by Leo Yi Yang Lee, Jie Zhou, Rebecca Frise, Daniel H. Goldhill, Paulina Koszalka, Edin J. Mifsud, Kaoru Baba, Takahiro Noda, Yoshinori Ando, Kenji Sato, Aoe-Ishikawa Yuki, Takao Shishido, Takeki Uehara, Steffen Wildum, Elke Zwanziger, Neil Collinson, Klaus Kuhlbusch, Barry Clinch, Aeron C. Hurt, Wendy S. Barclay Influenza viruses cause seasonal outbreaks and pose a continuous pandemic threat. Although vaccines are available for influenza control, their efficacy varies each season and a vaccine...
13h
by Muhammad Fahim Raza, Yichen Wang, Zhaohui Cai, Shuai Bai, Zhichao Yao, Umar Anwar Awan, Zhenyu Zhang, Weiwei Zheng, Hongyu Zhang Gut symbiotic bacteria have a substantial impact on host physiology and ecology. However, the contribution of gut microbes to host fitness during long-term low-temperature stress is still unclear. This study examined the role of gut microbiota in host low-temperature stress resistance at molecular and biochemical levels in the oriental fruit fly Bactrocera dorsalis....
13h
by Cassandra M. Burke, Daniel J. Walsh, Kenneth M. K. Mark, Nathan R. Deleault, Koren A. Nishina, Umberto Agrimi, Michele A. Di Bari, Surachai Supattapone Prion diseases are caused by the misfolding of a host-encoded glycoprotein, PrPC, into a pathogenic conformer, PrPSc. Infectious prions can exist as different strains, composed of unique conformations of PrPSc that generate strain-specific biological traits, including distinctive patterns of PrPSc accumulation throughout the brain. Prion strains...
13h
by Amélie Dewitte, Typhanie Bouvenot, François Pierre, Isabelle Ricard, Elizabeth Pradel, Nicolas Barois, Anaïs Hujeux, Sébastien Bontemps-Gallo, Florent Sebbane In flea-borne plague, blockage of the flea's foregut by Yersinia pestis hastens transmission to the mammalian host. Based on microscopy observations, we first suggest that flea blockage results from primary infection of the foregut and not from midgut colonization. In this model, flea infection is characterized by the recurrent production...
13h
by Julie Tai-Schmiedel, Sharon Karniely, Betty Lau, Adi Ezra, Erez Eliyahu, Aharon Nachshon, Karen Kerr, Nicolás Suárez, Michal Schwartz, Andrew J. Davison, Noam Stern-Ginossar Viruses are known for their extremely compact genomes composed almost entirely of protein-coding genes. Nonetheless, four long noncoding RNAs (lncRNAs) are encoded by human cytomegalovirus (HCMV). Although these RNAs accumulate to high levels during lytic infection, their functions remain largely unknown. Here, we show...
13h
Abstract The community of symbiotic microorganisms that reside in our gastrointestinal tract is integral to human health. Fecal microbiota transplantation (FMT) has been shown to be highly effective in treating recurrent Clostridioides difficile infection (rCDI) and is now recommended by medical societies for patients suffering from rCDI who have failed to respond to conventional therapy. The main challenges with FMT are its accessibility, acceptability, lack of standardization,...
14h
Abstract Although extensive precautions are taken to limit batch-to-batch variation in pharmaceutical manufacturing, differences between lots may still exist, particularly in complex formulations. When polymerization is used in the production process, the potential for varying chain lengths and incorporation of different monomers increases the likelihood of batch-to-batch variation. This poses a significant challenge for demonstrating active pharmaceutical ingredient (API) sameness...
14h
Abstract The objective of the current study was to develop ziprasidone hydrochloride monohydrate (ZHM) nanocrystal–based orally dispersible tablet (ODT) formulations. Design of experiment approach was used to develop ODTs. The tablets were compressed using direct compression method and characterized with quality control tests. In vitro dissolution studies and Caco-2 cell permeability tests were executed. The hardness and friability values of nanocrystal-based ODTs were found...
14h
Biosensors, Vol. 10, Pages 39: Design and Fabrication of Capillary-Driven Flow Device for Point-Of-Care Diagnostics Biosensors doi: 10.3390/bios10040039 Authors: Sammer-ul Hassan Xunli Zhang Point-of-care (POC) diagnostics enables the diagnosis and monitoring of patients from the clinic or their home. Ideally, POC devices should be compact, portable and operatable without the requirement of expertise or complex fluid mechanical controls. This paper showcases a chip-and-dip device,...
14h
Hydroxychloroquine and chloroquine are medications that have been used for a long time. Their most common use is for the treatment and prophylaxis of malaria. However, these antimalarial drugs are known to also have anti-inflammatory and antiviral effects and are used for several chronic diseases such as systemic lupus erythematosus with low adverse effects. The antiviral action of hydroxychloroquine and chloroquine has been a point of interest to different researchers due to its mechanism of action....
14h
The 2019 bushfire catastrophe in Australia is only the most recent example of the increasing duration and intensity of wildfire events. In the past decade, the USA experienced 67 000 wildfires annually with an average 7 million acres burned. Over 34 000 US wildland firefighters (WLFFs) are engaged in arduous, high-risk duty, yet several features of this occupation limit our ability to understand the associated short-term and long-term health risks. For example, wildfire suppression activities are...
14h
Abstract Objectives The prognostic value of SUV on pretreatment F-18 FDG PET/CT imaging in patients with rectal cancer is a matter of debate. SUR is of prognostic value for survival in different cancers. In this study, we aimed to examine the potential prognostic value of SUR and other parameters in pretreatment F-18 FDG PET/CT for non-metastatic rectal cancer. Methods ...
14h
Abstract Objective 131I-meta-iodo-benzyl-guanidine (131I-MIBG) therapy has been used in children with high-risk neuroblastoma, who, in Japan, are cared for by trained nurses. To determine the safety of occupational radiation exposure in nurses, we retrospectively examined radiation exposure during therapy. Methods Sixty-two nurses who received radiation exposure...
17h
Abstract Purpose Obstructive sleep apnea (OSA) can induce dramatic nocturnal blood pressure fluctuations (NBPFs) and can be associated with nocturnal hypertension and arterial stiffness. We investigated the effect of short- and long-term continuous positive airway pressure (CPAP) therapy on NBPFs, nocturnal blood pressure (BP), and arterial stiffness in patients with coexisting cardiovascular diseases (CVD) and OSA (CVD/OSA). ...
14h
18h
Abstract Purpose In this study, we assessed the diagnostic accuracy of the device VitaLog (SWG Sportwerk GmbH & Co. KG, Dortmund, Germany) for estimation of respiratory rate (RR) variability. Methods VitaLog is a minimal-contact biomotion device that is placed under the mattress topper. It senses respiratory effort and body movement using a piezoelectric...
18h
Coulomb interactions are crucial in determining the ground state of an ideal two-dimensional electron gas (2DEG) in the limit of low electron densities(1). In this regime, Coulomb interactions dominate over single-particle phase-space filling. In silicon and gallium arsenide, electrons are typically localized at these low densities. In contrast, in transition-metal dichalcogenides (TMDs), Coulomb correlations in a 2DEG can be anticipated at experimentally relevant electron densities. Here, we investigate...
14h
A huge effort is underway to develop semiconductor nanostructures as low-noise qubits. A key source of dephasing for an electron spin qubit in GaAs and in naturally occurring Si is the nuclear spin bath. The electron spin is coupled to each nuclear spin by the hyperfine interaction. The same interaction also couples two remote nuclear spins via a common coupling to the delocalized electron. It has been suggested that this interaction limits both electron and nuclear spin coherence, but experimental...
14h
The enzyme 11β-HSD1 plays a crucial role in the tissue-specific regulation of cortisol levels and it has been associated with various diseases. Inhibition of 11β-HSD1 is an attractive intervention strategy and the discovery of novel selective 11β-HSD1 inhibitors is of high relevance. In this study, we identified and evaluated a new series of selective peptide 11β-HSD1 inhibitors with potential for skin care applications. This novel scaffold was designed with the aid of molecular modeling and two...
14h
Previous studies have shown that inhibition of cortisol biosynthesis in skin leads to accelerated wound healing. Here, pyridylmethyl pyridine type 11β-hydroxylase (CYP11B1) inhibitors were optimized for topical application to avoid systemic side effects. The resulting very potent, non-toxic CYP11B1 inhibitor 14 (IC; 50; = 0.8 nM) exhibited good selectivity over 11β-HSD1, CYP17A1 and CYP19A1. The compound showed high stability toward human plasma (t; 1/2; = > 150 min, as a substitute for wound...
14h
We consider a bipartite scenario where two parties hold ensembles of 1/2-spins which can only be measured collectively. We give numerical arguments supporting the conjecture that in this scenario no Bell inequality can be violated for arbitrary numbers of spins if only first order moment observables are available. We then give a recipe to achieve a significant Bell violation with a split many-body system when this restriction is lifted. This highlights the strong requirements needed to detect bipartite...
14h
Density functional theory calculations are computationally extremely expensive for systems containing many atoms due to their intrinsic cubic scaling. This fact has led to the development of so-called linear scaling algorithms during the last few decades. In this way it becomes possible to perform ab initio calculations for several tens of thousands of atoms within reasonable walltimes. However, even though the use of linear scaling algorithms is physically well justified, their implementation often...
14h
Joule energy loss due to resistive heating is omnipresent in today's electronic devices whereas quantum-mechanical dissipation is largely unexplored. Here, we experimentally observe a suppression of the Joule dissipation in Bi2Te3 due to topologically protected surface states. Instead, a different type of dissipation mechanism is observed by pendulum atomic force microscopy, which is related to single-electron tunnelling resonances into image potential states that are slightly above the Bi2Te3 surface....
14h
Background The tool CLEO in French language is designed for estimating the potential relevance of pharmacists' interventions (PIs) in three independent dimensions with regard to process-related, clinical, economic, and humanistic impact. Objective We aimed to translate CLEO into German (CLEO; de; ), to demonstrate its feasibility in daily practice, and to validate the German version. Setting Convenience sample of three Swiss hospitals with established clinical pharmacy services. Method We translated...
15h
The burden of asthma and COPD among patients is high and people affected are frequently hospitalized due to exacerbations. There are numerous reasons for the lack of disease control in asthma and COPD patients. It is associated with non-adherence to guidelines on the part of the health care provider and with poor inhalation technique and/or non-adherence to the prescribed treatment plan by the patient. This study aims to present data on inhaler technique and its impact on quality of life (QoL) and...
15h
Since 2010, Swiss pharmacists have been offering their patients a Polymedication Check (PMC), a new cognitive pharmacy service in the form of a medication review for patients taking ≥4 prescribed medicines for a period >3 months. While a first publication of this project reported on the impact of the PMC on patients' adherence, the present paper focuses on humanistic outcomes.; This randomized controlled trial was conducted in 54 Swiss community pharmacies. After recruitment, the intervention...
15h
Background Medication review is important in an era, in which polypharmacy is increasing. To date, no agreed international definition of medication review exists. Objective The aim was to reach agreement on an internationally applicable definition of medication review. Setting An international group of experts in medication review. Methods A working group of the Pharmaceutical Care Network Europe (PCNE) was established to agree on a definition including a classification of medication review. First,...
15h
The Drug-Associated Risk Tool (DART) has been developed as a self-administered questionnaire for patients with the aim of stratifying patients according to their risk of drug-related problems (DRPs). We aimed to validate the ability of the questionnaire to distinguish between hospitalised patients showing lower and higher numbers of DRPs.; Cross-sectional study assessing the questionnaire's concurrent criterion validity.; Five geriatric and the associated physical and neurological rehabilitation...
15h
The strong-coupling regime of cavity quantum electrodynamics (QED) represents the light-matter interaction at the fully quantum level. Adding a single photon shifts the resonance frequencies-a profound nonlinearity. Cavity QED is a test bed for quantum optics(1-3) and the basis of photon-photon and atom-atom entangling gates(4,5). At microwave frequencies, cavity QED has had a transformative effect(6), enabling qubit readout and qubit couplings in superconducting circuits. At optical frequencies,...
15h
Inappropriate prescribing is linked to increased risks for adverse drug reactions and hospitalisation. Combining explicit and implicit criteria of inappropriate prescribing with the information obtained in patient interviews seems beneficial with regard to the identification of drug-related problems (DRPs) in hospitalised patients.; We aimed to investigate the inclusion of pharmacist interviews as part of medication reviews (including the use of explicit and implicit criteria of inappropriate prescribing)...
15h
Assessment of the impact of type 2 diabetes (T2DM) and metformin use on vitamin B12 (VB12) associated biomarkers and their suitability to represent VB12 supply.; Differences of VB12, holotranscobalamine (HoloTc), the biologically active fraction (%AB12)=HoloTc/VB12*100 and homocystein (Hcy) were analysed i) among diabetic outpatients with (DMMet+ ) and without metformin use (DMMet-) and ii) in comparison to an external non-diabetic reference group with low VB12 (<200 pmol/L).; VB12 associated...
15h
Human neuraminidases (NEU) are associated with human diseases including cancer, atherosclerosis, and diabetes. To obtain small molecule inhibitors as research tools for the study of their biological functions, we designed a library of 2-deoxy-2,3-didehydro- N-acetylneuraminic acid (DANA) analogues with modifications at C4 and C9 positions. This library allowed us to discover selective inhibitors targeting the human NEU3 isoenzyme. Our most selective inhibitor for NEU3 has a K; i; of 320 ± 40 nM and...
15h
Women with HIV infection are mainly of reproductive age and need safe, effective and affordable contraception to avoid unintended pregnancies. The aim of this study was to evaluate contraceptive use and unintended pregnancies in this population in Switzerland.; A self-report anonymous questionnaire on contraceptive methods, adherence to them, and unintended pregnancies was completed by women included in the Swiss HIV Cohort Study (SHCS) between November 2013 and June 2014. Sociodemographic characteristics...
15h
Adverse events (AEs) seriously affect patient safety and quality of care, and remain a pressing global issue. This study had three objectives: (1) to describe the proportions of patients affected by in-hospital AEs; (2) to explore the types and consequences of observed AEs; and (3) to estimate the preventability of in-hospital AEs.; We applied a scoping review method and concluded a comprehensive literature search in PubMed and CINAHL in May 2017 and in February 2018. Our target was retrospective...
15h
Trigger Tool-Based Automated Adverse Event Detection in Electronic Health Records: Systematic Review
Adverse events in health care entail substantial burdens to health care systems, institutions, and patients. Retrospective trigger tools are often manually applied to detect AEs, although automated approaches using electronic health records may offer real-time adverse event detection, allowing timely corrective interventions.; The aim of this systematic review was to describe current study methods and challenges regarding the use of automatic trigger tool-based adverse event detection methods in...
15h
Patient-centered care is a key element of high-quality healthcare and determined by individual, structural and process factors. Patient-centered care is associated with improved patient-reported, clinical and economic outcomes. However, while hospital-level characteristics influence patient-centered care, little evidence is available on the association of patient-centered care with characteristic such as the nurse work environment or implicit rationing of nursing care.; The aim of this study was...
15h
Factors at the level of family/healthcare worker, organization, and system are neglected in medication nonadherence research in heart transplantation (HTx). The 4-continent, 11-country cross-sectional Building Research Initiative Group: Chronic Illness Management and Adherence in Transplantation (BRIGHT) study used multistaged sampling to examine 36 HTx centers, including 36 HTx directors, 100 clinicians, and 1397 patients. Nonadherence to immunosuppressants-defined as any deviation in taking or...
15h
Emotional exhaustion among healthcare workers is a widely investigated, well-recognized problem, the incidence of which has recently been linked to work environment factors, particularly work/family conflict. However, another environmental feature that may be equally influential, but that is more amenable to nurse manager action, remains less recognized: shift schedule flexibility.; This study's main purposes were to assess variations in work schedule flexibility between Swiss acute care hospital...
15h
Bending and twisting around carbonâEuro"carbon single bonds are ubiquitous in natural and synthetic polymers. Force-induced changes were so far not measured at the single-monomer level, owing to limited ways to apply local forces. We quantified down to the submolecular level the mechanical response within individual poly-pyrenylene chains upon their detachment from a gold surface with an atomic force microscope at 5 K. Computer simulations based on a dedicated force field reproduce the experimental...
15h
High-dose melphalan and autologous stem cell transplantation (ASCT) are associated with high symptom burden. This study aimed to explore multiple myeloma (MM) patients' experience of symptom frequency, intensity, and distress during therapy.; This descriptive longitudinal study enrolled 29 MM patients who completed the 43-item PROVIVO questionnaire, measuring symptom experience across the dimensions of frequency, intensity, and distress at four assessment points: hospital admission (T0), leucocyte...
15h
The use of interactive health technology (IHT) is a promising pathway to tackle self-management problems experienced by many chronically ill patients, including solid organ transplant (Tx) patients. Yet, to ensure that the IHT is accepted and used, a human-centered design process is needed, actively involving end users in all steps of the development process. A first critical, predevelopment step involves understanding end users' characteristics. This study therefore aims to (a) select an IHT platform...
15h
We investigate and model a method for producing entanglement between two spatially separated Bose-Einstein condensates (BECs). In our approach, a spin-polarized BEC is squeezed using a (S-z)(2) interaction, then are split into two separate clouds. After the split, we consider that the particle number in each cloud collapses to a fixed number. We show that this procedure is equivalent to applying an interaction corresponding to squeezing each cloud individually plus an entangling operation. We analyze...
15h
We apply the parametrized, spherically symmetric explosion method PUSH to two sets of pre-explosion models suitable for SN 1987A: blue supergiants (BSGs) resulting from the merger of a main sequence star with a giant and red supergiants (RSGs) representing the end point of single-star stellar evolution. For each model, we perform a calibration of the PUSH method to the observational properties of SN. 1987A and calculate the detailed explosive nucleosynthesis yields. We find that such a calibration...
15h
Recent progress in the development of superconducting nanowire single-photon detectors (SNSPDs) has delivered excellent performance and has had a great impact on a range of research fields. The timing jitter, which denotes the temporal resolution of the detection, is a crucial parameter for many applications. Despite extensive work since their apparition, the lowest jitter achievable with SNSPDs is still not clear, and the origin of the intrinsic limits is not fully understood. Understanding its...
15h
The role of the divalent nature of tin is explored in tin monoxide, revealing a novel path for enhancing p-type conductivity. The consequences of oxygen off-stoichiometry indicate that a defect complex formed by a tin vacancy (V-Sn) and an impurity interstitial (D-i) leads to an increased number of free carriers as well as improved acceptor state stability when compared with the isolated V-Sn. In this study, we identify several elements that are able to stabilize such a defect complex configuration....
15h
Continuum models to handle solvent and electrolyte effects in an effective way have a long tradition in quantum-chemistry simulations and are nowadays also being introduced in computational condensed-matter and materials simulations. A key ingredient of continuum models is the choice of the solute cavity, i.e., the definition of the sharp or smooth boundary between the regions of space occupied by the quantum-mechanical (QM) system and the continuum embedding environment. The cavity, which should...
15h
The Minima Hopping global optimization method uses physically realizable molecular dynamics moves in combination with an energy feedback that guarantees the escape from any potential energy funnel. For the purpose of finding reaction pathways, we argue that Minima Hopping is particularly suitable as a guide through the potential energy landscape and as a generator for pairs of minima that can be used as input structures for methods capable of finding transition states between two minima. For Lennard-Jones...
15h
Optimizations of atomic positions belong to the most commonly performed tasks in electronic structure calculations. Many simulations like global minimum searches or characterizations of chemical reactions require performing hundreds or thousands of minimizations or saddle computations. To automatize these tasks, optimization algorithms must not only be efficient but also very reliable. Unfortunately, computational noise in forces and energies is inherent to electronic structure codes. This computational...
15h
Oscillons are spatially localised strong fluctuations of a scalar field. They can e.g. form after inflation when the scalar field potential is shallower than quadratic away from the minimum. Although oscillons are not protected by topology, they can be remarkably stable and have a significant impact on the (p)reheating phase. In this work we investigate the properties of oscillons in hilltop-shaped potentials, in particular the typical energies, shapes and lifetimes. In the first part of the paper,...
15h
A 3-dimensional GPU Poisson solver is developed for all possible combinations of free and periodic boundary conditions (BCs) along the three directions. It is benchmarked for various grid sizes and different BCs and a significant performance gain is observed for problems including one or more free BCs. The GPU Poisson solver is also benchmarked against two different CPU implementations of the same method and a significant amount of acceleration of the computation is observed with the GPU version.
16h
We use ab initio global structural prediction, and specifically the minima hopping method combined with high-throughput calculations, to explore the periodic table in search of novel oxide phases. In total, we study 183 different compositions of the form MXO2, where M = (Cu, Ag, Au) and X is an element of the periodic table. The choice of this specific set is motivated by the fact that it includes Cu delafossite compounds, which are the best-known p-type transparent conductive oxides. Our calculations...
16h
This chapter focuses on ferromagnetic nanotubes (FNTs) and their experimental investigation by techniques capable of measuring the response of individual specimens. This capability has developed recently and is now having a strong impact on our understanding of the behavior of real FNT structures. Despite the wealth of predictions on the equilibrium configurations and reversal modes of FNTs, direct experimental evidence of their magnetic behavior has emerged only recently. This is partly due to the...
16h
We consider a Floquet triple-layer setup composed of a two-dimensional electron gas with spin-orbit interactions, proximity coupled to an s-wave superconductor and to a ferromagnet driven at resonance. The ferromagnetic layer generates a time-oscillating Zeeman field which competes with the induced superconducting gap and leads to a topological phase transition. The resulting Floquet states support a second-order topological superconducting phase with a pair of localized zero-energy Floquet Majorana...
16h
The behavior of shock-compressed methane at high temperatures and pressures is studied using nonequilibrium molecular dynamics and linear-scaling tight-binding electronic structure theory in simulations containing as many as 1728 molecules. For certain piston velocities, a chemical dissociation wave evolves that lags behind the compressive shock front. At about 1 ps, the dissociation region consists mainly of molecular hydrogen and hydrocarbon polymers. Shock wave experiments, which access much longer...
17h
hotoredox catalysis is an old concept that has experienced a remarkable revival in the past decade, leading to important progress in organic synthesis. Many of the current photoredox applications are based on well-known RuII polypyridine and cyclometalated IrIII complexes, but there is now growing interest in the development of new photoredox catalysts. We review recent examples of new coordination compounds, which were synthesized for combined applications in photophysics and photoredox catalysis....
17h
The kinetics of MgO + + CH 4 was studied experimentally using the variable ion source, temperature adjustable selected ion flow tube (VISTA-SIFT) apparatus from 300 − 600 K and computationally by running and analyzing reactive atomistic simula- tions. Rate coefficients and product branching fractions were determined as a function of temperature. The reaction proceeded with a rate of k = 5 . 9 ± 1 . 5 × 10 − 10 ( T/ 300 K) − 0 . 5 ± 0 . 2 cm 3 s − 1 . MgOH + was the dominant product at all temperatures,...
17h
A series of copper(I) complexes of the type [Cu(HN-xantphos)(N^N)][PF6] and [Cu(BnN-xantphos)(N^N)][PF6], in which N^N = bpy, Mebpy and Me2bpy, HN-xantphos = 4,6-bis(diphenylphosphanyl)-10H-phenoxazine and BnN-xantphos = 10-benzyl-4,6-bis(diphenylphosphanyl)-10H-phenoxazine is described. The single crystal structures of [Cu(HN-xantphos)(Mebpy)][PF6] and [Cu(BnN-xantphos)(Me2bpy)][PF6] confirm the presence of N^N and P^P chelating ligands with the copper(I) atoms in distorted coordination environments....
18h
Electroencephalography (EEG), a dynamic real-time recording of electrical neocortical brain activity, began in the 1600s with the discovery of electrical phenomena and the concept of an “action current.” The galvanometer was introduced in the 1800s and the first bioelectrical observations of human brain signals were made in the 1900s. Certain EEG patterns were associated with brain disorders, increasing the clinical and scientific use of EEG. In the 1980s, technical advances allowed EEGs to be digitized...
18h
23h
Natural resource extraction projects offer both opportunities and risks for sustainable development and health in host communities. Often, however, the health of the community suffers. Health impact assessment (HIA) can mitigate the risks and promote the benefits of development but is not routinely done in the developing regions that could benefit the most.; Our study aims to investigate health and health determinants in regions affected by extractive industries in Burkina Faso, Ghana, Mozambique,...
23h
To eliminate soil-transmitted helminth (STH) infections as a public health problem, the administration of benzimidazole (BZ) drugs to children has recently intensified. But, as drug pressure increases, the development of anthelmintic drug resistance (AR) becomes a major concern. Currently, there is no global surveillance system to monitor drug efficacy and the emergence of AR. Consequently, it is unclear what the current efficacy of the used drugs is and whether AR is already present. The aim of...
23h
There is a growing international and regional interest in Health Research Systems (HRSs) in light of a global strategy for HRS stakeholders' (HRSSHs) active involvement. HRSSHs in Palestine have rarely been investigated with regard to uncertainties.; This study aimed to analyse perceptions of HRSSHs in order to understand their roles and involvement, identify gaps, and offer policy solutions for stakeholders' engagement in the Palestinian HRS.; This qualitative study targeted three local Palestinian...
23h
Respiratory syncytial virus (RSV) frequently causes acute lower respiratory infection in children under 5, representing a high burden in Gavi-eligible countries (mostly low-income and lower-middle-income). Since multiple RSV interventions, including vaccines and monoclonal antibody (mAb) candidates, are under development, we aim to evaluate the key drivers of the cost-effectiveness of maternal vaccination and infant mAb for 72 Gavi countries.; A static Multi-Country Model Application for RSV Cost-Effectiveness...
23h
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου