Related ArticlesMembrane retraction technique in bypass surgery for the treatment of adult moyamoya disease with deep-seated recipient artery. World Neurosurg. 2020 Apr 21;: Authors: Wang G, Qi S, Zhang G, Wen Y, Li M, Zhang S, Yin Y, Berdimyrat O, Feng W Abstract OBJECTIVE: To introduce a membrane retraction technique that can provide good exposure of deep-seated recipient arteries in cortical sulci and simplify the anastomosis procedure. METHODS:...
Sat Apr 25, 2020 15:21
Related ArticlesNeurological Complications in Patients with Left Ventricular Assist Devices: a Single Institution Retrospective Review. World Neurosurg. 2020 Apr 21;: Authors: Whitaker-Lea WA, Toms B, Toms JB, Shah KB, Quader M, Tang D, Kasirajan V, Rivet DJ, Reavey-Cantwell JF Abstract BACKGROUND: Neurological complications are common complications encountered by patients with Left Ventricular Assist Devices (LVAD). OBJECTIVE: This single center...
Sat Apr 25, 2020 15:21
Related ArticlesComparison of Radiation Exposure Among Three Different Endoscopic Discectomy Techniques for Lumbar Disc Herniation. World Neurosurg. 2020 Apr 21;: Authors: Merter A, Karaeminogullari O, Shibayama M PMID: 32330613 [PubMed - as supplied by publisher]
Sat Apr 25, 2020 15:21
Impact of osteoporosis on different type of short-segment posterior instrumentation for thoracolumbar burst fracture - a finite element analysis. World Neurosurg. 2020 Apr 20;: Authors: Liao JC Abstract OBJECTIVE: In Taiwan (my country), the proportion of people 65 years or older is over 14% in 2018, which is known as entering "aged society". More and more thoracolumbar burst fractures in the setting of osteoporosis happen nowadays. In this study, a...
Fri Apr 24, 2020 14:32
Related ArticlesAn Invited Commentary on "Long-term oncological outcomes in robotic versus laparoscopic approach for rectal cancer: a systematic review and meta-analysis" (Int J Surg 2020; Epub ahead of print). Int J Surg. 2020 Apr 21;: Authors: Chisthi MM PMID: 32330659 [PubMed - as supplied by publisher]
Sat Apr 25, 2020 14:47
Related ArticlesAn invited commentary on: "Evidence Based Management Guideline for the COVID-19 Pandemic - Review article". Int J Surg. 2020 Apr 21;: Authors: Akay S, Akay H PMID: 32330658 [PubMed - as supplied by publisher]
Sat Apr 25, 2020 14:47
Related ArticlesAn Invited Commentary on "Perioperative outcomes comparing laparoscopic with open repeat liver resection for post-hepatectomy recurrent liver cancer: a systematic review and meta-analysis" (Int J Surg 2020; Epub ahead of print). Int J Surg. 2020 Apr 21;: Authors: Angelico R, Gazia C PMID: 32330657 [PubMed - as supplied by publisher]
Sat Apr 25, 2020 14:47
Related ArticlesAn Invited Commentary on "Perioperative outcomes comparing laparoscopic with open repeat liver resection for post-hepatectomy recurrent liver cancer: a systematic review and meta-analysis" (Int J Surg 2020; Epub ahead of print). Int J Surg. 2020 Apr 21;: Authors: Abbaszadeh-Kasbi A, Reza Keramati M PMID: 32330656 [PubMed - as supplied by publisher]
Sat Apr 25, 2020 14:47
Related ArticlesDeveloping Guidelines for COVID-19 Management: A Moving Target. An invited commentary on "Evidence Based Management Guideline for the COVID-19 Pandemic - Review article". Int J Surg. 2020 Apr 21;: Authors: Gallaher J, Charles A PMID: 32330655 [PubMed - as supplied by publisher]
Sat Apr 25, 2020 14:47
Related ArticlesA drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex. Bioorg Chem. 2020 Apr 20;99:103866 Authors: Wu TY, Huang Q, Huang ZS, Hu MH, Tan JH Abstract Aberrant expression of c-MYC oncogene is significantly associated with the occurrence and development of malignant melanoma. Suppression of the c-MYC transcriptional activity accordingly provides a new idea for treating melanoma. Notably,...
Sat Apr 25, 2020 14:33
Related ArticlesHER3 targeting with an antibody-drug conjugate bypasses resistance to anti-HER2 therapies. EMBO Mol Med. 2020 Apr 24;:e11498 Authors: Gandullo-Sánchez L, Capone E, Ocaña A, Iacobelli S, Sala G, Pandiella A Abstract Despite impressive clinical benefit obtained with anti-HER2-targeted therapies, in advances stages, especially in the metastatic setting, HER2-positive tumors remain incurable. Therefore, it is important to develop novel...
Sat Apr 25, 2020 14:33
Related Articlesl-Serine transport in growing and maturing mouse oocytes. J Cell Physiol. 2020 Apr 24;: Authors: Zhang H, McClatchie T, Baltz JM Abstract Serine has roles in cell metabolism besides protein synthesis including providing one-carbon units to the folate cycle. Since growing mouse oocytes undergo a burst of folate accumulation as they near full size, we have investigated whether oocytes transport serine. Substantial serine transport appeared...
Sat Apr 25, 2020 14:33
Related ArticlesDesign, synthesis, and anticancer activity of novel 4-thiazolidinone-phenylaminopyrimidine hybrids. Mol Divers. 2020 Apr 23;: Authors: Türe A, Ergül M, Ergül M, Altun A, Küçükgüzel İ Abstract 4-Thiazolidinones and phenylaminopyrimidines are known as anticancer agents. Imatinib is the pioneer phenylaminopyrimidine derivative kinase inhibitor, which is used for the treatment of chronic myeloid leukemia. With a hybrid approach, a novel series...
Sat Apr 25, 2020 14:33
Related ArticlesREG γ knockdown suppresses proliferation by inducing apoptosis and cell cycle arrest in osteosarcoma. PeerJ. 2020;8:e8954 Authors: Yin Z, Jin H, Huang S, Qu G, Meng Q Abstract Background: Osteosarcoma (OS) is the most common malignant bone tumor with high mortality in children and adolescents. REG γ is overexpressed and plays oncogenic roles in various types of human cancers. However, the expression and potential roles of REG γ in...
Sat Apr 25, 2020 14:33
Related ArticlesNintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization. Acta Pharmacol Sin. 2020 Apr 23;: Authors: Zhou BY, Wang WB, Wu XL, Zhang WJ, Zhou GD, Gao Z, Liu W Abstract Keloid is a benign skin tumor characterized by its cell hyperproliferative activity, invasion into normal skin, uncontrolled growth, overproduction and deposition of extracellular matrices...
Sat Apr 25, 2020 14:33
Related ArticlesSKA1 regulates actin cytoskeleton remodelling via activating Cdc42 and influences the migration of pancreatic ductal adenocarcinoma cells. Cell Prolif. 2020 Apr;53(4):e12799 Authors: Li T, Liu X, Xu B, Wu W, Zang Y, Li J, Wei L, Qian Y, Xu H, Xie M, Wang Q, Wang L Abstract OBJECTIVES: Spindle and kinetochore-associated protein 1(SKA1), originally identified as a protein essential for proper chromosome segregation, has been recently...
Sat Apr 25, 2020 13:32
Related ArticlesComment on "Everolimus induces G1 cell arrest through autophagy-mediated protein degradation of cyclin D1 in breast cancer cells". Am J Physiol Cell Physiol. 2020 02 01;318(2):C448-C449 Authors: Pirtoli L, Belmonte G, Toscano M, Tini P, Miracco C PMID: 32027811 [PubMed - indexed for MEDLINE]
Sat Apr 25, 2020 13:32
LINC00514 drives osteosarcoma progression through sponging microRNA-708 and consequently increases URGCP expression. Aging (Albany NY). 2020 Apr 23;12: Authors: Yu D, Xu X, Li S, Zhang K Abstract Long intergenic nonprotein-coding RNA 00514 (LINC00514) is upregulated in papillary thyroid cancer and contributes to its aggressiveness. In this study, we thoroughly explored the expression profile, specific functions, and relevant molecular mechanism of...
Fri Apr 24, 2020 13:18
Tubulin inhibitors: Discovery of a new scaffold targeting extra-binding residues within the colchicine site through anchoring substituents properly adapted to their pocket by a semi-flexible linker. Bioorg Chem. 2020 Apr 06;99:103767 Authors: Maklad RM, AbdelHafez EMN, Abdelhamid D, Aly OM Abstract Bis-hydrazides 13a-h were designed and synthesized as potential tubulin inhibitors selectively targeting the colchicine site between α- and β-tubulin...
Fri Apr 24, 2020 13:18
Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice. PLoS Genet. 2020 Apr;16(4):e1008693 Authors: Yamazaki H, Kasai S, Mimura J, Ye P, Inose-Maruyama A, Tanji K, Wakabayashi K, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Cavener DR, Yamamoto M, Itoh K Abstract Amino acids exert many biological functions, serving as allosteric regulators and neurotransmitters,...
Fri Apr 24, 2020 13:18
Antitumor Effect of Cycle Inhibiting Factor Expression in Colon Cancer via Salmonella VNP20009. Anticancer Agents Med Chem. 2020 Apr 22;: Authors: Liu L, Zhang J, Gu M, Li G, Ni J, Fan M Abstract BACKGROUND: Colon cancer is one of the major causes of morbidity and mortality worldwide. Cycle inhibiting factors (Cifs) have been shown to deamidate Nedd8, resulting in cell cycle arrest. OBJECTIVE: To determine the antitumor effect of Cifs on...
Fri Apr 24, 2020 13:18
Crude Methanol Extract of Rosin Gum Exhibits Specific Cytotoxicity against Human Breast Cancer Cells via Apoptosis Induction. Anticancer Agents Med Chem. 2020 Apr 22;: Authors: El-Hallouty SM, Soliman AAF, Nassrallah A, Salamatullah A, Alkaltham MS, Kamal KY, Hanafy EA, Gaballa HS, Aboul-Soud MAM Abstract BACKGROUND: Rosin (Colophony) is a natural resin derived from species of the pine family Pinaceae. It has wide industrial applications including...
Fri Apr 24, 2020 13:18
Long non‑coding RNA SNHG1 promotes breast cancer progression by regulation of LMO4. Oncol Rep. 2020 Mar 04;: Authors: Xiong X, Feng Y, Li L, Yao J, Zhou M, Zhao P, Huang F, Zeng L, Yuan L Abstract Long non‑coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) was reported to be a critical regulator of tumorigenesis and is frequently deregulated in several cancer types. However, the exact mechanism by which SNHG1 contributes to breast cancer...
Fri Apr 24, 2020 13:18
Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma. Oncol Rep. 2020 Feb 21;: Authors: Wang Q, Han B, Huang W, Qi C, Liu F Abstract Glioma is the most commonly diagnosed primary intracranial malignant tumor with rapid growth, easy recurrence and thus poor prognosis. In the present study, the role of kinesin‑12 (KIF15) in glioma was revealed. Immunohistochemical staining and western blot analysis were used to...
Fri Apr 24, 2020 13:18
Iodine‑125 seed radiation induces ROS‑mediated apoptosis, autophagy and paraptosis in human esophageal squamous cell carcinoma cells. Oncol Rep. 2020 Apr 03;: Authors: Wang C, Li TK, Zeng CH, Fan R, Wang Y, Zhu GY, Guo JH Abstract Iodine‑125 (125I) seed brachytherapy has been proven to be a safe and effective treatment for advanced esophageal cancer; however, the mechanisms underlying its actions are not completely understood. In the present study,...
Fri Apr 24, 2020 13:18
Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis (Review). Mol Med Rep. 2020 Apr 02;: Authors: Song X, Zhang Y, Dai E Abstract Celastrol and triptolide, chemical compounds isolated from Tripterygium wilfordii hook (also known as thunder god vine), are effective against rheumatoid arthritis (RA). Celastrol targets numerous signaling pathways involving NF‑κB, endoplasmic reticulum Ca2+‑ATPase, myeloid differentiation...
Fri Apr 24, 2020 13:18
Long non‑coding RNA LINC00858 promotes TP53‑wild‑type colorectal cancer progression by regulating the microRNA‑25‑3p/SMAD7 axis. Oncol Rep. 2020 Feb 18;: Authors: Zhan J, Tong J, Fu Q Abstract Long non‑coding RNAs (lncRNAs) are involved in colorectal cancer (CRC) progression, however the mechanisms remain largely unknown. The present study aimed to reveal the role and possible molecular mechanisms of a new LNCRNA, LINC00858, in CRC. LINC00858 was...
Fri Apr 24, 2020 13:18
Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2‑UDP glucuronosyltransferase 1A metabolic axis activation. Oncol Rep. 2020 Feb 10;: Authors: Hao Q, Wang M, Sun NX, Zhu C, Lin YM, Li C, Liu F, Zhu WW Abstract The long pre‑cancerous state of colorectal cancer (CRC) provides an opportunity to prevent the occurrence and development of CRC. The detoxification of CRC food‑borne carcinogenic heterocyclic amines is highly...
Fri Apr 24, 2020 13:18
miR‑296‑3p promotes the proliferation of glioblastoma cells by targeting ICAT. Mol Med Rep. 2020 Mar 03;: Authors: Zhou J, Du G, Fu H Abstract MicroRNAs (miRNA/miRs) serve an important function in the regulation of gene expression, and have been indicated to mediate a number of cellular biological processes, including cell proliferation, the cell cycle, cell apoptosis and cell differentiation. The altered expression of miRNAs has been revealed to...
Fri Apr 24, 2020 13:18
MicroRNA‑145‑5p inhibits osteosarcoma cell proliferation by targeting E2F transcription factor 3. Int J Mol Med. 2020 Feb 17;: Authors: Li H, Pan R, Lu Q, Ren C, Sun J, Wu H, Wen J, Chen H Abstract Osteosarcoma is a common type of bone tumor that primarily occurs in children and young adults. MicroRNA (miRNA/miR) dysregulation is associated with the progression of osteosarcoma; therefore, the aim of the present study was to investigate the biological...
Fri Apr 24, 2020 13:18
The secretome of human dental pulp stem cells protects myoblasts from hypoxia‑induced injury via the Wnt/β‑catenin pathway. Int J Mol Med. 2020 Mar 04;: Authors: Zhang W, Yu L, Han X, Pan J, Deng J, Zhu L, Lu Y, Huang W, Liu S, Li Q, Liu Y Abstract Human dental pulp stem cells (hDPSCs) present several advantages, including their ability to be non‑invasively harvested without ethical concern. The secretome of hDPSCs can promote the functional recovery...
Fri Apr 24, 2020 13:18
Expression of BMP7 in cervical cancer and inhibition of epithelial‑mesenchymal transition by BMP7 knockdown in HeLa cells. Int J Mol Med. 2020 Feb 27;: Authors: Sun R, Guan H, Liu W, Liang J, Wang F, Li C Abstract The aim of the present study was to investigate the expression of bone morphogenetic protein 7 (BMP7) in cervical cancer tissues, the effect of BMP7 on the proliferation, migration and epithelial‑mesenchymal transition (EMT) of cervical...
Fri Apr 24, 2020 13:18
P53 vs NF-κB: the role of nuclear factor-kappa B in the regulation of p53 activity and vice versa. Cell Mol Life Sci. 2020 Apr 22;: Authors: Carrà G, Lingua MF, Maffeo B, Taulli R, Morotti A Abstract The onco-suppressor p53 is a transcription factor that regulates a wide spectrum of genes involved in various cellular functions including apoptosis, cell cycle arrest, senescence, autophagy, DNA repair and angiogenesis. p53 and NF-κB generally have...
Fri Apr 24, 2020 13:18
Exosome-Derived miR-486-5p Regulates Cell Cycle, Proliferation and Metastasis in Lung Adenocarcinoma via Targeting NEK2. Front Bioeng Biotechnol. 2020;8:259 Authors: Hu H, Xu H, Lu F, Zhang J, Xu L, Xu S, Jiang H, Zeng Q, Chen E, He Z Abstract Objective: This study aimed to describe the mechanism of exosome-derived miR-486-5p underlying the cell cycle and progression in lung adenocarcinoma (LUAD). Methods: Bioinformatics methods were applied...
Fri Apr 24, 2020 13:18
β-Phenethyl Isothiocyanate Induces Cell Death in Human Osteosarcoma through Altering Iron Metabolism, Disturbing the Redox Balance, and Activating the MAPK Signaling Pathway. Oxid Med Cell Longev. 2020;2020:5021983 Authors: Lv H, Zhen C, Liu J, Shang P Abstract Osteosarcoma is the most common primary malignancy of the skeleton in children and adults. The outcomes of people with osteosarcomas are unsatisfied. β-Phenethyl isothiocyanate (PEITC) exhibits...
Fri Apr 24, 2020 13:18
Vitamin C Treatment Rescues Prelamin A-Induced Premature Senescence of Subchondral Bone Mesenchymal Stem Cells. Stem Cells Int. 2020;2020:3150716 Authors: Qu YN, Zhang L, Wang T, Zhang HY, Yang ZJ, Yuan FF, Wang Y, Li SW, Jiang XX, Xie XH Abstract Aging is a predominant risk factor for many chronic conditions. Stem cell dysfunction plays a pivotal role in the aging process. Prelamin A, an abnormal processed form of the nuclear lamina protein lamin...
Fri Apr 24, 2020 13:18
Related ArticlesCABLES1 Deficiency Impairs Quiescence and Stress Responses of Hematopoietic Stem Cells in Intrinsic and Extrinsic Manners. Stem Cell Reports. 2019 08 13;13(2):274-290 Authors: He L, Beghi F, Baral V, Dépond M, Zhang Y, Joulin V, Rueda BR, Gonin P, Foudi A, Wittner M, Louache F Abstract Bone marrow (BM) niche cells help to keep adult hematopoietic stem cells (HSCs) in a quiescent state via secreted factors and induction of cell-cycle...
Fri Apr 24, 2020 13:18
Related ArticlesTargeting immune cells for cancer therapy. Redox Biol. 2019 07;25:101174 Authors: Gun SY, Lee SWL, Sieow JL, Wong SC Abstract Recent years have seen a renaissance in the research linking inflammation and cancer with immune cells playing a central role in smouldering inflammation in the tumor microenvironment. Diverse immune cell types infiltrate the tumor microenvironment, and the dynamic tumor-immune cell interplay gives rise to a...
Fri Apr 24, 2020 13:18
Related ArticlesSevere radiation necrosis refractory to surgical resection in patients with melanoma and brain metastases managed with ipilimumab/nivolumab and brain-directed stereotactic radiation therapy. World Neurosurg. 2020 Apr 21;: Authors: Shi DD, Arnaout O, Bi WL, Buchbinder EI, Cagney DN, Insco ML, Liu D, Schoenfeld JD, Aizer AA Abstract BACKGROUND: The use of targeted therapies and immune checkpoint inhibitors has drastically changed the management...
Sat Apr 25, 2020 14:56
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