a tutorial on making your own mask.The idea of using bleach to “detox” the body or prevent certain diseases is nothing new, but global panic over the novel-coronavirus pandemic means this dangerous DIY treatment is getting some more time in the spotlight. As Gabby Landsverk reported for Insider on Thursday, Christina Cuomo—wife...
Sat Apr 25, 2020 02:49
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