Medical leaders have said it is “unacceptable” for advance care plans—with or without a completed “Do not attempt to resuscitate” (DNAR) form—to be applied in a blanket manner to whole groups of...
11h
What might we learn from the covid-19 pandemic?1 Before the pandemic, a patient with complex comorbidities who was unwell at home would have been visited by a general practitioner. This would...
11h
Societies are responding to the covid-19 pandemic at breathtaking speed. Many of these ad hoc responses will have long lasting consequences, and we must make sure that today’s efforts do not threaten...
11h
Sofas?! What I’d give to sit down for five minutesWell, now maybe you can because two furniture retailers have been donating sofas to hospitals. Isn’t that amazing?Don’t couch your wordsSorry, I got...
11h
We know from analysing conflict and post-conflict transitions that such crises can pose as an opportunity for social transformation.1 Given the humanitarian challenges of the ongoing pandemic, we...
11h
The studyHodkinson A, Kontopantelis E, Adeniji C, et al. Accelerometer- and pedometer-based physical activity interventions among adults with cardiometabolic conditions: a systematic review and...
11h
Medical leaders have said it is “unacceptable” for advance care plans—with or without a completed “Do not attempt to resuscitate” (DNAR) form—to be applied in a blanket manner to whole groups of...
13h
What might we learn from the covid-19 pandemic?1 Before the pandemic, a patient with complex comorbidities who was unwell at home would have been visited by a general practitioner. This would...
13h
Societies are responding to the covid-19 pandemic at breathtaking speed. Many of these ad hoc responses will have long lasting consequences, and we must make sure that today’s efforts do not threaten...
14h
Sofas?! What I’d give to sit down for five minutesWell, now maybe you can because two furniture retailers have been donating sofas to hospitals. Isn’t that amazing?Don’t couch your wordsSorry, I got...
14h
We know from analysing conflict and post-conflict transitions that such crises can pose as an opportunity for social transformation.1 Given the humanitarian challenges of the ongoing pandemic, we...
15h
The studyHodkinson A, Kontopantelis E, Adeniji C, et al. Accelerometer- and pedometer-based physical activity interventions among adults with cardiometabolic conditions: a systematic review and...
15h
The US Centers for Disease Control and Prevention (CDC) has told Americans to wear cloth masks to prevent coronavirus transmission. President Donald Trump said at a press briefing last week that the...
15h
Paracetamol should be used in preference to non-steroidal anti-inflammatory drugs for managing fever in patients with suspected covid-19 until more evidence is available on the safety of NSAIDs, the...
16h
In normal times, the medical obligation to “first do no harm” applies to the actions of individual doctors on individual patients. During pandemics, the ethical imperatives shift: we must consider...
17h
Over 100 NHS hospitals have had a combined £13.4bn (€15.25bn; $16.48bn) in historical debts written off by the government to help them respond to the covid-19 pandemic.The move, effective from 1...
17h
The NHS can be ordered to pay for surrogacy treatment abroad if a hospital’s negligence leaves a woman infertile, the UK Supreme Court has ruled in a landmark judgment.By a 3-2 majority, the court...
18h
People are ignoring stroke symptoms and failing to ring 999 because they fear being a burden on the NHS in England during the covid-19 pandemic, the national clinical director for stroke has...
18h
Over the past few months covid-19 has dramatically changed how we live. The media and the government have rightly been concerned with the global health and economic implications of this pandemic,1...
18h
Everything changed in Seattle on 28 February 2020.The metropolitan region of about 3.5 million people in Washington State had already documented the first US case of covid-19 on 20 January in a 35...
18h
AbstractImmune checkpoint inhibitors (ICIs) are monoclonal antibodies that target inhibitory molecules, such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1...
18h
Prehabilitation involves interventions aimed at improving patients’ health before an anticipated upcoming physiologic stressor so that they are better able to withstand that stress. Prehabilitation...
18h
Any clinician who has ever felt unsupported could do no better than work with Emma Wheatley to boost their confidence and satisfaction in the workplace. As well as being a qualified coach and mentor...
18h
The heartburn and stomach ulcer drug Zantac (ranitidine) and its generic equivalent should be removed from pharmacy shelves and should be discarded if found at home, the US Food and Drug...
18h
Attendances at emergency departments in England have fallen significantly since the covid-19 lockdown, sparking concern that some people may be harmed by not accessing treatment.The Royal College of...
19h
As of 1 April 2020, there have been 29 474 confirmed cases of covid-19 in the UK.1 As discussed by Mahase, the UK government has enforced “social distancing” measures to curb transmission, protect...
19h
As of 1 April 2020, there have been 29 474 confirmed cases of covid-19 in the UK.1 As discussed by Mahase, the UK government has enforced “social distancing” measures to curb transmission, protect...
21h
Antibiotics, Vol. 9, Pages 165: Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase Antibiotics doi: 10.3390/antibiotics9040165 Authors: Hayes Satiaputra Sternicki Paparella Feng Lee Rodriguez Tieu Eijkelkamp Shearwin Pukala Abell Booker Polyak Biotin protein ligase (BPL) inhibitors are a novel class of antibacterial...
12h
Antibiotics, Vol. 9, Pages 164: Acquisition of Colistin Resistance Links Cell Membrane Thickness Alteration with a Point Mutation in the lpxD Gene in Acinetobacter baumannii Antibiotics doi: 10.3390/antibiotics9040164 Authors: Saleh Hesham Amin Samir Mohamed Acinetobacter baumannii is one of the most common causes of nosocomial infections in intensive care units. Its ability to acquire diverse mechanisms of resistance limits the therapeutic choices for its treatment....
15h
Antibiotics, Vol. 9, Pages 163: Dispensing Antibiotics without a Prescription for Acute Cough Associated with Common Cold at Community Pharmacies in Shenyang, Northeastern China: A Cross-Sectional Study Antibiotics doi: 10.3390/antibiotics9040163 Authors: Shi Chang Liu Zhai Hu Li Hayat Kabba Feng Yang Jiang Zhao Hu Fang : The inappropriate use of antibiotics is a major health issue in China. We aimed to assess nonprescription...
17h
Antibiotics, Vol. 9, Pages 162: Antibiotic Resistance of Gram-Negative Bacteria from Wild Captured Loggerhead Sea Turtles Antibiotics doi: 10.3390/antibiotics9040162 Authors: Monica Francesca Blasi Luciana Migliore Daniela Mattei Alice Rotini Maria Cristina Thaller Rosa Alduina Sea turtles have been proposed as health indicators of marine habitats and carriers of antibiotic-resistant bacterial strains, for their longevity and migratory lifestyle. Up to now, a...
19h
ObjectivesThe aim of this clustered, randomised controlled trial was to assess the effectiveness of a lumbopelvic postural feedback device for changing postural behaviour in a group of healthcare workers. We hypothesised that workers exposed to auditory postural feedback would reduce the number of times forward bending posture is adopted at work.MethodsThis was a participant and assessor blinded, randomised, sham-controlled trial with blocked cluster random allocation. We recruited healthcare workers...
12h
Abstract Osteoporosis (OP) is a systemic bone metabolic disorder, which negatively affects the quality of life in the elders and postmenopausal females. Healthy volunteers and postmenopausal females with OP were enrolled in the present study. Bone densitometry (BMD) was detected by dual-energy X-ray absorptiometry (DXA). CD14+PBMCs and C2C12 cells were cultured to induce osteoclast differentiation and osteoblast differentiation, respectively. The interaction between miR‑140-3p...
12h
Abstract Extracellular acidification is a well-known driver of tumorigenesis that has been extensively studied. In contrast, the role of endosomal pH is novel and relatively unexplored. There is emerging evidence from a growing number of studies showing that the pH of endosomal compartments controls proliferation, migration, stemness, and sensitivity to chemoradiation therapy in a variety of tumors. Endosomes are a crucial hub, mediating cellular communication with the external...
12h
Cancers, Vol. 12, Pages 891: Targeting the Acidic Tumor Microenvironment: Unexpected Pro-Neoplastic Effects of Oral NaHCO3 Therapy in Murine Breast Tissue Cancers doi: 10.3390/cancers12040891 Authors: Ninna C. S. Voss Thomas Dreyer Mikkel B. Henningsen Pernille Vahl Bent Honoré Ebbe Boedtkjer The acidic tumor microenvironment modifies malignant cell behavior. Here, we study consequences of the microenvironment in breast carcinomas. Beginning at carcinogen-based...
12h
Cancers, Vol. 12, Pages 890: A Fluorescence-Based Wireless Capsule Endoscopy System for Detecting Colorectal Cancer Cancers doi: 10.3390/cancers12040890 Authors: Mohammad Wajih Alam Seyed Shahim Vedaei Khan A. Wahid Wireless capsule endoscopy (WCE) has been widely used in gastrointestinal (GI) diagnosis that allows the physicians to examine the interior wall of the human GI tract through a pain-free procedure. However, there are still several limitations of the technology,...
16h
Cancers, Vol. 12, Pages 888: Tumor Ulceration, Reduced Infiltration of CD8-Lymphocytes, High Neutrophil-to-CD8-Lymphocyte Ratio and Absence of MC Virus are Negative Prognostic Markers for Patients with Merkel Cell Carcinoma Cancers doi: 10.3390/cancers12040888 Authors: Simon Naseri Torben Steiniche Jeanette Bæhr Georgsen Rune Thomsen Morten Ladekarl Martin Heje Tine Engberg Damsgaard Marie Louise Bønnelykke-Behrndtz (1) Background: Merkel cell carcinoma...
17h
Cancers, Vol. 12, Pages 889: Immunotherapy in Metastatic Colorectal Cancer: Could the Latest Developments Hold the Key to Improving Patient Survival? Cancers doi: 10.3390/cancers12040889 Authors: Emmanouil Damilakis Dimitrios Mavroudis Maria Sfakianaki John Souglakos Immunotherapy has considerably increased the number of anticancer agents in many tumor types including metastatic colorectal cancer (mCRC). Anti-PD-1 (programmed death 1) and cytotoxic T-lymphocyte–associated...
17h
Cancers, Vol. 12, Pages 887: Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target Cancers doi: 10.3390/cancers12040887 Authors: Theo Battista Annarita Fiorillo Valerio Chiarini Ilaria Genovese Andrea Ilari Gianni Colotti The development of drug resistance is one of the main causes of failure in anti-cancer treatments. Tumor cells adopt many strategies to counteract the action of chemotherapeutic...
18h
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