Treating thyroid nodules by radiofrequency: is the delivered energy correlated with the volume reduction rate? A pilot study

Treating thyroid nodules by radiofrequency: is the delivered energy correlated with the volume reduction rate? A pilot study:

Abstract

Objective

Radiofrequency ablation (RFA) was proven as effective in reducing thyroid nodules’ volume. However, whether technical procedure aspects could influence the volume reduction rate (VRR) has not been clarified. This retrospective pilot study aimed to analyze the correlation of RFA power, duration, and energy with VRR.

Methods

During the period from June to December 2018 two primary-care centers treated benign thyroid nodules of adult outpatients according to the same RFA procedure. Technical parameters to be investigated were the following: median power (P_median), effective time of treatment (T_eff), energy calculated as P_median × T_eff (E_calc), and energy delivered per mL as Kcal × 4184 × nodule’s volume (E_del). Continuous variables were analyzed by the Mann–Whitney test. Data of 1-year posttreatment follow-up were collected on December 2019 and the correlation of the above parameters with VRR was analyzed by linear regression.

Results

Forty-one nodules were included and their 1-year VRR was 66.6%. RFA was performed with a P_median of 55 W, T_eff 10.24 min, E_calc 31,380 J, and E_del 1473 J/mL. E_del was significantly correlated with VRR (p = 0.014) while P_median, T_eff, and E_calc not. A strong correlation of E_del with VRR was found in nodules <10 mL (p = 0.001) while no significant correlation was observed in nodules >10 mL.

Conclusions

This study showed that the energy delivered with RFA is the only technical parameter significantly correlated with the VRR of thyroid nodules.