Publication date: Available online 23 April 2020Source: Clinical TherapeuticsAuthor(s): Ying Dai, Guanyang Lin, Dawei Shi
Fri Apr 24, 2020 18:02
Abstract In pituitary adenoma (PA), invasiveness is the main cause of recurrence and poor prognosis. Thus, identifying specific biomarkers for diagnosis and effective treatment of invasive PAs is of great clinical significance. In this study, from the Gene Expression Omnibus database, we obtained and combined several microarrays of PA by the “sva” R package. Weighted gene co-expression network analysis was performed to construct a scale-free topology model and analyze the relationships...
Mon Apr 27, 2020 03:00
Abstract Purpose Short stature in children is a significant medical problem which, without proper diagnosis and treatment, can lead to long-term consequences for physical and psychological health in adult life. Since human height is a polygenic and highly heritable trait, numerous variants in the genes involved in growth—including the growth hormone (GH1) gene—have been identified as causes of short stature. ...
Mon Apr 27, 2020 03:00
Abstract Background Pseudohypoparathyroidism (PHP) is a rare disorder characterized by hypocalcemia, hyperphosphatemia, and resistance to parathyroid hormone (PTH). According to different GNAS mutations, PHP is divided into several subtypes, among which autosomal-dominant PHP1B (AD-PHP1B) is caused by STX16 deletion and epigenetic alteration of GNAS. Although the deletion of STX16 exons 2−6 is commonly observed, other mutations involving...
Sun Apr 26, 2020 03:00
Abstract Purpose Propylthiouracil (PTU)-induced hypothyroidism is a well-established model for assessing hormonal and morphological changes in thyroid as well as other central and peripheral tissues. Somatostatin (SST) is known to regulate hormonal secretion and synthesis in endocrine tissues; however, nothing is currently known about the distribution of SST and its receptor in hypothyroidism. ...
Sat Apr 25, 2020 03:00
Abstract Purpose Germline mutations in the aryl-hydrocarbon receptor interacting protein (AIP) have been identified often in the setting of familial isolated pituitary adenoma (FIPA). To date there is no strong evidence linking germline AIP mutations to other neoplasms apart from the pituitary. Our primary objective was to investigate the prevalence of AIP gene mutations and mutations in genes that have been associated with neuroendocrine...
Fri Apr 24, 2020 03:00
Abstract Purpose Although quality of life (QoL) is improved in patients with acromegaly after disease control, QoL correlates only weakly with traditional biomarkers. Our objective is to investigate a potential relation between the new serum biomarker soluble Klotho (sKlotho), GH and insulin-like growth factor 1 (IGF-1) levels, and QoL. Methods In...
Fri Apr 24, 2020 03:00
Abstract Purpose Statins are the mainstay of treatment for patients with familial hypercholesterolaemia (FH). However, their efficacy and safety in children and adolescents with FH has not been well-documented. The purpose of this study was to systematically investigate and meta-analyze the best available evidence from randomized-controlled trials (RCTs) regarding the efficacy and safety of statins in this population. ...
Fri Apr 24, 2020 03:00
Although support staff at the front desk are the first point of contact in the audiology clinic, they rarely receive formal training in Person-Centered Care (PCC). To address this gap, the Ida Institute has launched a new tailored online course, to specifically help support staff integrate PCC in their everyday work, enhance patient interaction, and fundamentally improve the overall patient experience. The new course, Getting Started with Person-Centered Care for Support Staff, was developed...
Mon Apr 27, 2020 12:50
Although support staff at the front desk are the first point of contact in the audiology clinic, they rarely receive formal training in Person-Centered Care (PCC). To address this gap, the Ida Institute has launched a new tailored online course, to specifically help support staff integrate PCC in their everyday work, enhance patient interaction, and fundamentally improve the overall patient experience. The new course, Getting Started with Person-Centered Care for Support Staff, was developed...
Mon Apr 27, 2020 12:50
Publication date: Available online 25 April 2020Source: Sleep MedicineAuthor(s): Leo Sher
Mon Apr 27, 2020 20:21
Publication date: Available online 23 April 2020Source: Sleep MedicineAuthor(s): Afik Faerman, Katherine A. Kaplan, Jamie M. Zeitzer
Fri Apr 24, 2020 17:12
Publication date: Available online 23 April 2020Source: Sleep MedicineAuthor(s): Matteo Cesari, Julie A.E. Christensen, Maria-Lucia Muntean, Brit Mollenhauer, Friederike Sixel-Döring, Helge B.D. Sorensen, Claudia Trenkwalder, Poul Jennum
Fri Apr 24, 2020 17:12
Publication date: Available online 23 April 2020Source: Sleep MedicineAuthor(s): Bing Cao, Yan Chen, Roger S. McIntyre
Fri Apr 24, 2020 17:12
Publication date: Available online 23 April 2020Source: Sleep MedicineAuthor(s): Janna Mantua, Alexxa Bessey, Bradley Ritland, Jacob Naylor, Richard Chabuz, Ashlee B. McKeon, Vincent F. Capaldi, Walter J. Sowden
Fri Apr 24, 2020 17:12
Publication date: Available online 25 April 2020Source: Behavioural Brain ResearchAuthor(s): Cristina Fernandez-Baizan, Jorge L. Arias, Marta Mendez
Mon Apr 27, 2020 20:21
Publication date: Available online 25 April 2020Source: Behavioural Brain ResearchAuthor(s): LongEn Yang, Jingtao Wang, Dongmei Wang, Guojun Hu, ZiYuan Liu, Dongni Yan, Nazar Serikuly, Erik Alpyshov, Konstantin A. Demin, Tatiana Strekalova, Murilo S. de Abreu, Cai Song, Allan Kalueff
Mon Apr 27, 2020 20:21
Publication date: Available online 24 April 2020Source: Behavioural Brain ResearchAuthor(s): Danielle J. Houwing, Kirsten Schuttel, Eline L. Struik, Chantal Arling, Anouschka S. Ramsteijn, I. Heinla, Jocelien D.A. Olivier
Sat Apr 25, 2020 19:41
Publication date: Available online 24 April 2020Source: Behavioural Brain ResearchAuthor(s): Linlin Zhang, Yongzhao Fan, Xiaoyang Kong, Wu Hao
Sat Apr 25, 2020 19:41
Publication date: Available online 24 April 2020Source: Behavioural Brain ResearchAuthor(s): Gabriele Cheiran Pereira, Elisa Piton, Brenda Moreira dos Santos, Rossano Menezes da Silva, Amanda Spring de Almeida, Diéssica Padilha Dalenogare, Naieli Souto Schiefelbein, Maria Fernanda Pessano Fialho, Rafael Noal Moresco, Gabriela Trevisan dos Santos, Sara Marchesan, Guilherme Vargas Bochi
Sat Apr 25, 2020 19:41
Publication date: Available online 24 April 2020Source: Behavioural Brain ResearchAuthor(s): Alexa R. Soares, Kelsea R. Gildawie, Jennifer A. Honeycutt, Heather C. Brenhouse
Fri Apr 24, 2020 13:14
Publication date: Available online 25 April 2020Source: The Journal of Prosthetic DentistryAuthor(s): Theodore V. Tso, Denny Chao, Jeffrey Tanner, Earl G. Freymiller, Jay Jayanetti
Mon Apr 27, 2020 20:05
Publication date: Available online 24 April 2020Source: The Journal of Prosthetic DentistryAuthor(s): Inês Margarida Carrilho Baltazar Vaz, José Fausto Pimentel Coelho Lino Carracho
Fri Apr 24, 2020 20:07
Publication date: Available online 23 April 2020Source: The Journal of Prosthetic DentistryAuthor(s): Yi Gao, Jiyao Li, Bo Dong, Min Zhang
Fri Apr 24, 2020 20:07
Publication date: Available online 23 April 2020Source: The Journal of Prosthetic DentistryAuthor(s): Byoung-Heon Kim, Bo-Ah Lee, Seong-Ho Choi, Young-Taek Kim
Fri Apr 24, 2020 20:07
Publication date: Available online 23 April 2020Source: The Journal of Prosthetic DentistryAuthor(s): Lindsay McHutchion, Daniel Aalto
Fri Apr 24, 2020 20:07
Purpose: To assess early outcomes of corneal neurotization for postherpetic neurotrophic keratopathy (NK). Methods: Retrospective analysis of patients who underwent corneal neurotization for postherpetic NK by a single experienced oculoplastic surgeon was performed. Collected data included stage and etiology of NK as well as comorbidities, prior treatment history, neurotization technique, donor nerve site, preoperative and postoperative examination findings (i.e., ocular surface quality,...
Thu Apr 23, 2020 03:00
A 22-year-old woman presented with an acute compressive optic neuropathy due to a ruptured ethmoido-orbital mucocele. She underwent urgent orbital decompression and drainage of the mucocele via an endoscopic approach. Postoperatively, her course was complicated by an orbital compartment syndrome supervened, exhibiting severe eyelid edema caused by infiltration with mucin and mucin-containing macrophages (“muciphages”). Biopsy of the eyelid showed infiltration with “muciphages,” macrophages laden...
Thu Apr 23, 2020 03:00
Eyelid metastases are relatively rare, and they can occasionally lead the way to an unknown primary malignancy elsewhere. The authors report a case of 65-year-old diabetic gentleman with a right-sided eyelid lesion that was present for 1 month and turned out to be a presenting sign of a previously undiagnosed pancreatic adenocarcinoma. The eyelid mass had been treated elsewhere for 2 weeks for a presumed infectious lesion, using systemic antibiotics and was then referred to us in view of no response....
Thu Apr 23, 2020 03:00
Acute dacryocystitis causing visual loss due to development of orbital complications like central retinal artery or ophthalmic artery occlusion, retinal vein occlusions, and optic neuritis is rare but a known entity. However, development of scleral abscess and panophthalmitis as a complication of acute dacryocystitis, leading to loss of vision, has not been described earlier. To the best of the authors’ knowledge, this is the first report describing this mode of visual loss in acute dacryocystitis....
Thu Apr 23, 2020 03:00
No abstract available
Thu Apr 23, 2020 03:00
The authors report a case of extremely uncommon malignancy of lacrimal gland epithelial-myoepithelial carcinoma. This carcinoma is more commonly encountered in salivary glands and comprises 1% of all salivary gland tumors. Its occurrence in the orbit is very rare with only 6 cases reported in the literature, most of which arose in a pleomorphic adenoma. Epithelial-myoepithelial carcinoma is primarily a tumor of older adults, with a peak incidence in the sixth and seventh decades of life. The present...
Thu Apr 23, 2020 03:00
Abstract Background and aims The rising tide of diabetes mellitus (DM) and prediabetes (PDM) is urgently calling for strategies easily applicable to anticipate diagnosis. We assessed the effectiveness of random capillary blood glucose (RCBG), administration of a validated DM risk questionnaire, or the combination of both. Materials and methods RCBG...
Mon Apr 27, 2020 03:00
Monthly fluctuations in 25-hydroxy-vitamin D levels in day and rotating night shift hospital workers
Abstract Purpose Epidemiological studies have suggested that indoor hospital employees, either day or night shift workers, are at high risk of metabolic and cardiovascular diseases. Interestingly, previous reports have also described a higher prevalence of vitamin D (25OHD) deficiency among these workers. However, few studies have determined the monthly variations in 25OHD levels in indoor hospital employees. ...
Mon Apr 27, 2020 03:00
Abstract Background Diabetic ketoacidosis (DKA) is potentially a lethal complication of uncontrolled, especially type 1, diabetes. Understanding the mechanisms underlying adipokine involvement in the regulation of glucose metabolism is important to prevent complications of hyperglycemia. The role of novel adipokines during DKA in human remains unclear. Method ...
Mon Apr 27, 2020 03:00
Abstract Background Hormonal disorders are often associated with abnormal levels of bone turnover markers (BTMs). N-terminal propeptide of type I procollagen (PINP) and serum C-terminal cross-linking telopeptide of type I collagen (CTX-I) are the reference markers of bone formation and bone resorption, respectively. Methods A comprehensive literature...
Sat Apr 25, 2020 03:00
Abstract Purpose Gestational diabetes mellitus (GDM) is the most common metabolic disorder in pregnancy, with increasing prevalence worldwide and still unclear pathogenic mechanisms. Extracellular vesicles (EVs) are emerging as potential biomarkers of disease-specific pathways in metabolic disorders, but their potential role in GDM is not fully understood. Therefore, the main aim of this study was to evaluate the link between EVs and...
Sat Apr 25, 2020 03:00
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