Abstract The use of new psychoactive substances (NPSs) as a substitute for illegal drugs is increasing rapidly and is a serious threat to public health. 25C-NBF is a newly synthesized phenethylamine-type NPS that acts as a 5-hydroxyindoleacetic acid (5-HT) receptor agonist, but little is known about its pharmacological effects. Considering that NPSs have caused unexpected harmful effects leading to emergency and even death, scientific confirmation of the potential adverse effects...
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Abstract Purpose Isocitrate dehydrogenase (IDH) mutations lead to formation of the oncometabolite 2-hydroxyglutarate (2-HG), which is elevated in several solid and liquid tumors. Ivosidenib (AG-120) is a targeted, potent, oral inhibitor of the mutant IDH1 protein. We describe detailed pharmacokinetics and pharmacodynamics of ivosidenib in patients with advanced hematologic malignancies with an IDH1 mutation treated in a phase I study (ClinicalTrials.gov...
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Publication date: Available online 15 April 2020Source: GeneAuthor(s): Peng Ren, Feilong Deng, Ye Wang, Jinshan Ran, Jingjing Li, Lingqian Yin, Xianqing Liu, Shiyi Chen, Chaowu Yang, Xiaosong Jiang, Yiping Liu
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Abstract Background The effectiveness of exercise in managing cardiovascular (CV) health and function is well established. Less clear is the process for optimising the safety and efficacy of an intervention, particularly how objective assessments might inform this process. Objective The aim of this review was to investigate the cited evidence underpinning...
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Following publication of the original article [1], the authors reported an error in the author group.
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Obesity plays an important role in the development of chronic diseases like cardiovascular diseases and diabetes. The possible underlying mechanism for this connection is that adipose tissue secretes an array ...
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Publication date: Available online 14 April 2020Source: Journal of Controlled ReleaseAuthor(s): Ning Liao, Bing Pang, Han Jin, Xiaoguang Xu, Lu Yan, Huixin Li, Dongyan Shao, Junling Shi
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Publication date: Available online 14 April 2020Source: Journal of Controlled ReleaseAuthor(s): Firas Al-Zubaydi, Dayuan Gao, Dipti Kakkar, Shike Li, Derek Adler, Jennifer Holloway, Zoltan Szekely, Zichao Gu, Nancy Chan, Shicha Kumar, Susan Love, Patrick J. Sinko
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Related ArticlesSurface analysis of an eagle talon from Krapina. Sci Rep. 2020 Apr 14;10(1):6329 Authors: Radovčić D, Birarda G, Sršen AO, Vaccari L, Radovčić J, Frayer DW Abstract The Krapina white-tailed eagle talons represent a kind of jewelry worn by Krapina Neandertals some 130,000 years ago. New inspection of one Krapina talon (386.1) revealed a fiber, sealed by a thin silicate coating, adhering to the surface within a wide cut mark, as well as...
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Related ArticlesToxicity of Carlina Oxide-A Natural Polyacetylene from the Carlina acaulis Roots-In Vitro and In Vivo Study. Toxins (Basel). 2020 Apr 09;12(4): Authors: Wnorowski A, Wnorowska S, Wojas-Krawczyk K, Grenda A, Staniak M, Michalak A, Woźniak S, Matosiuk D, Biała G, Wójciak M, Sowa I, Krawczyk P, Strzemski M Abstract There are several reports indicating that the roots of the Carlina acaulis L. used to be commonly applied as a treatment measure...
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Publication date: Available online 14 April 2020Source: Trends in ImmunologyAuthor(s): Shelley M. Lawrence, Ross Corriden, Victor Nizet
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J. Intell., Vol. 8, Pages 17: The Relation of Scientific Creativity and Evaluation of Scientific Impact to Scientific Reasoning and General Intelligence Journal of Intelligence doi: 10.3390/jintelligence8020017 Authors: Sternberg Todhunter Litvak Sternberg In many nations, grades and standardized test scores are used to select students for programs of scientific study. We suggest that the skills that these assessments measure are related to success in science, but only peripherally...
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J. Intell., Vol. 8, Pages 16: Imagine: Design for Creative Thinking, Learning, and Assessment in Schools Journal of Intelligence doi: 10.3390/jintelligence8020016 Authors: Yigal Rosen Kristin Stoeffler Vanessa Simmering Although not generally included in classroom activities of the past, cultivating creative thinking is considered one of the core strands in future-focused learning in schools. Learning focused on creative thinking is uncommon in school, mainly due to a lack of consensus...
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Related ArticlesDental clearance of cancer patients - A preventive step in oncology therapy. Oral Oncol. 2020 Apr 10;:104677 Authors: Barrett R, Tasgaonkar N PMID: 32284214 [PubMed - as supplied by publisher]
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Upper airway morphological changes in obstructive sleep apnoea: effect of age on pharyngeal anatomy.
Related ArticlesUpper airway morphological changes in obstructive sleep apnoea: effect of age on pharyngeal anatomy. J Laryngol Otol. 2020 Apr 14;:1-8 Authors: Gao F, Li YR, Xu W, An YS, Wang HJ, Xian JF, Han DM Abstract OBJECTIVE: To evaluate the upper airway morphology changes associated with ageing in adult Chinese patients with obstructive sleep apnoea. METHODS: A total of 124 male patients diagnosed with obstructive sleep apnoea by overnight...
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Publication date: Available online 14 April 2020Source: Experimental Cell ResearchAuthor(s): Iñaki Merino-Valverde, Emanuela Greco, Maria Abad
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Abstract Background Glandular odontogenic cyst (GOC) is an extremely rare developmental jawbone cyst, tending to recurrence owing to its aggressive behavior. There has been no reported case of presence of GOC simultaneous with odontoma. We presented a case of GOC associated with odontoma with special reference to the diagnostic imaging and the histopathological features. Case...
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Abstract Patients with anosmia exhibit structural and functional brain abnormalities. The present study explored changes in brain white matter (WM) in non-neurodegenerative anosmia using diffusion-tensor-based network analysis. Twenty patients with anosmia and sixteen healthy controls were recruited in the cross-sectional, case–control study. Participants underwent olfactory tests (orthonasal and retronasal), neuropsychological assessment (cognitive function and depressive symptoms)...
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We study scattering theory for parameter models of finitely many relativistic -sphere and -sphere plus Coulomb interactions. We provide the mathematical definitions of the Hamiltonians, solve the resolvent equations, and compute the nonrelativistic limits for both models. We obtain new results related to spectral properties and scattering data.
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