Abstract Compared to adult EEG, EEG signals recorded from pediatric populations have shorter recording periods and contain more artifact contamination. Therefore, pediatric EEG data necessitate specific preprocessing approaches in order to remove environmental noise and physiological artifacts without losing large amounts of data. However, there is presently a scarcity of standard automated preprocessing pipelines suitable for pediatric EEG. In an effort to achieve greater standardization of EEG...
7h
Abstract There is limited knowledge about the impact of task load on experts’ integration of contextual priors and visual information during dynamic and rapidly evolving anticipation tasks. We examined how experts integrate contextual priors––specifically, prior information regarding an opponent's action tendencies––with visual information such as movement kinematics, during a soccer‐specific anticipation task. Furthermore, we combined psychophysiological measures and retrospective self‐reports...
7h
Abstract Research shows that the visual system monitors the environment for changes. For example, a left‐tilted bar, a deviant, that appears after several presentations of a right‐tilted bar, standards, elicits a classic visual mismatch negativity (vMMN): greater negativity for deviants than standards in event‐related potentials (ERPs) between 100 and 300 ms after onset of the deviant. The classic vMMN is contributed to by adaptation; it can be distinguished from the genuine vMMN that, through...
7h
Abstract Purpose Fine-needle aspiration (FNA) is widely used for the diagnosis of thyroid nodules detected by ultrasonography. However, the cytology of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) often leads to unnecessary thyroid surgery. This study aimed to identify a strategy to reduce unnecessary surgeries in patients with AUS/FLUS nodules. ...
7h
Abstract Purpose Investigate the pathways of glycerol-3-P (G3P) generation for triacylglycerol (TAG) synthesis in retroperitoneal (RWAT) and epididymal (EWAT) white adipose tissues from high-fat diet (HFD)-fed mice. Methods Mice were fed for 8 weeks a HFD and glycolysis, glyceroneogenesis and direct phosphorylation of glycerol were evaluated, respectively,...
11h
Abstract Background If mild parkinsonian signs can be a marker for Parkinson's disease (PD) development, an impaired Timed Up and Go test (TUG) should also be a marker for prodromal PD. Objectives To investigate whether the Timed Up and Go test is associated with PD. Methods We included 1,196,614 participants at 66 years of age who underwent the National Screening Program for Transitional Ages for Koreans between 2009 and 2014. Timed Up and Go test times were classified...
7h
Abstract The recent global severe acute respiratory distress syndrome coronavirus 2 pandemic is changing the world we live in. As we learn about the virus and the pandemic, it is becoming evident that it is an age‐associated problem that affects the human population. Severe acute respiratory distress syndrome coronavirus 2 is one of seven coronaviruses known to infect humans. These are large enveloped non‐segmented positive‐sense RNA viruses. Our knowledge of severe acute respiratory distress syndrome...
7h
Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy
Abstract Background Multiple system atrophy (MSA) is a rare, untreatable neurodegenerative disorder characterized by accumulation of α‐synuclein in oligodendroglial inclusions. As such, MSA is a synucleinopathy along with Parkinson's disease (PD) and dementia with Lewy bodies. Activation of the abelson tyrosine kinase c‐Abl leads to phosphorylation of α‐synuclein at tyrosine 39, thereby promoting its aggregation and subsequent neurodegeneration. The c‐Abl inhibitor nilotinib used for the treatment...
22h
Abstract Having been given the opportunity to write this article about Jean Bousquet is certainly an honour and an absolute pleasure. Jean ‐ born in 1946 ‐hassurely everything that is neededto become a Legend.This term is usually reserved for a famous person of ancient times,however,Jeanis certainly not ancient,given that he isso extremely alert and up to date.
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ABSTRACT Thunderstorm asthma risk in geographic regions with temperate grasses is strongly correlated with the trifecta of ryegrass pollen (RGP) sensitization (serum RGP‐specific IgE), seasonal allergic rhinitis (SAR) and exposure to a thunderstorm during the pollen season.[1,2] Perennial ryegrass (Lolium perenne) is a wind‐pollinated pasture grass prevalent in southeastern Australia, North America and Southern Europe.
7h
Ubqln2 is abnormally expressed in HCC but its role remains unknown. Here, we reported that Ubqln2, an independent risk factor for HCC, is a potential prognostic marker in HCC patients. Ubqln2 expression is positively associated with mutated CTNNB1. Abstract Purpose Hepatocellular carcinoma (HCC) is a common malignant cancer and the third leading cause of death worldwide. The molecular mechanism of HCC remains unclear. Recent studies have demonstrated that the ubiquitin‐proteasome system (UPS)...
8h
We analyzed next-generation sequencing data from 11,134 non-small cell lung cancers (NSCLCs), including 100 pulmonary sarcomatoid carcinomas (PSCs). Mutations in Protection of telomeres 1 (POT1) were 6.7-times more common in PSC (28%) than other NSCLC (P=5.1x10-17), often co-occurred with KRAS mutations, and were less likely to co-occur with TP53 mutations. POT1 mutations may present opportunities for molecularly-stratified prognostication and therapy.
8h
Although most of ROS1-rearranged NSCLCs respond to treatment with crizotinib, acquired resistance occurs in virtually all patients. Mechanisms of resistance to crizotinib are heterogenous and therapeutic options upon disease progression are limited. In this study we demonstrated that sequential crizotinib followed by lorlatinib is associated with improved survival outcomes in patients with ROS1-rearranged advanced NSCLC, with a combined median progression-free survival to sequential crizotinib-lorlatinib...
8h
The standard method of detection of epidermal growth factor receptor (EGFR) mutations is the amplification of the refractory mutation system (ARMS) in tissue, blood, and cerebrospinal fluid (CSF) samples. Circulating tumor cells (CTCs) harvested from the CSF, using CellSearch® technology, are used for ARMS analysis. This may further enhance the sensitivity and effectiveness of the diagnosis of meningeal metastases and may be a preferred detection method protocol for liquid biopsy of non-small cell...
8h
Cover of this issue. Multiplex fluorescent immunohistochemistry of esophageal cancer biopsies. CD86 (red), CD163 (green), CD206 (magenta) and DAPI (blue) are shown. See also Yamamoto et al. (pp. https://doi.org/10.1111/cas.143281103–1112 of this issue).
8h
Abstract KRAS mutation is frequently seen in a subtype of ovarian cancer categorized as type 1. The KRAS‐MAPK pathway, which is closely involved in type 1 cancer progression, is under the regulation of receptor tyrosine kinases (RTKs). AXL, one of the RTKs, has been reported to be overexpressed in ovarian cancer and contributes to the poor prognosis. However, there is no useful target‐based agent against such gene profiles. We examined the combined effect of the dual RAF/MEK inhibitor CH5126766...
23h
Abstract Background We sought to describe changes in demographic variables, process of care measures, and outcomes of patients treated in a regional ST‐segment elevation myocardial infarction (STEMI) program over the last 15 years. Methods We describe demographic variables, process of care measures, and outcomes of patients treated in the program in various 5‐year time periods: 2003–2007 (n = 1,821), 2008–2012 (n = 1,968), and 2013–2018 (n = 2,223). The primary outcome measures were...
8h
Abstract Background Polymer‐based bioresorbable scaffolds (PBBS) have been assessed for coronary revascularization with mixed outcomes. Few studies have targeted pediatric‐specific scaffolds. We sought to assess safety, efficacy, and short‐term performance of a dedicated drug‐free PBBS pediatric scaffold compared to a standard low‐profile bare metal stent (BMS) in central and peripheral arteries of weaned piglets. Methods Forty‐two devices (22 Elixir poly‐L‐lactic‐acid‐based pediatric...
8h
Abstract Objectives To study the safety of stent avoidance, frequency of change in management decisions, and its cost implications while using a fractional flow reserve (FFR)‐guided treatment strategy for intermediate‐grade coronary artery stenosis. Background The impact of FFR in guiding management decisions and its cost implications has not been studied after imposition of a ceiling on stent prices by the Government of India. Methods In 400 patients with 477 intermediate‐grade...
8h
Abstract Objectives To describe the development of a quality collaborative for congenital cardiac catheterization centers in low and middle‐income countries (LMICs) including pilot study data and a novel procedural efficacy measure. Background Absence of congenital cardiac catheterization registries in LMICs led to the development of the International Quality Improvement Collaborative Congenital Heart Disease Catheterization Registry (IQIC‐CHDCR). As a foundation for this initiative,...
8h
Abstract Objective To evaluate predictors of procedural success of percutaneous coronary intervention (PCI) of chronic total coronary occlusions (CTOs) in a non‐infarct‐related artery following ST‐segment elevation myocardial infarction (STEMI), and demonstrate the effect on left ventricular functionality (LVF), infarct size (IS), and pro‐arrhythmic electrocardiogram (ECG) parameters. Background Predictors of unsuccessful revascularization of a CTO are numerous, although following...
8h
Abstract Objectives We aimed to investigate the prognostic utility of the anatomical CABG SYNTAX and logistic clinical SYNTAX scores for mortality after percutaneous coronary intervention (PCI) in patients with prior coronary artery bypass grafts (CABG). Background The anatomical SYNTAX score evaluated the anatomical complexity of coronary artery disease and helped predict the prognosis of patients undergoing PCI. The anatomical CABG SYNTAX score was derived from the anatomical SYNTAX...
8h
Key Points Stroke occurs infrequently following percutaneous coronary intervention (PCI) with 30‐day and 1‐year cumulative incidence of 0.4 and 1.5%, respectively. Patient comorbidities, acute presentations, and complex coronary lesions are more prevalent among patients who sustain a stroke. The occurrence of stroke is associated with higher short‐term and overall mortality compared with bleeding or myocardial infarction.
8h
Key Points Ventricular pacing is mandatory in many structural interventions, with associated risks like tamponade and capture loss. The Tempo pacing wire was designed to deal with these issues incorporating an elastomeric balloon on the tip and an active fixation system. In this initial multicenter experience, Tempo pacing wire demonstrated an outstanding performance in both safety and efficacy aspects of ventricular pacing during and after structural interventions.
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Key Points Limited information is available about the performance of bioabsorbable‐polymer drug‐eluting stents in the setting of acute myocardial infarction. Patients treated with these stents presenting with acute myocardial infarction are at higher risk of adverse events compared with stable patients. Further clinical trials are needed to fully understand the role of bioabsorbable‐polymer drug‐eluting stents in patients presenting with acute myocardial infarction.
8h
Key Points Valve‐in‐valve (VIV) transcatheter aortic valve replacement (TAVR) does not increase cerebrovascular risk compared with TAVR in native aortic valves; the only predictors of new brain lesions were age and postdilatation. Wise choice of the biological valve at the time of surgical aortic replacement, routine use of cerebral protection devices, and new therapeutic paths may be important. Larger studies are needed, hopefully with systematic postdilatation or bioprosthetic valve fracture...
8h
Key Points Of adults, 12% have PAD, with nearly 30% older than 70 years with the disorder. With obesity, diabetes mellitus, tobacco abuse, hypercholesterolemia, and poorly controlled hypertension, the incidence of PAD continues to increase. Endovascular treatment of femoropopliteal disease has an alarmingly high rate of restenosis, even with new technology with target lesion revascularization rates at 40–60% at 1 year. Intravascular lithotripsy appears to be safe and acutely effective,...
8h
Key Points A simple, widely applicable and reproducible risk predictor may improve patient care, risk stratification, and clinical decision making for symptomatic severe aortic stenosis (sAS) patients undergoing transcatheter aortic valve implantation (TAVI). Baseline severe left ventricular diastolic dysfunction identified by E/A ratio in sAS patients undergoing TAVI is associated with increased post‐procedural all‐cause mortality or heart failure hospitalization but is not an independent...
8h
Key Points Most (87.6%) of residual atrial L‐R shunts after Gore Cardioform septal occluder implant disappear by 12 months. Residual leaks at implantation were more common in larger defects with smaller retro‐aortic rims, and multiple fenestrations. While most residual defects close in 12 months, we unfortunately do not yet have a clear idea why or which of the 13% do not close.
8h
Key Points Telesupport means guidance of a procedure performed at one location by another clinician at a different location. In a pilot study, 21 percutaneous coronary interventions and nine catheter ablations were successfully performed without complications with telesupport from a remote university hospital. Telesupport is a powerful tool that can be especially useful when urgent care is needed or when transfer is not an option, but it also has limitations, such as network failure or difficulties...
8h
Key Points Contrast‐induced nephropathy (CIN) is a major cause of morbidity and mortality among patients undergoing angiographic procedures. Limiting contrast dose and administration of intravenous normal saline appear to be the best approaches to reducing CIN, but the timing, dose, and duration of optimal hydration is poorly understood. The REMEDIAL III trial protocol outlines two different targeted hydration regimens (guided either by continuous measurement of urine output or by initial...
8h
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