Abstract Outcomes for patients with metastatic and recurrent osteosarcoma remain poor and a better understanding of the biology of this malignancy is critical to the development of prognostic biomarkers and novel therapies. The purpose of this study was to establish a biobank of osteosarcoma which has the potential of monitoring tumors dynamically with exosomes, to facilitate clinical and basic scientific research. The osteosarcoma biological specimen and clinical data of osteosarcoma...
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Related ArticlesThe Effect of Immediate Versus Delayed Port Access on 30-Day Infection Rate. J Infus Nurs. 2020 May/Jun;43(3):167-171 Authors: Tancredi TS, Kissane JL, Lynch FC, Li M, Kong L, Waybill PN Abstract This study compared the 30-day infection risk of chest ports accessed on the same day as placement and chest ports with delayed initial access. The aim was to evaluate a larger data set that provided evidence for the development of port access...
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Related ArticlesFrom ISET to InDRE. IV. Institute of Epidemiological Diagnosis and Reference: new orientation, 1990-2012. Gac Med Mex. 2020;156(2):124-131 Authors: Guzmán-Bracho MDC, Ramírez-Hernández JA, Rodríguez-Pérez ME, Viesca-Treviño C, Díaz-Quiñonez JA Abstract From 1990 to 2012, the Sanitary and Tropical Diseases Institute experienced the most important changes. In 1989, its name and orientation were modified to become the National Institute...
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Related ArticlesModeling Hippocampal CA1 Gabaergic Synapses of Audiogenic Rats. Int J Neural Syst. 2020 Apr 14;:2050022 Authors: Pena RFO, Ceballos CC, De Deus JL, Roque AC, Garcia-Cairasco N, Maurício Leão R, Cunha AOS Abstract Wistar Audiogenic Rats (WARs) are genetically susceptible to sound-induced seizures that start in the brainstem and, in response to repetitive stimulation, spread to limbic areas, such as hippocampus. Analysis of the distribution...
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Related ArticlesConvergent and discriminant validity of the Serbian version of the Central Sensitization Inventory. Pain Pract. 2020 Apr 14;: Authors: Knezevic A, Neblett R, Colovic P, Jeremic-Knezevic M, Bugarski-Ignjatovic V, Klasnja A, Pantelinac S, Pjevic M Abstract OBJECTIVES: The goal of the present study was to explore additional evidence of validity of the Serbian version of the Central Sensitization Inventory (CSI), a patient-reported outcome...
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Related ArticlesHow to develop clinical reasoning in medical students and interns based on illness script theory: An experimental study. Med J Islam Repub Iran. 2020;34:9 Authors: Delavari S, Monajemi A, Baradaran HR, Kyaw Myint P, Yaghmaei M, Soltani Arabshahi SK Abstract Background: Although theory explains the development of illness script, it does not provide answers how medical students develop scripts in their learning. To fill the knowledge gap...
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Related ArticlesApplied strategy in the Iowa Gambling Task: Comparison of individuals with Parkinson's disease to healthy controls. J Clin Exp Neuropsychol. 2020 Apr 14;:1-11 Authors: Kjær SW, Callesen MB, Larsen L, Borghammer P, Østergaard K, Damholdt MF Abstract Introduction: Decision-making impairments in Parkinson's disease (PD) have frequently been measured using the Iowa Gambling Task (IGT), though results have been inconsistent. At present, task...
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Related ArticlesRecalibrating Veterinary Medicine through Animal Welfare Science and Ethics for the 2020s. Animals (Basel). 2020 Apr 09;10(4): Authors: De Paula Vieira A, Anthony R Abstract What should leading discourses and innovation regarding animal welfare look like for the veterinary profession in the 2020s? This essay considers four main challenges into which veterinarians are increasingly being drawn, as they respond to increasing public expectation...
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Related Articles[Clinical efficacy of acupuncture combined with modified Xiangfu Decoction in treatment of menopausal insomnia cause by liver Qi stagnation]. Zhongguo Zhong Yao Za Zhi. 2020 Mar;45(6):1460-1464 Authors: Yan XL, Yu YD, Yang DD Abstract To evaluate the efficacy and safety of acupuncture combined with modified Xiangfu Decoction in the treatment of menopausal insomnia case by liver Qi stagnation. Totally 120 cases were randomly divided into...
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Related ArticlesStanding Up against Gender Bias and Harassment - A Matter of Professional Ethics. N Engl J Med. 2020 Apr 09;382(15):1385-1387 Authors: Mello MM, Jagsi R PMID: 32268023 [PubMed - indexed for MEDLINE]
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Related ArticlesInitial Invasive or Conservative Strategy for Stable Coronary Disease. N Engl J Med. 2020 04 09;382(15):1395-1407 Authors: Maron DJ, Hochman JS, Reynolds HR, Bangalore S, O'Brien SM, Boden WE, Chaitman BR, Senior R, López-Sendón J, Alexander KP, Lopes RD, Shaw LJ, Berger JS, Newman JD, Sidhu MS, Goodman SG, Ruzyllo W, Gosselin G, Maggioni AP, White HD, Bhargava B, Min JK, Mancini GBJ, Berman DS, Picard MH, Kwong RY, Ali ZA, Mark DB, Spertus JA, Krishnan...
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Related ArticlesHealth-Status Outcomes with Invasive or Conservative Care in Coronary Disease. N Engl J Med. 2020 04 09;382(15):1408-1419 Authors: Spertus JA, Jones PG, Maron DJ, O'Brien SM, Reynolds HR, Rosenberg Y, Stone GW, Harrell FE, Boden WE, Weintraub WS, Baloch K, Mavromatis K, Diaz A, Gosselin G, Newman JD, Mavromichalis S, Alexander KP, Cohen DJ, Bangalore S, Hochman JS, Mark DB, ISCHEMIA Research Group Abstract BACKGROUND: In the ISCHEMIA...
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Related ArticlesThe utility of a single simple question in the evaluation of patients with nondiabetic polyneuropathy. Muscle Nerve. 2020 04;61(4):526-529 Authors: Abraham A, Lovblom LE, Bril V Abstract INTRODUCTION: A single and simple question, namely "What percentage of normal (PoNL) do you feel regarding your disease?" is feasible and valid in myasthenia gravis. In this study, we aimed to determine the validity of this question in patients with...
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Related ArticlesIn Reply to Kassam and Ellaway. Acad Med. 2020 01;95(1):10 Authors: Gengoux GW, Roberts LW PMID: 31860620 [PubMed - indexed for MEDLINE]
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Related ArticlesAcknowledging a Holistic Framework for Learner Wellness: The Human Capabilities Approach. Acad Med. 2020 01;95(1):9-10 Authors: Kassam A, Ellaway R PMID: 31860619 [PubMed - indexed for MEDLINE]
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Related ArticlesEffects of the Proactive interdisciplinary self-management (PRISMA) program on self-reported and clinical outcomes in type 2 diabetes: a pragmatic randomized controlled trial. BMC Endocr Disord. 2019 Dec 11;19(1):139 Authors: du Pon E, Kleefstra N, Cleveringa F, van Dooren A, Heerdink ER, van Dulmen S Abstract BACKGROUND: Diabetes self-management education can be helpful for patients with type 2 diabetes in managing their condition....
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Related ArticlesConsiderations before initiating therapy in Parkinsonism: basing on the quality of life. J Neurol. 2019 Dec;266(12):3119-3125 Authors: He SJ, Liu ZY, Yang YJ, Shen C, Du YJ, Zhou XY, Zhao J, Sun YM, Yang K, Wu JJ, Liu FT, Wang J Abstract OBJECTIVE: Improvement of quality-of-life (QoL) has been termed as a primary objective in initiating therapy in both Parkinson's disease (PD) and multiple system atrophy Parkinsonian subtype (MSA-P)....
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Related ArticlesA matter of life and longer life. J Aging Stud. 2019 Sep;50:100800 Authors: Kostick K, Fowler LR, Scott CT Abstract While the major scientific discoveries that would extend the length and health of human lives are not yet here, the research that could create them is already underway. As prospects for a world in which extended and improved lives inches closer into reality, the discourse about what to consider as we move forward grows...
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Related ArticlesOlder migrants' civic participation: A topic in need of attention. J Aging Stud. 2019 Sep;50:100790 Authors: Torres S, Serrat R Abstract The number of international migrants around the world has steadily increased, as has the number of people that belong to the older segments of our populations. Due to these demographic transformations, topics that have yet to receive scholarly attention have begun to receive the attention of research...
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Related ArticlesSelf-management for adults with epilepsy: Aggregate Managing Epilepsy Well Network findings on depressive symptoms. Epilepsia. 2019 09;60(9):1921-1931 Authors: Sajatovic M, Johnson EK, Fraser RT, Cassidy KA, Liu H, Pandey DK, Quarells RC, Scal P, Schmidt S, Shegog R, Spruill TM, Janevic MR, Tatsuoka C, Jobst BC Abstract OBJECTIVE: To assess depressive symptom outcomes in a pooled sample of epilepsy self-management randomized controlled...
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Related ArticlesThe Donor Letter Project: Learning Professionalism and Fostering Empathy in an Anatomy Curriculum. J Med Humanit. 2019 Dec;40(4):607-612 Authors: Kaye A, Miranda M, Jones T Abstract While cadaver dissection remains an unmatched learning tool for structural anatomy, recent shifts in medical culture and pedagogy indicate that developing humanistic practices and fostering empathic responses are crucial components of early medical education....
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Related Articles(Re)Defining success in epilepsy surgery: The importance of relative seizure reduction in patient-reported quality of life. Epilepsia. 2019 10;60(10):2078-2085 Authors: Sheikh S, Thompson N, Bingaman W, Gonzalez-Martinez J, Najm I, Jehi L Abstract OBJECTIVE: Previous work has suggested that seizure outcome is the most important predictor of quality of life (QoL) after epilepsy surgery, but it is unknown which specific seizure outcome...
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Related ArticlesHow Does Comprehensive Care Impact Life of Pediatric Patients With Hemophilia? Results From a Center in a Developing Country. J Pediatr Hematol Oncol. 2019 11;41(8):601-605 Authors: Villarreal-Martínez L, Meléndez-Aguirre A, Cantú-Moreno M, Garay-Mendoza D, Garza JA, Ibarra-Ramírez M, Quiroga-Treviño M, Pope-Salazar SE, Velasco-Ruiz I Abstract BACKGROUND: Quality of life (QoL) has been included as a marker of treatment effectiveness...
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Related ArticlesPredictors of multiple domains of functioning in Veterans with posttraumatic stress disorder: Results from the Mind Your Heart Study. Depress Anxiety. 2019 11;36(11):1026-1035 Authors: Arenson MB, McCaslin SE, Cohen BE Abstract BACKGROUND: Those with posttraumatic stress disorder (PTSD) have lower overall functioning than healthy controls. However, this population is not homogenous, and those with PTSD have a wide range of functional...
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Related ArticlesMapping the kidney disease quality of life 36-item short form survey (KDQOL-36) to the EQ-5D-3L and the EQ-5D-5L in patients undergoing dialysis. Eur J Health Econ. 2019 Nov;20(8):1195-1206 Authors: Yang F, Wong CKH, Luo N, Piercy J, Moon R, Jackson J Abstract OBJECTIVES: To develop algorithms mapping the Kidney Disease Quality of Life 36-Item Short Form Survey (KDQOL-36) onto the 3-level EQ-5D questionnaire (EQ-5D-3L) and the 5-level...
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Related ArticlesHeartburn and dyspepsia symptom severity improves after treatment and correlates with histology in adults with eosinophilic esophagitis. Dis Esophagus. 2019 Nov 13;32(9): Authors: Eluri S, Perjar I, Betancourt R, Randall C, Raja S, Woosley JT, Shaheen NJ, Dellon ES Abstract Non-dysphagia symptoms, such as heartburn and dyspepsia, are poorly characterized in adults with eosinophilic esophagitis (EoE). It is unclear if treatment improves...
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Related ArticlesHow law can help solve the collective action problem of antimicrobial resistance. Bioethics. 2019 09;33(7):798-804 Authors: Hoffman SJ, Bakshi R, Rogers Van Katwyk S Abstract Antimicrobial resistance is a global collective action problem with dire consequences for human health. This article considers how domestic and international legal mechanisms can be used to address antimicrobial resistance and overcome the governance and political...
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Related ArticlesQuality of life after pancreas transplantation: time to look again. Curr Opin Organ Transplant. 2019 08;24(4):451-455 Authors: Hanlon M, Cooper M, Abrams P Abstract PURPOSE OF REVIEW: To summarize the existing body of literature regarding quality of life after pancreas transplantation, discuss the limitations of existing studies and make an argument for the need for future investigation on this important topic using standard verifiable...
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Related ArticlesMight there be a medical conscience? Bioethics. 2019 09;33(7):835-841 Authors: Ben-Moshe N Abstract I defend the feasibility of a medical conscience in the following sense: a medical professional can object to the prevailing medical norms because they are incorrect as medical norms. In other words, I provide an account of conscientious objection that makes use of the idea that the conscience can issue true normative claims, but the claims...
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Related ArticlesCutting red tape to manage public health threats: An ethical dilemma of expediting antibiotic drug innovation. Bioethics. 2019 09;33(7):785-791 Authors: Munthe C, Nijsingh N Abstract Antibiotic resistance, arising when bacteria develop defences against antibiotics, is creating a public health threat of massive proportions. This raises challenging questions for standard notions in bioethics when suitable policy is to be characterized...
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Related ArticlesNo impact of an extensive social intervention program on return to work and quality of life after acute cardiac event: a cluster-randomized trial in patients with negative occupational prognosis. Int Arch Occup Environ Health. 2019 11;92(8):1109-1120 Authors: Salzwedel A, Wegscheider K, Schulz-Behrendt C, Dörr G, Reibis R, Völler H Abstract OBJECTIVES: To examine the effectiveness of extensive social therapy intervention during inpatient...
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Related ArticlesFirst-Line Therapy for Immune Thrombocytopenia. Hamostaseologie. 2019 Aug;39(3):259-265 Authors: Mithoowani S, Arnold DM Abstract Immune thrombocytopenia (ITP) is an autoimmune disease affecting blood platelets that causes thrombocytopenia and an increased risk of bleeding. First-line therapy is indicated for patients with bleeding complications or who are at increased risk of bleeding, and the decision to initiate therapy depends not...
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Related ArticlesImmunomodulatory Second-Line Therapies for Immune Thrombocytopenia. Hamostaseologie. 2019 Aug;39(3):266-271 Authors: Lambert MP Abstract Management of immune thrombocytopenia (ITP) is complex requiring communication between patients and caregivers to establish a mutual understanding of the impact of the patient's disease on quality of life, the current symptoms and risk of morbidity/mortality and the goals of therapy. The currently available...
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Related ArticlesUnderstanding the unmet sexual health needs of women with breast cancer. Menopause. 2019 08;26(8):811-813 Authors: Faubion SS, Kingsberg SA PMID: 31166311 [PubMed - indexed for MEDLINE]
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Related ArticlesAssociation Between Adiposity and Perceived Physical Fatigability in Mid- to Late Life. Obesity (Silver Spring). 2019 07;27(7):1177-1183 Authors: Martinez-Amezcua P, Simonsick EM, Wanigatunga AA, Urbanek JK, Chiles Shaffer N, Ferrucci L, Schrack JA Abstract OBJECTIVE: This study aimed to compare and contrast the associations between measures of adiposity and fat distribution and perceived fatigability among well-functioning individuals...
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Related ArticlesBioethical Issues and Secondary Prevention for Nonoffending Individuals with Pedophilia. Camb Q Healthc Ethics. 2019 04;28(2):264-275 Authors: Heasman A, Foreman T Abstract Child sexual abuse is a global problem with significant emotional, psychological, and financial implications to victims, perpetrators, and society. Most child sexual abuse prevention programs target young children or those who have already engaged in abusive behavior,...
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Related ArticlesReconsidering the Moralization of Health: Practices Versus Concepts, and What We Can Learn from Evidence-based Research. Camb Q Healthc Ethics. 2019 04;28(2):215-224 Authors: Thomas SJ Abstract This article aims to do two things. First, it argues that moralization of health occurs not only at the practical level of individual healthcare choices and health states, but also at the conceptual level of health itself. This is most evident...
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Related ArticlesHealth as the Moral Principle of Post-Genomic Society: Data-Driven Arguments Against Privacy and Autonomy. Camb Q Healthc Ethics. 2019 04;28(2):201-214 Authors: Snell K Abstract In Finland, as well as all over the globe, great weight is put on the possibilities of large data collections and 'big data' for generating economic growth, enhancing medical research, and boosting health and wellbeing in totally new ways. This massive data gathering...
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Hydralazine is a common vasodilator which has been used for the treatment of hypertension and heart failure. Hydralazine can induce antineutrophil cytoplasmic antibody-associated vasculitis due to its auto-imm...
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Fasciotomy is a life-saving procedure to treat acute compartment syndrome, a surgical emergency. As fasciotomy dramatically improves wound pain, it should be performed as soon as possible. Moreover, delays in ...
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A severe pneumonia-associated respiratory syndrome caused by a new coronavirus was identified in December 2019 (COVID-19), spread rapidly and has become a world-wide public health challenge. About 25% of COVID...
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