Related ArticlesAntibiotic resistance as a tragedy of the commons: An ethical argument for a tax on antibiotic use in humans. Bioethics. 2019 09;33(7):776-784 Authors: Giubilini A Abstract To the extent that antibiotic resistance (ABR) is accelerated by antibiotic consumption and that it represents a serious public health emergency, it is imperative to drastically reduce antibiotic consumption, particularly in high-income countries. I present the problem...
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Related ArticlesEngagement as co-constructing knowledge: A moral necessity in public health research. Bioethics. 2019 09;33(7):805-813 Authors: Pratt B Abstract Undertaking engagement in public health research is ethically essential. There is a growing emphasis on practicing engagement as the co-construction of knowledge, which goes beyond other common forms of engagement in health research practice: consulting and informing. Taking such an approach...
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Related ArticlesLocal retro-orbicularis oculus fat (ROOF) resection in upper blepharoplasty: A retrospective evaluation study of 65 bilateral upper blepharoplasties. J Plast Reconstr Aesthet Surg. 2019 Aug;72(8):1373-1378 Authors: Zhang YS, Zhou Q, Zhang J, Niu GZ, Huang XY, Liu CY, Qiu YP, Zheng CY, Bi YL Abstract BACKGROUND: Puffy upper eyelids are normal in Asians, and full-incision blepharoplasty is commonly performed to remove some orbital fat...
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Related ArticlesQuality of life following aesthetic liposuction: A prospective outcome study. J Plast Reconstr Aesthet Surg. 2019 Aug;72(8):1363-1372 Authors: Papadopulos NA, Kolassa MJ, Henrich G, Herschbach P, Kovacs L, Machens HG, Klöppel M Abstract BACKGROUND: The authors' previous research suggested the hypothesis that aesthetic surgery in general has a positive impact on quality of life (QoL). This prospective study aimed to investigate the indication-specific...
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Related ArticlesInpatient Enhanced Multidisciplinary Care Effects on the Quality of Life for Parkinson Disease: A Quasi-Randomized Controlled Trial. J Geriatr Psychiatry Neurol. 2019 07;32(4):186-194 Authors: Marumoto K, Yokoyama K, Inoue T, Yamamoto H, Kawami Y, Nakatani A, Fukazawa Y, Hosoe Y, Yamasaki A, Domen K Abstract OBJECTIVES: To compare the effects of inpatient enhanced multidisciplinary care (EMC) and multidisciplinary rehabilitation (MR)...
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Related ArticlesERα Gene Promoter Methylation in Cognitive Function and Quality of Life of Patients With Alzheimer Disease. J Geriatr Psychiatry Neurol. 2019 07;32(4):221-228 Authors: Li KX, Sun Q, Wei LL, Du GH, Huang X, Wang JK Abstract OBJECTIVE: Alzheimer disease (AD) has been recognized as a progressive neurodegenerative disorder. This study aims to investigate the effects of estrogen receptor α (ERα) gene promoter methylation on the cognitive...
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Related ArticlesEpidemiology and Clinical Manifestations of Immune Thrombocytopenia. Hamostaseologie. 2019 Aug;39(3):238-249 Authors: Kohli R, Chaturvedi S Abstract Immune thrombocytopenia (ITP) occurs with an incidence rate of 1.6 to 3.9 per 100,000 patient-years, which increases with age and has a slight female preponderance. ITP is termed acute, persistent or chronic when its duration is <3 months, 3 to 12 months and >12 months, respectively....
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Related ArticlesA Prospective Cohort Study on the Impact of Reflexology in Patients With Breast Cancer Using the MYCaW Scale. Clin Breast Cancer. 2019 04;19(2):e319-e326 Authors: Kapila AK, Herd A, Knife N, Chaplin P, Patel A Abstract INTRODUCTION: Breast cancer treatment and recovery remain physically and psychologically challenging for patients. Reflexology has been studied as a complementary therapy to help relieve patients of the physical and psychological...
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Related ArticlesPsychosocial consequences of living kidney donation: a prospective multicentre study on health-related quality of life, donor-recipient relationships and regret. Nephrol Dial Transplant. 2019 06 01;34(6):1045-1055 Authors: Wirken L, van Middendorp H, Hooghof CW, Sanders JF, Dam RE, van der Pant KAMI, Wierdsma JM, Wellink H, van Duijnhoven EM, Hoitsma AJ, Hilbrands LB, Evers AWM Abstract BACKGROUND: Previous studies have indicated decreased...
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Related ArticlesWomen's experience of vulvovaginal symptoms associated with menopause. Menopause. 2019 04;26(4):341-349 Authors: Shifren JL, Zincavage R, Cho EL, Magnavita A, Portman DJ, Krychman ML, Simon JA, Kingsberg SA, Rosen RC Abstract OBJECTIVE: This study describes women's experiences of the genitourinary syndrome of menopause (GSM) elicited through focus groups and cognitive debriefing sessions during development of a novel patient-reported...
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Related ArticlesSegmental phenol-Croton oil chemical peels for treatment of periorbital or perioral rhytides. J Am Acad Dermatol. 2019 Dec;81(6):e165-e166 Authors: Lee KC, Sterling JB, Wambier CG, Soon SL, Landau M, Rullan P, Brody HJ, International Peeling Society PMID: 30528504 [PubMed - indexed for MEDLINE]
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Related ArticlesStudy description and baseline characteristics of the population enrolled in a multinational, observational study of teriparatide in postmenopausal women with osteoporosis: the Asia and Latin America Fracture Observational Study (ALAFOS). Curr Med Res Opin. 2019 06;35(6):1041-1049 Authors: Chen CH, Elsalmawy AH, Ish-Shalom S, Lim SJ, Al-Ali NS, Cunha-Borges JL, Yang H, Casas N, Altan L, Moll T, Gurbuz S, Brnabic AJM, Burge RT, Marin F Abstract...
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Chemosensors, Vol. 8, Pages 28: Electrochemical Aptasensor for Detection of Dopamine Chemosensors doi: 10.3390/chemosensors8020028 Authors: Hisham Abu-Ali Cansu Ozkaya Frank Davis Nik Walch Alexei Nabok This work presents a proof of concept of a novel, simple, and sensitive method of detection of dopamine, a neurotransmitter within the human brain. We propose a simple electrochemical method for the detection of dopamine using a dopamine-specific aptamer labeled with an electrochemically...
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Publication date: Available online 14 April 2020Source: BiochimieAuthor(s): Kristian A. Torres-Bonilla, Patrícia C. Panunto, Beatriz B. Pereira, Duvan F. Zambrano, James Herrán-Medina, Manuel H. Bernal, Stephen Hyslop
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Abstract It is now evident that transcriptional gene regulation usually requires the re-organization of chromatin architecture. Increasing evidence suggested various kinds of RNAs are involved in this process. Especially the nascent RNAs retained at their site of transcription can serve as a scaffold for organizing transcriptionally either favorable or unfavorable chromatin structures. An emerging concept of phase separation explains how these chromatin structures can be maintained...
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Related ArticlesNeuropsychiatric Symptoms in Mild Cognitive Impairment: A Literature Review. Dement Geriatr Cogn Disord. 2020 Apr 14;:1-13 Authors: Martin E, Velayudhan L Abstract BACKGROUND: Neuropsychiatric symptoms (NPS) in dementia have received much attention due to their high prevalence and their significant implications. NPS in mild cognitive impairment (MCI), a clinical concept proposed as an intermediate state between normal aging and dementia,...
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Related ArticlesAutomated Remote Monitoring for Peritoneal Dialysis and Its Impact on Blood Pressure. Cardiorenal Med. 2020 Apr 14;:1-11 Authors: Yeter HH, Akcay OF, Ronco C, Derici U Abstract INTRODUCTION: Peritoneal dialysis (PD) provides a safe, home-based continuous renal replacement therapy for patients. The adherence of the patients to the prescribed dialysis fluids cannot always be monitored by physicians. Remote monitoring automated peritoneal...
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Related ArticlesLight interventions and sleep, circadian, behavioral, and psychological disturbances in dementia: A systematic review of methods and outcomes. Sleep Med Rev. 2020 Mar 19;52:101310 Authors: Hjetland GJ, Pallesen S, Thun E, Kolberg E, Nordhus IH, Flo E Abstract Dementia is a devastating disease with a global impact, and there is an urgent need for effective interventions to alleviate the accompanying disturbances in behavior, mood, sleep,...
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Related ArticlesReinventing polysomnography in the age of precision medicine. Sleep Med Rev. 2020 Mar 20;52:101313 Authors: Lim DC, Mazzotti DR, Sutherland K, Mindel JW, Kim J, Cistulli PA, Magalang UJ, Pack AI, de Chazal P, Penzel T, SAGIC Investigators Abstract For almost 50 years, sleep laboratories around the world have been collecting massive amounts of polysomnographic (PSG) physiological data to diagnose sleep disorders, the majority of which...
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Related ArticlesImmunotherapy for GRIN2A and GRIN2D-related epileptic encephalopathy. Epilepsy Res. 2020 Apr 02;163:106325 Authors: Hausman-Kedem M, Menascu S, Greenstein Y, Fattal-Valevski A Abstract BACKGROUND: GRIN-related developmental-epileptic encephalopathies are associated with a spectrum of neurodevelopmental disorders, including intellectual disability, epilepsy including continuous spike-and-wave during sleep syndrome (CSWS), or epilepsy-aphasia...
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Related ArticlesUse of the Whole Child Assessment to identify children at risk of poor outcomes. Child Abuse Negl. 2020 Apr 11;104:104489 Authors: Marie-Mitchell A, Watkins HBR, Copado IA, Distelberg B Abstract BACKGROUND: Screening for Adverse Childhood Experiences (ACEs) in pediatric patients has the potential to prevent poor health outcomes associated with ACEs. Only a limited number of tools screen for all ten ACEs in all pediatric age groups, and...
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Related ArticlesModeling regional changes in dynamic stability during sleep and wakefulness. Neuroimage. 2020 Apr 11;:116833 Authors: Ipiña IP, Kehoe PD, Kringelbach M, Laufs H, Ibañez A, Deco G, Perl YS, Tagliazucchi E Abstract Global brain states are frequently placed within a unidimensional continuum by correlational studies, ranging from states of deep unconsciousness to ordinary wakefulness. An alternative is their multidimensional and mechanistic...
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Related ArticlesDoes the perigestational exposure to chlorpyrifos and/or high-fat diet affect respiratory parameters and diaphragmatic muscle contractility in young rats? Food Chem Toxicol. 2020 Apr 11;:111322 Authors: El Khayat El Sabbouri H, Gay-Quéheillard J, Joumaa WH, Delanaud S, Guibourdenche M, Darwiche W, Djekkoun N, Bach V, Ramadan W Abstract The perinatal period is characterized by developmental stages with high sensitivity to environmental...
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Related ArticlesEfficacy of continuous positive airway pressure (CPAP) for improvements in sleepiness, cognition, mood and quality of life in elderly patients with obstructive sleep apnea: Systematic review and meta-analysis of randomized controlled trials. Chest. 2020 Apr 11;: Authors: Labarca G, Saavedra D, Dreyse J, Jorquera J, Barbe F Abstract INTRODUCTION: Obstructive sleep apnea (OSA) is commonly found in the elderly population (≥ 65 years old),...
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Related ArticlesDeterminants of cone- and rod-function in geographic atrophy: AI-based structure-function correlation. Am J Ophthalmol. 2020 Apr 11;: Authors: Pfau M, Emde LV, Dysli C, Möller PT, Thiele S, Lindner M, Schmid M, Rubin DL, Fleckenstein M, Holz FG, Schmitz-Valckenberg S Abstract PURPOSE: o investigate the association between retinal microstructure and cone- and rod-function in geographic atrophy (GA) secondary to age-related macular degeneration...
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Related ArticlesImproved Prognosis in Cystic Fibrosis: Consideration for Intensive Care During the COVID-19 Pandemic. Am J Respir Crit Care Med. 2020 Apr 14;: Authors: Ramos KJ, Pilewski JM, Faro A, Marshall BC PMID: 32289235 [PubMed - as supplied by publisher]
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Related ArticlesEtiologies of apnea of infancy. Pediatr Pulmonol. 2020 Apr 14;: Authors: Ginsburg D, Maken K, Deming D, Welch M, Fargo R, Kaur P, Terry M, Tinsley L, Ischander M Abstract BACKGROUND: To date there are limited data in the literature to guide the initial evaluation for etiologies of apnea in full-term infants born at greater than or equal to 37 weeks conceptional age (apnea of infancy [AOI]). Pediatricians and pediatric pulmonologists are...
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Related ArticlesParanoid delusions • ideas of reference • sleep problems • Dx? J Fam Pract. 2020 Apr;69(3):E11-E15 Authors: Chan S, Chik I, Wilson BA Abstract ► Paranoid delusions ► Ideas of reference ► Sleep problems ► Multiple, vague somatic symptoms.PMID: 32289132 [PubMed - as supplied by publisher]
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Related ArticlesUnexpected predicted length variation for the coding sequence of the sleep related gene, BHLHE41 in gorilla amidst strong purifying selection across mammals. PLoS One. 2020;15(4):e0223203 Authors: Unadkat K, Whittall JB Abstract There is a molecular basis for many sleep patterns and disorders involving circadian clock genes. In humans, "short-sleeper" behavior has been linked to specific amino acid substitutions in BHLHE41 (DEC2), yet...
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Related ArticlesPredicting Deep Hypnotic State From Sleep Brain Rhythms Using Deep Learning: A Data-Repurposing Approach. Anesth Analg. 2020 May;130(5):1211-1221 Authors: Belur Nagaraj S, Ramaswamy SM, Weerink MAS, Struys MMRF Abstract BACKGROUND: Brain monitors tracking quantitative brain activities from electroencephalogram (EEG) to predict hypnotic levels have been proposed as a labor-saving alternative to behavioral assessments. Expensive clinical...
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Related ArticlesAn Automated Algorithm Incorporating Poincaré Analysis Can Quantify the Severity of Opioid-Induced Ataxic Breathing. Anesth Analg. 2020 May;130(5):1147-1156 Authors: Ermer SC, Farney RJ, Johnson KB, Orr JA, Egan TD, Brewer LM Abstract BACKGROUND: Opioid-induced respiratory depression (OIRD) is traditionally recognized by assessment of respiratory rate, arterial oxygen saturation, end-tidal CO2, and mental status. Although an irregular...
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Related ArticlesEffects of a Tailored Brief Behavioral Therapy Application on Insomnia Severity and Social Disabilities Among Workers With Insomnia in Japan: A Randomized Clinical Trial. JAMA Netw Open. 2020 Apr 01;3(4):e202775 Authors: Okajima I, Akitomi J, Kajiyama I, Ishii M, Murakami H, Yamaguchi M Abstract Importance: According to the stepped-care model, there is a medium to large effect size for using cognitive behavioral therapy for insomnia that...
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Related ArticlesDiagnosis and Management of Obstructive Sleep Apnea: A Review. JAMA. 2020 Apr 14;323(14):1389-1400 Authors: Gottlieb DJ, Punjabi NM Abstract Importance: Obstructive sleep apnea (OSA) affects 17% of women and 34% of men in the US and has a similar prevalence in other countries. This review provides an update on the diagnosis and treatment of OSA. Observations: The most common presenting symptom of OSA is excessive sleepiness,...
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Related ArticlesIntegrating sleep, physical activity, and diet quality to estimate all-cause mortality risk: a combined compositional clustering and survival analysis of the NHANES 2005-2006 cycle. Am J Epidemiol. 2020 Apr 14;: Authors: Del Pozo Cruz B, McGregor DE, Del Pozo Cruz J, Buman MP, Palarea-Albaladejo J, Alfonso-Rosa RM, Chastin SFM Abstract We aimed to compare all-cause mortality risk across clusters of adults 50+ (n = 1,035) with common lifestyle...
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Related ArticlesMental health burden for the public affected by the COVID-19 outbreak in China: Who will be the high-risk group? Psychol Health Med. 2020 Apr 14;:1-12 Authors: Huang Y, Zhao N Abstract In December, 2019, an outbreak of respiratory illness caused by Coronavirus disease 2019 (COVID-19) emerged in Wuhan, China and spread rapidly to other parts of China and around the world. We aimed to identify high-risk groups whose mental health conditions...
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Related ArticlesIntraocular cataract lens replacement and light exposure potentially impact procedural learning in older adults. J Sleep Res. 2020 Apr 14;:e13043 Authors: Chellappa SL, Bromundt V, Frey S, Schlote T, Goldblum D, Cajochen C, Reichert CF Abstract Procedural learning declines with age and appropriately timed light exposure can improve cognitive performance in older individuals. Because cataract reduces light transmission and is associated...
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Related ArticlesPositional obstructive sleep apnea in an obese pediatric population. J Clin Sleep Med. 2020 Apr 14;: Authors: Selvadurai S, Voutsas G, Kassner A, Massicotte C, Katz SL, Propst EJ, Narang I Abstract STUDY OBJECTIVES: Positional obstructive sleep apnea (POSA) is a phenotype of obstructive sleep apnea (OSA) where sleep-related obstructive events occur predominantly in supine position. Limited knowledge exists regarding the presence of POSA...
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