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Objectives: To conduct a cost-utility analysis comparing drug strategies involving octreotide, lanreotide, pasireotide, and pegvisomant for the treatment of patients with acromegaly who have failed surgery, from a Brazilian public payer perspective. Methods: A probabilistic cohort Markov model was developed. One-year cycles were employed. The patients started at 45 years of age and were followed lifelong. Costs, efficacy, and quality of life parameters were retrieved from the literature. A discount...
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Introduction. Kisspeptin (KP) neurons in the rostral periventricular area (RP3V) of female rodents mediate positive estrogen feedback to gonadotropin-releasing hormone neurons and thus, play fundamental role in the mid-cycle luteinizing hormone (LH) surge. The RP3V is sexually dimorphic and male rodents with lower KP cell numbers are unable to mount estrogen-induced LH surges. Objective. To find and characterize the homologous KP neurons in the human brain, we studied formalin-fixed post mortem hypothalami....
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ACS NanoDOI: 10.1021/acsnano.9b08953
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ACS NanoDOI: 10.1021/acsnano.0c00098
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ACS NanoDOI: 10.1021/acsnano.9b07090
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ACS NanoDOI: 10.1021/acsnano.0c00435
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ACS NanoDOI: 10.1021/acsnano.0c00602
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ACS NanoDOI: 10.1021/acsnano.9b09147
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ACS NanoDOI: 10.1021/acsnano.0c01804
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U.K. artificial intelligence (AI) software developer Behold.ai has received...Read more on AuntMinnieEurope.comRelated Reading: Behold.ai joins forces with Wellbeing on AI for COVID-19 Behold.ai trains AI to detect COVID-19 on x-ray Behold.ai wins FDA approval for red dot AI algorithm NHS trust adds AI to radiology reporting AI start-up Behold.AI appoints chief medical officer
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The McCormick Place convention center in Chicago is being converted into an...Read more on AuntMinnieEurope.comRelated Reading: Radiologist joins Italy's tally of 87 doctors to die of COVID-19 Iranian researchers develop COVID-19 AI software N. Ireland suspends routine screening due to COVID-19 6 radiology clinic staff test positive for COVID-19
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The U.K. Royal College of Radiologists (RCR) has published fresh advice on...Read more on AuntMinnieEurope.comRelated Reading: RCR issues advice on nonurgent imaging, trainees RCR sees no role for CT in coronavirus diagnosis RCR announces response to coronavirus threat RCR posts clinical, interventional radiology curricula RCR seeks applicants for oncology research fellowships
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Radiographers and radiological technologists shouldn't be left out of the process...Read more on AuntMinnieEurope.comRelated Reading: Sonographer struck off for incompetence U.K. radiographer gets struck off register for hate crime Success with AI rests on ethics and 'explainability' QA checks have only minor impact on radiographer reporting Radiographers: Don't be the anonymous lead apron
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Making use of radiomics, an artificial intelligence (AI) algorithm can accurately...Read more on AuntMinnieEurope.comRelated Reading: Ultrasound CADx software can stratify thyroid nodules Ultrasound shows thyroid cancer spike after Fukushima Ultrasound-based CAD pinpoints thyroid nodules TI-RADS works best for classifying thyroid nodules on US Shear-wave elastography assists in thyroid cancer
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Swiss researchers have developed FlowVN, a deep‑learning model that can reconstruct...Read more on AuntMinnieEurope.comRelated Reading: Video beers, virtual lunches become vital part of work routine 3D printing can bolster cardiac management Novel contrast-free MRI technique measures heart strain AI can help facilitate gadolinium-free cardiac MRI 4D flow MRI shows smallest hint of LV dysfunction
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Background Liver cancer incidence has increased for several decades in the United States. Recently, reports have suggested that rates of hepatocellular carcinoma (HCC), the dominant form of liver cancer, had declined in certain groups. However, to the authors' knowledge, the most recent histology‐specific liver cancer rates have not been reported to date. Methods The authors examined the incidence of HCC and intrahepatic cholangiocarcinoma (ICC) from 1992 through 2016 using data from...
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Background This study assessed the impact of Affordable Care Act (ACA) Medicaid expansion on health insurance rates and receipt of cardiovascular‐related preventive screenings (body mass index, glycated hemoglobin [HbA1c], low‐density lipoproteins, and blood pressure) for cancer survivors seen in community health centers (CHCs). Methods This study identified cancer survivors aged 19 to 64 years with at least 3 CHC visits in 13 states from the Accelerating Data Value Across a National...
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Background The effectiveness of local surgery for bone metastases (BM) arising from renal cell carcinoma (RCC) remains uncertain. Herein, the authors performed what to the best of their knowledge is the first investigation of the outcomes of Chinese patients with RCC and BM. Methods Data were collected for 168 patients with RCC and BM who were treated at Changzheng Hospital in Shanghai, China, between March 2009 and December 2018. All patients underwent local surgery for BM arising from...
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Background The surgical treatment of patients with renal cell carcinoma (RCC) with venous tumor thrombus (VTT) is challenging. In the current study, the authors have reported their surgical outcomes and experience with en bloc retroperitoneal laparoscopic radical nephrectomy (LRN) with inferior vena cava (IVC) thrombectomy for patients with RCC with level 0 to II VTT. Methods A retrospective review of the clinical records of 78 patients who underwent retroperitoneal LRN with IVC thrombectomy...
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China still lacks statistical data regarding the incidence of gastrointestinal stromal tumors (GISTs). Data from 3 regions have demonstrated that the incidence of GISTs in China is similar to that in the United States. Furthermore, no significant differences between both nations with regard to epidemiological characteristics and genotyping of GISTs have been reported. Chinese physicians are demonstrating an increased interest in studies regarding GISTs. Currently, to the authors' knowledge, China...
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Background Platinum‐based chemotherapy is recommended for the treatment of advanced gastroenteropancreatic neuroendocrine carcinoma (GEP‐NEC). The objective of the current phase 2 study was to compare the efficacy and toxicity between etoposide and cisplatin (EP) and irinotecan and cisplatin (IP) as first‐line treatment in patients with advanced GEP‐NEC. Methods Patients with advanced, poorly differentiated GEP‐NEC randomly were assigned to receive EP or IP. The primary endpoint was the...
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Background A quantitative nephrometry scoring system specifically for renal sinus tumors will assist in classifying surgical complexity and treatment planning. Methods By using preoperative computed tomography, magnetic resonance imaging, and 3‐dimensional image reconstruction, 5 critical components were assessed: the ratio of the sinus area occupied by the tumor in relation to the whole sinus area (R), the compression of the renal segmental vessels or collection system by the tumor (O),...
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Background New immunotherapeutic approaches are urgently needed for metastatic rhabdomyosarcoma, which is associated with poor survival and unsatisfactory treatment outcomes. Platelet‐derived growth factor receptor α (PDGFRA) plays an essential role in the onset and development of rhabdomyosarcoma and is a new potential therapeutic target for rhabdomyosarcoma. The objective of this study was to generate humanized PDGFRA single‐chain variable fragment‐based chimeric antigen receptor (CAR)‐modified...
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Background Imatinib is the standard treatment for patients with gastrointestinal stromal tumors (GISTs), but there is significant variation in imatinib plasma trough concentrations (Cmin) among patients. The imatinib Cmin distribution at different doses and the correlation of adverse reactions with Cmin in Chinese patients with GIST from a high‐volume center were evaluated. Methods From July 1, 2017 to December 31, 2018, patients who were receiving imatinib treatment for GIST were prospectively...
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Background Cancer and its treatment represent major stressors requiring that patients make multiple adaptations. Despite evidence that poor adaptation to stressors is associated with more distress and negative affect (NA), neuroimmune dysregulation and poorer health outcomes, current understanding is very limited of how NA covaries with central nervous system changes to account for these associations. Methods NA was correlated with brain metabolic activity using 18F‐fluorodeoxyglucose...
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Background Patients with chronic conditions are treated by many providers, which can increase the risk of communication gaps across providers and potential harm to patients. However, to the authors' knowledge, the extent of fragmented care among this population is unknown. In the current study, the authors sought to determine whether cancer survivors have more fragmented care than noncancer controls and to quantify the extent of fragmentation. Methods Data from the REasons for Geographic...
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Background The phase 3 KATHERINE trial demonstrated significantly improved invasive disease–free survival with adjuvant trastuzumab emtansine (T‐DM1) versus trastuzumab in patients with HER2‐positive early breast cancer and residual invasive disease after neoadjuvant chemotherapy plus HER2‐targeted therapy. Methods Patients who received taxane‐ and trastuzumab‐containing neoadjuvant therapy (with/without anthracyclines) and had residual invasive disease (breast and/or axillary nodes)...
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Background The unmonitored use of complementary medicine in patients with cancer can be associated with an increased risk of safety‐related issues, such as lower adherence to conventional cancer therapies. Training oncology physicians to advise their patients about the effectiveness and safety of these therapies could improve this situation. Methods The objective of this study was to develop and pretest a consultation framework that has high potential to be widely implemented. The framework...
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Background Glioma is the most common malignant brain cancer. Accessibility to health care is an important factor affecting cancer outcomes in the US general population. The US Military Health System (MHS) provides universal health care to its beneficiaries. It is unknown whether this universal health care has translated into improved survival outcomes among MHS beneficiaries with glioma. This study compared the overall survival of patients with glioma in the MHS with the overall survival of patients...
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Front Cover: The cover image is based on the Research Article FANCL gene mutations in premature ovarian insufficiency by Yajuan Yang et al., https://doi.org/10.1002/humu.23997.
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