Background Amaranthus hybridus L. is an annual, erect or less commonly ascending herb that is a member of the Amaranthaceae family. Polysaccharides extracted from traditional Chinese medicines may be effective substances with antioxidant activity. Methods In this study, we isolated crude polysaccharides from A. hybridus (AHP-M) using microwave-assisted extraction. Then, the AHP-M was purified by chromatography with DEAE-32 cellulose, and two fractions, AHP-M-1 and AHP-M-2, were obtained....
Wed Apr 29, 2020 03:00
Extracellular matrix (ECM) proteins play an essential role in various biological processes in multicellular organisms, and their abnormal regulation can lead to many diseases. For large-scale ECM protein identification, especially through proteomic-based techniques, a theoretical reference database of ECM proteins is required. In this study, based on the experimentally verified ECM datasets and by the integration of protein domain features and a machine learning model, we developed ECMPride, a flexible...
Wed Apr 29, 2020 03:00
Overstocking can be a major issue in the dairy cattle industry, leading to negative changes in feeding and resting behavior. Additional stress imposed and alterations in feeding behavior may significantly impact the rumen microbiome. The rumen microbiome is responsible for the successful conversion of feed to usable energy for its host. Thus, understanding the effects of stocking density on the rumen microbiome is imperative for further elucidation of potentially negative consequences of overstocking...
Wed Apr 29, 2020 03:00
Background As key negative regulators of gene expression, microRNAs (miRNAs) play an important role in the onset and progression of hepatocellular carcinoma (HCC). This study aimed to identify the miRNAs involved in HCC carcinogenesis and their regulated genes. Methods The Gene Expression Omnibus (GEO) dataset (GSE108724) was chosen and explored to identify differentially expressed miRNAs using GEO2R. For the prediction of potential miRNA target genes, the miRTarBase was explored. Enrichment...
Wed Apr 29, 2020 03:00
Objective Genome sequencing (GS) is promising for unsolved leukodystrophies, but its efficacy has not been prospectively studied. Methods A prospective time‐delayed cross‐over design trial of GS to assess the efficacy of GS as a first‐line diagnostic tool for genetic white matter disorders took place between 12/01/2015 – 09/27/2017. Patients were randomized to receive GS immediately with concurrent standard of care (SoC) testing, or to receive SoC testing for four months followed by GS....
Tue Apr 28, 2020 22:41
Mon Apr 27, 2020 19:06
Mon Apr 27, 2020 19:04
Related ArticlesDysbiosis of Fecal Microbiota in Allergic Rhinitis Patients. Am J Rhinol Allergy. 2020 Apr 27;:1945892420920477 Authors: Liu X, Tao J, Li J, Cao X, Li Y, Gao X, Fu Y PMID: 32340468 [PubMed - as supplied by publisher]
Wed Apr 29, 2020 13:36
Related ArticlesATF5 involved in radioresistance in nasopharyngeal carcinoma by promoting epithelial-to-mesenchymal phenotype transition. Eur Arch Otorhinolaryngol. 2020 Apr 28;: Authors: Shuai Y, Fan E, Zhong Q, Feng G, Chen Q, Gou X, Zhang G Abstract PURPOSE: This study aimed to investigate the effects of activating transcription factor-5 (ATF5) on nasopharyngeal carcinoma (NPC) cell radioresistance. METHODS: HONE-1 nasopharyngeal carcinoma...
Wed Apr 29, 2020 13:33
Related ArticlesComparison of electrophysiological parameters between perimodiolar and lateral wall electrodes in paediatric cochlear implant users. Eur Arch Otorhinolaryngol. 2020 Apr 28;: Authors: Zarowski A, Molisz A, Mylanus EAM, Miserus JHM, Leblans M, van Dinther J, Siebert J, Offeciers EF Abstract PURPOSE: (1) To compare the in vivo impedances of electrical contacts of the Nucleus Contour Advance (CA) perimodiolar electrodes and the Nucleus Slim...
Wed Apr 29, 2020 13:33
Related ArticlesA review of the 8th edition of the AJCC staging system for oropharyngeal cancer according to HPV status. Eur Arch Otorhinolaryngol. 2020 Apr 27;: Authors: Machczyński P, Majchrzak E, Niewinski P, Marchlewska J, Golusiński W Abstract BACKGROUND: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased substantially in recent decades, particularly p16-positive human papillomavirus (HPV)-related OPSCC, which has risen...
Wed Apr 29, 2020 13:33
Related ArticlesImpact of stopping trastuzumab in early breast cancer: a population-based study in Ontario, Canada. J Natl Cancer Inst. 2020 Apr 28;: Authors: Rushton M, Lima I, Tuna M, Johnson C, Ivars J, Pritchard K, Hawken S, Dent S Abstract BACKGROUND: Adjuvant trastuzumab for early stage (I-III) HER2 positive breast cancer (BC) has led to statistically significant improvement in cancer outcomes but carries a risk of cardiotoxicity. Trastuzumab is...
Wed Apr 29, 2020 15:30
Related ArticlesAddition of tucatinib to trastuzumab and chemotherapy improves survival for patients with metastatic, HER2-positive breast cancer. Cancer. 2020 May 15;126(10):2113 Authors: Printz C PMID: 32343407 [PubMed - as supplied by publisher]
Wed Apr 29, 2020 15:30
Related ArticlesRisk of hepatotoxicity with trastuzumab emtansine in breast cancer patients: a systematic review and meta-analysis. Ther Adv Drug Saf. 2020;11:2042098620915058 Authors: Cobert AM, Helms C, Larck C, Moore DC Abstract Background: Trastuzumab emtansine (T-DM1) is an anti-HER2 antibody-drug conjugate indicated for the treatment of HER2-positive breast cancer. One of the most severe adverse events reported with T-DM1 is hepatotoxicity. The...
Wed Apr 29, 2020 13:32
Related ArticlesTrastuzumab cardiotoxicity in HER2-positive breast cancer patients in tertiary health care center, sultanate of Oman. J Oncol Pharm Pract. 2020 Apr 27;:1078155220919888 Authors: Alghafar DA, Younos I, Baimani KA, Al-Salhi D, Al-Riyami A, Rizvi S, Buckley NE PMID: 32340535 [PubMed - as supplied by publisher]
Wed Apr 29, 2020 13:32
Dynamics and coupling of fractional-order models of the motor cortex and central pattern generators.
Related ArticlesDynamics and coupling of fractional-order models of the motor cortex and central pattern generators. J Neural Eng. 2020 Apr 28;: Authors: Lu Q Abstract OBJECTIVE: Fractional calculus plays a key role in the analysis of neural dynamics. In particular, fractional calculus has been recently exploited for analyzing complex biological systems and capturing intrinsic phenomena. Also, artificial neural networks have been shown to have complex...
Wed Apr 29, 2020 15:33
Publication date: Available online 28 April 2020Source: Clinics in Plastic SurgeryAuthor(s): Osvaldo Saldanha, Andrés I. Ordenes, Carlos Goyeneche, Nicolas Oyarce, Martha Paredes, Osvaldo Saldanha Filho, Cristianna Bonetto Saldanha
Wed Apr 29, 2020 13:31
Related ArticlesOsteochondroma of the temporal styloid process: a common disease in a rare but vulnerable location. Clin Imaging. 2020 Apr 19;65:5-7 Authors: Chaturvedi R, Lin GY, Wang W, Smitaman E Abstract Osteochondromas, the most common benign bone tumor, are typically asymptomatic and discovered incidentally by imaging. Most frequently, osteochondromas occur at the metaphyses of long bones, and rarely involve the head and neck. We report the...
Wed Apr 29, 2020 14:29
Related ArticlesCOVID-19 and anosmia in Tehran, Iran. Med Hypotheses. 2020 Apr 23;141:109757 Authors: Gilani S, Roditi R, Naraghi M Abstract Patients with acute olfactory disorders typically present to the otolaryngologist with both acute hyposmia and less often with anosmia. With the onset of COVID-19 we have noticed an increase in the number of patients who have presented with new onset of complete smell loss to the senior author's practice in...
Wed Apr 29, 2020 14:29
Related ArticlesA bench-top model of middle ear effusion diagnosed with optical tympanometry. Int J Pediatr Otorhinolaryngol. 2020 Apr 20;134:110054 Authors: Shreim S, Abouzari M, Weidling J, White S, Goshtasbi K, Pham N, Djalilian HR, Botvinick E Abstract OBJECTIVES: To assess the validity of a bench-top model of an optical tympanometry device to diagnose in vitro model of middle ear effusion (MEE). METHODS AND MATERIALS: We illuminated...
Wed Apr 29, 2020 14:29
Related ArticlesCongenital soft tissue stenosis of the external auditory canal with canal cholesteatoma: Case report and literature review. Int J Pediatr Otorhinolaryngol. 2020 Apr 21;134:110053 Authors: Windsor AM, Ruiz R, O'Reilly RC Abstract Congenital external auditory canal stenosis (EACS) is a spectrum of abnormalities affecting the external and middle ear. We report a 6 year-old patient with EACS affecting the lateral fibrocartilaginous canal...
Wed Apr 29, 2020 14:29
Related ArticlesApplication of star poly(ethylene glycol) derivatives in drug delivery and controlled release. J Control Release. 2020 Apr 25;: Authors: Zhao X, Si J, Huang D, Li K, Xin Y, Sui M Abstract Multi-arm star poly(ethylene glycol) (PEG) polymers have a number of advantages over linear PEG polymers when used as carriers for drug delivery and controlled release. For instance, they have more terminals that can be modified to form multi-functional...
Wed Apr 29, 2020 14:29
Related ArticlesProsthodontic rehabilitation of head and neck cancer patients - challenges and new developments. Oral Dis. 2020 Apr 28;: Authors: Vosselman N, Alberga J, Witjes MHJ, Raghoebar GM, Reintsema H, Vissink A, Korfage A Abstract Head and neck cancer treatment can severely alter oral function and aesthetics, and reduce quality of life. The role of maxillofacial prosthodontists in multidisciplinary treatment of head and neck cancer patients...
Wed Apr 29, 2020 14:29
Related ArticlesReply to Survivors of cancer despite poor quality of care are heroes. Cancer. 2020 Apr 28;: Authors: Bigelow EO, Blackford AL, Eytan DF, Eisele DW, Fakhry C PMID: 32343837 [PubMed - as supplied by publisher]
Wed Apr 29, 2020 14:29
Related ArticlesOptimizing your telemedicine visit during the COVID-19 pandemic: Practice guidelines for patients with head and neck cancer. Head Neck. 2020 Apr 28;: Authors: Prasad A, Brewster R, Newman JG, Rajasekaran K Abstract The COVID-19 epidemic has resulted in many hospitals and practices to cancel in-person outpatient clinic visits, where head and neck patients receive their critical longitudinal care. Out of necessity, most practices have...
Wed Apr 29, 2020 14:29
Related ArticlesOral radiation-induced sarcomas: Systematic review. Head Neck. 2020 Apr 28;: Authors: de Souza LL, Pontes HAR, Santos-Silva AR, Fernandes LA, Batista LAL, Lopes MA, Khan W, Pontes FSC Abstract BACKGROUND: The aim of this study was to integrate the available data published on radiation-induced sarcoma of the oral cavity into an analysis of its clinical features, treatment modalities and prognostic factors. METHODS: An electronic...
Wed Apr 29, 2020 14:29
Related ArticlesSalivary gland disease in the era of COVID-19 pandemic. Head Neck. 2020 Apr 28;: Authors: Soldatova L, Rassekh CH, Baloch ZW, Jalaly JB, Sedora-Roman NI, Loevner LL, Cognetti DM, Witt RL, Dulguerov P Abstract Coronavirus disease 2019 (COVID-19) pandemic forced significant changes in current approach to outpatient evaluation of common otolaryngology complaints as hospitals around the world are trying to limit the spread of the virus...
Wed Apr 29, 2020 14:29
Related ArticlesSpecial considerations for elderly patients with head and neck cancer during the COVID-19 pandemic. Head Neck. 2020 Apr 28;: Authors: Sharma A, Crosby DL Abstract Elderly patients with head and neck cancer are at increased risk of adverse outcomes during and after treatment of head and neck cancer. COVID-19 severity and mortality can be expected to be significantly greater in elderly patients with head and neck cancer, given that...
Wed Apr 29, 2020 14:29
Related ArticlesOptical Biopsy: Automated Classification of Airway Endoscopic Findings Using a Convolutional Neural Network. Laryngoscope. 2020 Apr 28;: Authors: Dunham ME, Kong KA, McWhorter AJ, Adkins LK Abstract OBJECTIVES/HYPOTHESIS: Create an autonomous computational system to classify endoscopy findings. STUDY DESIGN: Computational analysis of vocal fold images at an academic, tertiary-care laryngology practice. METHODS:...
Wed Apr 29, 2020 14:29
Related ArticlesReal world NHS drug survival and efficacy data for Secukinumab in chronic plaque psoriasis. J Eur Acad Dermatol Venereol. 2020 Apr 28;: Authors: Goon PKC, Banfield CC, Bello O, Abraham T, Lim HY, Summerfield E, Shalders K, Sudhoff H, Mallett RB Abstract We want to present real world data on Secukinumab, a fully human monoclonal antibody neutralizing IL-17A. There is a general paucity of data on real world UK NHS usage of this drug....
Wed Apr 29, 2020 14:29
Related ArticlesIn Reference to The Medial Sural Artery Perforator Flap: A Better Option in Complex Head and Neck Reconstruction? Laryngoscope. 2020 Apr 28;: Authors: Silva AK, Portugal L, Blair EA PMID: 32343425 [PubMed - as supplied by publisher]
Wed Apr 29, 2020 14:29
Related ArticlesIn Response to "Regarding the MSAP Flap: A Better Option in Complex Head and Neck Reconstruction?" Laryngoscope. 2020 Apr 28;: Authors: Daar DA, Taufique ZM, Cohen LE, Thanik VD, Levine JP, Jacobson AS PMID: 32343418 [PubMed - as supplied by publisher]
Wed Apr 29, 2020 14:29
Related ArticlesLeveraging COVID-19-Inspired Changes to Advance Otolaryngology-Here to Stay. JAMA Otolaryngol Head Neck Surg. 2020 Apr 28;: Authors: Khariwala SS, Weinreich HM, McCoul ED, Graboyes E, Francis DO, Baldassari C, Poetker DM, Tunkel DE, Davies L PMID: 32343298 [PubMed - as supplied by publisher]
Wed Apr 29, 2020 14:29
Related ArticlesTemporal Bone Encephaloceles: Utility of Preoperative Imaging. Otolaryngol Head Neck Surg. 2020 Apr 28;:194599820918566 Authors: Worrall DM, Pai A, Garneau JC, Perez ER, Cosetti MK, Smouha EE, Wanna GB Abstract OBJECTIVE: To determine the diagnostic efficacy and clinical value of preoperative computed tomography (CT) and magnetic resonance imaging (MRI) among patients with suspected temporal bone encephaloceles (TBE). STUDY...
Wed Apr 29, 2020 14:29
Related ArticlesContralateral Tongue Muscle Activation during Hypoglossal Nerve Stimulation. Otolaryngol Head Neck Surg. 2020 Apr 28;:194599820917147 Authors: Sturm JJ, Modik O, Koutsourelakis I, Suurna MV Abstract OBJECTIVE: The effectiveness of upper airway stimulation via hypoglossal nerve stimulation for obstructive sleep apnea depends upon the pattern of tongue muscle activation produced. This study investigated the nature of contralateral tongue...
Wed Apr 29, 2020 14:29
Related ArticlesGuidance for management of cancer surgery during the COVID-19 pandemic. Can J Surg. 2020 May 01;63(22):S2-S4 Authors: Finley C, Prashad A, Camuso N, Daly C, Aprikian A, Ball CG, Bentley J, Charest D, Fata P, Helyer L, O'Connell D, Moloo H, Seely A, Werier J, Zhong T, Earle CC Abstract Summary: During the coronavirus disease 2019 (COVID-19) pandemic, delaying lifesaving cancer surgeries must be done with extreme caution and thoughtfulness....
Wed Apr 29, 2020 14:29
Related Articles[A Wearable System for Cervical Spondylosis Prevention Based on Artificial Intelligence]. Zhongguo Yi Liao Qi Xie Za Zhi. 2020 Jan 08;44(1):33-37 Authors: Li S, Zhou P, Xiao W, Zhou G Abstract Accompanied by changes in modern work and lifestyle, the incidence of cervical spondylosis has increased year by year. In view of the fact long-term fixed posture of the head and neck is one of the main causes of cervical spondylosis, a set...
Wed Apr 29, 2020 14:29
Related Articles[Experimental Study of MAR Algorithm in Metal Artifact Removal of CT Simulator]. Zhongguo Yi Liao Qi Xie Za Zhi. 2020 Jan 08;44(1):24-27 Authors: Bi F, Tu W, Shi H, Feng K, Fan W, Hu H Abstract OBJECTIVE: To explore the application value of MAR algorithm in metal artifact removal of CT simulator. METHODS: CT phantom with titanium plate was scanned using conventional algorithms and MAR algorithms, respectively. Artifact index(AI),...
Wed Apr 29, 2020 14:29
Related ArticlesRespiratory and pulmonary complications in head and neck cancer patients: An evidence-based review for the COVID-19 era. Head Neck. 2020 Apr 28;: Authors: Silverman DA, Lin C, Tamaki A, Puram SV, Carrau RL, Seim NB, Eskander A, Rocco JW, Old MO, Kang SY Abstract Pulmonary complications and infections frequently affect patients with head and neck squamous cell carcinoma (HNSCC). Common characteristics can predispose these patients...
Wed Apr 29, 2020 14:29
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