Up to one-third of individuals with obsessive-compulsive disorder (OCD) do not benefit from evidence-based psychotherapy. We examined the efficacy of mindfulness-based cognitive therapy (MBCT) as a complementary treatment option. In a prospective, bicentric, assessor-blinded, randomized, and actively controlled clinical trial, 125 patients with OCD and residual symptoms after cognitive behavioral therapy (CBT) were randomized to either an MBCT group (n=61) or to a psychoeducational group (OCD-EP;...
18h
What happens to the great amount of information on social media and other Internet platforms after our death? Even while alive it is hardly possible for anyone to control the storage and dissemination of personal data on the Internet. How and for what reasons should we therefore try to make arrangements regarding what happens to this data when we pass away? Our next of kin do not usually know much about our various online activities, nor do they have access to the passwords necessary to deactivate...
20h
Harold's 165 mph winds make it the 4th strongest tropical cyclone on record in the Southeast Pacific -- Read more on ScientificAmerican.com
9h
The director of IBM Research explains how the COVID-19 High Performance Computing Consortium came together in just a few days -- Read more on ScientificAmerican.com
9h
Beautiful new footage ventures into a lake that's among the most remote on Earth -- Read more on ScientificAmerican.com
12h
Here’s how they can get it -- Read more on ScientificAmerican.com
13h
Yes, the young people around you are still learning. What are you going to teach them? -- Read more on ScientificAmerican.com
14h
We don’t know for sure, but if we can, it probably won’t be easy, cheap or fast -- Read more on ScientificAmerican.com
16h
It’s because the more we learn, the more questions we find to ask -- Read more on ScientificAmerican.com
18h
Abstract Radiation-shielding of healthy tissue is mandatory in breast intraoperative electron radiotherapy (IOERT). In this regard, dedicated radioprotection disks have been introduced. The aim of this study was to evaluate and compare the performance of three radioprotection disks widely used for breast IOERT. A Monte Carlo simulation approach was used for this purpose. The considered disks included Al + Pb, PMMA + Copper, and PTFE + Steel. They were stimulated by means of the...
9h
by Boyang Liu, Ingo Gregor, H.-Arno Müller, Jörg Großhans The protein phosphatase Cdc25 is a key regulator of the cell cycle by activating Cdk-cyclin complexes. Cdc25 is regulated by its expression levels and post-translational mechanisms. In early Drosophila embryogenesis, Cdc25/Twine drives the fast and synchronous nuclear cycles. A pause in the cell cycle and the remodeling to a more generic cell cycle mode with a gap phase are determined by Twine inactivation and destruction in early interphase...
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by Quinn K. Langdon, David Peris, Juan I. Eizaguirre, Dana A. Opulente, Kelly V. Buh, Kayla Sylvester, Martin Jarzyna, María E. Rodríguez, Christian A. Lopes, Diego Libkind, Chris Todd Hittinger The wild, cold-adapted parent of hybrid lager-brewing yeasts, Saccharomyces eubayanus, has a complex and understudied natural history. The exploration of this diversity can be used both to develop new brewing applications and to enlighten our understanding of the dynamics of yeast evolution in the wild....
9h
by Yongxin Mu, Houzhi Yu, Tongbin Wu, Jianlin Zhang, Sylvia M. Evans, Ju Chen O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) is the only enzyme catalyzing O-GlcNAcylation. Although it has been shown that OGT plays an essential role in maintaining postnatal heart function, its role in heart development remains unknown. Here we showed that loss of OGT in early fetal cardiomyocytes led to multiple heart developmental defects including hypertrabeculation, biventricular dilation, atrial...
9h
by Thibaut Paul Patrick Sellinger, Diala Abu Awad, Markus Moest, Aurélien Tellier Several methods based on the Sequential Markovian coalescence (SMC) have been developed that make use of genome sequence data to uncover population demographic history, which is of interest in its own right and is a key requirement to generate a null model for selection tests. While these methods can be applied to all possible kind of species, the underlying assumptions are sexual reproduction in each generation...
9h
by Sarmi Nath, Ganesh Nagaraju FANCJ helicase mutations are known to cause hereditary breast and ovarian cancers as well as bone marrow failure syndrome Fanconi anemia. FANCJ plays an important role in the repair of DNA inter-strand crosslinks and DNA double-strand breaks (DSBs) by homologous recombination (HR). Nonetheless, the molecular mechanism by which FANCJ controls HR mediated DSB repair is obscure. Here, we show that FANCJ promotes DNA end resection by recruiting CtIP to the sites of...
9h
by Marjolaine Rousselle, Paul Simion, Marie-Ka Tilak, Emeric Figuet, Benoit Nabholz, Nicolas Galtier Whether adaptation is limited by the beneficial mutation supply is a long-standing question of evolutionary genetics, which is more generally related to the determination of the adaptive substitution rate and its relationship with species effective population size (Ne) and genetic diversity. Empirical evidence reported so far is equivocal, with some but not all studies supporting a higher adaptive...
9h
Stimulating brown adipose tissue (BAT) activity represents a promising therapy for overcoming metabolic diseases. mTORC2 is important for regulating BAT metabolism, but its downstream targets have not been fully characterized. In this study, we apply proteomics and phosphoproteomics to investigate the downstream effectors of mTORC2 in brown adipocytes. We compare wild-type controls to isogenic cells with an induced knockout of the mTORC2 subunit RICTOR (Rictor-iKO) by stimulating each with insulin...
10h
Abstract Purpose There are no models for German women that predict absolute risk of invasive breast cancer (BC), i.e., the probability of developing BC over a prespecified time period, given a woman’s age and characteristics, while accounting for competing risks. We thus validated two absolute BC risk models (BCRAT, BCRmod) developed for US women in German women. BCRAT uses a woman’s medical, reproductive, and BC family history; BCRmod...
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The FDA approved the first and only erythroid maturation agent for the treatment of anemia in patients with lower-risk myelodysplastic syndromes. (Source: CancerNetwork)
10h
The director of the National Institute of Allergy and Infectious Diseases spoke with The New England Journal of Medicine in a podcast about how physicians can approach talking to patients regarding COVID-19. (Source: CancerNetwork)
10h
Abstract A recent review of the neuroimaging literature on emotional similarity brought to light some of the drawbacks of the latest studies. The authors discussed important methodological considerations for future work in this field, which predominantly involved stimulus selection. In general, we feel that their suggestions are valuable, but we hold that, depending on the specific scientific question(s) under investigation (e.g., individual differences), some of the suggestions...
10h
Infantile myofibroma is a rare benign tumor usually diagnosed before the age of 2 and found in the head and neck but much more rarely in the orbital region. There have only been 7 cases of periorbital myofibromas reported in children in the literature to date. The current case is of an 8-year-old boy with a left upper eyelid myofibroma confirmed on histopathological and immunochemical analysis. A literature review of periorbital myofibromas has been performed to bring the reader up-to-date with the...
10h
Purpose: We evaluated the effects of aspirin versus placebo in patients undergoing upper eyelid blepharoplasty and/or levator advancement or plication blepharoptosis repair in this randomized, prospective study. Methods: Patients who presented between October 2017 and April 2019 requiring blepharoptosis repair and/or upper eyelid blepharoplasty who were taking 81 mg aspirin were randomized to receive 1 week of aspirin tablets or 1 week of placebo tablets prior to surgery. Postoperative complications,...
10h
Purpose: To report the development and clinical findings of a universal trans-punctal lacrimal microendoscope design. Methods: In this study, we examined a unique and original “2-bend” (i.e., double-angle) rigid lacrimal microendoscope designed for universal applications for anatomical variations. The shape of endoscope was initially evaluated in 6 lacrimal systems of cadavers (4 Caucasian-cadaver lacrimal systems and 2 Asian-cadaver lacrimal systems). Second, a prospective clinical study...
10h
Purpose: To study the in vivo morphology of nasolacrimal duct (NLD) openings into the inferior meatus. Methods: Patients undergoing endoscopic dacryocystorhinostomy and lacrimal intubation had endoscopic real-time examination of the NLD opening. Morphology of NLD openings (size, shape, mucosal folds), and their location from the axilla of the inferior turbinate were assessed. Results: Forty-three lacrimal systems of 39 adult patients (11 males, 28 females) with a mean age of 61 years...
10h
Purpose: Subperiosteal orbital lesions are most commonly abscesses secondary to sinusitis but, in rare cases, may represent other processes. Here, the authors compare the clinical and radiographic presentation of subperiosteal abscesses and alternate subperiosteal processes (“masqueraders”) in an effort to establish distinguishing preoperative diagnostic criteria. Methods: A retrospective chart review of cases of subperiosteal orbital lesions that underwent surgical intervention over a 3-year...
10h
Purpose: To examine the fine anatomic structures between levator aponeurosis and Müller muscle in front of the tarsus. Materials and Methods: Postmortem specimens of 6 Chinese males (5 elderly men, aging from 68 to 86 years; 1 child, 10 years old) were used. A 3-μm thickness sagittal section of the central part of the upper eyelid was prepared, and the samples were examined microscopically by using hematoxylin–eosin, Masson trichrome, and anti-smooth muscle actin antibodies staining. Results:...
10h
A 47-year-old man who presented with subacute binocular diplopia and a left head turn was found to have a right sixth nerve palsy and right optic disc edema. Radiologic imaging revealed a non-lytic right greater sphenoid wing mass with a dural tail, suggestive of a sphenoid wing meningioma. The patient underwent an orbitotomy with lesion biopsy; histopathologic analysis and subsequent imaging revealed the diagnosis of metastatic clear cell renal cell carcinoma. He developed new metastases despite...
10h
Purpose: Lacrimal outflow imaging has been limited in clinical practice due to a combination of modality limitations and efficacy of clinical testing. Cone beam computed tomography dacryocystography (CBCT DCG) has certain advantages over other modalities that may enhance clinical utility. This study was intended to understand the relationships between symptoms, syringing and CBCT DCG in a population of patients presenting with tearing. Methods: Cross-sectional cohort study of adult patients...
10h
Purpose: An anatomical and histological study of the conjoint fascial sheath of the levator and superior rectus (CFS) was carried out by using the cadavers for teaching. Methods: Three adult Asian cadaver heads fixed in formalin were used. The CFS was exposed by the same surgeon in each case. Then the CFS was observed and measured in vivo and ex vivo. And the CFS, the levator and the frontal muscle were removed from the same eye for histological study. Results: The CFS was located 2.1...
10h
Purpose The aim of this review is to describe the role of precision medicine in the diagnosis, treatment, and monitoring of cow's milk allergy. Recent findings The development of ‘omics’ sciences in the field of food allergy has led to a better understanding of the allergenicity of cow's milk proteins and significant advances in the knowledge of the pathogenesis and mechanisms of cow's milk allergy. Omics-based technologies allow the practitioner to better differentiate cow's milk allergy...
10h
Purpose of review In the last years, the interest of the scientific community toward food protein-induced enterocolitis syndrome (FPIES) has grown exponentially. We review here the peculiar characteristics of this syndrome. Recent findings The recent publication of the First International Consensus Guidelines allowed a positive interaction between different research groups with the aim of improving the diagnosis and management of patients affected by FPIES. Summary Several fixed points...
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Purpose of review To perform a nonsystematic review of the literature on the microbiota in the different types of non-IgE-mediated food allergy. Recent findings The commonest non-IgE-mediated disorders managed by allergists include: eosinophilic esophagitis, food protein-induced enteropathy, food protein-induced enterocolitis syndrome, and food protein-induced allergic proctocolitis. The review of the literature describes how at phylum level we observe an increase of Proteobacteria in eosinophilic...
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Abstract Purpose Investigate the possibility of delivering teriparatide orally using nanoemulsion. Method Teriparatide was allowed to interact with chitosan in the presence of HPβCD.The formed polyelectrolyte complex (PEC) was characterized by DSC, FTIR, DLS and for entrapment efficiency. PEC was the incorporated in an oil phase consisting of...
10h
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