Prostate cancer is among the most common types of cancer in men. Early detection and proper medical intervention is crucial to ensuring successful treatment. Here we describe a patient clinically presenting with castrate-resistant prostate carcinoma. Comprehensive genomic profiling identified a PTEN inactivating mutation in the patient’s tumor. After being heavily pretreated, the patient showed stable disease on everolimus, a PI3K-Akt-mTOR pathway inhibitor. Case Rep Oncol 2020;13:456–461
Mon Apr 27, 2020 12:47
669 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2020/04/27PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Apr 27, 2020 14:13
Related ArticlesPrognostic significance of immunohistochemical markers and histological classification in malignant canine mammary tumors. Vet Comp Oncol. 2020 Apr 26;: Authors: Pastor N, Ezquerra LJ, Santella M, Caballé NC, Tarazona R, Durán ME Abstract Canine mammary carcinoma represents a model for the study of human breast cancer, although the prognostic value of various clinical, histological and immunohistochemical parameters has shown contradictory...
Mon Apr 27, 2020 16:11
Related ArticlesCorrelation between urinary chromium level and semen quality in men attending an andrology laboratory. Environ Sci Pollut Res Int. 2020 Apr 26;: Authors: Pokhrel G, Shi Y, Wang W, Khatiwada SU, Sun Z, Yan J, Liu J, Zheng D Abstract Chromium is an essential element that is required for the normal physiology but can be toxic to humans above a certain level. In spite of growing interest in research on chromium exposure to human health consensus...
Mon Apr 27, 2020 16:11
Related ArticlesCan the enteric nervous system be an alternative entrance door in SARS-CoV2 neuroinvasion? Brain Behav Immun. 2020 Apr 23;: Authors: Esposito G, Pesce M, Seguella L, Sanseverino W, Lu J, Sarnelli G PMID: 32335192 [PubMed - as supplied by publisher]
Mon Apr 27, 2020 16:11
Related ArticlesRedox signaling in the pathogenesis of human disease and the regulatory role of autophagy. Int Rev Cell Mol Biol. 2020;352:189-214 Authors: Pervaiz S, Bellot GL, Lemoine A, Brenner C Abstract Aberrant cell death signaling and oxidative stress are implicated in myriad of human pathological states such as neurodegenerative, cardiovascular, metabolic and liver diseases, as well as drug-induced toxicities. While regulated cell death and mild...
Mon Apr 27, 2020 16:11
Related ArticlesThe primary tumor resection in patients with distant metastatic laryngeal carcinoma. Eur Arch Otorhinolaryngol. 2020 Apr 25;: Authors: Lin Z, Lin H, Chen X, Xu Y, Wu X, Ke X, Lin C Abstract BACKGROUND: The role of primary tumor resection in patients with distant metastatic laryngeal carcinoma (DMLC) has not been clarified completely. Thus, we used propensity score matching (PSM) and survival analysis to address this issue. METHODS:...
Mon Apr 27, 2020 15:59
Related ArticlesCan we predict the altered subjective quality assessment of sound after ear canal surgery? Eur Arch Otorhinolaryngol. 2020 Apr 25;: Authors: Zwemstra MR, Brienesse P, Ebbens FA, de Wolf MJF, van Spronsen E Abstract PURPOSE: To correlate the subjective quality assessment of ear canal acoustics of the participants to the objective measurement of the ear canal acoustics. The objective ear canal acoustics is the frequency-dependent modulation...
Mon Apr 27, 2020 15:59
Related ArticlesManagement and outcomes of vascular reconstruction in carotid body tumor resection: retrospective analysis of 60 cases. Eur Arch Otorhinolaryngol. 2020 Apr 25;: Authors: Sevil FC Abstract PURPOSE: Carotid body tumors (CBTs) are rare tumors of the head and neck area. We evaluated outcomes after carotid body tumor resection (CBR) requiring vascular reconstruction. METHODS: We retrospectively reviewed the patients, who underwent...
Mon Apr 27, 2020 15:59
Related ArticlesThe predictive and prognostic value of low skeletal muscle mass for dose-limiting toxicity and survival in head and neck cancer patients receiving concomitant cetuximab and radiotherapy. Eur Arch Otorhinolaryngol. 2020 Apr 25;: Authors: Huiskamp LFJ, Chargi N, Devriese LA, de Jong PA, de Bree R Abstract PURPOSE: This study aims to investigate the predictive value of low skeletal muscle mass (SMM) for cetuximab dose-limiting toxicity (DLT)...
Mon Apr 27, 2020 15:59
Related ArticlesImportant knowledge items with regard to the benefits of exercise for patients with epilepsy: Findings of a qualitative study from Palestine. Epilepsy Behav. 2020 Apr 23;108:107099 Authors: Shawahna R, Abdelhaq I Abstract OBJECTIVES: Physicians and complementary alternative medicine (CAM) specialists are not formally educated/trained on the benefits of exercises for people living with epilepsy (PWE). This study was performed to develop...
Mon Apr 27, 2020 15:32
Related ArticlesCannabis sativa: much more beyond Δ9-tetrahydrocannabinol. Pharmacol Res. 2020 Apr 23;:104822 Authors: Alves P, Amaral C, Teixeira N, Correia-da-Silva G Abstract Cannabis is the most used illicit drug worldwide and its medicinal use is under discussion, being regulated in several countries. However, the psychotropic effects of Δ9-tetrahydrocannabinol (THC), the main psychoactive compound of Cannabis sativa, are of concern. Thus, the interest...
Mon Apr 27, 2020 15:32
Imported cysticercosis in Spain: A retrospective case series from the +REDIVI Collaborative Network.
Related ArticlesImported cysticercosis in Spain: A retrospective case series from the +REDIVI Collaborative Network. Travel Med Infect Dis. 2020 Apr 23;:101683 Authors: Herrador Z, Pérez-Molina JA, Henríquez Camacho CA, Rodriguez-Guardado A, Bosch-Nicolau P, Calabuig E, Domínguez-Castellano A, Pérez-Jacoiste MA, Ladrón de Guevara MC, Mena A, Ruiz-Giardin JM, Torrús D, Wikman-Jorgensen P, Benito A, López-Vélez R, REDIVI Study Group Abstract BACKGROUND:...
Mon Apr 27, 2020 15:32
Related ArticlesA selective naV1.1 activator with potential for treatment of dravet syndrome epilepsy. Biochem Pharmacol. 2020 Apr 23;:113991 Authors: Chow CY, Chin YKY, Ma L, Undheim EAB, Herzig V, King GF Abstract Dravet syndrome (DS) is a catastrophic epileptic encephalopathy characterised by childhood-onset polymorphic seizures, multiple neuropsychiatric comorbidities, and increased risk of sudden death. Heterozygous loss-of-function mutations in...
Mon Apr 27, 2020 15:32
Related ArticlesOutcome of Permanent Vascular Access with Vein ≤ 2.2 mm in Diameter. World J Surg. 2020 Apr 26;: Authors: Hussain T, Farooqui F Abstract OBJECTIVE: End-stage renal disease patients with vein diameter of ≤2.2 mm can undergo autogenous arteriovenous fistula (AVF) formation with the acceptable results. METHODS: This observational retrospective study of prospectively collected data analyzed end-stage renal disease patients with a...
Mon Apr 27, 2020 15:59
Related ArticlesAuthor's Reply: Emergency Department Versus Operating Suite Intubation in Operative Trauma Patients: Does Location Matter? World J Surg. 2020 Apr 26;: Authors: Dumas RP, Seamon MJ PMID: 32335693 [PubMed - as supplied by publisher]
Mon Apr 27, 2020 15:59
Related ArticlesAerosol box, An Operating Room Security Measure in COVID-19 Pandemic. World J Surg. 2020 Apr 26;: Authors: Leyva Moraga FA, Leyva Moraga E, Leyva Moraga F, Juanz González A, Ibarra Celaya JM, Ocejo Gallegos JA, Barreras Espinoza JA PMID: 32335692 [PubMed - as supplied by publisher]
Mon Apr 27, 2020 15:59
Related ArticlesWe Asked the Experts: How Do We Maintain Surgical Quality Standards for Enhanced Recovery Programs After Cancer Surgery During the COVID-19 Outbreak? World J Surg. 2020 Apr 26;: Authors: Doussot A, Heyd B, Lakkis Z PMID: 32335691 [PubMed - as supplied by publisher]
Mon Apr 27, 2020 15:59
Related ArticlesDeciphering MET-dependent modulation of global cellular responses to DNA damage by quantitative phosphoproteomics. Mol Oncol. 2020 Apr 26;: Authors: Bensimon A, Koch JP, Francica P, Roth SM, Riedo R, Glück AA, Orlando E, Blaukat A, Aebersold DM, Zimmer Y, Aebersold R, Medová M Abstract Increasing evidence suggests that interference with growth factor receptor tyrosine kinases (RTKs) signaling can affect DNA damage response (DDR) networks,...
Mon Apr 27, 2020 14:55
Related ArticlesMdm2 - open questions. Cancer Sci. 2020 Apr 26;: Authors: Dobbelstein M, Levine AJ Abstract The Mdm2 oncoprotein and its association with p53 were discovered 30 years ago, and a cornucopia of activities and regulatory pathways have been associated with it. In this review, we will raise questions about Mdm2 and its cousin Mdm4 that we consider worth pursuing in future research, reaching from molecular structures and intracellular activities...
Mon Apr 27, 2020 14:55
Related ArticlesCombination of CHEK1/2 inhibition and ionizing radiation results in abscopal tumor response through increased micronuclei formation. Oncogene. 2020 Apr 25;: Authors: Chao HH, Karagounis IV, Thomas C, François NB, Facciabene A, Koumenis C, Maity A Abstract We explore a novel strategy of activating immune signaling through increased micronuclei formation utilizing a cell cycle checkpoint inhibitor to drive cell cycle progression following...
Mon Apr 27, 2020 14:55
Related ArticlesBevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook. Cancer Treat Rev. 2020 Mar 26;86:102017 Authors: Garcia J, Hurwitz HI, Sandler AB, Miles D, Coleman RL, Deurloo R, Chinot OL Abstract When the VEGF-A-targeting monoclonal antibody bevacizumab (Avastin®) entered clinical practice more than 15 years ago, it was one of the first targeted therapies and the first approved angiogenesis...
Mon Apr 27, 2020 14:55
An evaluation of hepatocellular carcinoma practice guidelines from a radiation oncology perspective.
Related ArticlesAn evaluation of hepatocellular carcinoma practice guidelines from a radiation oncology perspective. Radiother Oncol. 2020 Apr 02;148:73-81 Authors: Rim CH, Cheng J, Huang WY, Kimura T, Lee V, Zeng ZC, Seong J Abstract INTRODUCTION: External beam radiotherapy (EBRT) is actively used for hepatocellular carcinoma (HCC) treatment in clinical practice but has not got attention in several guidelines owing to the lack of high-level evidences....
Mon Apr 27, 2020 14:55
Related ArticlesBRAF mutation and age in differentiated thyroid cancer risk stratification: Two sides of the same coin. Oral Oncol. 2020 Apr 23;106:104732 Authors: Subash A, Sinha P, Singh A Abstract BRAF V600E mutation is seen in about 45% of patients with Papillary Thyroid Carcinoma (PTC). Thyroid cancers are among the unique cancers where the age influences the prognosis. Current evidence suggests BRAF mutation in the presence of other risk factors...
Mon Apr 27, 2020 14:55
Related ArticlesThe Effectiveness of Dignity Therapy as Applied to End-of-Life Cancer Patients in Taiwan: A Quasi-experimental Study. Asian Nurs Res (Korean Soc Nurs Sci). 2020 Apr 23;: Authors: Li YC, Feng YH, Chiang HY, Ma SC, Wang HH Abstract PURPOSE: The study aimed to determine the effectiveness of dignity therapy for end-of-life cancer patients. MEATHODS: This was a quasi-experimental study design with a non-randomized controlled...
Mon Apr 27, 2020 14:55
Related ArticlesAttitudes and Beliefs Towards Advance Care Planning among Underserved Chinese-American Immigrants. J Pain Symptom Manage. 2020 Apr 23;: Authors: Dhingra L, Cheung W, Breuer B, Huang P, Lam K, Chen J, Zhou X, Chang V, Chui T, Hicks S, Portenoy R Abstract CONTEXT: Many in the rapidly-growing Chinese-American population are non-English-speaking and medically-underserved, and few engage in advance care planning (ACP). Evaluating culturally-determined...
Mon Apr 27, 2020 14:55
Related ArticlesEpidermal Growth Factor Receptor Inhibitors and Other Tyrosine Kinase Inhibitors for Solid Tumors. Infect Dis Clin North Am. 2020 Apr 22;: Authors: Ruiz-Camps I, Aguilar-Company J Abstract This article analyzes the risk of infection associated with small molecule kinase inhibitors used to treat solid organ malignancies and establishes specific recommendations. Most of these drugs are orally administered and have the ability to inhibit...
Mon Apr 27, 2020 14:55
Publication date: Available online 25 April 2020Source: Acta HistochemicaAuthor(s): Fali Zhao, Yi Wu, Wei Yang, Dongdong Wu, Can Wang, Fengmin Zhang
Mon Apr 27, 2020 13:53
Related Articles[CAR-T cell development and other gene therapy: Everything is not so easy]. Bull Cancer. 2020 Apr;107(4):408-409 Authors: Dalle JH, Baudoux E, Caillat-Zucman S, Colledani F, Pereira M, Bruno B, Nguyen S, Robin M, Rubio MT, Bay JO PMID: 32334675 [PubMed - as supplied by publisher]
Mon Apr 27, 2020 15:49
Related Articles[Covid-19, the Société française du cancer (SFC) and the BulletinduCancer]. Bull Cancer. 2020 Apr;107(4):393-394 Authors: Rodrigues M PMID: 32334674 [PubMed - as supplied by publisher]
Mon Apr 27, 2020 15:49
Related Articles[Freedom, equality, fraternity facing the COVID-19]. Bull Cancer. 2020 Apr;107(4):391-392 Authors: Bay JO, L'Allemain G PMID: 32334673 [PubMed - as supplied by publisher]
Mon Apr 27, 2020 15:49
Related ArticlesGiniClust3: a fast and memory-efficient tool for rare cell type identification. BMC Bioinformatics. 2020 Apr 25;21(1):158 Authors: Dong R, Yuan GC Abstract BACKGROUND: With the rapid development of single-cell RNA sequencing technology, it is possible to dissect cell-type composition at high resolution. A number of methods have been developed with the purpose to identify rare cell types. However, existing methods are still not scalable...
Mon Apr 27, 2020 15:50
Related ArticlesHigh dimensional model representation of log-likelihood ratio: binary classification with expression data. BMC Bioinformatics. 2020 Apr 25;21(1):156 Authors: Foroughi Pour A, Pietrzak M, Dalton LA, Rempała GA Abstract BACKGROUND: Binary classification rules based on a small-sample of high-dimensional data (for instance, gene expression data) are ubiquitous in modern bioinformatics. Constructing such classifiers is challenging due to (a)...
Mon Apr 27, 2020 15:50
Related ArticlesA single-model quality assessment method for poor quality protein structure. BMC Bioinformatics. 2020 Apr 25;21(1):157 Authors: Ouyang J, Huang N, Jiang Y Abstract BACKGROUND: Quality assessment of protein tertiary structure prediction models, in which structures of the best quality are selected from decoys, is a major challenge in protein structure prediction, and is crucial to determine a model's utility and potential applications....
Mon Apr 27, 2020 15:50
Related ArticlesBacteriology of Sputum Samples: A Descriptive Cross-sectional Study in a Tertiary Care Hospital. JNMA J Nepal Med Assoc. 2020 Jan;58(221):24-28 Authors: Raghubanshi BR, Karki BMS Abstract INTRODUCTION: Lower respiratory tract infection is a common infection and accounts for a greater burden of disease worldwide. It is a great challenge to the clinician and still more, with increasing antimicrobial resistance. Its empirical treatment...
Mon Apr 27, 2020 15:52
Related ArticlesClinical and epidemiological features of COVID-19 family clusters in Beijing, China. J Infect. 2020 Apr 23;: Authors: Song R, Han B, Song M, Wang L, Conlon CP, Dong T, Tian D, Zhang W, Chen Z, Zhang F, Shi M, Li X Abstract BACKGROUND: Since its discovery, SARS-CoV-2 has been spread throughout China before becoming a global pandemic. In Beijing, family clusters are the main mode of human-human transmission accounting for 57.6% of the...
Mon Apr 27, 2020 15:52
Related ArticlesTorsion of Granulosa Cell Tumor of the Ovary in a Preschool Patient: A Rare Cause of Acute Abdomen. Am J Case Rep. 2020 Apr 26;21:e921689 Authors: Siviero I, da Silva de Oliveira JT, Forny DN, Méio IB, Bertrand Simões BC, Rezende Penna CR, Antunes Chagas VL Abstract BACKGROUND Granulosa cell tumor of the ovary is very rare in childhood; its most common clinical manifestation is isosexual precocious puberty. Clinical presentation as acute...
Mon Apr 27, 2020 15:50
Related ArticlesA rare anomalous origin of the right vertebral artery from the internal carotid artery with an aberrant right subclavian artery. World Neurosurg. 2020 Apr 23;: Authors: Ota T, Fujitani S, Fujimoto S, Saito H, Ueda M Abstract An anomalous origin of the right vertebral artery (VA) from the right internal carotid artery occurs rarely. The case of a patient who underwent carotid artery stenting for right internal carotid artery stenosis is...
Mon Apr 27, 2020 15:49
Related ArticlesCarotid web of missed diagnosis: a case report. World Neurosurg. 2020 Apr 23;: Authors: Ren T, Sun S, Qu X, Gao Y Abstract BACKGROUND: The carotid web (CW), an atypical fibromuscular dysplasia, is a rare disease and may cause ischemic stroke. It is challenging to recognize CW promptly and treat it accordingly. Here we report an initially misdiagnosed case of CW. CASE DESCRIPTION: A 48-year-old male with recurrent cerebral infarction...
Mon Apr 27, 2020 15:49
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου