Abstract Purpose Development of zeta potential changing SEDDS containing newly synthesized derivative stearic acid phosphotyrosine amide. Methods Stearoyl chloride was conjugated with phosphotyrosine, which is substrate for the brush border enzyme intestinal alkaline phosphate. The synthesized derivative...
10h
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
10h
Contagion was a film released in 2011 about a fictional pandemic of a virus called MEV-1 which kills between 25 and 30 per cent of those it infected. Here is our review of the film originally published in September 2011, now that it's on Netflix
11h
An unusually round and symmetrical deposit on Mars may be the result of an impact that popped the surface of the planet, causing a volcanic eruption less than 200,000 years ago
11h
Soil’s earthy smell comes from chemicals produced by bacteria called Streptomyces, which use the odour to attract springtails to help disperse their spores
12h
Glass has an unusual atomic structure that resembles a liquid frozen in place, making it hard to predict how it will behave. DeepMind has developed an AI capable of doing so, which may also be able to predict traffic jams
12h
In 2012, mathematician Shinichi Mochizuki produced a proof claiming to solve the long-standing ABC conjecture, but no one understood it. Most mathematicians still don't, but it will now be published in a journal
13h
The age of a whale shark can be determined by dating the rings of growth in their cartilage, a method that has confirmed that these animals can live for at least 50 years
13h
Is our love affair with AI really about building a new kind of deity to meet human needs no amount of rationality can fill? Max Barry's disturbing novel Providence lays out the case, says Sally Adee
15h
With all the unknowns about covid-19, any numbers you hear about death tolls or how long restrictions will last should be taken not just with a pinch of salt but with a sack of it
17h
The age of a whale shark can be determined by carbon dating the rings of growth in their cartilage, a method that has confirmed that these animals can live for at least 50 years
23h
In melanoma brain metastases patients, complications after GKRS are not significantly increased if IT/TT treatment is performed at the time of or after radiosurgery, and a clear benefit in distant control and survival is seen. Thus, concomitant treatment of MBM with GKRS and IT/TT seems to be a safe and powerful treatment option. Abstract Background Few safety data of concurrent stereotactic radiosurgery and targeted therapy (TT) or immunotherapy (IT) are available. The aim of the study was...
11h
Low dose radiotherapy is a valuable and non‐toxic treatment option in the form of indolent lymphoma. The effectiveness of low‐dose radiotherapy is similarly maintained when repeated once or even twice (RT1, RT2 and RT3). Abstract Purpose In patients with indolent B‐cell non‐Hodgkin's lymphoma (B‐NHL), one course of low‐dose radiotherapy (LD‐RT) 2 × 2 Gy is emerging as new option of therapy in palliative setting. Efficacy of LD‐RT when repeated remains to be determinate. This study aims to assess...
11h
The transcriptional data of circRNAs and mRNAs were deeply detected by high‐throughput RNA sequencing and systematically analyzed using bioinformatics in patients with BC; and these eight dysregulated circRNAs were also verified by real‐time qRT‐PCR. Correlation analysis of clinicopathological features and survival analyses of circRNAs in BC were conducted. Functional experiments with circ_0077837 and circ_0004826 overexpression significantly weakened the progression of BC cells. Abstract Growing...
11h
Inhibited SNHG3 could suppress the progression of prostate cancer cells. MiR‐577 could bind to SNHG3 and regulate the progression of prostate cancer. SNHG3/miR‐577/SMURF1 axis was found in prostate cancer cells. SNHG3/miR‐577/SMURF1 axis could modulate the progression of prostate cancer cells. SNHG3 inhibition could reduce the progression of prostate tumor. Abstract Prostate cancer remains one of the most prevalent cancers and the main causes of cancer‐related deaths in males. Various articles...
11h
Our studies in chronic insulin‐treated HCT‐116 cells suggested that metformin could inhibit Bcl‐2 expression, and its mitochondrial translocation to facilitate mitochondrial apoptosis via AMPK/Erk signaling pathway. Abstract Background Several studies have suggested that drug resistance in colon cancer patients with diabetes may be associated with long‐term insulin administration, which in turn decreases the survival rate. Metformin is a commonly used drug to treat diabetes but has been recently...
11h
Mass spectrometry‐based profiling identified proteomic changes associated with recurrent somatic FBXW7 mutations and shared in two biologically distinct serous endometrial cancer cell lines. Most notably, a correlation between PADI2 protein and FBXW7 mutation was demonstrated in serous endometrial cancer cells and confirmed in an endometrioid endometrial cancer cell line. PADI2 protein expression was further demonstrated in primary serous endometrial tumors. Abstract Background Despite advancements...
11h
Abstract The larynx and vocal folds sit at the crossroad between digestive and respiratory tracts and fulfill multiple functions related to breathing, protection and phonation. They develop at the head and trunk interface through a sequence of morphogenetic events that require precise temporo-spatial coordination. We are beginning to understand some of the molecular and cellular mechanisms that underlie critical processes such as specification of the laryngeal field, epithelial...
11h
Abstract Background Perihematomal edema (PHE) growth in intracranial hemorrhage (ICH) is a biomarker for worse outcomes. Although the management of PHE is potentially beneficial for ICH patients, there is currently no proven clinical therapy that both reduces PHE and improves outcomes in this population. Objective To examine the safety and tolerability of...
11h
Όταν κάποιος ομολογεί, χωρίς να το θέλει, την αλήθεια κάνοντας γλωσσικό σφάλμα, χρησιμοποιούμε τη φράση Γλώσσα λανθάνουσα τα αληθή λέγει. Ναι, αυτή είναι η σωστή φράση και όχι «Γλώσσα λανθάνουσα την αλήθεια λέει (ή αλήθεια λέγει)». Πιο αναλυτικά: Τα λάθη που γίνονται στην ομιλία, από βιασύνη ή παραδρομή, φανερώνουν τις αληθινές σκέψεις ή επιθυμίες αυτού που ομιλεί. […]
11h
Ο χρόνος γυρίζει πίσω, περισσότερο από 100 χρόνια, εικόνες μοναδικές! Οι φωτογραφίες είναι ένα πραγματικό ταξίδι στον χρόνο από το 1897 μέχρι περίπου το 1955… φωτογραφικό υλικό: Γιάννης Δεσποτάκης
12h
«ζαβαρακατρανέμια». Το τραγούδι γράφτηκε στα χρόνια της Χούντας και το μήνυμά του ήταν αντιδικτατορικό. Τους στίχους και τη μουσική έχει γράψει ο Γιάννης Μαρκόπουλος και το τραγούδησε για πρώτη φορά ο Νίκος Ξυλούρης το 1968 στο δίσκο «Επιχείρησις Απόλλων». Οι στίχοι του τραγουδιού είναι: Ζαβαρακατρανέμια ζαβαρακατρανέμιαΑλληλούια αλληλούιαΖαβαρακατρανέμιαίλεως ίλεως λάμαλάμα νάμα νάμα νέμιαΑλληλούια αλληλούιαΊλεως ίλεως ίλεωςίλεως […]
13h
Κουκουμάφκα ή Κουκουμάθκα Κουκουμάφκα: Λέγεται κι έτσι η κουκουβάγια στους νομούς της κεντρικής και ανατολικής κυρίως Μακεδονίας…” Aναφέρεται και ως Κουκουμάτσια (στα αρβανίτικα). Είναι βουλγάρικη λέξη (кукумявка= κουκουβάγια, γλαύκα), θηλυκό ουσιαστικό όπως και στα ελληνικά. Και στις δυο γλώσσες οι αντίστοιχες λέξεις είναι ηχομιμητικές, και διαφέρουν ανάλογα πώς ακούς τη φωνή του πουλιού: κουκουβάγια < από το […]
22h
Abstract Objective To investigate the occurrence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection. Methods Patients with laboratory-confirmed COVID-19 infection were recruited from 12 European hospitals. The following epidemiological and clinical outcomes have been studied: age, sex, ethnicity, comorbidities,...
11h
Abstract Purpose The endoscopic approach to tympanoplasty is gaining popularity, but its adoption for the palisade tympanoplasty technique is unstudied. The aim of the present study was to evaluate the effectiveness of endoscopic cartilage palisade tympanoplasty compared to one-piece composite cartilage-perichondrium grafts for tympanic membrane closure in adult patients with subtotal perforations. ...
17h
Abstract Purpose The olfactory groove (OG) is a common site of iatrogenic cerebrospinal fluid (CSF) leak during endoscopic sinus surgery. We aimed to evaluate the prevalence of CSF leak during endoscopic removal of osteomas involving the OG and identify CT findings indicating increased risk of this complication. Methods A retrospective review was conducted...
19h
by Ming Li, Christopher B. Ball, Geoffrey Collins, Qiaolin Hu, Donal S. Luse, David H. Price, Jeffery L. Meier Herpesvirus late promoters activate gene expression after viral DNA synthesis has begun. Alphaherpesviruses utilize a viral immediate-early protein to do this, whereas beta- and gammaherpesviruses primarily use a 6-member set of viral late-acting transcription factors (LTF) that are drawn to a TATT sequence in the late promoter. The betaherpesvirus, human cytomegalovirus (HCMV), produces...
11h
by Xuan Zhong, Lu Feng, Ru Zang, Cao-Qi Lei, Qing Yang, Hong-Bing Shu The retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5), sense cytoplasmic viral RNA and initiate innate antiviral responses. How RIG-I and MDA5 are differentially regulated remains enigmatic. In this study, we identified the guanylate-binding protein (GBP) and zinc-finger FYVE domain-containing protein ZFYVE1 as a negative regulator of MDA5- but...
11h
by Nicole Caduff, Donal McHugh, Anita Murer, Patrick Rämer, Ana Raykova, Vanessa Landtwing, Lisa Rieble, Christian W. Keller, Michael Prummer, Laurent Hoffmann, Janice K. P. Lam, Alan K. S. Chiang, Friedrich Raulf, Tarik Azzi, Christoph Berger, Tina Rubic-Schneider, Elisabetta Traggiai, Jan D. Lünemann, Michael Kammüller, Christian Münz Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication after organ transplantation frequently associated with the Epstein-Barr...
11h
by Dylan H. de Vries, Vasiliki Matzaraki, Olivier B. Bakker, Harm Brugge, Harm-Jan Westra, Mihai G. Netea, Lude Franke, Vinod Kumar, Monique G. P. van der Wijst Candida bloodstream infection, i.e. candidemia, is the most frequently encountered life-threatening fungal infection worldwide, with mortality rates up to almost 50%. In the majority of candidemia cases, Candida albicans is responsible. Worryingly, a global increase in the number of patients who are susceptible to infection (e.g. immunocompromised...
11h
by Vincent R. Graziano, Forrest C. Walker, Elizabeth A. Kennedy, Jin Wei, Khalil Ettayebi, Madison S. Strine, Renata B. Filler, Ebrahim Hassan, Leon L. Hsieh, Arthur S. Kim, Abimbola O. Kolawole, Christiane E. Wobus, Lisa C. Lindesmith, Ralph S. Baric, Mary K. Estes, Robert C. Orchard, Megan T. Baldridge, Craig B. Wilen Murine norovirus (MNoV) is an important model of human norovirus (HNoV) and mucosal virus infection more broadly. Viral receptor utilization is a major determinant of cell tropism,...
11h
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