Opinion statement Phosphatidylinositol 3-kinase (PI3K) inhibitors represent a novel class of agents targeting the key cellular regulatory PI3K/AKT/mTOR pathway involved in crucial functions such as cellular proliferation, cell cycle regulation, protein synthesis, and cell motility. This review starts with an overview of the PI3K pathway and the rationale for its targeting in lymphoma and potential on-target side effects of PI3K inhibition. With three agents now FDA approved...
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Opinion statement Despite its rarity, hairy cell leukemia (HCL) remains a fascinating disease and the physiopathology is becoming more and more understood. The accurate diagnosis of HCL relies on the recognition of hairy cells by morphology and flow cytometry (FCM) in the blood and/or bone marrow (BM). The BRAF V600E mutation, an HCL-defining mutation, represents a novel diagnostic parameter and a potential therapeutic target. The precise cellular origin of HCL is a late-activated...
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Opinion statement Pancreatic neuroendocrine neoplasms (PanNENs) are increasingly recognized entities, whose incidence has dramatically grown during the last two decades. Surgery plays a pivotal role in their management as it represents the only chance of cure. Since PanNENs display a wide range of aggressiveness, their surgical management needs to be tailored on tumor’s and patient’s characteristics. Currently, there are several open questions and burning issues in the field...
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Opinion statement The capacity of cells to modify their phenotypes from epithelial to mesenchymal (epithelial-to-mesenchymal transition or EMT) and vice versa provides them with a dynamic plasticity essential for human life, from embryogenesis to wound healing. Current knowledge about carcinogenetic mechanisms leaves little doubts on the pivotal participation of these interchangeable processes in cancer development, and their influence has been quite clearly established in the...
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Opinion statement Myelofibrosis (MF) is a clonal disorder of the pluripotent hematopoietic stem cell, whose clinical manifestations can be extremely heterogeneous, including cytopenias, organomegaly, constitutional symptoms, and cachexia. Median survival ranges from approximately 3.5 to 5.5 years; while the most frequent cause of death is the evolution to acute myeloid leukemia, also other conditions such as progression without transformation, complications due to cytopenias...
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Opinion statement Oncologists should be able to discern the salient clinical features of the most common germline mutations that give rise to neuroendocrine tumors. Astute recognition of an index patient affected by a hereditary syndrome can lead to a “tip-of-the-iceberg” phenomenon whereby their entire kindred can then be proactively monitored and managed potentially with substantial reduction of morbidity and mortality. Through careful history-taking, as well as thoughtful...
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Opinion statement The choice of the right treatment regimen for recurrent ovarian cancer (rOC) remains a case-by-case decision. It is based on multiple factors that involve patient characteristics and biological factors at the same time. The prioritization of factors is still subject to changes with a trend towards a more personalized medicine. Therefore, participation and engagement in clinical studies constitutes a substantial need for the future development of the treatment...
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Opinion statement With greater understanding of underlying biology and development of effective BRAF-targeted therapy and immunotherapy, along with remarkable advances in local treatment such as stereotactic radiosurgery, melanoma brain metastasis (MBM) is witnessing continually improving outcome, with 1-year overall survival rate approaching 85%. Given disease complexity and myriad treatment options, all patients with MBM should ideally be evaluated in a multidisciplinary setting...
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Authors: Grasiele S.V. Tavares, Débora V.C. Mendonça, Isabela A.G. Pereira, João A. Oliveira-da-Silva, Fernanda F. Ramos, Daniela P. Lage, Amanda S. Machado, Lívia M. Carvalho, Thiago A.R. Reis, Luísa Perin, Ana Maria R.S. Carvalho, Flaviano M. Ottoni, Fernanda Ludolf, Camila S. Freitas, Raquel S. Bandeira, Alessandra M. Silva, Miguel A. Chávez-Fumagalli, Mariana C. Duarte, Daniel Menezes-Souza, Ricardo J. Alves, Bruno M. Roatt and Eduardo A.F. Coelho.<br />Parasite Vol. 27 , page 29<br...
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Authors: Ehsan Ahmadpour, Hanie Safarpour, Lihua Xiao, Mehdi Zarean, Kareem Hatam-Nahavandi, Aleksandra Barac, Stephane Picot, Mohammad Taghi Rahimi, Salvatore Rubino, Mahmoud Mahami-Oskouei, Adel Spotin, Sanam Nami and Hossein Bannazadeh Baghi.<br />Parasite Vol. 27 , page 27<br />Published online: 30/04/2020<br /> Keywords: Cryptosporidium infection ; HIV ; AIDS ; Systematic review.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/tUj3bNacxaU" height="1"...
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Development of MALDI-TOF mass spectrometry for the identification of lice isolated from farm animals
Authors: Basma Ouarti, Maureen Laroche, Souad Righi, Mohamed Nadir Meguini, Ahmed Benakhla, Didier Raoult and Philippe Parola.<br />Parasite Vol. 27 , page 28<br />Published online: 30/04/2020<br /> Keywords: MALDI-TOF MS ; Lice ; Phthiraptera ; Anoplura ; Mallophaga.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/r7GRn-f9Pxg" height="1" width="1" alt=""/>
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Related ArticlesCan imaging impact the coronavirus pandemic? Indian J Radiol Imaging. 2020 Jan-Mar;30(1):1-3 Authors: Kohli A PMID: 32341629 [PubMed]
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On March 11, 2020, the World Health Organization designated "coronavirus disease 2019" (Covid-19) a global pandemic. As the number of cases in the United States continues to grow, political leaders are encouraging physical (or "social") distancing to slow the rate of transmission. The goal of this…
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As Covid-19 spreads throughout the United States, schools and child care facilities are balancing their role of helping to prevent disease transmission with ensuring access to food for children who rely on the federal nutrition safety net. Together, the U.S. Department of Agriculture (USDA)…
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This August marks the 75th anniversary of the conclusion of World War II. In history’s largest, most destructive war, an estimated 80 million people, or roughly 3% of the world population, died. Nearly 420,000 Americans were killed, and 670,000 were wounded. These grim numbers were mitigated,…
Wed Apr 29, 2020 03:00
To the Editor: Data on Covid-19 in patients with immune-mediated inflammatory disease who have received anticytokine biologics, other immunomodulatory therapies, or both on a long-term basis are scarce. Trials to assess the efficacy of antirheumatic therapies such as hydroxychloroquine and…
Wed Apr 29, 2020 03:00
To the Editor: Despite the risk of rapid respiratory failure and cardiac complications due to Covid-19, it is unclear whether there is an association between Covid-19 and out-of-hospital cardiac arrest. The Lombardy region of Italy was among the first areas to have an outbreak of Covid-19 outside…
Wed Apr 29, 2020 03:00
How long will this pandemic last? When will we find a treatment or vaccine? Which drug should we give our patients? Will we run out of personal protective equipment (PPE)? When will everyone return to work? We find ourselves in a time of great economic, social, and medical uncertainty. Faced with a…
Tue Apr 28, 2020 03:00
To rapidly communicate short reports of innovative responses to Covid-19 around the world, along with a range of current thinking on policy and strategy relevant to the pandemic, the Journal has initiated the Covid-19 Notes series. The Covid-19 pandemic has created major dilemmas for providers in…
Tue Apr 28, 2020 03:00
To the Editor: To address the coronavirus (Covid-19) pandemic, strict social containment measures have been adopted worldwide, and health care systems have been reorganized to cope with the enormous increase in the numbers of acutely ill patients. During this same period, some changes in the…
Tue Apr 28, 2020 03:00
To rapidly communicate information on the global clinical effort against Covid-19, the Journal has initiated a series of case reports that offer important teaching points or novel findings. The case reports should be viewed as observations rather than as recommendations for evaluation or treatment.…
Tue Apr 28, 2020 03:00
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Wed Apr 29, 2020 03:00
British Journal of Cancer, Published online: 30 April 2020; doi:10.1038/s41416-020-0827-5Stearoyl-CoA-desaturase-1 regulates gastric cancer stem-like properties and promotes tumour metastasis via Hippo/YAP pathway
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British Journal of Cancer, Published online: 30 April 2020; doi:10.1038/s41416-020-0846-2Scheduling nab-paclitaxel combined with gemcitabine as first-line treatment for metastatic pancreatic adenocarcinoma
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Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.
Tue Apr 28, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Tue Apr 28, 2020 10:00
Abstract Objective Mesenchymal stem cells (MSCs), one of the most important stromal cells in the tumor microenvironment, play a major role in the immunomodulation and development of tumors. In contrast to immunomodulatory effects of bone marrow-derived MSCs, resident MSCs were not well studied in tumor. The aim of this study was to compare the immunomodulatory properties and protein secretion profiles of MSCs isolated from breast tumor...
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Abstract Radiotherapy can elicit abscopal effects in non-irradiated metastases, particularly under immune checkpoint blockade (ICB). We report on two elderly patients with oligometastatic melanoma treated with anti-PD-1 and stereotactic body radiation therapy (SBRT). Before treatment, patient 1 showed strong tumor infiltration with exhausted CD8+ T cells and high expression of T cell-attracting chemokines. This patient rapidly mounted a complete response, now ongoing for more...
Wed Apr 29, 2020 03:00
Oncogenesis, Published online: 29 April 2020; doi:10.1038/s41389-020-0226-zACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis
Wed Apr 29, 2020 03:00
Oncogenesis, Published online: 28 April 2020; doi:10.1038/s41389-020-0224-1Desmoplastic small round cell tumor is dependent on the EWS-WT1 transcription factor
Tue Apr 28, 2020 03:00
Surgical Infections, Ahead of Print.
Tue Apr 28, 2020 10:00
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