Gene drive-based strategies for modifying populations face the problem that genes encoding cargo and the drive mechanism are subject to separation, mutational inactivation, and loss of efficacy. Resilience, an ability to respond to these eventualities in ways that restore population modification with functional genes, is needed for long-term success. Here,...
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Signaling pathways that sense amino acid abundance are integral to tissue homeostasis and cellular defense. Our laboratory has previously shown that halofuginone (HF) inhibits the prolyl-tRNA synthetase catalytic activity of glutamyl-prolyl-tRNA synthetase (EPRS), thereby activating the amino acid response (AAR). We now show that HF treatment selectively inhibits inflammatory responses...
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Lysosomal storage diseases (LSDs) are typically caused by a deficiency in a soluble acid hydrolase and are characterized by the accumulation of undegraded substrates in the lysosome. Determining the role of specific cell types in the pathogenesis of LSDs is a major challenge due to the secretion and subsequent uptake...
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Pancreatic islets regulate glucose homeostasis through coordinated actions of hormone-secreting cells. What underlies the function of the islet as a unit is the close approximation and communication among heterogeneous cell populations, but the structural mediators of islet cellular cross talk remain incompletely characterized. We generated mice specifically lacking β-cell primary...
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Invariant natural killer T (iNKT) cells serve as early rapid responders in the innate immune response to self-derived autoantigens and pathogen-derived danger signals and antigens. iNKT cells can serve both as helpers for effector B cells and negatively regulate autoreactive B cells. Specifically, iNKT cells drive B cell proliferation, class...
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Adaptation to environmental changes is crucial for cell fitness. In Saccharomyces cerevisiae, variations in external osmolarity trigger the activation of the stress-activated protein kinase Hog1 (high-osmolarity glycerol 1), which regulates gene expression, metabolism, and cell-cycle progression. The activation of this kinase leads to the regulation of G1, S, and G2...
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Malaria caused by the apicomplexan parasite Plasmodium falciparum has served as a strong evolutionary force throughout human history, selecting for red blood cell polymorphisms that confer innate protection against severe disease. Recently, gain-of-function mutations in the mechanosensitive ion channel PIEZO1 were shown to ameliorate Plasmodium parasite growth, blood–brain barrier dysfunction,...
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Graphene-based films with high toughness have many promising applications, especially for flexible energy storage and portable electrical devices. Achieving such high-toughness films, however, remains a challenge. The conventional mechanisms for improving toughness are crack arrest or plastic deformation. Herein we demonstrate black phosphorus (BP) functionalized graphene films with record toughness...
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Stem cell transplantation can improve behavioral recovery after stroke in animal models but whether stem cell–derived neurons become functionally integrated into stroke-injured brain circuitry is poorly understood. Here we show that intracortically grafted human induced pluripotent stem (iPS) cell–derived cortical neurons send widespread axonal projections to both hemispheres of rats...
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We report here the pressure-induced amorphization and reversible structural transformation between two amorphous forms of SO2: molecular amorphous and polymeric amorphous, with the transition found at 26 GPa over a broad temperature regime, 77 K to 300 K. The transformation was observed by both Raman spectroscopy and X-ray diffraction in...
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A skyrmion state in a noncentrosymmetric helimagnet displays topologically protected spin textures with profound technological implications for high-density information storage, ultrafast spintronics, and effective microwave devices. Usually, its equilibrium state in a bulk helimagnet occurs only over a very restricted magnetic field–temperature phase space and often in the low-temperature region...
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Earth’s core is likely the largest reservoir of carbon (C) in the planet, but its C abundance has been poorly constrained because measurements of carbon’s preference for core versus mantle materials at the pressures and temperatures of core formation are lacking. Using metal–silicate partitioning experiments in a laser-heated diamond anvil...
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In eukaryotic photosynthetic organisms, the conversion of solar into chemical energy occurs in thylakoid membranes in the chloroplast. How thylakoid membranes are formed and maintained is poorly understood. However, previous observations of vesicles adjacent to the stromal side of the inner envelope membrane of the chloroplast suggest a possible role...
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Soil mixing over long (>102 y) timescales enhances nutrient fluxes that support soil ecology, contributes to dispersion of sediment and contaminated material, and modulates fluxes of carbon through Earth’s largest terrestrial carbon reservoir. Despite its foundational importance, we lack robust understanding of the rates and patterns of soil mixing, largely...
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In the wake of community coronavirus disease 2019 (COVID-19) transmission in the United States, there is a growing public health concern regarding the adequacy of resources to treat infected cases. Hospital beds, intensive care units (ICUs), and ventilators are vital for the treatment of patients with severe illness. To project...
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Responses of extreme precipitation to global warming are of great importance to society and ecosystems. Although observations and climate projections indicate a general intensification of extreme precipitation with warming on global scale, there are significant variations on the regional scale, mainly due to changes in the vertical motion associated with...
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Do large datasets provide value to psychologists? Without a systematic methodology for working with such datasets, there is a valid concern that analyses will produce noise artifacts rather than true effects. In this paper, we offer a way to enable researchers to systematically build models and identify novel phenomena in...
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Carbon pricing is often presented as the primary policy approach to address climate change. We challenge this position and offer “sustainability transition policy” (STP) as an alternative. Carbon pricing has weaknesses with regard to five central dimensions: 1) problem framing and solution orientation, 2) policy priorities, 3) innovation approach, 4)...
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PSYCHOLOGICAL AND COGNITIVE SCIENCES Correction for “Officer characteristics and racial disparities in fatal officer-involved shootings,” by David J. Johnson, Trevor Tress, Nicole Burkel, Carley Taylor, and Joseph Cesario, which was first published July 22, 2019; 10.1073/pnas.1903856116 (Proc. Natl. Acad. Sci. U.S.A. 116, 15877–15882). The authors wish to note the following:...
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Image-guided therapy developer Brainlab has received the CE Mark for its ExacTrac...Read more on AuntMinnieEurope.comRelated Reading: Brainlab teams up with Magic Leap Brainlab, Varian team up on product integrations Brainlab ships planning software package Brainlab appoints new COO Brainlab supports radiation oncology forum in Munich
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Dutch artificial intelligence (AI) software developer Thirona has introduced...Read more on AuntMinnieEurope.comRelated Reading: Can AI help detect tuberculosis on chest x-rays? Video from ECR 2018: Wiro Niessen on how AI can help you German start-up wins grant for deep-learning project Technique boosts x-ray CAD results for TB
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Simon Guest, a U.K. radiographer who worked at Furness General Hospital in...Read more on AuntMinnieEurope.comRelated Reading: Confusion reigns over payment of COVID-19 work in France How is global radiology bearing up in COVID-19 pandemic? Hard truths from COVID-19 front line in Paris Radiologist joins Italy's tally of 87 doctors to die of COVID-19 Italian ultrasound pioneer dies of COVID-19
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Workforce shortages in clinical radiology are increasing year-on-year, resulting...Read more on AuntMinnieEurope.comRelated Reading: RCR issues advice on nonurgent imaging, trainees Interventional radiology: How many to make a team? Video from UKIO 2019: Erika Denton on turnaround times New report finds serious shortage of oncologists in U.K. Severe shortage of cardiac CT scanners blights U.K.
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Cancers, Vol. 12, Pages 1021: STAT5 is Expressed in CD34+/CD38− Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms Cancers doi: 10.3390/cancers12041021 Authors: Emir Hadzijusufovic Alexandra Keller Daniela Berger Georg Greiner Bettina Wingelhofer Nadine Witzeneder Daniel Ivanov Emmanuel Pecnard Harini Nivarthi Florian K. M. Schur Yüksel Filik Christoph Kornauth Heidi A. Neubauer Leonhard Müllauer...
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Cancers, Vol. 12, Pages 1023: Knockdown of UTX/KDM6A Enriches Precursor Cell Populations in Urothelial Cell Cultures and Cell Lines Cancers doi: 10.3390/cancers12041023 Authors: Alexander Lang Patcharawalai Whongsiri Merve Yilmaz Tobias Lautwein Patrick Petzsch Annemarie Greife Cagatay Günes Karl Köhrer Günter Niegisch Michèle Hoffmann Wolfgang A. Schulz The histone demethylase UTX (gene: KDM6A) directs cell and tissue differentiation during...
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Cancers, Vol. 12, Pages 1024: Current Strategies and Future Perspectives for Precision Medicine in Pancreatic Cancer Cancers doi: 10.3390/cancers12041024 Authors: Ivonne Regel Julia Mayerle Ujjwal Mukund Mahajan Current standard-of-care for patients with pancreatic ductal adenocarcinoma (PDAC) focusses on chemotherapeutic regimens and pancreatic cancer surgery. However, limited treatment options, late diagnosis in advanced tumor stages and the aggressive behavior of PDAC...
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Cancers, Vol. 12, Pages 1022: The Role of Anti-Angiogenics in Pre-Treated Metastatic BRAF-Mutant Colorectal Cancer: A Pooled Analysis Cancers doi: 10.3390/cancers12041022 Authors: Fabio Gelsomino Andrea Casadei-Gardini Daniele Rossini Alessandra Boccaccino Gianluca Masi Chiara Cremolini Andrea Spallanzani Massimo Giuseppe Viola Ingrid Garajovà Massimiliano Salati Maria Teresa Elia Francesco Caputo Chiara Santini Alfredo Falcone Stefano...
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Cancers, Vol. 12, Pages 1019: Canonical BMP Signaling Executes Epithelial-Mesenchymal Transition Downstream of SNAIL1 Cancers doi: 10.3390/cancers12041019 Authors: Patrick Frey Antoine Devisme Monika Schrempp Geoffroy Andrieux Melanie Boerries Andreas Hecht Epithelial-mesenchymal transition (EMT) is a pivotal process in development and disease. In carcinogenesis, various signaling pathways are known to trigger EMT by inducing the expression of EMT transcription...
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Cancers, Vol. 12, Pages 1018: Moesin (MSN) as a Novel Proteome-Based Diagnostic Marker for Early Detection of Invasive Bladder Urothelial Carcinoma in Liquid-Based Cytology Cancers doi: 10.3390/cancers12041018 Authors: Jeong Hwan Park Cheol Lee Dohyun Han Jae Seok Lee Kyung Min Lee Min Ji Song Kwangsoo Kim Heonyi Lee Kyung Chul Moon Youngsoo Kim Minsun Jung Ji Hye Moon Hyebin Lee Han Suk Ryu Bladder urothelial carcinoma (BUC) is...
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Cancers, Vol. 12, Pages 1020: The Challenges and Opportunities of LncRNAs in Ovarian Cancer Research and Clinical Use Cancers doi: 10.3390/cancers12041020 Authors: Salamini-Montemurri Lamas-Maceiras Barreiro-Alonso Vizoso-Vázquez Rodríguez-Belmonte Quindós-Varela Cerdán Ovarian cancer is one of the most lethal gynecological malignancies worldwide because it tends to be detected late, when the disease has already spread, and prognosis is poor. In this...
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Cancers, Vol. 12, Pages 1017: Preclinical Targeted α- and β−-Radionuclide Therapy in HER2-Positive Brain Metastasis Using Camelid Single-Domain Antibodies Cancers doi: 10.3390/cancers12041017 Authors: Janik Puttemans Yana Dekempeneer Jos L. Eersels Heleen Hanssens Pieterjan Debie Marleen Keyaerts Albert D. Windhorst Frank van der Aa Quentin Lecocq Karine Breckpot Alfred Morgenstern Frank Bruchertseifer Tony Lahoutte Nick Devoogdt Matthias...
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Cancers, Vol. 12, Pages 1016: Epigenetic Research in Stem Cell Bioengineering—Anti-Cancer Therapy, Regenerative and Reconstructive Medicine in Human Clinical Trials Cancers doi: 10.3390/cancers12041016 Authors: Claudia Dompe Krzysztof Janowicz Greg Hutchings Lisa Moncrieff Maurycy Jankowski Mariusz J. Nawrocki Małgorzata Józkowiak Paul Mozdziak Jim Petitte Jamil A. Shibli Marta Dyszkiewicz-Konwińska Małgorzata Bruska Hanna Piotrowska-Kempisty...
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Cancers, Vol. 12, Pages 1015: A Combination of Radiotherapy, Hyperthermia, and Immunotherapy Inhibits Pancreatic Tumor Growth and Prolongs the Survival of Mice Cancers doi: 10.3390/cancers12041015 Authors: Javed Mahmood Allen A. Alexander Santanu Samanta Shriya Kamlapurkar Prerna Singh Ali Saeed France Carrier Xuefang Cao Hem D Shukla Zeljko Vujaskovic Background: Pancreatic cancer (PC) is the fourth-most-deadly cancer in the United States with...
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Abstract Purpose To report early toxicity and 5‑year clinical outcomes of adjuvant breast inversely planned intensity-modulated radiotherapy with simultaneously integrated boost (IMRT-SIB) after breast-conserving surgery for early stage breast cancer patients. Patients and methods In all, 467 patients including 406 invasive breast cancer and 61 ductal carcinoma...
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Publication date: Available online 21 April 2020Source: BrachytherapyAuthor(s): Vonetta M. Williams, Jenna M. Kahn, Matthew M. Harkenrider, Junzo Chino, Jonathan Chen, L. Christine Fang, Emily F. Dunn, Emma Fields, Jyoti S. Mayadev, Ramesh Rengan, Daniel Petereit, Brandon A. Dyer
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Publication date: Available online 21 April 2020Source: BrachytherapyAuthor(s): Brandon A. Dyer, Zilong Yuan, Jianfeng Qiu, Liting Shi, Cari Wright, Stanley H. Benedict, Richard Valicenti, Jyoti S. Mayadev, Yi Rong
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Publication date: Available online 20 April 2020Source: BrachytherapyAuthor(s): Christopher J. Tien, Daniel W. Pinkham, Zhe (Jay) Chen
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