Background and Objective: Camel milk has nutritional and therapeutic properties. Quinoa flour has been incorporated into many kinds of food because of its various nutrients and bio-actives. This study aimed to investigate the effect of using quinoa flour on the properties of low-fat camel milk processed cheese spread (LF-CMPCS) made from fermented retentate camel milk as a camel cheese base. Materials and Methods: Quinoa flour was used to substitute 1, 3 and 5% of the camel cheese base made with...
18h
Background and Objective: Lactic acid bacteria are generally recognized as safe that could be beneficial for several uses in food industry to get their health benefits. The present study was focused on the isolation and identification of some new lactic acid bacteria that might be naturally occurred in the honeybees stomach and tried to explore their benefits. Materials and Methods: Twenty five isolates of lactic acid bacteria were isolated from the stomach of three different types of Egyptian...
18h
Background and Objective: Climate change affecting on weather in many different ways especially drought and temperature rise. This will drastically down plant production, if not start looking for another source to increase water productivity to cope up with water stress conditions. In this study efforts were conducted to interpret the use of anti-transpirants to conserving irrigation water, aiding plant survival under dry conditions and protecting plant against drought stress. Materials and Methods:...
18h
Background and Objective: Pseudomonas aeruginosa is a free living bacterium in widely different areas such as plants, soil, water and other moist locations. It is pathogenic to plants and humans. P. aeruginosa causes several disease symptoms to plants such as wet rot and curved leaves. The virulent bacterial viruses of P. aeruginosa were found to be of widespread occurrence in nature and isolated from widely different sources. Bacterial viruses were applied to control pathogenic bacteria in different...
18h
Abstract Fragility hip fractures and their associated morbidity and mortality pose a global healthcare problem. Several pharmaceutical products have been postulated to alter bone architecture and contribute to fragility hip fractures. We searched four electronic databases from inception to September 2017. Inclusion criteria were the following: (1) adult patients with fragility hip fractures, (2) full text in English, (3) minimum one-year follow-up, and (4) reporting of at least...
1h
Abstract Since 1996, transgenic Bacillus thuringiensis (Bt) cotton has been commercially grown in numerous countries in an effort to stem the losses caused by key lepidopteran pests. However, the development of pest resistance to Bt toxins has jeopardized the continued utilization of Bt cotton. As a strategy designed to circumvent the development of resistance, Bt cotton varieties expressing two or more toxins targeting the same pest have been introduced. Nevertheless, from the...
2h
Abstract Clinical use of CuO nanoparticles (NPs) as antibacterials can be hampered by their toxicity to human cells. We hypothesized that certain surface functionalizations of CuO NPs may render NPs toxic to bacteria, but still be relatively harmless to human cells. To control this hypothesis, the toxicity of differently functionalized CuO NPs to bacteria Escherichia coli vs human cells (THP-1 macrophages and HACAT keratinocytes) was compared using similar conditions and end points....
2h
The global incidence of the sexually transmitted disease gonorrhea is expected to rise due to the spread of Neisseria gonorrhoeae strains with decreased susceptibility to extended-spectrum cephalosporins (ESCs). ESC resistance is conferred by mosaic variants of penicillin-binding protein 2 (PBP2) that have diminished capacity to form acylated adducts with cephalosporins. To elucidate the molecular mechanisms of ESC resistance, we conducted a biochemical and high-resolution structural analysis of...
3h
Much of our current knowledge of biological chemistry is founded in the structure-function relationship, whereby sequence determines structure that determines function. Thus, the discovery that a large fraction of the proteome is intrinsically disordered, while being functional, has revolutionized our understanding of proteins and raised new and interesting questions. Many intrinsically disordered proteins (IDPs) have been determined to undergo a disorder to order transition when recognizing their...
3h
While epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) exert a breakthrough effect, the incidence of skin disorders as a side effect has significantly reduced patients’ quality of life...
3h
This article focuses on the roles and mechanism of lncRNA CRNDE on the progression of HCC.
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Leukemia stem cells (LSCs) in play an important role in the initiation, relapse, and progression of acute myeloid leukemia (AML), and in the development of chemotherapeutic drug resistance in AML. Studies rega...
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To investigate the clinical and pathological characteristics of appendiceal mucinous adenocarcinoma with peritoneal metastasis and analyze the prognostic factors.
3h
There is no consensus on the therapeutic approach to ECOG 2 patients with locally advanced non-small-cell lung cancer (LA-NSCLC), despite the sizable percentage of these patients in clinical practice. This stu...
3h
Hepatocellular carcinoma (HCC) is a highly morbid condition with lack of effective treatment options. HCC arises from chronically inflamed and damaged liver tissue; therefore, chemoprevention may be a useful strategy to reduce HCC incidence. Several reports suggest that Epigallocatechin gallate (EGCG), extracted from green tea, can suppress liver inflammation and fibrosis in animal models, but its role in HCC chemoprevention is not well established. In this study, male Wistar rats were injected with...
3h
Evidence suggests that physical activity(PA) is positively associated with health-related quality of life(QOL) in colorectal cancer(CRC) survivors. However, little is known regarding long-term effects of PA on QOL and if pre-diagnosis PA is associated with QOL in the years after diagnosis. Our study aimed to investigate the association of pre- and post-diagnosis PA with long-term QOL in CRC survivors. This study is based on a population-based cohort from Germany of 1781 newly diagnosed CRC survivors...
3h
The reason as to why the severity of peanut-allergic reactions varies widely in severity is not understood. To address this, Do et al (p 1219) used multi-omic approaches to identify genes and networks driving this severity. Twenty-one peanut-allergic children ages 7-17 years were given increasing doses of peanut until they reacted. The scientists sampled blood from the participants before they ate, as they reacted, and after their reaction. Additional highlights from the study include:
3h
Epigenetics has been discussed as a potential factor influencing the pathophysiology and severity of inflammatory skin diseases. In recent years, emerging evidence suggests that epigenetic mechanisms are involved in the pathophysiology of not only atopic dermatitis (AD) and psoriasis (PSO) but also lupus erythematosus and oral lichen. A systematic review of the literature was undertaken to provide an unbiased and comprehensive update on the involvement of methylation patterns in inflammatory skin...
3h
Autoimmune bullous skin diseases, such as pemphigus and pemphigoid, may enable clarification of the mechanisms of immune regulation in the skin. Pemphigus and pemphigoid are mediated by essentially IgG autoantibodies against structural proteins of the desmosomes at cell-cell junctions and hemidesmosomes at epidermal-dermal junctions, respectively, and are characterized by blisters and erosions in the skin and/or mucous membranes. Intensive investigation over the last 3 decades has identified their...
3h
Genetic variants that increase the expression of the orosomucoid-like protein 3 (ORMDL3) gene, which encodes an inhibitor of de novo synthesis of sphingolipids, have been associated with increased risk of childhood-onset nonallergic asthma. Ono et al (J Clin Invest 2020 Jan 13. doi: https://doi.org/10.1172/JCI130860) identified that asthma-risk ORMDL3 variants modulate sphingolipid activity in human subjects. More specifically, lower blood levels of multiple types of sphingolipids and de novo sphingolipid...
3h
Autoimmune bullous diseases (AIBDs) are prototypical organ-specific autoimmune diseases of the skin and mucous membranes.1,2 In 1953, Lever divided AIBDs into the 2 groups, pemphigus and pemphigoid diseases, depending on the location of the lesions. The major autoantigens in pemphigus diseases are keratinocyte cell surface adhesion molecules at desmosomes, and those of pemphigoid diseases are components of the epidermal basement membrane zone (BMZ) (Fig 1). Such autoantigens are depicted in Fig 1.
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The Editors wish to acknowledge the contributions of the following colleagues in the field of allergy and immunology who served as reviewers for JACI during 2019.
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Get important practice updates for 2020 from leading experts at the 2020 AAAAI Practice Management Workshop, July 17-19 in Washington, DC.
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The following activities offer AMA PRA Category 1 Credit™ and meet the American Board of Allergy and Immunology (ABAI) requirements for Part II or Part IV Maintenance of Certification (MOC):
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Autophagy is significantly upregulated in conjunctival inflamed VKC tissues. The TNF-α enhanced autophagy in conjunctival fibroblast cultures suggests that modulators of autophagy may be a new therapeutic strategy for the treatment of VKC.
6h
Pollen exposure induces local and systemic allergic immune responses in sensitized individuals, but nonsensitized individuals also are exposed to pollen. The kinetics of symptom expression under natural pollen exposure have never been systematically studied, especially in subjects without allergy.
6h
ACS NanoDOI: 10.1021/acsnano.0c00604
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ACS NanoDOI: 10.1021/acsnano.9b09618
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ACS NanoDOI: 10.1021/acsnano.0c00959
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ACS NanoDOI: 10.1021/acsnano.9b10195
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ACS NanoDOI: 10.1021/acsnano.0c00393
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ACS NanoDOI: 10.1021/acsnano.0c00883
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Cd exposure is a non-traditional risk factor of cardiovascular disease and mortality by promoting the development of atherosclerosis. The development of atherosclerosis can be monitored non-invasively by measu...
5h
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