Related ArticlesLong-term outcomes of Gillies and McLaughlin's dynamic muscle support in irreversible facial paralysis: A retrospective single-centre study with 25-year follow-up. J Plast Reconstr Aesthet Surg. 2020 Mar 17;: Authors: Schlosshauer T, Kueenzlen L, Groetsch T, Kuehn S, Sader R, Rieger U Abstract The aim of this study was to evaluate the long-term outcomes of Gillies and McLaughlin's dynamic muscle support with regard to functional outcomes...
Sat Apr 25, 2020 15:54
Nature Communications, Published online: 27 April 2020; doi:10.1038/s41467-020-15695-xMurine ILCs can modulate T cell responses in MHCII-dependent manner. Here the authors show that human ILCs process and present antigens and induce T-cell responses upon exposure to IL-1-family cytokines; along with the article by Lehmann et al, this work elucidates how cytokines set context specificity of ILC-T cell crosstalk by regulating ILC antigen presentation.
Mon Apr 27, 2020 03:00
Nature Communications, Published online: 27 April 2020; doi:10.1038/s41467-020-15907-4The transition to agriculture brought major changes to human populations in Europe during the Neolithic period. Here, Cubas and colleagues analyse lipid residues from Neolithic pottery from along the Atlantic coast of Europe to trace the spread of dairy production and shifts in diet.
Mon Apr 27, 2020 03:00
Nature Communications, Published online: 27 April 2020; doi:10.1038/s41467-020-16015-zUltraviolet-C radiation sources are important for disinfection and photochemical water purification, but development of persistent phosphors is needed for other applications. Here the authors report praseodymium-doped silicate ultraviolet-C persistent phosphors for self-sustained glowing tags in bright light.
Mon Apr 27, 2020 03:00
Nature Communications, Published online: 27 April 2020; doi:10.1038/s41467-020-15906-5Tissue clearing has revolutionised histology, but limited penetration of antibodies and stains into thick tissue segments is still a bottleneck. Here, the authors characterise optically cleared tissue as an electrolyte gel and apply this knowledge to stain the entirety of thick tissue samples.
Mon Apr 27, 2020 03:00
Nature Communications, Published online: 27 April 2020; doi:10.1038/s41467-020-15817-5The cell adhesion molecule E-selectin regulates haematopoietic stem cell self-renewal in the bone marrow vascular niche. Here, the authors show E-selectin adhesion directly induces survival signaling in acute myeloid leukaemia and therapeutic inhibition improves chemotherapy outcomes in mice.
Mon Apr 27, 2020 03:00
Nature Communications, Published online: 27 April 2020; doi:10.1038/s41467-020-15728-5Synthetic platforms coupled with artificial intelligent algorithms are highly desirable for advancing the discovery of new materials with target properties. Here the authors demonstrate the use of an autonomous laboratory for the discovery of optically active CsPbBr3 inorganic perovskite nanocrystals.
Mon Apr 27, 2020 03:00
Nature Communications, Published online: 27 April 2020; doi:10.1038/s41467-020-15949-8Developing autonomous self-healing materials for application under extreme conditions is challenging. Here, the authors design a highly stretchable elastomer by incorporation of H-bonds and disulphide methathesis, which shows efficient self-healing under extreme conditions.
Mon Apr 27, 2020 03:00
Nature Communications, Published online: 27 April 2020; doi:10.1038/s41467-020-15834-4Neutrophils employ several mechanisms to control the growth of fungi, including enzymes, reactive oxygen species, extracellular traps, and formation of “swarms”. Here, Hopke et al. study how the different mechanisms work together, using an in vitro assay with human neutrophils and clusters of live Candida cells.
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Nature Communications, Published online: 24 April 2020; doi:10.1038/s41467-020-15838-0Senolytics have the potential to extend healthspan by selectively killing senescent cells (SCs), but senolytics that target Bcl-xl may cause platelet toxicity. Here, the authors generated a Bcl-xl proteolysis-targeting chimera (PROTAC) senolytic, which effectively clears SCs and rejuvenates tissue stem and progenitor cells in naturally aged mice without causing severe thrombocytopenia.
Fri Apr 24, 2020 03:00
Nature Communications, Published online: 24 April 2020; doi:10.1038/s41467-020-15583-4A puzzle in metallic glass research is the existence of the fractional power law in reciprocal space, whilst its origin remains controversial. Zhang et al. show that nonuniform local deformations under compression induce this phenomenon and quantify the power law exponent at both two and three dimensions.
Fri Apr 24, 2020 03:00
Nature Communications, Published online: 24 April 2020; doi:10.1038/s41467-020-15743-6Idiopathic pulmonary fibrosis (IPF) is a devastating disease with poor prognosis. Here, the authors show that deficiency of the E3 ubiqutin-protein ligase Nedd4-2 in airway epithelial cells causes IPF-like disease in adult mice. This model may aid studies of the pathogenesis and therapy of IPF.
Fri Apr 24, 2020 03:00
Nature Communications, Published online: 24 April 2020; doi:10.1038/s41467-020-15941-2Gene regulation and metabolism co-ordinate self-renewal and differentiation of neural precursors (NPCs) in the developing brain. Here the authors show that methylglyoxal, a glycolytic intermediate metabolite, promotes GADPH-dependent translational repression of Notch1, thereby promoting NPC differentiation.
Fri Apr 24, 2020 03:00
Nature Communications, Published online: 24 April 2020; doi:10.1038/s41467-020-16048-4SARS-CoV-2 uses ACE2 as the entry receptor. Here, the authors show that an ACE2-Ig fusion protein inhibits entry of virus pseudotyped with the SARS-CoV-2 spike protein, show differential binding kinetics of SARS-CoV and SARSCoV-2 spike proteins to ACE2, and determine pharmakocinetic parameters of ACE2-Ig in mice.
Fri Apr 24, 2020 03:00
Nature Communications, Published online: 24 April 2020; doi:10.1038/s41467-020-16003-3Human papilloma virus (HPV) E7 protein destabilizes the retinoblastoma protein (Rb) by inducing its ubiquitination in cervical cancer cells, however proteasomal degradation requires cleavage of Rb after Lys 810 and so far it has been unclear how Rb cleavage contributes to its degradation. Here, the authors combine cell based and in vitro assays and show that calpain cleavage exposes a region in Rb that is recognized...
Fri Apr 24, 2020 03:00
Nature Communications, Published online: 24 April 2020; doi:10.1038/s41467-020-15918-1Development of porous proton-transporting materials combining stability and high performance has remained a challenge. Here, the authors report a stable covalent organic framework with excellent proton conductivity in which nitrogen sites on pore walls confine and stabilize a H3PO4 network in the channels via hydrogen-bonding interactions.
Fri Apr 24, 2020 03:00
Nature Communications, Published online: 24 April 2020; doi:10.1038/s41467-020-15750-7Retreating subduction zones are enabled by the development of faults at the edges of the slab, but the physical mechanisms controlling fault propagation remain debated. Here, the authors find that oceanic crust recycling is controlled by weakening of fractures forming at the edges of slabs.
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Related ArticlesSpliced X-box binding protein 1 induces liver cancer cell death via activating the Mst1-JNK-mROS signalling pathway. J Cell Physiol. 2020 Apr 26;: Authors: Song J, Zhao W, Lu C, Shao X Abstract Previous studies have found that the primary pathogenesis of liver cancer progression is linked to excessive cancer cell proliferation and rapid metastasis. Although therapeutic advances have been made for the treatment of liver cancer, the mechanism...
Mon Apr 27, 2020 14:18
Related ArticlesBiomechanical stimulation effects on the metabolism of adipocyte. J Cell Physiol. 2020 Apr 24;: Authors: Mor-Yossef Moldovan L, Kislev N, Lustig M, Pomeraniec L, Benayahu D Abstract Adipose tissue plays a leading role in obesity, which, in turn, can lead to Type 2 diabetes. Adipocytes (AD) respond to the biomechanical stimulation experienced in fat tissue under static stretch during prolonged sitting or lying. To investigate the effect...
Sat Apr 25, 2020 14:33
Related ArticlesImmune-related long noncoding RNA signature for predicting survival and immune checkpoint blockade in hepatocellular carcinoma. J Cell Physiol. 2020 Apr 24;: Authors: Zhang Y, Zhang L, Xu Y, Wu X, Zhou Y, Mo J Abstract Long noncoding RNAs (lncRNAs) show multiple functions, including immune response. Recently, the immune-related lncRNAs have been reported in some cancers. We first investigated the immune-related lncRNA signature as a potential...
Sat Apr 25, 2020 14:33
Related ArticlesLong intergenic noncoding RNA 00844 promotes apoptosis and represses proliferation of prostate cancer cells through upregulating GSTP1 by recruiting EBF1. J Cell Physiol. 2020 Apr 24;: Authors: Qiu K, Zheng Z, Huang Y Abstract Accumulating evidence have suggested the function of long noncoding RNAs as crucial players in the pathogenesis of prostate cancer (PC), a urologic tumor in male with poor prognosis. This study was designed to explore...
Sat Apr 25, 2020 14:33
Development and validation of a novel epigenetic signature for predicting prognosis in colon cancer.
Related ArticlesDevelopment and validation of a novel epigenetic signature for predicting prognosis in colon cancer. J Cell Physiol. 2020 Apr 24;: Authors: Luo D, Liu Q, Shan Z, Cai S, Li Q, Li X Abstract Epigenetic factors play a critical role in carcinogenesis by imparting a distinct feature to the chromatin architecture. The present study aimed to develop a novel epigenetic signature for evaluating the relapse-free survival of colon cancer patients....
Sat Apr 25, 2020 14:33
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