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Τετάρτη 29 Απριλίου 2020

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Oral radiation‐induced sarcomas: Systematic review
Abstract Background The aim of this study was to integrate the available data published on radiation‐induced sarcoma of the oral cavity into an analysis of its clinical features, treatment modalities and prognostic factors. Methods An electronic search was undertaken in September 2019. The eligibility criteria included publications that had enough clinical and histological information to confirm the diagnosis. Results Forty‐two publications with 122 radiation‐induced sarcoma...
Head & Neck
22h
Optimizing your telemedicine visit during the COVID‐19 pandemic: Practice guidelines for patients with head and neck cancer
Abstract The COVID‐19 epidemic has resulted in many hospitals and practices to cancel in‐person outpatient clinic visits, where head and neck patients receive their critical longitudinal care. Out of necessity, most practices have been encouraged to use telemedicine as a method to maintain a continuum of care with their patients. As a result, the prevalence of telemedicine has grown rapidly during this pandemic, without allowing the physicians and patients to be adequately educated on how best...
Head & Neck
22h
Special considerations for elderly patients with head and neck cancer during the COVID‐19 pandemic
Abstract Elderly patients with head and neck cancer are at increased risk of adverse outcomes during and after treatment of head and neck cancer. COVID‐19 severity and mortality can be expected to be significantly greater in elderly patients with head and neck cancer, given that increased age, comorbidities, and presence of malignancy are known risk factors for disease severity and mortality in patients with COVID‐19. Therefore, their management requires multidisciplinary consensus and patient...
Head & Neck
22h
Salivary gland disease in the era of COVID‐19 pandemic
Abstract Coronavirus disease 2019 (COVID‐19) pandemic forced significant changes in current approach to outpatient evaluation of common otolaryngology complaints as hospitals around the world are trying to limit the spread of the virus and to preserve health care resources. These changes raise a lot of questions regarding patient triage and treatment decisions in clinical situations when it is unclear if the workup and management can be postponed. In this communication, we present our approach...
Head & Neck
22h
Respiratory and pulmonary complications in head and neck cancer patients: An evidence‐based review for the COVID‐19 era
Pulmonary complications and infections frequently affect patients with head and neck squamous cell carcinoma (HNSCC). Common characteristics can predispose these patients to the development of severe respiratory illness, which may be particularly relevant during the 2019 coronavirus disease (COVID‐19) pandemic.
Head & Neck
22h
An Overview of COVID‐19 Testing and Implications for Otolaryngologists
Abstract Background Testing for SARS‐CoV‐2 is important for decision making prior to surgery in otolaryngology. An understanding of current and developing testing methods is important for interpreting test results. Methods We performed a literature review of current evidence surrounding SARS‐CoV‐2 diagnostic testing highlighting its utility, limitations, and implications for otolaryngologists. Results The currently accepted RT‐PCR test for SARS‐CoV‐2 has varying sensitivity...
Head & Neck
22h
Head and neck surgical oncology in the time of a pandemic: Subsite‐specific triage guidelines during the COVID‐19 pandemic
ABSTRACT Background COVID‐19 pandemic has strained human and material resources around the world. Practices in surgical oncology had to change in response to these resource limitations, triaging based on acuity, expected oncologic outcomes, availability of supportive resources, and safety of healthcare personnel. Methods The MD Anderson Head and Neck Surgery Treatment Guidelines Consortium devised the following to provide guidance on triaging Head and Neck cancer (HNC) surgeries...
Head & Neck
22h
Changing practice patterns in Head & Neck Oncologic Surgery in the early COVID‐19 era
Abstract Background The COVID‐19 pandemic has changed healthcare, challenged by resource constraints and fears of transmission. We report the surgical practice pattern changes in a Head and Neck Surgery department of a tertiary cancer care center and discuss the issues surrounding multidisciplinary care during the pandemic. Methods We report data regarding outpatient visits, multidisciplinary treatment planning conference, surgical caseload, and modifications of oncologic therapy...
Head & Neck
22h
Objective evaluation of anosmia and ageusia in COVID‐19 patients: a single‐center experience on 72 cases
Abstract Background The firsts European case series are detecting a very high frequency of chemosensitive disorders in COVID‐19 patients, ranging between 19.4% and 88%. Methods Olfactory and gustatory function was objectively tested in 72 COVID‐19 patients treated at University Hospital of Sassari. Results Overall, 73.6% of the patients reported having or having had chemosensitive disorders. Olfactory assessment showed variable degree hyposmia in 60 cases and anosmia in...
Head & Neck
22h
Editorial: How Fragile We Are
Head & Neck
22h
Major head and neck reconstruction during the COVID‐19 pandemic: The University of Pittsburgh approach
Abstract The 2019 novel coronavirus (COVID‐19) pandemic has created significant challenges to the delivery of care for patients with advanced head and neck cancer requiring multimodality therapy. Performing major head and neck ablative surgery and reconstruction is a particular concern given the extended duration and aerosolizing nature of these cases. In this manuscript, we describe our surgical approach to provide timely reconstructive care and minimize infectious risk to the providers, patients,...
Head & Neck
22h
Navigating the impact of COVID‐19 on palliative care for head and neck cancer
Abstract Health care services are being confronted by a daily dilemma of who can receive critical care and who cannot. In a palliative care clinic, this apprehension gets exemplified, as these patients have limited life expectancy. The head and neck region further makes things critical, as it comprises of all the sites through which the SARS‐CoV‐2 can be transmitted. This document strives to define the ways in which the head and neck cancer services can contribute to better patient care in a triage...
Head & Neck
22h
Thyroid surgery during COVID‐19 pandemic: Principles and philosophies
Head & Neck
22h
Head and neck cancer: A high‐risk population for COVID‐19
Head & Neck
22h
Considerations for head and neck oncology practices during the coronavirus disease 2019 (COVID‐19) pandemic: Wuhan and Toronto experience
Abstract The practices of head and neck surgical oncologists must evolve to meet the unprecedented needs placed on our health care system by the Coronavirus disease 2019 (COVID‐19) pandemic. Guidelines are emerging to help guide the provision of head and neck cancer care, though in practice, it can be challenging to operationalize such recommendations. Head and neck surgeons at Wuhan University faced significant challenges in providing care for their patients. Similar challenges were faced by the...
Head & Neck
22h
Tobacco use and vaping in the COVID‐19 era
Abstract Health crises have become a popular topic of discussion. In the wave of the ongoing pandemic, experts have suggested the role of vaping and other tobacco product use exemplifying the vulnerability of the population to contract the COVID‐19. We discuss some of the events that led up to these conclusions and also offer a unique insight into another form of tobacco use that is potentially propagating its spread especially in the South Asian region—chewed tobacco. Both of these have been a...
Head & Neck
22h
Ultrastructural Alterations in Granular Neurons of the Dentate Fascia Caused by Intrahippocampal Injection of Beta-Amyloid 1-42
The deposition of beta-amyloid (Aβ) in the brain is detected in Alzheimer’s disease and during ageing. Until now, ultrastructural studies of changes caused by Aβ in the dentate gyrus are very scarce. The effects of Aβ 1-42 injection into the CA1 field of rat hippocampus were studied by electron microscopy. In 2 weeks after injection of aggregated Aβ in low concentrations, destructive changes were seen in the structure of dentate gyrus cells, which consisted in a decrease in the number of dentate...
Latest Results for Bulletin of Experimental Biology and Medicine
22h
The impact of COVID‐19 pandemic on patients with chronic plaque psoriasis being treated with biologic therapy: the Northern Italy experience
Abstract The “severe acute respiratory syndrome coronavirus 2” (SARS‐CoV‐2) has spread over the four continents, causing the respiratory manifestations of Coronavirus disease‐19 (COVID‐19) and satisfying the epidemiological criteria for a pandemic [1]. As of April 1, 2020, more than one million COVID‐19 positive cases have been identified and more than 54,000 deaths have occurred worldwide [2]. In Italy, 110,574 positive cases, 49,285 hospitalized patients and 13,155 deaths out of a population...
British Journal of Dermatology
22h
Percentage of scalp‐hair loss as a primary endpoint in alopecia areata trials
British Journal of Dermatology
22h
Rising incidence of basal cell carcinoma in women in Iceland: is it sunbed use?
British Journal of Dermatology
22h
Infinity hair: a new trichoscopic finding for chemotherapy‐induced alopecia
British Journal of Dermatology
22h
CXCL10/IP‐10, an early biomarker for late sequelae in DRESS?
British Journal of Dermatology
22h
Topical rapamycin combined with calcitriol in treating angiofibromas in tuberous sclerosis complex
British Journal of Dermatology
22h
Combination of CD47 and SIRPα constituting the "don't eat me signal" is a prognostic factor in diffuse large B‐cell lymphoma
Abstract The interaction between CD47 and signal‐regulatory protein alpha (SIRPα) inhibits phagocytosis, thus affecting the clinical outcomes of neoplastic diseases. Although CD47 upregulation is associated with poor prognosis in several malignancies, the effect of SIRPα expression and its co‐expression with CD47 remains unclear. This study aimed to investigate the clinicopathological effect of CD47 and SIRPα expression in diffuse large B‐cell lymphoma (DLBCL). Immunostaining of 120 biopsy samples...
Cancer Science
22h
Nitric oxide affects cisplatin cytotoxicity oppositely in A2780 and A2780‐CDDP cells via Connexin 32/gap junction
Abstract Chemoresistance is a main obstacle in ovarian cancer therapy and new treatment strategies and further information regarding the mechanism of cisplatin are urgently needed. Nitric oxide has a critical role in modulating the activity of chemotherapeutic drugs and our previous work shows that Connexin32 contributes to cisplatin resistance. However, whether Nitric oxide is involved in Connexin32‐mediated cisplatin resistance remains unknown. In this study, with A2780 and A2780 cisplatin‐resistant...
Cancer Science
22h
Cancer stem cells in Epstein‐Barr virus‐associated gastric carcinoma
Abstract Cancer stem cells (CSCs) play a decisive role in the development and progression of cancer. To investigate CSCs in Epstein‐Barr virus (EBV)‐associated carcinoma (EBVaGC), we screened previously reported stem cell markers of gastric cancer in EBV‐infected gastric cancer cell lines (TMK1, NUGC3) and identified CD44v6v9 double positive cells as candidate CSCs. CD44v6/v9+/+ cells were sorted from EBVaGC cell line (SNU719) cells and EBV‐infected TMK1 cells and these cell populations showed...
Cancer Science
22h
Phase III randomized, double‐blind study of paclitaxel with and without Everolimus in patients with advanced gastric or esophagogastric junction carcinoma who have progressed after therapy with a fluoropyrimidine/platinum‐containing regimen (RADPAC)
Abstract The RADPAC trial evaluated paclitaxel with everolimus in patients with advanced gastroesophageal cancer (GEC) who have progressed after therapy with a fluoropyrimidine/platinum‐containing regimen. Patients were randomly assigned to receive paclitaxel (80 mg/m2) on day 1, 8 and 15 plus everolimus (10mg daily, arm B) d1‐d28 or placebo (arm A), repeated every 28 days. Primary end point was overall survival (OS). Efficacy was assessed in the intention‐to‐treat population and safety in all...
Int J Cancer
23h
Body size, body composition and endometrial cancer risk among postmenopausal women in UK Biobank
Abstract Previous studies on the association of adiposity with endometrial cancer risk have mostly used body mass index (BMI) as the main exposure of interest. Whether more precise measures of body fat, such as body fat percentage and fat mass estimated by bioimpedance analyses, are better indicators of risk than BMI is unknown. The role of central adiposity and fat‐free mass in endometrial cancer development remains unclear. We used Cox regression models to estimate hazard ratios (HR) and corresponding...
Int J Cancer
23h
Rare germline genetic variants and risk of aggressive prostate cancer
Abstract Few genetic risk factors have been demonstrated to be specifically associated with aggressive prostate cancer (PrCa). Here, we report a case‐case study of PrCa comparing the prevalence of germline pathogenic/likely pathogenic (P/LP) genetic variants in 787 men with aggressive disease and 769 with non‐aggressive disease. Overall, we observed P/LP variants in 11.4% of men with aggressive PrCa and 9.8% of men with non‐aggressive PrCa (two‐tailed Fisher’s exact tests, P = 0.28). The proportion...
Int J Cancer
23h
Issue Information
Int J Cancer
23h
Issue Information
Int J Cancer
23h
Gastric-cancer-derived mesenchymal stem cells: a promising target for resveratrol in the suppression of gastric cancer metastasis
Abstract The tumor microenvironment (TM) is an essential factor of tumor progression. Mesenchymal stem cells (MSCs) are important components of the TM and play critical roles in cancer metastasis. Resveratrol (RES) is a potential antitumor drug that has attracted extensive attention. However, it remains unclear whether RES can exert its antitumor activity by targeting MSCs located in the TM. In this study, we demonstrated that the conditioned medium of gastric-cancer-derived MSCs...
Latest Results for Human Cell
23h

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